Due to maintenance work, this service may be impaired on Sunday February 1st between 12.00 pm and 06.00 pm CEST.
PROSITE documentation PDOC00534

Histidinol dehydrogenase signature




Description

Histidinol dehydrogenase (EC 1.1.1.23) (HDH) catalyzes the terminal step in the biosynthesis of histidine in bacteria, fungi, and plants, the four-electron oxidation of L-histidinol to histidine.

In bacteria HDH is a single chain polypeptide; in fungi it is the C-terminal domain of a multifunctional enzyme which catalyzes three different steps of histidine biosynthesis; and in plants it is expressed as nuclear encoded protein precursor which is exported to the chloroplast [1].

As a signature pattern we selected a highly conserved region located in the central part of HDH. This region does not correspond to the part of the enzyme that, in most, but not all HDH sequences contains a cysteine residue which, in Salmonella typhimurium, has been said [2] to be important for the catalytic activity of the enzyme.

Last update:

April 2006 / Pattern revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

HISOL_DEHYDROGENASE, PS00611; Histidinol dehydrogenase signature  (PATTERN)


References

1AuthorsNagai A., Ward E., Beck J., Tada S., Chang J.-Y., Scheidegger A., Ryals J.
TitleStructural and functional conservation of histidinol dehydrogenase between plants and microbes.
SourceProc. Natl. Acad. Sci. U.S.A. 88:4133-4137(1991).
PubMed ID2034659

2AuthorsGrubmeyer C.T., Gray W.R.
TitleA cysteine residue (cysteine-116) in the histidinol binding site of histidinol dehydrogenase.
SourceBiochemistry 25:4778-4784(1986).
PubMed ID3533140



PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to
Prosite License or see: prosite_license.html.

Miscellaneous

View entry in original PROSITE document format
View entry in raw text format (no links)