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	PROSITE documentation PDOC51271

The WINGS APART-LIKE (WAPL) protein of Drosophila melanogaster regulates heterochromatin structure. It is required to hold sister chromatids of meiotic heterochromatin together and is implicated in both heterochromatin pairing during female meiosis and the modulation of position-effect variegation (PEV). Although the high-sequence conservation is limited to a third of the protein sequence, a WAPL homologue has been identified in mammals. Mammalian WAPL may play a significant role in meiosis as does the Drosophila one. Human WAPL is overexpressed in invasive human cervical cancers and is often associated with cervical carcinogenesis [1,2].

The profile we developed covers the entire WAPL domain.

Last update:

January 2007 / Profile revised.

PROSITE method (with tools and information) covered by this documentation:

WAPL, PS51271; WAPL domain profile  (MATRIX)

• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 5
  • detected by PS51271: 4 (true positives)
  • undetected by PS51271: 1 (1 false negative and 0 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS51271:
  NONE.
• Domain architecture view of Swiss-Prot proteins matching PS51271
  
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS51271
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS51271
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS51271
• View ligand binding statistics of PS51271
• Matching PDB structures: 4K6J [ALL]

1	Authors	Oikawa K., Ohbayashi T., Kiyono T., Nishi H., Isaka K., Umezawa A., Kuroda M., Mukai K.
	Title	Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression.
	Source	Cancer Res. 64:3545-3549(2004).
	PubMed ID	15150110
	DOI	10.1158/0008-5472.CAN-03-3822

2	Authors	Kuroda M., Oikawa K., Ohbayashi T., Yoshida K., Yamada K., Mimura J., Matsuda Y., Fujii-Kuriyama Y., Mukai K.
	Title	A dioxin sensitive gene, mammalian WAPL, is implicated in spermatogenesis.
	Source	FEBS Lett. 579:167-172(2005).
	PubMed ID	15620708
	DOI	10.1016/j.febslet.2004.11.070

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