|PROSITE documentation PDOC00964
Endogenous opioids neuropeptides precursors signature
Vertebrate endogenous opioids neuropeptides are released by post-translational
proteolytic processing of precursor proteins. These precursor proteins consist
of a signal sequence followed by a conserved region of about 50 residues, a
variable length region and the sequence of the various neuropeptides. Three
types of precursors are currently known:
- Preproenkephalin A (gene PENK) which is processed to produce the peptides
Met-enkephalin (6 copies) and Leu-enkephalin,
- Preproenkephalin B (gene PDYN) which is processed to produce the peptides
neoendorphin, dynorphin, leumorphin, rimorphin and leu-enkephalin.
- Prepronocipeptin (gene PNOC) which is processed to produce the peptides
nociceptin (orphanin FQ) as well as two other potential neuropeptides.
The conserved region in the N-terminal of these precursors contains six
cysteines that are probably involved in disulfide bonds. This region could be
important for the processing of the neuropeptides .
May 2004 / Text revised.
PROSITE method (with tools and information) covered by this documentation:
|OPIOIDS_PRECURSOR, PS01252; Endogenous opioids neuropeptides precursors signature (PATTERN)
The 6 C's may be involved in disulfide bonds
|Sequences in UniProtKB/Swiss-Prot known to belong to this class detected by PS01252:
||17 true positives with 3 partials.
|Other sequence(s) in UniProtKB/Swiss-Prot detected by PS01252:
||Mollereau C., Simons M.-J., Soularue P., Liners F., Vassart G., Meunier J.-C., Parmentier M.
||Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene.
||Proc. Natl. Acad. Sci. U.S.A. 93:8666-8670(1996).
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