|PROSITE documentation PDOC50215|
ADAMs are transmembrane proteins containing both a disintegrin (see <PDOC00351>) and a metalloprotease domain . About two third of the proteins with an ADAM type metalloprotease domain also contain the zinc protease pattern (see <PDOC00129>) which locates the active site of these proteases. As they contain an adhesion domain and a protease domain, ADAM proteins potentially have both cell adhesion and protease activities. They play a role in various biological processes, including fertilization, neurogenesis, myogenesis, embryonic TGF-α release and inflammatory response .
ADAMTS proteins  form a closely related family of proteases. In these proteins, the metalloprotease and disintegrin domains are flanked by thrombospondin type I (TSP1) repeat (see <PDOC50092>). ADAMTS proteins are soluble, extracellular matrix proteases those known substrates are other extracellular matrix proteins .
ADAM proteins also share the metalloprotease and disintegrin domains with the disintegrin class of peptides that are present in snake venom [2,4]. Together, they form the adamlysin/reprolysin subfamily of the metzincin superfamily of Zn-dependent metalloproteinases .
Some proteins known to contain an ADAM metalloprotease domain are listed below:
December 2001 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Wolfsberg T.G., Straight P.D., Gerena R.L., Huovila A.P., Primakoff P., Myles D.G., White J.M.|
|Title||ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain.|
|Source||Dev. Biol. 169:378-383(1995).|
|2||Authors||Primakoff P., Myles D.G.|
|Title||The ADAM gene family: surface proteins with adhesion and protease activity.|
|Source||Trends Genet. 16:83-87(2000).|
|3||Authors||Tang B.L., Hong W.|
|Title||ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats.|
|Source||FEBS Lett. 445:223-225(1999).|
|4||Authors||Black R.A., White J.M.|
|Title||ADAMs: focus on the protease domain.|
|Source||Curr. Opin. Cell Biol. 10:654-659(1998).|