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PROSITE documentation PDOC00384

Ribosomal protein L2 signature

Description:

Ribosomal protein L2 is one of the proteins from the large ribosomal subunit. In Escherichia coli, L2 is known to bind to the 23S rRNA and to have peptidyltransferase activity. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [1,2], groups:

  • Eubacterial L2.
  • Algal and plant chloroplast L2.
  • Cyanelle L2.
  • Archaebacterial L2.
  • Plant L2.
  • Slime mold L2.
  • Marchantia polymorpha mitochondrial L2.
  • Paramecium tetraurelia mitochondrial L2.
  • Fission yeast K5, K37 and KD4.
  • Yeast YL6.
  • Vertebrate L8.

As a signature pattern, we selected the best conserved region located in the C-terminal section of these proteins.

Last update:

November 1997 / Text revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

RIBOSOMAL_L2, PS00467; Ribosomal protein L2 signature  (PATTERN)
Consensus pattern: P-x(2)-R-G-[STAIV](2)-x-N-[APK]-x-[DE]
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: 4
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00467
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00467
• Scan Swiss-Prot/TrEMBL entries against PS00467
• view ligand binding statistics
Matching PDB structures: 1FFK 1GIY 1JJ2 1K5Y ... [ALL]

References:

1 AuthorsMarty I., Meyer Y.
TitlecDNA nucleotide sequence and expression of a tobacco cytoplasmic ribosomal protein L2 gene.
SourceNucleic Acids Res. 20:1517-1522(1992).
PubMed ID1579444
2 AuthorsOtaka E., Hashimoto T., Mizuta K., Suzuki K.
SourceProtein Seq. Data Anal. 5:301-313(1993).

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