|PROSITE documentation PDOC00925
Iodothyronine deiodinases active site
Iodothyronine deiodinase (EC 188.8.131.52) (DI) [1,2] is the vertebrate enzyme
responsible for the deiodination of the prohormone thyroxine (T4 or 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3 (3,5,3'-triiodothyronine) and of T3 into the inactive metabolite T2 (3,3'-diiodothyronine). Three types of DI are known. All known DI are proteins of
about 250 residues that contain a selenocysteine at their active site.
As a signature pattern we selected the best conserved region, it is located
in the central part of the enzyme and contains the active site selenocysteine.
January 2008 / Pattern updated.
PROSITE method (with tools and information) covered by this documentation:
|T4_DEIODINASE, PS01205; Iodothyronine deiodinases active site (PATTERN)
The C/U is the active site selenocysteine residue
|Sequences known to belong to this class detected by the pattern:
|Other sequence(s) detected in Swiss-Prot:
||St Germain D.L.
||(In) Thyroid hormone metabolism: molecular biology and alternative pathways, Wu S.Y., Visser T.J., Eds., pp45-66, CRC Press, Ann Arbor, (1994).
||Davey J.C., Becker K.B., Schneider M.J., St Germain D.L., Galton V.A.
||Cloning of a cDNA for the type II iodothyronine deiodinase.
||J. Biol. Chem. 270:26786-26789(1995).
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