|PROSITE documentation PDOC00815|
Pyridoxamine 5'-phosphate oxidase (EC 184.108.40.206) is a FMN flavoprotein involved in the de novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate. It oxidizes pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P. The sequences of the enzyme from bacterial (genes pdxH or fprA)  and fungal (gene PDX3)  sources show that this protein has been highly conserved throughout evolution.
PdxH is evolutionary related  to one of the enzymes in the phenazine biosynthesis protein pathway, phzD (also known as phzG).
As a signature pattern, we selected a highly conserved region located in the C-terminal part of these enzymes.Last update:
April 2006 / Pattern revised.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Lam H.-M., Winkler M.E.|
|Title||Characterization of the complex pdxH-tyrS operon of Escherichia coli K-12 and pleiotropic phenotypes caused by pdxH insertion mutations.|
|Source||J. Bacteriol. 174:6033-6045(1992).|
|2||Authors||Loubbardi A., Marcireau C., Karst F., Guilloton M.|
|Title||Sterol uptake induced by an impairment of pyridoxal phosphate synthesis in Saccharomyces cerevisiae: cloning and sequencing of the PDX3 gene encoding pyridoxine (pyridoxamine) phosphate oxidase.|
|Source||J. Bacteriol. 177:1817-1823(1995).|
|3||Authors||Pierson L.S. III, Gaffney T., Lam S., Gong F.|
|Title||Molecular analysis of genes encoding phenazine biosynthesis in the biological control bacterium. Pseudomonas aureofaciens 30-84.|
|Source||FEMS Microbiol. Lett. 134:299-307(1995).|