ProRule PRU01197
General rule information
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| Accession | PRU01197 |
| Dates | 2-JAN-2018 (Created)
19-NOV-2022 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51850; KARI_N |
Name | KARI N-terminal domain |
| Function | Ketol-acid reductoisomerase (KARI; EC 1.1.1.86), also known as acetohydroxy acid isomeroreductase (AHIR or AHAIR), catalyzes the conversion of acetohydroxy acids into dihydroxy valerates in the second step of the biosynthetic pathway for the essential branched-chain amino acids valine, leucine, and isoleucine. KARIs are composed of two types of domains, an N- terminal Rossmann fold domain and one or two C-terminal knotted domains. |
| Scope(s) |
Bacteria Archaea Eukaryota |
| Example(s) | A7GMU0 (ILVC_BACCN); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the ketol-acid reductoisomerase family. |
Keywords
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Gene Ontology
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| GO:0004455; Molecular function:ketol-acid reductoisomerase activity | |
| GO:0009097; Biological process:isoleucine biosynthetic process | |
| GO:0009099; Biological process:valine biosynthetic process | |
| case <FTGroup:1> | |
| GO:0050661; Molecular function:NADP binding | |
Features
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| From: PS51850 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="KARI N-terminal Rossmann #" | |||||||||
| BINDING | 27 | 30 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
1 | ||||||||
| ACT_SITE | 110 | 110 | H | |||||||||
| BINDING | 50 | 50 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
R | 1 | |||||||
| BINDING | 55 | 55 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
S | 1 | |||||||
| BINDING | 136 | 136 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
G | 1 | |||||||
Additional information
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| Size range | 135-205 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [49] Bacteria [593] Eukaryota [7] All [ 649 ]
- Retrieve set of proteins with 3D structure for this domain