Home ScanProsite ProRule Documents Downloads Links Funding
PROSITE documentation PDOC00545

GHMP kinases putative ATP-binding domain

Description:

The following kinases contains, in their N-terminal section, a conserved Gly/ Ser-rich region which is probably involved in the binding of ATP [1]. These kinases are listed below.

We have called this group of kinases 'GHMP' (from the first letter of their substrate).

Last update:

December 2001 / Pattern and text revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

GHMP_KINASES_ATP, PS00627; GHMP kinases putative ATP-binding domain  (PATTERN)
Consensus pattern: [LIVM]-[PK]-x-[GSTA]-x(0,1)-G-[LM]-[GS]-S-S-[GSA]-[GSTAC]
Sequences known to belong to this class detected by the pattern: ALL, except for P.aeruginosa homoserine kinase which does not seem to be homologous with the other GHMP kinases
Other sequence(s) detected in Swiss-Prot: 1
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00627
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00627
• Scan Swiss-Prot/TrEMBL entries against PS00627
• view ligand binding statistics
Matching PDB structures: 1FWK 1FWL 1H72 1H73 ... [ALL]

Reference:

1 AuthorsTsay Y.H., Robinson G.W.
TitleCloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase.
SourceMol. Cell. Biol. 11:620-631(1991).
PubMed ID1846667

Copyright:

PROSITE is copyright. It is produced by the Swiss Institute of Bioinformatics (SIB). There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: http://www.expasy.org/prosite/prosite_license.htm.

Miscellaneous:

View entry in original PROSITE document format
View entry in raw text format (no links)