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Pyrokinins are insect neuropeptides that mediate visceral muscle contractile
activity (myotropic activity) . The pyrokinins are peptides of 8 to 16
amino acids that share the amide-blocked C-terminal sequence Phe-Xaa-Pro-Arg-Leu-NH2, where Xaa is either Gly, Ser, Thr, or Val. This pentapeptide is
sufficient to elicit a significant myotropic activity. The same C-terminal
sequence is present in the following insect neuropeptides:
Pheromone biosynthesis activating neuropeptide (PBAN). PBAN is a hormone
that controls sex pheromone production in female moths as well as
eliciting pyrokinin-like myotropic activity.
Pheromonotropin , from Pseudaletia separata, which also controls sex
Bombyx mori diapause hormone (DH).
If the sequence is processed, the peptide ends with a C-terminal
amidated Leu while in a precursor sequence it is always followed by a Gly
which subsequently provides the amide group.
December 1992 / Text revised.
PROSITE method (with tools and information) covered by this documentation:
Nachman R.J., Roberts V.A., Dyson H.J., Holman G.M., Tainer J.A.
Active conformation of an insect neuropeptide family.
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