Home ScanProsite ProRule Documents Downloads Links Funding
PROSITE documentation PDOC01000

Dihydrodipicolinate reductase signature

Description:

Dihydrodipicolinate reductase (EC 1.3.1.26) catalyzes the second step in the biosynthesis of diaminopimelic acid and lysine, the NAD or NADP-dependent reduction of 2,3-dihydrodipicolinate into 2,3,4,5-tetrahydrodipicolinate. This enzyme is present in bacteria (gene dapB) and higher plants.

As a signature pattern we selected the best conserved region in this enzyme. It is located in the central section and is part of the substrate-binding region [1].

Last update:

December 2004 / Pattern and text revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

DAPB, PS01298; Dihydrodipicolinate reductase signature  (PATTERN)
Consensus pattern: [ERND]-[IVL]-x-[ED]-x-H-x(3)-K-x-[DE]-x(2)-S-[GA]-[TAS]-[ALCGS]
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS01298
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS01298
• Scan Swiss-Prot/TrEMBL entries against PS01298
• view ligand binding statistics
Matching PDB structures: 1ARZ 1C3V 1DIH 1DRU ... [ALL]

Reference:

1 AuthorsScapin G., Blanchard J.S., Sacchettini J.C.
TitleThree-dimensional structure of Escherichia coli dihydrodipicolinate reductase.
SourceBiochemistry 34:3502-3512(1995).
PubMed ID7893645

Copyright:

PROSITE is copyright. It is produced by the Swiss Institute of Bioinformatics (SIB). There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: http://www.expasy.org/prosite/prosite_license.htm.

Miscellaneous:

View entry in original PROSITE document format
View entry in raw text format (no links)