Entry: PS00064

General information about the entry

Entry name [info] L_LDH
Accession [info] PS00064
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); MAY-1991 (DATA UPDATE); MAY-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC00062
Associated ProRule [info] PRU10002

Name and characterization of the entry

Description [info] L-lactate dehydrogenase active site.
Pattern [info]
[LIVMA]-G-[EQ]-H-G-[DN]-[ST].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_06 which contains 551'385 sequence entries.


Total number of hits 306 in 306 different sequences
Number of true positive hits 298 in 298 different sequences
Number of 'unknown' hits 0
Number of false positive hits 8 in 8 different sequences
Number of false negative sequences 12
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 97.39 %
Recall (true positives / (true positives + false negatives)) 96.13 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 4
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
298 sequences

DHL2_WEICO  (P14295    ), LDH1_BACAN  (Q81RW4    ), LDH1_BACC1  (P62047    ), 
LDH1_BACCR  (Q81EP4    ), LDH1_BACCZ  (Q63CN1    ), LDH1_BACHK  (Q6HK31    ), 
LDH1_BIFL2  (E8MJ15    ), LDH1_BIFLO  (P59050    ), LDH1_CLOAB  (Q97MD1    ), 
LDH1_ENTFA  (Q839C1    ), LDH1_LACAC  (Q5FMB0    ), LDH1_LACJO  (P62052    ), 
LDH1_LACLA  (Q01462    ), LDH1_LACLC  (P04034    ), LDH1_LACPL  (P56512    ), 
LDH1_LISIN  (Q92F65    ), LDH1_LISMF  (Q724K3    ), LDH1_LISMO  (P33380    ), 
LDH1_STAA1  (A7WXP7    ), LDH1_STAA2  (A6TY25    ), LDH1_STAA3  (Q2FK29    ), 
LDH1_STAA8  (Q2G218    ), LDH1_STAA9  (A5IPA9    ), LDH1_STAAB  (Q2YV38    ), 
LDH1_STAAC  (Q5HJD7    ), LDH1_STAAE  (A6QDL6    ), LDH1_STAAM  (P65255    ), 
LDH1_STAAN  (P65256    ), LDH1_STAAR  (Q6GK73    ), LDH1_STAAS  (Q6GCN4    ), 
LDH1_STAAT  (A8Z0K3    ), LDH1_STAAW  (P65257    ), LDH2_BACAN  (Q81K80    ), 
LDH2_BACC1  (P62048    ), LDH2_BACCR  (Q816G3    ), LDH2_BACCZ  (Q632G8    ), 
LDH2_BACHK  (Q6HC14    ), LDH2_BIFL2  (E8ME30    ), LDH2_BIFLO  (P0CW93    ), 
LDH2_ENTFA  (Q838C9    ), LDH2_LACAC  (Q5FKK7    ), LDH2_LACJO  (P62053    ), 
LDH2_LACLA  (Q9CII4    ), LDH2_LACLC  (P0C2T6    ), LDH2_LACLM  (P0CI34    ), 
LDH2_LACLN  (D8KFT1    ), LDH2_LACPL  (P59390    ), LDH2_LISIN  (Q92BI0    ), 
LDH2_LISMF  (Q71ZD6    ), LDH2_LISMO  (Q8Y6Z6    ), LDH2_STAA1  (A7X6Y1    ), 
LDH2_STAA2  (A6U4Y2    ), LDH2_STAA3  (Q2FDQ7    ), LDH2_STAA8  (Q2G1Y5    ), 
LDH2_STAA9  (A5IW27    ), LDH2_STAAB  (Q2YWF6    ), LDH2_STAAC  (Q5HCV0    ), 
LDH2_STAAE  (A6QK89    ), LDH2_STAAM  (P65258    ), LDH2_STAAN  (P99119    ), 
LDH2_STAAR  (Q6GDK1    ), LDH2_STAAS  (Q6G674    ), LDH2_STAAT  (P0C7U6    ), 
LDH2_STAAW  (Q8NUM9    ), LDH3_BACAN  (Q81XJ7    ), LDH3_BACC1  (P62049    ), 
LDH3_BACCR  (Q815X8    ), LDH3_BACCZ  (Q631X2    ), LDH3_BACHK  (Q6HBQ8    ), 
LDH6A_HUMAN (Q6ZMR3    ), LDH6B_BOVIN (Q3T056    ), LDH6B_HUMAN (Q9BYZ2    ), 
LDH6B_MACFA (Q4R816    ), LDHA_ALLMI  (Q9PW06    ), LDHA_AMBME  (Q9W7M6    ), 
LDHA_BOSMU  (A0A1F3    ), LDHA_BOVIN  (P19858    ), LDHA_CAICA  (Q98SL2    ), 
LDHA_CHAAC  (P69080    ), LDHA_CHAGU  (O93541    ), LDHA_CHICK  (P00340    ), 
LDHA_CHIRA  (P69081    ), LDHA_COLLI  (Q9PW07    ), LDHA_CYPCA  (Q9W7K5    ), 
LDHA_DANRE  (Q9PVK5    ), LDHA_DISEL  (Q9PW61    ), LDHA_DISMA  (O93544    ), 
LDHA_ELEMC  (O93542    ), LDHA_FUNHE  (Q92055    ), LDHA_GILMI  (P69083    ), 
LDHA_GILSE  (P69084    ), LDHA_GOBGI  (O93540    ), LDHA_HARAN  (O93537    ), 
LDHA_HORVU  (P22988    ), LDHA_HUMAN  (P00338    ), LDHA_LEPNU  (O93545    ), 
LDHA_LYCDA  (Q9PW58    ), LDHA_MACFA  (Q9BE24    ), LDHA_MONDO  (Q9XT87    ), 
LDHA_MOUSE  (P06151    ), LDHA_NOTAN  (P69085    ), LDHA_NOTNE  (O93539    ), 
LDHA_PAGBO  (P69086    ), LDHA_PANTR  (Q5R1W9    ), LDHA_PARCR  (O93538    ), 
LDHA_PARMG  (O93543    ), LDHA_PATTE  (O93546    ), LDHA_PELSJ  (Q98SL0    ), 
LDHA_PIG    (P00339    ), LDHA_PONAB  (Q5R5F0    ), LDHA_PYTRG  (Q9W7L3    ), 
LDHA_RABIT  (P13491    ), LDHA_RAT    (P04642    ), LDHA_RHINC  (O93401    ), 
LDHA_RHIOR  (Q9P4B6    ), LDHA_SCEUN  (Q9W7L5    ), LDHA_SCEWO  (P79912    ), 
LDHA_SPHAG  (O13276    ), LDHA_SPHID  (O13277    ), LDHA_SPHLU  (O13278    ), 
LDHA_SQUAC  (P00341    ), LDHA_TRASE  (Q9PT43    ), LDHA_TREBE  (P69082    ), 
LDHA_XENLA  (P42120    ), LDHBA_DANRE (Q9PVK4    ), LDHBB_DANRE (Q6DGK2    ), 
LDHB_ALLMI  (Q9PW05    ), LDHB_ANAPL  (P13743    ), LDHB_ANGRO  (Q9YGL2    ), 
LDHB_BOVIN  (Q5E9B1    ), LDHB_CAICA  (Q98SL1    ), LDHB_CHICK  (P00337    ), 
LDHB_COLLI  (Q9PW04    ), LDHB_FUNHE  (P20373    ), LDHB_FUNPA  (P42122    ), 
LDHB_HORVU  (P22989    ), LDHB_HUMAN  (P07195    ), LDHB_MACFA  (Q4R5B6    ), 
LDHB_MONDO  (Q9XT86    ), LDHB_MOUSE  (P16125    ), LDHB_PANTR  (A5A6N7    ), 
LDHB_PELSJ  (Q98SK9    ), LDHB_PIG    (P00336    ), LDHB_POLSE  (Q1EG91    ), 
LDHB_RABIT  (P13490    ), LDHB_RAT    (P42123    ), LDHB_RHIOR  (Q9P4B5    ), 
LDHB_SCEUN  (Q9W7L4    ), LDHB_SCEWO  (P79913    ), LDHB_SQUAC  (Q9YI05    ), 
LDHB_TRASE  (Q9PT42    ), LDHB_XENLA  (P42119    ), LDHC_FUNHE  (Q06176    ), 
LDHC_HUMAN  (P07864    ), LDHC_MOUSE  (P00342    ), LDHC_PIG    (Q9TSX5    ), 
LDHC_RAT    (P19629    ), LDHC_VULVU  (Q29563    ), LDHC_XENLA  (P42121    ), 
LDHP_BACPS  (P14561    ), LDHX_BACPS  (P20619    ), LDH_AGRVS   (B9JTR0    ), 
LDH_BACCA   (P10655    ), LDH_BACCL   (Q59244    ), LDH_BACHD   (Q9K5Z8    ), 
LDH_BACLD   (Q65NP0    ), LDH_BACME   (P00345    ), LDH_BACMF   (A7Z152    ), 
LDH_BACP2   (A8F9Q8    ), LDH_BACSK   (Q5WE04    ), LDH_BACSU   (P13714    ), 
LDH_BIFA0   (B8DSV5    ), LDH_BORAP   (Q0SP77    ), LDH_BORBP   (Q662S5    ), 
LDH_BORBU   (O51114    ), LDH_BORBZ   (B7J121    ), LDH_BORHD   (B2S1S1    ), 
LDH_BORT9   (A1QYN6    ), LDH_CAEEL   (Q27888    ), LDH_CHLT3   (B3QX21    ), 
LDH_CLOB1   (A7FU32    ), LDH_CLOB6   (C3KVF0    ), LDH_CLOBH   (A5I1Z6    ), 
LDH_CLOBJ   (C1FMZ1    ), LDH_CLOBK   (B1IKX1    ), LDH_CLOBL   (A7GDK3    ), 
LDH_CLOBM   (B1L1N3    ), LDH_CLOP1   (Q0TUX8    ), LDH_CLOPE   (Q8XP62    ), 
LDH_CLOPS   (Q0SWR1    ), LDH_CLOTE   (Q892U0    ), LDH_CLOTH   (Q8KQC4    ), 
LDH_CORDI   (P62050    ), LDH_COREF   (Q8FLV6    ), LDH_CORGB   (A4QHW5    ), 
LDH_CORGL   (Q8NLN0    ), LDH_CORJK   (Q4JY42    ), LDH_DEIRA   (P50933    ), 
LDH_DESRM   (A4J898    ), LDH_DESVH   (P62051    ), LDH_DESVV   (A1VG02    ), 
LDH_DROME   (Q95028    ), LDH_FERNB   (A7HM89    ), LDH_FUSNN   (Q8RED8    ), 
LDH_GEODF   (B9LZ61    ), LDH_GEOKA   (Q5L2S0    ), LDH_GEOSE   (P00344    ), 
LDH_GEOSW   (C5D5V2    ), LDH_GEOTN   (A4IKL5    ), LDH_GLOVI   (Q7NG49    ), 
LDH_KOSOT   (C5CGP2    ), LDH_LACCA   (P00343    ), LDH_LACDB   (Q04CN9    ), 
LDH_LACHE   (O32765    ), LDH_LACPE   (P56511    ), LDH_LACS1   (Q1WSG2    ), 
LDH_LACSK   (P50934    ), LDH_LACSS   (Q38V71    ), LDH_MACCJ   (B9E9F9    ), 
LDH_MAIZE   (P29038    ), LDH_MESFL   (Q6F0L9    ), LDH_MOOTA   (Q2RHG3    ), 
LDH_MYCCT   (Q2SS50    ), LDH_MYCGE   (P47698    ), LDH_MYCH2   (P0C0J2    ), 
LDH_MYCH7   (Q4A8M8    ), LDH_MYCHJ   (P0C0J3    ), LDH_MYCHY   (P0C0J4    ), 
LDH_MYCMO   (Q6KIP9    ), LDH_MYCMS   (P62054    ), LDH_MYCPE   (Q8EUG3    ), 
LDH_MYCPN   (P78007    ), LDH_OCEIH   (Q8ELF0    ), LDH_PEDAC   (Q59645    ), 
LDH_PEDPA   (Q03DZ7    ), LDH_PETMA   (P33571    ), LDH_PETMO   (A9BGZ9    ), 
LDH_PROAC   (Q6A9C3    ), LDH_PSELT   (A8F6M1    ), LDH_SALRD   (Q2S4R2    ), 
LDH_SCHPO   (Q9P7P7    ), LDH_STACT   (B9DN51    ), LDH_STAEQ   (Q5HL31    ), 
LDH_STAES   (Q8CMZ0    ), LDH_STAHJ   (Q4L941    ), LDH_STAS1   (Q49YJ3    ), 
LDH_STRA1   (Q3K1C8    ), LDH_STRA3   (Q8E5N4    ), LDH_STRA5   (Q8DZY3    ), 
LDH_STRE4   (C0M7H8    ), LDH_STREI   (Q59828    ), LDH_STREM   (B4U309    ), 
LDH_STRGC   (A8AXK9    ), LDH_STRMU   (P26283    ), LDH_STRP1   (P65259    ), 
LDH_STRP2   (Q04K99    ), LDH_STRP3   (P0DC18    ), LDH_STRP4   (B5E4V6    ), 
LDH_STRP6   (Q5XC59    ), LDH_STRP7   (C1C7I6    ), LDH_STRP8   (P65261    ), 
LDH_STRPB   (Q1JBQ9    ), LDH_STRPC   (Q1JLP1    ), LDH_STRPD   (Q1JGU2    ), 
LDH_STRPF   (Q1J6L1    ), LDH_STRPG   (A2REG9    ), LDH_STRPI   (B1IC17    ), 
LDH_STRPJ   (B8ZQ84    ), LDH_STRPM   (Q48TK0    ), LDH_STRPN   (P0A3M9    ), 
LDH_STRPQ   (P0DC19    ), LDH_STRPZ   (B5XLJ8    ), LDH_STRR6   (P0A3N0    ), 
LDH_STRS2   (A4W1K6    ), LDH_STRS7   (C0MFB5    ), LDH_STRSV   (A3CN70    ), 
LDH_STRSY   (A4VVA3    ), LDH_STRT1   (Q5LZ83    ), LDH_STRT2   (Q5M3T6    ), 
LDH_STRTD   (Q03K30    ), LDH_STRTR   (Q60009    ), LDH_STRU0   (B9DS53    ), 
LDH_STRZJ   (C1CEH8    ), LDH_STRZP   (C1CKW1    ), LDH_STRZT   (C1CR83    ), 
LDH_SYNJA   (Q2JRH2    ), LDH_SYNJB   (Q2JJQ1    ), LDH_THEAQ   (P13715    ), 
LDH_THECA   (P06150    ), LDH_THEMA   (P16115    ), LDH_THEP1   (A5IL75    ), 
LDH_THEP3   (B0KDA4    ), LDH_THEPX   (B0K226    ), LDH_THESQ   (B1LAF5    ), 
LDH_THESW   (Q7X5C9    ), LDH_THET2   (P62055    ), LDH_THET8   (Q5SJA1    ), 
LDH_TREDE   (P62056    )
» more

UniProtKB/Swiss-Prot
False negative sequences
12 sequences

LDH2_CLOAB  (Q97DC6    ), LDH3_LACLA  (Q9CGG8    ), LDH_BOTBR   (P93052    ), 
LDH_LACF3   (B2GBW0    ), LDH_LACRE   (Q8GMJ0    ), LDH_MYCGA   (O52354    ), 
LDH_MYCPU   (Q98PG4    ), LDH_PLABA   (Q7SI97    ), LDH_PLABE   (P84793    ), 
LDH_PLAFD   (Q27743    ), LDH_SELRU   (Q9EVR0    ), LDH_TOXGO   (Q27797    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

LDH_PLAFA   (P13774    )

		
UniProtKB/Swiss-Prot
False positive sequences
8 sequences

MDH_ARCFU   (O08349    ), MDH_METJA   (Q60176    ), MDH_METKA   (Q8TWG5    ), 
MDH_METMP   (Q6LZI3    ), MTNA_CALS8  (A4XKS3    ), NTPA_CLOTE  (Q891I4    ), 
SPSA1_ORYSI (A2WYE9    ), SPSA1_ORYSJ (Q0JGK4    )
» more

PDB
[Detailed view]
77 PDB

1A5Z; 1EZ4; 1HYH; 1I0Z; 1I10; 1LDB; 1LDM; 1LDN; 1LLC; 1LLD; 1LTH; 1T2F; 1V6A; 2E37; 2LDB; 2LDX; 2V65; 2V6B; 2V6M; 2V7P; 2XXB; 2XXJ; 2ZQY; 2ZQZ; 3D0O; 3D4P; 3H3F; 3H3J; 3LDH; 3PQD; 3PQE; 3PQF; 3VKU; 3VKV; 3VPF; 3VPG; 3VPH; 3ZZN; 4A73; 4AJ1; 4AJ2; 4AJ4; 4AJE; 4AJH; 4AJI; 4AJJ; 4AJK; 4AJL; 4AJN; 4AJO; 4AJP; 4AL4; 4I8X; 4I9H; 4I9N; 4I9U; 4JNK; 4L4R; 4L4S; 4LMR; 4LN1; 4M49; 4OJN; 4OKN; 4QO7; 4QO8; 4QSM; 4QT0; 4R68; 4R69; 4RLS; 5ES3; 5LDH; 6LDH; 8LDH; 9LDB; 9LDT
» more

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