|PROSITE documentation PDOC00925|
Iodothyronine deiodinase (EC 18.104.22.168) (DI) [1,2] is the vertebrate enzyme responsible for the deiodination of the prohormone thyroxine (T4 or 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3 (3,5,3'-triiodothyronine) and of T3 into the inactive metabolite T2 (3,3'-diiodothyronine). Three types of DI are known. All known DI are proteins of about 250 residues that contain a selenocysteine at their active site.
As a signature pattern we selected the best conserved region, it is located in the central part of the enzyme and contains the active site selenocysteine.Last update:
January 2008 / Pattern updated.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||St Germain D.L.|
|Source||(In) Thyroid hormone metabolism: molecular biology and alternative pathways, Wu S.Y., Visser T.J., Eds., pp45-66, CRC Press, Ann Arbor, (1994).|
|2||Authors||Davey J.C., Becker K.B., Schneider M.J., St Germain D.L., Galton V.A.|
|Title||Cloning of a cDNA for the type II iodothyronine deiodinase.|
|Source||J. Biol. Chem. 270:26786-26789(1995).|