|PROSITE documentation PDOC50077
HEAT repeat profile
The HEAT repeat is a tandemly repeated, 37-47 amino acids long module
occurring in a number of cytoplasmic proteins, including the four name-giving
proteins huntingtin, elongation factor 3 (EF3), the 65 Kd α regulatory
subunit of protein phosphatase 2A (PP2A) and the yeast PI3-kinase TOR1 .
Arrays of HEAT repeats consists of 3 to 36 units forming a rod-like helical
structure and appear to function as protein-protein interaction surfaces. It
has been noted that many HEAT repeat-containing proteins are involved in
intracellular transport processes.
In the crystal structure of PP2A PR65/A , the HEAT repeats consist of pairs
of antiparallel α helices.
December 2001 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|HEAT_REPEAT, PS50077; HEAT repeat profile (MATRIX)
|Sequences known to belong to this class detected by the profile:
|Other sequence(s) detected in Swiss-Prot:
|Matching PDB structures:
1B3U 1F59 1GCJ 1IBR ... [ALL]
||Andrade M.A., Bork P.
||HEAT repeats in the Huntington's disease protein.
||Nat. Genet. 11:115-116(1995).
||Groves M.R., Hanlon N., Turowski P., Hemmings B.A., Barford D.
||The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.
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