There has been a number of studies relative to the specificity of cAMP- and
cGMP-dependent protein kinases [1,2,3]. Both types of kinases appear to share
a preference for the phosphorylation of serine or threonine residues found
close to at least two consecutive N-terminal basic residues. It is important
to note that there are quite a number of exceptions to this rule.
June 1988 / First entry.
PROSITE method (with tools and information) covered by this documentation:
Fremisco J.R., Glass D.B., Krebs E.G.
J. Biol. Chem. 255:4240-4245(1980).
Glass D.B., Smith S.B.
Phosphorylation by cyclic GMP-dependent protein kinase of a synthetic peptide corresponding to the autophosphorylation site in the enzyme.
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