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The HEAT repeat is a tandemly repeated, 37-47 amino acids long module occurring in a number of cytoplasmic proteins, including the four name-giving proteins huntingtin, elongation factor 3 (EF3), the 65 Kd α regulatory subunit of protein phosphatase 2A (PP2A) and the yeast PI3-kinase TOR1 [1]. Arrays of HEAT repeats consists of 3 to 36 units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that many HEAT repeat-containing proteins are involved in intracellular transport processes.

In the crystal structure of PP2A PR65/A [2], the HEAT repeats consist of pairs of antiparallel α helices.

December 2001 / First entry.

PROSITE method (with tools and information) covered by this documentation:

HEAT_REPEAT, PS50077; HEAT repeat profile  (MATRIX)

Sequences known to belong to this class detected by the profile: ALL Other sequence(s) detected in Swiss-Prot: 1

• Domain architecture view of Swiss-Prot proteins matching PS50077 • Retrieve an alignment of Swiss-Prot true positive hits:   Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format • Retrieve the sequence logo from the alignment • Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS50077 • Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS50077 • Scan Swiss-Prot/TrEMBL entries against PS50077 • view ligand binding statistics

Matching PDB structures: 1B3U 1F59 1GCJ 1IBR ... [ALL]

1	Authors	Andrade M.A., Bork P.
	Title	HEAT repeats in the Huntington's disease protein.
	Source	Nat. Genet. 11:115-116(1995).
	PubMed ID	7550332
	DOI	10.1038/ng1095-115

2	Authors	Groves M.R., Hanlon N., Turowski P., Hemmings B.A., Barford D.
	Title	The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.
	Source	Cell 96:99-110(1999).
	PubMed ID	9989501

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