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ProRule PRU01242


General rule information [?]

Accession PRU01242
Dates 10-MAY-2019 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51894; CV_3CL_PRO
Name Caliciviridae (CV) 3C-like protease (3CLpro) domain
Function The generation of mature Caliciviridae proteins requires that proteolytic clevages be effected at specific sites of the large polyprotein translated from the viral genomic RNA. This polyprotein processing is carried out by a 3C-like cysteine protease (3CLpro). The CV 3CLpro domain is predicted to contain a catalytic triad constituted of His, Asp and Cys residues, where the Cys likely represents the nucleophilic residue and Asp the acidic residue.
Scope(s) Viruses
Caliciviridae
Example(s) Q9QEJ5 (POLG_PESV);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=3.4.22.66;
case <FTGroup:1>

Comments [?]

case <FTGroup:1>
CATALYTIC ACTIVITY Reaction=Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu-|-Xaa and the P1' position is occupied by Gly-|-Yaa.; EC=3.4.22.66;

Keywords [?]

Hydrolase
Protease
Thiol protease
end case

Gene Ontology [?]

GO:0004197; Molecular function:cysteine-type endopeptidase activity

Features [?]

From: PS51894
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C24"
ACT_SITE 32 32 /note="For 3CLpro activity" H 1
ACT_SITE 53 53 /note="For 3CLpro activity" [DE] 1
ACT_SITE 116 116 /note="For 3CLpro activity" C 1

Additional information [?]

Size range 130-160 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]