PROSITE documentation PDOC00102

Phosphoglycerate kinase signature

Description

Phosphoglycerate kinase (EC 2.7.2.3) (PGK) [1] catalyzes the second step in the second phase of glycolysis, the reversible conversion of 1,3-diphospho-glycerate to 3-phosphoglycerate with generation of one molecule of ATP. PGK is found in all living organisms and its sequence has been highly conserved throughout evolution. It is a two-domain protein; each domain is composed of six repeats of an α/β structural motif. As a signature pattern for PGK's, we selected a conserved region in the N-terminal region.

Last update:

July 1999 / Pattern and text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

PGLYCERATE_KINASE, PS00111; Phosphoglycerate kinase signature  (PATTERN)
Consensus pattern: [KRHGTCVN]-[VT]-[LIVMF]-[LIVMC]-R-x-D-x-N-[SACV]-P
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE
• Retrieve an alignment of Swiss-Prot true positive hits:
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• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00111
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00111
• Scan Swiss-Prot/TrEMBL entries against PS00111
• view ligand binding statistics
Matching PDB structures: 13PK 16PK 1FW8 1HDI ... [ALL]

Reference

1 Authors Watson H.C., Littlechild J.A.
Title Isoenzymes of phosphoglycerate kinase: evolutionary conservation of the structure of this glycolytic enzyme.
Source Biochem. Soc. Trans. 18:187-190(1990).
PubMed ID 2379683

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