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PROSITE documentation PDOC00751

Mannitol dehydrogenases signature

Description:

The following dehydrogenases have been shown [1] to be evolutionary related:

  • Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17) (gene mtlD), which catalyzes the NAD-dependent reduction of mannitol 1-phosphate into fructose 6-phosphate.
  • Mannitol 2-dehydrogenase (EC 1.1.1.67) (gene mtlK), which catalyzes the NAD-dependent reduction of mannitol into fructose.
  • Mannonate oxidoreductase (EC 1.1.1.57) (fructuronate reductase) (gene uxuB), which catalyzes the NAD-dependent reduction of fructuronate into mannonate.
  • Escherichia coli hypothetical protein ydfI.
  • Escherichia coli hypothetical protein yeiQ.
  • Yeast hypothetical protein YEL070w.

As a signature pattern, we selected a conserved region located in the central section of these enzymes.

Last update:

November 1997 / Pattern and text revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

MANNITOL_DHGENASE, PS00974; Mannitol dehydrogenases signature  (PATTERN)
Consensus pattern: [LIVMY]-x-[FS]-x(2)-[STAGCV]-x-V-D-R-[IV]-x-[PS]
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: 1
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00974
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00974
• Scan Swiss-Prot/TrEMBL entries against PS00974
• view ligand binding statistics
Matching PDB structures: 3H2Z [ALL]

Reference:

1 AuthorsSchneider K.-H., Giffhorn F., Kaplan S.
TitleCloning, nucleotide sequence and characterization of the mannitol dehydrogenase gene from Rhodobacter sphaeroides.
SourceJ. Gen. Microbiol. 139:2475-2484(1993).
PubMed ID8254318

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