|PROSITE documentation PDOC00102
Phosphoglycerate kinase signature
Phosphoglycerate kinase (EC 220.127.116.11) (PGK)  catalyzes the second step in
the second phase of glycolysis, the reversible conversion of 1,3-diphospho-glycerate to 3-phosphoglycerate with generation of one molecule of ATP. PGK
is found in all living organisms and its sequence has been highly conserved
throughout evolution. It is a two-domain protein; each domain is composed of
six repeats of an α/β structural motif. As a signature pattern for
PGK's, we selected a conserved region in the N-terminal region.
July 1999 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|PGLYCERATE_KINASE, PS00111; Phosphoglycerate kinase signature (PATTERN)
|Sequences in UniProtKB/Swiss-Prot known to belong to this class detected by PS00111:
||626 true positives with 86 false negatives and 9 partials.
|Other sequence(s) in UniProtKB/Swiss-Prot detected by PS00111:
|Matching PDB structures:
13PK 16PK 1FW8 1HDI ... [ALL]
||Watson H.C., Littlechild J.A.
||Isoenzymes of phosphoglycerate kinase: evolutionary conservation of the structure of this glycolytic enzyme.
||Biochem. Soc. Trans. 18:187-190(1990).
PROSITE is copyright. It is produced by the SIB Swiss Institute
Bioinformatics. There are no restrictions on its use by non-profit
institutions as long as its content is in no way modified. Usage by and
for commercial entities requires a license agreement. For information
about the licensing scheme send an email to
View entry in original PROSITE document format
View entry in raw text format (no links)