|PROSITE documentation PDOC50822|
The Piwi box (or Sting domain) is an about 40 to 80 amino-acid conserved region, which was first identified in the C-terminal part of Drosophila Piwi and Sting proteins, and of related proteins from human, Caenorhabditis elegans, Arabidopsis thaliana, fission yeast and Dictyostelium discoideum [1,2]. It was later recognized that this conserved region is part of a larger 300-amino-acid domain, called Piwi, which is also found in some prokaryotic proteins of unknown function . The Piwi domain containing proteins are often involved in stem-cell maintenance and/or post-transcriptional gene silencing (PTGS) through RNA interference (RNAi), the mechanism through which double-stranded RNAs (dsRNAs) silence cognate genes . Neither the structure nor the function of the Piwi domain are known.
Some proteins known to contain a Piwi domain are listed below:
The profile we have developed covers the entire Piwi domain.Last update:
May 2002 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Cox D.N., Chao A., Baker J., Chang L., Qiao D., Lin H.|
|Title||A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal.|
|Source||Genes Dev. 12:3715-3727(1998).|
|2||Authors||Schmidt A., Palumbo G., Bozzetti M.P., Tritto P., Pimpinelli S., Schafer U.|
|Title||Genetic and molecular characterization of sting, a gene involved in crystal formation and meiotic drive in the male germ line of Drosophila melanogaster.|
|3||Authors||Cerutti L., Mian N., Bateman A.|
|Title||Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain.|
|Source||Trends Biochem. Sci. 25:481-482(2000).|
|4||Authors||Cox D.N., Chao A., Lin H.|
|Title||piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells.|