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Iodothyronine deiodinase (EC 1.97.1.10) (DI) [1,2] is the vertebrate enzyme responsible for the deiodination of the prohormone thyroxine (T4 or 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3 (3,5,3'-triiodothyronine) and of T3 into the inactive metabolite T2 (3,3'-diiodothyronine). Three types of DI are known. All known DI are proteins of about 250 residues that contain a selenocysteine at their active site.

As a signature pattern we selected the best conserved region, it is located in the central part of the enzyme and contains the active site selenocysteine.

January 2008 / Pattern updated.

PROSITE method (with tools and information) covered by this documentation:

T4_DEIODINASE, PS01205; Iodothyronine deiodinases active site  (PATTERN)

Consensus pattern: R-P-L-[IV]-x-[NS]-F-G-S-[CA]-[TS]-[CU]-P-x-F The C/U is the active site selenocysteine residue Sequences known to belong to this class detected by the pattern: ALL Other sequence(s) detected in Swiss-Prot: NONE

• Retrieve an alignment of Swiss-Prot true positive hits:   Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format • Retrieve the sequence logo from the alignment • Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS01205 • Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS01205 • Scan Swiss-Prot/TrEMBL entries against PS01205 • view ligand binding statistics

1	Authors	St Germain D.L.
	Source	(In) Thyroid hormone metabolism: molecular biology and alternative pathways, Wu S.Y., Visser T.J., Eds., pp45-66, CRC Press, Ann Arbor, (1994).

2	Authors	Davey J.C., Becker K.B., Schneider M.J., St Germain D.L., Galton V.A.
	Title	Cloning of a cDNA for the type II iodothyronine deiodinase.
	Source	J. Biol. Chem. 270:26786-26789(1995).
	PubMed ID	7592917

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