Entry: PS00064

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General information about the entry

Entry name [info] L_LDH
Accession [info] PS00064
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); MAY-1991 (DATA UPDATE); MAR-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00062
Associated ProRule [info] PRU10002

Name and characterization of the entry

Description [info] L-lactate dehydrogenase active site.
Pattern [info]
[LIVMA]-G-[EQ]-H-G-[DN]-[ST].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_04 which contains 544'996 sequence entries.


Total number of hits 306 in 306 different sequences
Number of true positive hits 298 in 298 different sequences
Number of 'unknown' hits
Number of false positive hits 8 in 8 different sequences
Number of false negative sequences 12
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 97.39 %
Recall (true positives / (true positives + false negatives)) 96.13 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 4
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
298 sequences

DHL2_WEICO  (P14295), LDH1_BACAN  (Q81RW4), LDH1_BACC1  (P62047), 
LDH1_BACCR  (Q81EP4), LDH1_BACCZ  (Q63CN1), LDH1_BACHK  (Q6HK31), 
LDH1_BIFL2  (E8MJ15), LDH1_BIFLO  (P59050), LDH1_CLOAB  (Q97MD1), 
LDH1_ENTFA  (Q839C1), LDH1_LACAC  (Q5FMB0), LDH1_LACJO  (P62052), 
LDH1_LACLA  (Q01462), LDH1_LACLC  (P04034), LDH1_LACPL  (P56512), 
LDH1_LISIN  (Q92F65), LDH1_LISMF  (Q724K3), LDH1_LISMO  (P33380), 
LDH1_STAA1  (A7WXP7), LDH1_STAA2  (A6TY25), LDH1_STAA3  (Q2FK29), 
LDH1_STAA8  (Q2G218), LDH1_STAA9  (A5IPA9), LDH1_STAAB  (Q2YV38), 
LDH1_STAAC  (Q5HJD7), LDH1_STAAE  (A6QDL6), LDH1_STAAM  (P65255), 
LDH1_STAAN  (P65256), LDH1_STAAR  (Q6GK73), LDH1_STAAS  (Q6GCN4), 
LDH1_STAAT  (A8Z0K3), LDH1_STAAW  (P65257), LDH2_BACAN  (Q81K80), 
LDH2_BACC1  (P62048), LDH2_BACCR  (Q816G3), LDH2_BACCZ  (Q632G8), 
LDH2_BACHK  (Q6HC14), LDH2_BIFL2  (E8ME30), LDH2_BIFLO  (P0CW93), 
LDH2_ENTFA  (Q838C9), LDH2_LACAC  (Q5FKK7), LDH2_LACJO  (P62053), 
LDH2_LACLA  (Q9CII4), LDH2_LACLC  (P0C2T6), LDH2_LACLM  (P0CI34), 
LDH2_LACLN  (D8KFT1), LDH2_LACPL  (P59390), LDH2_LISIN  (Q92BI0), 
LDH2_LISMF  (Q71ZD6), LDH2_LISMO  (Q8Y6Z6), LDH2_STAA1  (A7X6Y1), 
LDH2_STAA2  (A6U4Y2), LDH2_STAA3  (Q2FDQ7), LDH2_STAA8  (Q2G1Y5), 
LDH2_STAA9  (A5IW27), LDH2_STAAB  (Q2YWF6), LDH2_STAAC  (Q5HCV0), 
LDH2_STAAE  (A6QK89), LDH2_STAAM  (P65258), LDH2_STAAN  (P99119), 
LDH2_STAAR  (Q6GDK1), LDH2_STAAS  (Q6G674), LDH2_STAAT  (P0C7U6), 
LDH2_STAAW  (Q8NUM9), LDH3_BACAN  (Q81XJ7), LDH3_BACC1  (P62049), 
LDH3_BACCR  (Q815X8), LDH3_BACCZ  (Q631X2), LDH3_BACHK  (Q6HBQ8), 
LDH6A_HUMAN (Q6ZMR3), LDH6B_BOVIN (Q3T056), LDH6B_HUMAN (Q9BYZ2), 
LDH6B_MACFA (Q4R816), LDHA_ALLMI  (Q9PW06), LDHA_AMBME  (Q9W7M6), 
LDHA_BOSMU  (A0A1F3), LDHA_BOVIN  (P19858), LDHA_CAICA  (Q98SL2), 
LDHA_CHAAC  (P69080), LDHA_CHAGU  (O93541), LDHA_CHICK  (P00340), 
LDHA_CHIRA  (P69081), LDHA_COLLI  (Q9PW07), LDHA_CYPCA  (Q9W7K5), 
LDHA_DANRE  (Q9PVK5), LDHA_DISEL  (Q9PW61), LDHA_DISMA  (O93544), 
LDHA_ELEMC  (O93542), LDHA_FUNHE  (Q92055), LDHA_GILMI  (P69083), 
LDHA_GILSE  (P69084), LDHA_GOBGI  (O93540), LDHA_HARAN  (O93537), 
LDHA_HORVU  (P22988), LDHA_HUMAN  (P00338), LDHA_LEPNU  (O93545), 
LDHA_MACFA  (Q9BE24), LDHA_MONDO  (Q9XT87), LDHA_MOUSE  (P06151), 
LDHA_NOTAN  (P69085), LDHA_NOTCO  (O93539), LDHA_PAGBO  (P69086), 
LDHA_PANTR  (Q5R1W9), LDHA_PARCR  (O93538), LDHA_PARMG  (O93543), 
LDHA_PATTE  (O93546), LDHA_PELSJ  (Q98SL0), LDHA_PIG    (P00339), 
LDHA_PONAB  (Q5R5F0), LDHA_PYTRG  (Q9W7L3), LDHA_RABIT  (P13491), 
LDHA_RAT    (P04642), LDHA_RHIDE  (Q9PW58), LDHA_RHINC  (O93401), 
LDHA_RHIOR  (Q9P4B6), LDHA_SCEUN  (Q9W7L5), LDHA_SCEWO  (P79912), 
LDHA_SPHAG  (O13276), LDHA_SPHID  (O13277), LDHA_SPHLU  (O13278), 
LDHA_SQUAC  (P00341), LDHA_TRASC  (Q9PT43), LDHA_TREBE  (P69082), 
LDHA_XENLA  (P42120), LDHBA_DANRE (Q9PVK4), LDHBB_DANRE (Q6DGK2), 
LDHB_ALLMI  (Q9PW05), LDHB_ANAPL  (P13743), LDHB_ANGRO  (Q9YGL2), 
LDHB_BOVIN  (Q5E9B1), LDHB_CAICA  (Q98SL1), LDHB_CHICK  (P00337), 
LDHB_COLLI  (Q9PW04), LDHB_FUNHE  (P20373), LDHB_FUNPA  (P42122), 
LDHB_HORVU  (P22989), LDHB_HUMAN  (P07195), LDHB_MACFA  (Q4R5B6), 
LDHB_MONDO  (Q9XT86), LDHB_MOUSE  (P16125), LDHB_PANTR  (A5A6N7), 
LDHB_PELSJ  (Q98SK9), LDHB_PIG    (P00336), LDHB_POLSE  (Q1EG91), 
LDHB_RABIT  (P13490), LDHB_RAT    (P42123), LDHB_RHIOR  (Q9P4B5), 
LDHB_SCEUN  (Q9W7L4), LDHB_SCEWO  (P79913), LDHB_SQUAC  (Q9YI05), 
LDHB_TRASC  (Q9PT42), LDHB_XENLA  (P42119), LDHC_FUNHE  (Q06176), 
LDHC_HUMAN  (P07864), LDHC_MOUSE  (P00342), LDHC_PIG    (Q9TSX5), 
LDHC_RAT    (P19629), LDHC_VULVU  (Q29563), LDHC_XENLA  (P42121), 
LDHP_BACPS  (P14561), LDHX_BACPS  (P20619), LDH_AGRVS   (B9JTR0), 
LDH_BACA2   (A7Z152), LDH_BACCA   (P10655), LDH_BACCL   (Q59244), 
LDH_BACHD   (Q9K5Z8), LDH_BACLD   (Q65NP0), LDH_BACME   (P00345), 
LDH_BACP2   (A8F9Q8), LDH_BACSK   (Q5WE04), LDH_BACSU   (P13714), 
LDH_BIFA0   (B8DSV5), LDH_BORAP   (Q0SP77), LDH_BORBU   (O51114), 
LDH_BORBZ   (B7J121), LDH_BORGA   (Q662S5), LDH_BORHD   (B2S1S1), 
LDH_BORT9   (A1QYN6), LDH_CAEEL   (Q27888), LDH_CHLT3   (B3QX21), 
LDH_CLOB1   (A7FU32), LDH_CLOB6   (C3KVF0), LDH_CLOBH   (A5I1Z6), 
LDH_CLOBJ   (C1FMZ1), LDH_CLOBK   (B1IKX1), LDH_CLOBL   (A7GDK3), 
LDH_CLOBM   (B1L1N3), LDH_CLOP1   (Q0TUX8), LDH_CLOPE   (Q8XP62), 
LDH_CLOPS   (Q0SWR1), LDH_CLOTE   (Q892U0), LDH_CLOTH   (Q8KQC4), 
LDH_CORDI   (P62050), LDH_COREF   (Q8FLV6), LDH_CORGB   (A4QHW5), 
LDH_CORGL   (Q8NLN0), LDH_CORJK   (Q4JY42), LDH_DEIRA   (P50933), 
LDH_DESRM   (A4J898), LDH_DESVH   (P62051), LDH_DESVV   (A1VG02), 
LDH_DROME   (Q95028), LDH_FERNB   (A7HM89), LDH_FUSNN   (Q8RED8), 
LDH_GEODF   (B9LZ61), LDH_GEOKA   (Q5L2S0), LDH_GEOSE   (P00344), 
LDH_GEOSW   (C5D5V2), LDH_GEOTN   (A4IKL5), LDH_GLOVI   (Q7NG49), 
LDH_KOSOT   (C5CGP2), LDH_LACCA   (P00343), LDH_LACDB   (Q04CN9), 
LDH_LACHE   (O32765), LDH_LACPE   (P56511), LDH_LACS1   (Q1WSG2), 
LDH_LACSK   (P50934), LDH_LACSS   (Q38V71), LDH_MACCJ   (B9E9F9), 
LDH_MAIZE   (P29038), LDH_MESFL   (Q6F0L9), LDH_MOOTA   (Q2RHG3), 
LDH_MYCCT   (Q2SS50), LDH_MYCGE   (P47698), LDH_MYCH2   (P0C0J2), 
LDH_MYCH7   (Q4A8M8), LDH_MYCHJ   (P0C0J3), LDH_MYCHY   (P0C0J4), 
LDH_MYCMO   (Q6KIP9), LDH_MYCMS   (P62054), LDH_MYCPE   (Q8EUG3), 
LDH_MYCPN   (P78007), LDH_OCEIH   (Q8ELF0), LDH_PEDAC   (Q59645), 
LDH_PEDPA   (Q03DZ7), LDH_PETMA   (P33571), LDH_PETMO   (A9BGZ9), 
LDH_PROAC   (Q6A9C3), LDH_SALRD   (Q2S4R2), LDH_SCHPO   (Q9P7P7), 
LDH_STACT   (B9DN51), LDH_STAEQ   (Q5HL31), LDH_STAES   (Q8CMZ0), 
LDH_STAHJ   (Q4L941), LDH_STAS1   (Q49YJ3), LDH_STRA1   (Q3K1C8), 
LDH_STRA3   (Q8E5N4), LDH_STRA5   (Q8DZY3), LDH_STRE4   (C0M7H8), 
LDH_STREI   (Q59828), LDH_STREM   (B4U309), LDH_STRGC   (A8AXK9), 
LDH_STRMU   (P26283), LDH_STRP1   (P65259), LDH_STRP2   (Q04K99), 
LDH_STRP3   (P0DC18), LDH_STRP4   (B5E4V6), LDH_STRP6   (Q5XC59), 
LDH_STRP7   (C1C7I6), LDH_STRP8   (P65261), LDH_STRPB   (Q1JBQ9), 
LDH_STRPC   (Q1JLP1), LDH_STRPD   (Q1JGU2), LDH_STRPF   (Q1J6L1), 
LDH_STRPG   (A2REG9), LDH_STRPI   (B1IC17), LDH_STRPJ   (B8ZQ84), 
LDH_STRPM   (Q48TK0), LDH_STRPN   (P0A3M9), LDH_STRPQ   (P0DC19), 
LDH_STRPZ   (B5XLJ8), LDH_STRR6   (P0A3N0), LDH_STRS2   (A4W1K6), 
LDH_STRS7   (C0MFB5), LDH_STRSV   (A3CN70), LDH_STRSY   (A4VVA3), 
LDH_STRT1   (Q5LZ83), LDH_STRT2   (Q5M3T6), LDH_STRTD   (Q03K30), 
LDH_STRTR   (Q60009), LDH_STRU0   (B9DS53), LDH_STRZJ   (C1CEH8), 
LDH_STRZP   (C1CKW1), LDH_STRZT   (C1CR83), LDH_SYNJA   (Q2JRH2), 
LDH_SYNJB   (Q2JJQ1), LDH_THEAQ   (P13715), LDH_THECA   (P06150), 
LDH_THELT   (A8F6M1), LDH_THEMA   (P16115), LDH_THEP1   (A5IL75), 
LDH_THEP3   (B0KDA4), LDH_THEPX   (B0K226), LDH_THESQ   (B1LAF5), 
LDH_THESW   (Q7X5C9), LDH_THET2   (P62055), LDH_THET8   (Q5SJA1), 
LDH_TREDE   (P62056)
» More

UniProtKB/Swiss-Prot
False negative sequences
12 sequences

LDH2_CLOAB  (Q97DC6), LDH3_LACLA  (Q9CGG8), LDH_BOTBR   (P93052), 
LDH_LACF3   (B2GBW0), LDH_LACRE   (Q8GMJ0), LDH_MYCGA   (O52354), 
LDH_MYCPU   (Q98PG4), LDH_PLABA   (Q7SI97), LDH_PLABE   (P84793), 
LDH_PLAFD   (Q27743), LDH_SELRU   (Q9EVR0), LDH_TOXGO   (Q27797)
» More

UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

LDH_PLAFA   (P13774)

		
UniProtKB/Swiss-Prot
False positive sequences
8 sequences

MDH_ARCFU   (O08349), MDH_METJA   (Q60176), MDH_METKA   (Q8TWG5), 
MDH_METMP   (Q6LZI3), MTNA_CALS8  (A4XKS3), NTPA_CLOTE  (Q891I4), 
SPSA1_ORYSI (A2WYE9), SPSA1_ORYSJ (Q0JGK4)
» More

PDB
[Detailed view]
65 PDB

1A5Z; 1EZ4; 1HYH; 1I0Z; 1I10; 1LDB; 1LDM; 1LDN; 1LLC; 1LLD; 1LTH; 1T2F; 1V6A; 2E37; 2LDB; 2LDX; 2V65; 2V6B; 2V6M; 2V7P; 2XXB; 2XXJ; 2ZQY; 2ZQZ; 3D0O; 3D4P; 3H3F; 3H3J; 3LDH; 3PQD; 3PQE; 3PQF; 3VKU; 3VKV; 3VPF; 3VPG; 3VPH; 3ZZN; 4A73; 4AJ1; 4AJ2; 4AJ4; 4AJE; 4AJH; 4AJI; 4AJJ; 4AJK; 4AJL; 4AJN; 4AJO; 4AJP; 4AL4; 4I8X; 4I9H; 4I9N; 4I9U; 4JNK; 4LMR; 4LN1; 4M49; 5LDH; 6LDH; 8LDH; 9LDB; 9LDT
» More

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