ProRule PRU01256

Accession	PRU01256
Dates	19-SEP-2019 (Created) 19-NOV-2022 (Last updated, Version 6)
Data class	Domain;
Predictors	PROSITE; PS51908; ZF_UBZ4
Name	Zinc finger UBZ4-type
Function	The ubiquitin-binding zinc finger (UBZ) is a type of zinc- coordinating beta-beta-alpha fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families. Type 4 UBZs are CCHC-type zinc fingers found in Y-family translesion polymerase kappa, Werner helicase- interacting protein 1 (WRNIP1), and Rad18.
Scope(s)	Eukaryota
Example(s)	Q9UBT6 (POLK_HUMAN);

From: PS51908
Key	From	To	Description	Tag	Condition	FTGroup
case <Feature:PS51908:4=C> and <Feature:PS51908:7=C> and <Feature:PS51908:19=H> and <Feature:PS51908:23=C>
ZN_FING	from	to	/note="UBZ4-type #"
else case <Feature:PS51908:4=[CH]> and <Feature:PS51908:7=[CH]> and <Feature:PS51908:19=[CH]> and <Feature:PS51908:23=[CH]>
ZN_FING	from	to	/note="UBZ4-type #; atypical"
else
ZN_FING	from	to	/note="UBZ4-type #; degenerate"
end case
BINDING	4	4	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	7	7	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	19	19	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	23	23	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1