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PROSITE documentation PDOC00868

Shikimate kinase signature

Description:

Shikimate kinase (EC 2.7.1.71) catalyzes the fifth step in the biosynthesis from chorismate of the aromatic amino acids (the shikimate pathway) in bacteria (gene aroK or aroL), plants and in fungi (where it is part of a multifunctional enzyme which catalyzes five consecutive steps in this pathway).

Shikimate kinase is a small protein of about 200 residues. As a signature pattern we selected a conserved region that contains a run of three glycines.

Note:

Proteins belonging to this family also contain a copy of the ATP/GTP- binding motif 'A' (P-loop) (see <PDOC00017>).

Last update:

November 1995 / First entry.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

SHIKIMATE_KINASE, PS01128; Shikimate kinase signature  (PATTERN)
Consensus pattern: [KR]-x(2)-E-x(3)-[LIVMF]-x(8,12)-[LIVMF](2)-[SA]-x-G(3)-x-[LIVMF]
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: 2.
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS01128
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS01128
• Scan Swiss-Prot/TrEMBL entries against PS01128
• view ligand binding statistics
Matching PDB structures: 1E6C 1KAG 1L4U 1L4Y ... [ALL]

Reference:

Copyright:

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