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PROSITE documentation PDOC00056

Ribosomal protein S18 signature

Description:

Ribosomal protein S18 is one of the proteins from the small ribosomal subunit. subunit. In Escherichia coli, S18 has been involved in aminoacyl-tRNA binding [1]. It appears to be situated at the tRNA A-site of the ribosome. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [2], groups:

  • Eubacterial S18.
  • Algal and plant chloroplast S18.
  • Cyanelle S18.

As a signature pattern, we selected a conserved region in the central section of the protein. This region contains two basic residues which may be involved in RNA-binding.

Last update:

April 2006 / Pattern revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

RIBOSOMAL_S18, PS00057; Ribosomal protein S18 signature  (PATTERN)
Consensus pattern: [IVRLP]-[DYN]-[YLF]-x(2,3)-[LIVMTPFS]-x(2)-[LIVM]-x(2)-[FYTS]-[LIVMT]-[STNQG]-[DERPN]-x(1,2)-[GYAH]-[KCR]-[LIVM]-x(3)-[RHG]-[LIVMASR]
Sequences known to belong to this class detected by the pattern: ALL, except for Euglena gracilis S18
Other sequence(s) detected in Swiss-Prot: NONE
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00057
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00057
• Scan Swiss-Prot/TrEMBL entries against PS00057
• view ligand binding statistics
Matching PDB structures: 1FJG 1GIX 1HNW 1HNX ... [ALL]

References:

1 AuthorsMcDougall J., Choli T., Kruft V., Kapp U., Wittmann-Liebold B.
TitleThe complete amino acid sequence of ribosomal protein S18 from the moderate thermophile Bacillus stearothermophilus.
SourceFEBS Lett. 245:253-260(1989).
PubMed ID2647521
2 AuthorsOtaka E., Hashimoto T., Mizuta K.
SourceProtein Seq. Data Anal. 5:285-300(1993).

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