Entry: PS00066
General information about the entry
Entry nameHMG_COA_REDUCTASE_1
Accession numberPS00066
Entry typePATTERN
DateAPR-1990 (CREATED); APR-2006 (DATA UPDATE); DEC-2011 (INFO UPDATE).
PROSITE DocumentationPDOC00064
Name and characterization of the entry
DescriptionHydroxymethylglutaryl-coenzyme A reductases signature 1.
Pattern[RKH]-x-{Y}-{I}-x-{I}-{L}-D-x-M-G-x-N-x-[LIVMA].
Numerical results
  • UniProtKB/Swiss-Prot release number: 01, total number of sequence entries in that release: 534242.
  • Total number of hits in UniProtKB/Swiss-Prot: 58 hits in 58 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 50 hits in 50 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 8 hits in 8 different sequences
  • Number of known missed hits: 2
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 1
  • Precision (true hits / (true hits + false positives)): 86.21 %
  • Recall (true hits / (true hits + false negatives)): 96.15 %
Comments
  • Taxonomic range: Archaebacteria, Eukaryotes, Prokaryotes (Bacteria)
  • Maximum known number of repetitions of the pattern in a single protein: 1
  • VERSION: 2
Cross-references
UniProtKB/Swiss-ProtTrue positive hits:
HMDH1_ARATH (P14891), HMDH1_DICDI (P34135), HMDH1_GOSHI (O64966), 
HMDH1_HEVBR (P29057), HMDH1_ORYSI (A2X8W3), HMDH1_ORYSJ (Q0DY59), 
HMDH1_YEAST (P12683), HMDH2_ARATH (P43256), HMDH2_CAPAN (Q9XEL8), 
HMDH2_DICDI (P34136), HMDH2_GOSHI (O64967), HMDH2_SOLLC (P48022), 
HMDH2_SOLTU (Q41437), HMDH2_YEAST (P12684), HMDH3_HEVBR (Q00583), 
HMDH3_ORYSJ (Q9XHL5), HMDH3_SOLTU (Q41438), HMDH_AERPE  (Q9YAS4), 
HMDH_AGRIP  (O76819), HMDH_ARCFU  (O28538), HMDH_ASPTE  (Q9Y7D2), 
HMDH_ASPTN  (Q0C8L9), HMDH_BLAGE  (P54960), HMDH_CAMAC  (P48021), 
HMDH_CATRO  (Q03163), HMDH_CRIGR  (P00347), HMDH_CYBJA  (O74164), 
HMDH_DROME  (P14773), HMDH_GIBFU  (Q12577), HMDH_HALVD  (Q59468), 
HMDH_HUMAN  (P04035), HMDH_MAIZE  (O24594), HMDH_MESAU  (P09610), 
HMDH_METJA  (Q58116), HMDH_METTH  (O26662), HMDH_MOUSE  (Q01237), 
HMDH_NICSY  (Q01559), HMDH_PHYBL  (Q12649), HMDH_PIG    (Q1W675), 
HMDH_PONAB  (Q5R6N3), HMDH_PYRAB  (Q9V1R3), HMDH_PYRHO  (O59469), 
HMDH_RABIT  (Q29512), HMDH_RAT    (P51639), HMDH_SCHMA  (P16237), 
HMDH_SCHPO  (Q10283), HMDH_STRPU  (P16393), HMDH_SULSO  (O08424), 
HMDH_XENLA  (P20715), MVAA_PSEMV  (P13702)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
HMDH1_SOLTU (P48020), HMDH_BORBU  (O51628)
`Potential' hits (partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences):
HMDH2_HEVBR (P29058)
False positive hits (sequences which do not belong to the set under consideration):
LIPR3_HUMAN (Q17RR3), MSP_TRELE   (Q8RMC0), RH48_ARATH  (Q9C8S9), 
RN5A_MOUSE  (Q05921), SYP_STRA1   (Q3JZ37), SYP_STRA3   (Q8E362), 
SYP_STRA5   (Q8DXD8), VG27_BPT4   (P17172)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]
1DQ8; 1DQ9; 1DQA; 1HW8; 1HW9; 1HWI; 1HWJ; 1HWK; 1HWL; 1QAX; 1QAY; 1R31; 1R7I; 1T02; 2Q1L; 2Q6B; 2Q6C; 2R4F; 3BGL; 3CCT; 3CCW; 3CCZ; 3CD0; 3CD5; 3CD7; 3CDA; 3CDB;

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