|PROSITE documentation PDOC00751
Mannitol dehydrogenases signature
The following dehydrogenases have been shown  to be evolutionary related:
- Mannitol-1-phosphate 5-dehydrogenase (EC 22.214.171.124) (gene mtlD), which
catalyzes the NAD-dependent reduction of mannitol 1-phosphate into fructose
- Mannitol 2-dehydrogenase (EC 126.96.36.199) (gene mtlK), which catalyzes the
NAD-dependent reduction of mannitol into fructose.
- Mannonate oxidoreductase (EC 188.8.131.52) (fructuronate reductase) (gene
uxuB), which catalyzes the NAD-dependent reduction of fructuronate into
- Escherichia coli hypothetical protein ydfI.
- Escherichia coli hypothetical protein yeiQ.
- Yeast hypothetical protein YEL070w.
As a signature pattern, we selected a conserved region located in the central
section of these enzymes.
November 1997 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|MANNITOL_DHGENASE, PS00974; Mannitol dehydrogenases signature (PATTERN)
|Sequences in UniProtKB/Swiss-Prot known to belong to this class detected by PS00974:
||126 true positives with 42 false negatives and 1 partial.
|Other sequence(s) in UniProtKB/Swiss-Prot detected by PS00974:
||1 false positive.
|Matching PDB structures:
||Schneider K.-H., Giffhorn F., Kaplan S.
||Cloning, nucleotide sequence and characterization of the mannitol dehydrogenase gene from Rhodobacter sphaeroides.
||J. Gen. Microbiol. 139:2475-2484(1993).
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