ProRule PRU01253
General rule information
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| Accession | PRU01253 |
| Dates | 18-SEP-2019 (Created)
19-NOV-2022 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51905; ZF_UBZ1 |
Name | Zinc finger UBZ1-type |
| Function | The ubiquitin-binding zinc finger (UBZ) is a type of zinc- coordinating beta-beta-alpha fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families. Type 1 UBZs are CCHH-type zinc fingers found in tandem UBZ domains of TAX1-binding protein 1 (TAX1BP1). |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | Q9V9Y9 (SPNF_DROME); |
Propagated annotation
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Keywords
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| Zinc-finger | |
| case <Feature:PS51905:4=[CH]> and <Feature:PS51905:7=[CH]> and <Feature:PS51905:23=[CH]> and <Feature:PS51905:27=[CH]> | |
| Zinc | |
| Metal-binding | |
| end case | |
Features
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| From: PS51905 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <Feature:PS51905:4=C> and <Feature:PS51905:7=C> and <Feature:PS51905:23=H> and <Feature:PS51905:27=H> | ||||||||||||
| ZN_FING | from | to | /note="UBZ1-type #" | |||||||||
| else case <Feature:PS51905:4=[CH]> and <Feature:PS51905:7=[CH]> and <Feature:PS51905:23=[CH]> and <Feature:PS51905:27=[CH]> | ||||||||||||
| ZN_FING | from | to | /note="UBZ1-type #; atypical" | |||||||||
| else | ||||||||||||
| ZN_FING | from | to | /note="UBZ1-type #; degenerate" | |||||||||
| end case | ||||||||||||
| BINDING | 4 | 4 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 7 | 7 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 23 | 23 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 27 | 27 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
Additional information
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| Size range | 20-30 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-2 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [24] All [ 24 ]
- Retrieve set of proteins with 3D structure for this domain