Entry: PS00068

General information about the entry

Entry name [info] MDH
Accession [info] PS00068
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); OCT-1993 (DATA UPDATE); JUN-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC00066
Associated ProRule [info] PRU10004

Name and characterization of the entry

Description [info] Malate dehydrogenase active site signature.
Pattern [info]
[LIVM]-T-[TRKMN]-L-D-x(2)-R-[STA]-x(3)-[LIVMFY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_07 which contains 551'705 sequence entries.


Total number of hits 230 in 230 different sequences
Number of true positive hits 226 in 226 different sequences
Number of 'unknown' hits 0
Number of false positive hits 4 in 4 different sequences
Number of false negative sequences 115
Number of 'partial' sequences 21
Precision (true positives / (true positives + false positives)) 98.26 %
Recall (true positives / (true positives + false negatives)) 66.28 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 5
Site [info] active_site at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
226 sequences

MDHA_DICDI  (Q54GE6    ), MDHC1_ARATH (P93819    ), MDHC2_ARATH (P57106    ), 
MDHC_BETVU  (Q9SML8    ), MDHC_BOVIN  (Q3T145    ), MDHC_CANAL  (P83778    ), 
MDHC_CHICK  (Q5ZME2    ), MDHC_DICDI  (Q54VM2    ), MDHC_ECHGR  (Q04820    ), 
MDHC_FELCA  (Q7YRU4    ), MDHC_HUMAN  (P40925    ), MDHC_MAIZE  (Q08062    ), 
MDHC_MEDSA  (O48905    ), MDHC_MESCR  (O24047    ), MDHC_MOUSE  (P14152    ), 
MDHC_ORYSJ  (Q7XDC8    ), MDHC_PIG    (P11708    ), MDHC_RAT    (O88989    ), 
MDHC_XENLA  (Q6PAB3    ), MDHC_XENTR  (Q6DIY9    ), MDHC_YEAST  (P22133    ), 
MDHG1_ARATH (Q9ZP05    ), MDHG1_BRANA (Q43743    ), MDHG2_ARATH (O82399    ), 
MDHG2_BRANA (Q9XFW3    ), MDHG_CITLA  (P19446    ), MDHG_CUCSA  (P46488    ), 
MDHG_ORYSJ  (Q42972    ), MDHG_SOYBN  (P37228    ), MDHM1_ARATH (Q9ZP06    ), 
MDHM2_ARATH (Q9LKA3    ), MDHM_BOVIN  (Q32LG3    ), MDHM_CAEEL  (O02640    ), 
MDHM_CHLRE  (Q42686    ), MDHM_CITLA  (P17783    ), MDHM_EUCGU  (P46487    ), 
MDHM_FRAAN  (P83373    ), MDHM_HUMAN  (P40926    ), MDHM_MACFA  (Q4R568    ), 
MDHM_MOUSE  (P08249    ), MDHM_PIG    (P00346    ), MDHM_PONAB  (Q5NVR2    ), 
MDHM_RAT    (P04636    ), MDHM_YEAST  (P17505    ), MDHP1_SORBI (P17606    ), 
MDHP2_SORBI (P37229    ), MDHP_ARATH  (Q9SN86    ), MDHP_FLABI  (P46489    ), 
MDHP_MAIZE  (P15719    ), MDHP_MEDSA  (O48902    ), MDHP_MESCR  (Q05145    ), 
MDHP_PEA    (P21528    ), MDHP_SPIOL  (P52426    ), MDHP_YEAST  (P32419    ), 
MDH_ACTSZ   (Q5U907    ), MDH_AERHH   (A0KG16    ), MDH_AERS4   (A4SIV0    ), 
MDH_AKKM8   (B2UKY5    ), MDH_ALCBS   (Q0VQ52    ), MDH_ALISL   (B6EL39    ), 
MDH_ALKEH   (Q0ABE6    ), MDH_ARTAT   (A1R2B5    ), MDH_CELJU   (B3PHI3    ), 
MDH_CITK8   (A8AQC8    ), MDH_COLP3   (Q47VL0    ), MDH_COXB1   (B6J7Q0    ), 
MDH_COXB2   (B6IZN7    ), MDH_COXBN   (A9KFT9    ), MDH_COXBR   (A9NDV1    ), 
MDH_COXBU   (Q83C87    ), MDH_CROS8   (A7MNR3    ), MDH_ECO24   (A7ZSD0    ), 
MDH_ECO27   (B7UJW8    ), MDH_ECO45   (B7MBZ7    ), MDH_ECO55   (B7LHU4    ), 
MDH_ECO57   (P61891    ), MDH_ECO5E   (B5YSW2    ), MDH_ECO7I   (B7NKU9    ), 
MDH_ECO81   (B7N0M1    ), MDH_ECO8A   (B7M0U8    ), MDH_ECOBW   (C4ZSX4    ), 
MDH_ECODH   (B1XHK9    ), MDH_ECOHS   (A8A545    ), MDH_ECOK1   (A1AGC9    ), 
MDH_ECOL5   (Q0TCN0    ), MDH_ECOL6   (P61890    ), MDH_ECOLC   (B1IQP3    ), 
MDH_ECOLI   (P61889    ), MDH_ECOLU   (B7NDL4    ), MDH_ECOSE   (B6I1V4    ), 
MDH_ECOSM   (B1LGK2    ), MDH_ECOUT   (Q1R6A3    ), MDH_EDWI9   (C5BF98    ), 
MDH_ENT38   (A4WF48    ), MDH_ERWT9   (B2VGW7    ), MDH_ESCF3   (B7LRL0    ), 
MDH_FRAAA   (Q0RE66    ), MDH_FRASC   (Q2J7E7    ), MDH_HAEDU   (Q7VP41    ), 
MDH_HAEI8   (Q4QL89    ), MDH_HAEIE   (A5UCQ1    ), MDH_HAEIG   (A5UIX3    ), 
MDH_HAEIN   (P44427    ), MDH_HAES1   (Q0I491    ), MDH_HALHL   (A1WV94    ), 
MDH_HISS2   (B0UUR6    ), MDH_IDILO   (Q5R030    ), MDH_KLEOX   (P61894    ), 
MDH_KLEP3   (B5XSQ7    ), MDH_KLEP7   (A6TEQ3    ), MDH_KLEVA   (P61896    ), 
MDH_KOCRD   (B2GKC8    ), MDH_LEGPA   (Q5X2T6    ), MDH_LEGPC   (A5IEF4    ), 
MDH_LEGPH   (Q5ZT13    ), MDH_LEGPL   (Q5WU94    ), MDH_LEPBJ   (Q04RS5    ), 
MDH_LEPBL   (Q051U6    ), MDH_LEPIC   (P61975    ), MDH_LEPIN   (Q8F4A2    ), 
MDH_MANSM   (Q65T37    ), MDH_METCA   (Q60B71    ), MDH_MORJA   (Q6AW21    ), 
MDH_MORMI   (Q6AW23    ), MDH_MORS2   (Q7X3X5    ), MDH_MORS5   (P48364    ), 
MDH_MYCA1   (A0QCI6    ), MDH_MYCBO   (P0A5J7    ), MDH_MYCBP   (A1KI28    ), 
MDH_MYCBT   (C1AMN4    ), MDH_MYCLE   (P50917    ), MDH_MYCMM   (B2HRH5    ), 
MDH_MYCPA   (P61976    ), MDH_MYCTA   (A5U1T8    ), MDH_MYCTO   (P9WK12    ), 
MDH_MYCTU   (P9WK13    ), MDH_MYCUA   (A0PVV1    ), MDH_NOCFA   (Q5YTI1    ), 
MDH_NOCSJ   (A1SMP3    ), MDH_PARUW   (Q6MAA3    ), MDH_PASMU   (Q9CN86    ), 
MDH_PECAS   (Q6D9D1    ), MDH_PECCC   (P61897    ), MDH_PECCP   (C6DKH1    ), 
MDH_PHOLL   (Q7MYW9    ), MDH_PHOPR   (P37226    ), MDH_PROAC   (Q6A6Z5    ), 
MDH_PROMH   (B4F2A1    ), MDH_PSEA6   (Q15YH0    ), MDH_PSEHT   (Q3IFH4    ), 
MDH_PSYA2   (Q4FQU7    ), MDH_PSYCK   (Q1Q932    ), MDH_PSYIN   (A1SRP8    ), 
MDH_RAOTE   (P61895    ), MDH_RHOJR   (Q0S365    ), MDH_RHOOB   (C1B155    ), 
MDH_RUBXD   (Q1AWH4    ), MDH_SACEN   (A4FFX3    ), MDH_SALA4   (B5F7L9    ), 
MDH_SALAR   (A9MNX5    ), MDH_SALCH   (Q57JA9    ), MDH_SALDC   (B5FIT7    ), 
MDH_SALEP   (B5R0N2    ), MDH_SALG2   (B5REV7    ), MDH_SALHS   (B4TJT3    ), 
MDH_SALMU   (Q59838    ), MDH_SALNS   (B4T769    ), MDH_SALPA   (Q7WS85    ), 
MDH_SALPB   (A9N855    ), MDH_SALPC   (C0PZQ4    ), MDH_SALPK   (B5BGR3    ), 
MDH_SALSV   (B4TWK9    ), MDH_SALTI   (Q8Z3E0    ), MDH_SALTY   (P25077    ), 
MDH_SHEAM   (A1S3C4    ), MDH_SHEB2   (B8EB55    ), MDH_SHEB5   (A3D075    ), 
MDH_SHEB8   (A6WSM1    ), MDH_SHEB9   (A9L340    ), MDH_SHEDO   (Q12R11    ), 
MDH_SHEFN   (Q07YA5    ), MDH_SHEHH   (B0TUH8    ), MDH_SHELP   (A3QB91    ), 
MDH_SHEON   (P82177    ), MDH_SHEPA   (A8H0U0    ), MDH_SHEPC   (A4YAE8    ), 
MDH_SHEPW   (B8CSY7    ), MDH_SHESA   (A0L113    ), MDH_SHESH   (A8FRU0    ), 
MDH_SHESM   (Q0HEW2    ), MDH_SHESR   (Q0HZ38    ), MDH_SHESW   (A1RFX8    ), 
MDH_SHEWM   (B1KGG7    ), MDH_SHIB3   (B2U1U9    ), MDH_SHIBS   (Q31WA4    ), 
MDH_SHIDS   (Q32BA3    ), MDH_SHIF8   (Q0T052    ), MDH_SHIFL   (Q83Q04    ), 
MDH_SHISS   (Q3YX11    ), MDH_STRAW   (Q82HS2    ), MDH_STRCO   (Q9K3J3    ), 
MDH_STRGG   (B1W3N4    ), MDH_THEFY   (Q47TT4    ), MDH_THET2   (P61977    ), 
MDH_THET8   (Q5SKV7    ), MDH_THETH   (P10584    ), MDH_TOBAC   (Q9FSF0    ), 
MDH_VIBCB   (A7MWD3    ), MDH_VIBCH   (Q9KUT3    ), MDH_VIBF1   (Q5E875    ), 
MDH_VIBFM   (B5FGF5    ), MDH_VIBMI   (Q9L8F6    ), MDH_VIBPA   (Q87SU7    ), 
MDH_VIBTL   (B7VID0    ), MDH_VIBVU   (Q8DEC2    ), MDH_VIBVY   (Q7MP97    ), 
MDH_YERE8   (A1JIV0    ), MDH_YERP3   (A7FMU2    ), MDH_YERPA   (Q1CBY7    ), 
MDH_YERPB   (B2K2N5    ), MDH_YERPE   (P61892    ), MDH_YERPG   (A9R584    ), 
MDH_YERPN   (Q1CEJ3    ), MDH_YERPP   (A4TRK3    ), MDH_YERPS   (P0C7R5    ), 
MDH_YERPY   (B1JMK1    )
» more

UniProtKB/Swiss-Prot
False negative sequences
115 sequences

MDH1_BURTA  (Q2T7J2    ), MDH1_BURVG  (A4JKE6    ), MDH1_RHOFT  (Q21XH1    ), 
MDH2_BURTA  (Q2T4T8    ), MDH2_BURVG  (A4JM71    ), MDH2_RHOFT  (Q21VT3    ), 
MDHM_BRANA  (Q43744    ), MDH_ACIAC   (A1TP96    ), MDH_ACIAD   (Q6F7X1    ), 
MDH_ACIB3   (B7GW58    ), MDH_ACIB5   (B7I9D2    ), MDH_ACIBC   (B2HZ52    ), 
MDH_ACIBS   (B0VQX5    ), MDH_ACIBT   (A3M928    ), MDH_ACIBY   (B0V6R7    ), 
MDH_ACICJ   (A5G320    ), MDH_ACIET   (B9MBP0    ), MDH_ACISJ   (A1W9K7    ), 
MDH_ACTP2   (A3N1U6    ), MDH_ACTP7   (B3H269    ), MDH_ACTPJ   (B0BQN0    ), 
MDH_AQUAR   (Q9ZF99    ), MDH_AROAE   (Q5NYA9    ), MDH_AZOSB   (A1K5Q9    ), 
MDH_BDEBA   (P61973    ), MDH_BORA1   (Q2L068    ), MDH_BORBR   (Q7WD94    ), 
MDH_BORPA   (Q7W5Q8    ), MDH_BORPD   (A9IIS3    ), MDH_BORPE   (Q7VW97    ), 
MDH_BURCA   (Q1BM38    ), MDH_BURCC   (B1K394    ), MDH_BURCH   (A0AZ43    ), 
MDH_BURCJ   (B4EFB0    ), MDH_BURCM   (Q0BAF9    ), MDH_BURL3   (Q393V1    ), 
MDH_BURM1   (A9AMD5    ), MDH_BURM7   (A3MBR2    ), MDH_BURM9   (A2S105    ), 
MDH_BURMA   (Q62AG8    ), MDH_BURMS   (A1UZ10    ), MDH_BURP0   (A3P7Q9    ), 
MDH_BURP1   (Q3JKE9    ), MDH_BURP6   (A3NM97    ), MDH_BURPS   (P80536    ), 
MDH_BURXL   (Q13S42    ), MDH_CHLAB   (Q5L5E3    ), MDH_CHLCV   (Q822E9    ), 
MDH_CHLFF   (Q255I4    ), MDH_CHLMU   (Q9PK18    ), MDH_CHLPN   (Q9Z6N1    ), 
MDH_CHLT2   (B0B7U5    ), MDH_CHLTA   (Q3KLX8    ), MDH_CHLTB   (B0BC10    ), 
MDH_CHLTR   (O84381    ), MDH_CHRVO   (Q7NZ60    ), MDH_CORDI   (P61974    ), 
MDH_COREF   (Q8FN62    ), MDH_CORGB   (A4QGA0    ), MDH_CORGL   (Q8NN33    ), 
MDH_CORJK   (Q4JWV0    ), MDH_CUPMC   (Q1LKG0    ), MDH_CUPNH   (Q0K8F5    ), 
MDH_CUPPJ   (Q46YU4    ), MDH_CUPTR   (B3R570    ), MDH_DECAR   (Q47C34    ), 
MDH_DEIDV   (C1CY73    ), MDH_DEIGD   (Q1IWC9    ), MDH_DEIRA   (Q9RXI8    ), 
MDH_DELAS   (A9BVK0    ), MDH_DESPS   (Q6AQI3    ), MDH_EHRRG   (Q5FGT9    ), 
MDH_HAEPS   (B8F5K4    ), MDH_HERAR   (A4G5Z9    ), MDH_JANMA   (A6SY47    ), 
MDH_LARHH   (C1DB66    ), MDH_LEPBA   (B0SF41    ), MDH_LEPBP   (B0SN74    ), 
MDH_LEPCP   (B1Y8A3    ), MDH_MAGMM   (A0L5T9    ), MDH_METPP   (A2SHT9    ), 
MDH_MYCVP   (A1T9L9    ), MDH_NITEC   (Q0AFK6    ), MDH_NITEU   (Q82WB9    ), 
MDH_NITMU   (Q2YAQ4    ), MDH_PARP8   (B2JQD2    ), MDH_PARPJ   (B2T9P8    ), 
MDH_POLNA   (A1VRQ1    ), MDH_POLNS   (B1XV63    ), MDH_POLSJ   (Q126N9    ), 
MDH_POLSQ   (A4SWW0    ), MDH_PSYWF   (A5WGM2    ), MDH_RALPJ   (B2U705    ), 
MDH_RALSO   (Q8XXW5    ), MDH_SACD2   (Q21K60    ), MDH_SERP5   (A8G8Y7    ), 
MDH_STRM5   (B4SLI5    ), MDH_STRMK   (B2FQL8    ), MDH_SYNFM   (A0LFF8    ), 
MDH_TERTT   (C5BU70    ), MDH_VARPS   (C5CSI5    ), MDH_VEREI   (A1WR02    ), 
MDH_WOLTR   (Q5GT41    ), MDH_XANAC   (Q8PNP8    ), MDH_XANC5   (Q3BWU8    ), 
MDH_XANC8   (Q4URH2    ), MDH_XANCB   (B0RU49    ), MDH_XANCP   (Q8PC25    ), 
MDH_XANOM   (Q2P736    ), MDH_XANOP   (B2SMP6    ), MDH_XANOR   (Q5H496    ), 
MDH_XYLF2   (B2I8M1    ), MDH_XYLFA   (Q9PE17    ), MDH_XYLFM   (B0U5Q1    ), 
MDH_XYLFT   (Q87E35    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
21 sequences

MDHM_CAPAA  (P86074    ), MDHM_IMPCY  (P84209    ), MDHM_SCHMA  (P37227    ), 
MDHM_TOBAC  (P82816    ), MDH_ACIDE   (P80540    ), MDH_ACTMI   (P19977    ), 
MDH_BURCE   (P80537    ), MDH_DELAC   (P80539    ), MDH_KIBAR   (P19978    ), 
MDH_KLEPN   (P0C1G4    ), MDH_KLEPR   (P0C1G5    ), MDH_MICGL   (P19979    ), 
MDH_NITAL   (P10887    ), MDH_PHEIM   (P19980    ), MDH_PLAVE   (P19981    ), 
MDH_PSEMZ   (P85920    ), MDH_STEMA   (P80541    ), MDH_STRAR   (P19982    ), 
MDH_STRRS   (P19983    ), MDH_THEAL   (P33163    ), MDH_VOGIN   (P80538    )
» more

UniProtKB/Swiss-Prot
False positive sequences
4 sequences

HIS4_CHRVO  (Q7P0F0    ), HIS4_THICR  (Q31E65    ), PX11E_ARATH (Q84JW1    ), 
TLR3_BOSTR  (Q0PV50    )
» more

PDB
[Detailed view]
29 PDB

1BDM; 1BMD; 1CIV; 1EMD; 1IZ9; 1MLD; 1SEV; 1SMK; 1WZE; 1WZI; 1Y7T; 2CMD; 2CVQ; 2DFD; 2PWZ; 3HHP; 4E0B; 4KDE; 4KDF; 4MDH; 4TVO; 4WLE; 4WLF; 4WLN; 4WLO; 4WLU; 4WLV; 5MDH; 7MDH
» more

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Direct ScanProsite submission