|PROSITE documentation PDOC00549
Ribosomal protein S4 signature
Ribosomal protein S4 is one of the proteins from the small ribosomal subunit.
In Escherichia coli, S4 is known to bind directly to 16S ribosomal RNA.
Mutations in S4 have been shown to increase translational error frequencies.
It belongs to a family of ribosomal proteins which, on the basis of sequence
similarities [1,2], groups:
- Eubacterial S4.
- Algal and plant chloroplast S4.
- Cyanelle S4.
- Archaebacterial S4.
- Mammalian S9.
- Yeast YS11 (SUP46).
- Marchantia polymorpha mitochondrial S4.
- Dictyostelium discoideum rp1024.
- Yeast protein NAM9 . NAM9 has been characterized as a suppressor for
ochre mutations in mitochondrial DNA. It could be a ribosomal protein that
acts as a suppressor by decreasing translation accuracy.
S4 is a protein of 171 to 205 amino-acid residues (except for NAM9 which is
much larger). The signature pattern for this protein is based on a conserved
region located in the central section of these proteins.
April 2006 / Pattern revised.
PROSITE method (with tools and information) covered by this documentation:
|RIBOSOMAL_S4, PS00632; Ribosomal protein S4 signature (PATTERN)
|Sequences known to belong to this class detected by the pattern:
|Other sequence(s) detected in Swiss-Prot:
|Matching PDB structures:
1C05 1C06 1EG0 1FJG ... [ALL]
||Mizuta K., Hashimoto T., Suzuki K.I., Otaka E.
||Yeast ribosomal proteins: XII. YS11 of Saccharomyces cerevisiae is a homologue to E. coli S4 according to the gene analysis.
||Nucleic Acids Res. 19:2603-2608(1991).
||Otaka E., Hashimoto T., Mizuta K.
||Protein Seq. Data Anal. 5:285-300(1993).
||Boguta M., Dmochowska A., Borsuk P., Wrobel K., Gargouri A., Lazowska J., Slonimski P.P., Szczesniak B., Kruszewska A.
||NAM9 nuclear suppressor of mitochondrial ochre mutations in Saccharomyces cerevisiae codes for a protein homologous to S4 ribosomal proteins from chloroplasts, bacteria, and eucaryotes.
||Mol. Cell. Biol. 12:402-412(1992).
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