Home ScanProsite ProRule Documents Downloads Links Funding
PROSITE documentation PDOC00982

Peptidase family U32 signature

Description:

Porphyromonas gingivalis collagenase (gene prtC) [1] is an enzyme that degrades type I collagen and that seems to require a metal cofactor. PrtC is evolutionary related to a number of uncharacterized proteins:

  • Escherichia coli hypothetical protein ydcP.
  • Escherichia coli hypothetical protein yegQ, and HI0419, the corresponding Haemophilus influenzae protein.
  • Escherichia coli hypothetical protein yhbU.
  • Helicobacter pylori hypothetical protein HP0169.
  • Methanococcus jannaschii hypothetical protein MJ0090.

A well conserved region containing two cysteines can be used as a signature pattern for these proteins.

Note:

These proteins belong to family U32 in the classification of peptidases [E1].

Last update:

November 1997 / First entry.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

PEPTIDASE_U32, PS01276; Peptidase family U32 signature  (PATTERN)
Consensus pattern: E-x-F-x(2)-G-[SA]-[LIVM]-C-x(4)-G-x-C-x-[LIVM]-S
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE.
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS01276
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS01276
• Scan Swiss-Prot/TrEMBL entries against PS01276
• view ligand binding statistics
Matching PDB structures: 1LK8 [ALL]

References:

1 AuthorsKato T., Takahashi N., Kuramitsu H.K.
TitleSequence analysis and characterization of the Porphyromonas gingivalis prtC gene, which expresses a novel collagenase activity.
SourceJ. Bacteriol. 174:3889-3895(1992).
PubMed ID1317840
E1
Sourcehttp://www.expasy.org/cgi-bin/lists?peptidas.txt

Copyright:

PROSITE is copyright. It is produced by the Swiss Institute of Bioinformatics (SIB). There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: http://www.expasy.org/prosite/prosite_license.htm.

Miscellaneous:

View entry in original PROSITE document format
View entry in raw text format (no links)