Entry: PS00068

Forthcoming changes to the profile format
General information about the entry

Entry name [info] MDH
Accession [info] PS00068
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); OCT-1993 (DATA UPDATE); JUN-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00066
Associated ProRule [info] PRU10004

Name and characterization of the entry

Description [info] Malate dehydrogenase active site signature.
Pattern [info]
[LIVM]-T-[TRKMN]-L-D-x(2)-R-[STA]-x(3)-[LIVMFY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_07 which contains 546'000 sequence entries.


Total number of hits 230 in 230 different sequences
Number of true positive hits 226 in 226 different sequences
Number of 'unknown' hits
Number of false positive hits 4 in 4 different sequences
Number of false negative sequences 115
Number of 'partial' sequences 21
Precision (true positives / (true positives + false positives)) 98.26 %
Recall (true positives / (true positives + false negatives)) 66.28 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 5
Site [info] active_site at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
226 sequences

MDHA_DICDI  (Q54GE6), MDHC1_ARATH (P93819), MDHC2_ARATH (P57106), 
MDHC_BETVU  (Q9SML8), MDHC_BOVIN  (Q3T145), MDHC_CANAL  (P83778), 
MDHC_CHICK  (Q5ZME2), MDHC_DICDI  (Q54VM2), MDHC_ECHGR  (Q04820), 
MDHC_FELCA  (Q7YRU4), MDHC_HUMAN  (P40925), MDHC_MAIZE  (Q08062), 
MDHC_MEDSA  (O48905), MDHC_MESCR  (O24047), MDHC_MOUSE  (P14152), 
MDHC_ORYSJ  (Q7XDC8), MDHC_PIG    (P11708), MDHC_RAT    (O88989), 
MDHC_XENLA  (Q6PAB3), MDHC_XENTR  (Q6DIY9), MDHC_YEAST  (P22133), 
MDHG1_ARATH (Q9ZP05), MDHG1_BRANA (Q43743), MDHG2_ARATH (O82399), 
MDHG2_BRANA (Q9XFW3), MDHG_CITLA  (P19446), MDHG_CUCSA  (P46488), 
MDHG_ORYSJ  (Q42972), MDHG_SOYBN  (P37228), MDHM1_ARATH (Q9ZP06), 
MDHM2_ARATH (Q9LKA3), MDHM_BOVIN  (Q32LG3), MDHM_CAEEL  (O02640), 
MDHM_CHLRE  (Q42686), MDHM_CITLA  (P17783), MDHM_EUCGU  (P46487), 
MDHM_FRAAN  (P83373), MDHM_HUMAN  (P40926), MDHM_MACFA  (Q4R568), 
MDHM_MOUSE  (P08249), MDHM_PIG    (P00346), MDHM_PONAB  (Q5NVR2), 
MDHM_RAT    (P04636), MDHM_YEAST  (P17505), MDHP1_SORBI (P17606), 
MDHP2_SORBI (P37229), MDHP_ARATH  (Q9SN86), MDHP_FLABI  (P46489), 
MDHP_MAIZE  (P15719), MDHP_MEDSA  (O48902), MDHP_MESCR  (Q05145), 
MDHP_PEA    (P21528), MDHP_SPIOL  (P52426), MDHP_YEAST  (P32419), 
MDH_ACTSZ   (Q5U907), MDH_AERHH   (A0KG16), MDH_AERS4   (A4SIV0), 
MDH_AKKM8   (B2UKY5), MDH_ALCBS   (Q0VQ52), MDH_ALISL   (B6EL39), 
MDH_ALKEH   (Q0ABE6), MDH_ARTAT   (A1R2B5), MDH_CELJU   (B3PHI3), 
MDH_CITK8   (A8AQC8), MDH_COLP3   (Q47VL0), MDH_COXB1   (B6J7Q0), 
MDH_COXB2   (B6IZN7), MDH_COXBN   (A9KFT9), MDH_COXBR   (A9NDV1), 
MDH_COXBU   (Q83C87), MDH_CROS8   (A7MNR3), MDH_ECO24   (A7ZSD0), 
MDH_ECO27   (B7UJW8), MDH_ECO45   (B7MBZ7), MDH_ECO55   (B7LHU4), 
MDH_ECO57   (P61891), MDH_ECO5E   (B5YSW2), MDH_ECO7I   (B7NKU9), 
MDH_ECO81   (B7N0M1), MDH_ECO8A   (B7M0U8), MDH_ECOBW   (C4ZSX4), 
MDH_ECODH   (B1XHK9), MDH_ECOHS   (A8A545), MDH_ECOK1   (A1AGC9), 
MDH_ECOL5   (Q0TCN0), MDH_ECOL6   (P61890), MDH_ECOLC   (B1IQP3), 
MDH_ECOLI   (P61889), MDH_ECOLU   (B7NDL4), MDH_ECOSE   (B6I1V4), 
MDH_ECOSM   (B1LGK2), MDH_ECOUT   (Q1R6A3), MDH_EDWI9   (C5BF98), 
MDH_ENT38   (A4WF48), MDH_ERWT9   (B2VGW7), MDH_ESCF3   (B7LRL0), 
MDH_FRAAA   (Q0RE66), MDH_FRASC   (Q2J7E7), MDH_HAEDU   (Q7VP41), 
MDH_HAEI8   (Q4QL89), MDH_HAEIE   (A5UCQ1), MDH_HAEIG   (A5UIX3), 
MDH_HAEIN   (P44427), MDH_HALHL   (A1WV94), MDH_HISS1   (Q0I491), 
MDH_HISS2   (B0UUR6), MDH_IDILO   (Q5R030), MDH_KLEOX   (P61894), 
MDH_KLEP3   (B5XSQ7), MDH_KLEP7   (A6TEQ3), MDH_KLEVA   (P61896), 
MDH_KOCRD   (B2GKC8), MDH_LEGPA   (Q5X2T6), MDH_LEGPC   (A5IEF4), 
MDH_LEGPH   (Q5ZT13), MDH_LEGPL   (Q5WU94), MDH_LEPBJ   (Q04RS5), 
MDH_LEPBL   (Q051U6), MDH_LEPIC   (P61975), MDH_LEPIN   (Q8F4A2), 
MDH_MANSM   (Q65T37), MDH_METCA   (Q60B71), MDH_MORJA   (Q6AW21), 
MDH_MORS2   (Q7X3X5), MDH_MORS5   (P48364), MDH_MYCA1   (A0QCI6), 
MDH_MYCBO   (P0A5J7), MDH_MYCBP   (A1KI28), MDH_MYCBT   (C1AMN4), 
MDH_MYCLE   (P50917), MDH_MYCMM   (B2HRH5), MDH_MYCPA   (P61976), 
MDH_MYCTA   (A5U1T8), MDH_MYCTO   (P9WK12), MDH_MYCTU   (P9WK13), 
MDH_MYCUA   (A0PVV1), MDH_NOCFA   (Q5YTI1), MDH_NOCSJ   (A1SMP3), 
MDH_PARUW   (Q6MAA3), MDH_PASMU   (Q9CN86), MDH_PECAS   (Q6D9D1), 
MDH_PECCC   (P61897), MDH_PECCP   (C6DKH1), MDH_PHOLL   (Q7MYW9), 
MDH_PHOPR   (P37226), MDH_PROAC   (Q6A6Z5), MDH_PROMH   (B4F2A1), 
MDH_PSEA6   (Q15YH0), MDH_PSEHT   (Q3IFH4), MDH_PSYA2   (Q4FQU7), 
MDH_PSYCK   (Q1Q932), MDH_PSYIN   (A1SRP8), MDH_RAOTE   (P61895), 
MDH_RHOOB   (C1B155), MDH_RHOSR   (Q0S365), MDH_RUBXD   (Q1AWH4), 
MDH_SACEN   (A4FFX3), MDH_SALA4   (B5F7L9), MDH_SALAR   (A9MNX5), 
MDH_SALCH   (Q57JA9), MDH_SALDC   (B5FIT7), MDH_SALEP   (B5R0N2), 
MDH_SALG2   (B5REV7), MDH_SALHS   (B4TJT3), MDH_SALMU   (Q59838), 
MDH_SALNS   (B4T769), MDH_SALPA   (Q7WS85), MDH_SALPB   (A9N855), 
MDH_SALPC   (C0PZQ4), MDH_SALPK   (B5BGR3), MDH_SALSV   (B4TWK9), 
MDH_SALTI   (Q8Z3E0), MDH_SALTY   (P25077), MDH_SHEAM   (A1S3C4), 
MDH_SHEB2   (B8EB55), MDH_SHEB5   (A3D075), MDH_SHEB8   (A6WSM1), 
MDH_SHEB9   (A9L340), MDH_SHEDO   (Q12R11), MDH_SHEFN   (Q07YA5), 
MDH_SHEHH   (B0TUH8), MDH_SHELP   (A3QB91), MDH_SHEON   (P82177), 
MDH_SHEPA   (A8H0U0), MDH_SHEPC   (A4YAE8), MDH_SHEPW   (B8CSY7), 
MDH_SHESA   (A0L113), MDH_SHESH   (A8FRU0), MDH_SHESM   (Q0HEW2), 
MDH_SHESR   (Q0HZ38), MDH_SHESW   (A1RFX8), MDH_SHEWM   (B1KGG7), 
MDH_SHIB3   (B2U1U9), MDH_SHIBS   (Q31WA4), MDH_SHIDS   (Q32BA3), 
MDH_SHIF8   (Q0T052), MDH_SHIFL   (Q83Q04), MDH_SHISS   (Q3YX11), 
MDH_STRAW   (Q82HS2), MDH_STRCO   (Q9K3J3), MDH_STRGG   (B1W3N4), 
MDH_THEFY   (Q47TT4), MDH_THET2   (P61977), MDH_THET8   (Q5SKV7), 
MDH_THETH   (P10584), MDH_TOBAC   (Q9FSF0), MDH_VIBCB   (A7MWD3), 
MDH_VIBCH   (Q9KUT3), MDH_VIBF1   (Q5E875), MDH_VIBFM   (B5FGF5), 
MDH_VIBMA   (Q6AW23), MDH_VIBMI   (Q9L8F6), MDH_VIBPA   (Q87SU7), 
MDH_VIBSL   (B7VID0), MDH_VIBVU   (Q8DEC2), MDH_VIBVY   (Q7MP97), 
MDH_YERE8   (A1JIV0), MDH_YERP3   (A7FMU2), MDH_YERPA   (Q1CBY7), 
MDH_YERPB   (B2K2N5), MDH_YERPE   (P61892), MDH_YERPG   (A9R584), 
MDH_YERPN   (Q1CEJ3), MDH_YERPP   (A4TRK3), MDH_YERPS   (P0C7R5), 
MDH_YERPY   (B1JMK1)
» More

UniProtKB/Swiss-Prot
False negative sequences
115 sequences

MDH1_ALBFT  (Q21XH1), MDH1_BURTA  (Q2T7J2), MDH1_BURVG  (A4JKE6), 
MDH2_ALBFT  (Q21VT3), MDH2_BURTA  (Q2T4T8), MDH2_BURVG  (A4JM71), 
MDHM_BRANA  (Q43744), MDH_ACIAC   (A1TP96), MDH_ACIAD   (Q6F7X1), 
MDH_ACIB3   (B7GW58), MDH_ACIB5   (B7I9D2), MDH_ACIBC   (B2HZ52), 
MDH_ACIBS   (B0VQX5), MDH_ACIBT   (A3M928), MDH_ACIBY   (B0V6R7), 
MDH_ACICJ   (A5G320), MDH_ACIET   (B9MBP0), MDH_ACISJ   (A1W9K7), 
MDH_ACTP2   (A3N1U6), MDH_ACTP7   (B3H269), MDH_ACTPJ   (B0BQN0), 
MDH_AQUAR   (Q9ZF99), MDH_AROAE   (Q5NYA9), MDH_AZOSB   (A1K5Q9), 
MDH_BDEBA   (P61973), MDH_BORA1   (Q2L068), MDH_BORBR   (Q7WD94), 
MDH_BORPA   (Q7W5Q8), MDH_BORPD   (A9IIS3), MDH_BORPE   (Q7VW97), 
MDH_BURCA   (Q1BM38), MDH_BURCC   (B1K394), MDH_BURCH   (A0AZ43), 
MDH_BURCJ   (B4EFB0), MDH_BURCM   (Q0BAF9), MDH_BURM1   (A9AMD5), 
MDH_BURM7   (A3MBR2), MDH_BURM9   (A2S105), MDH_BURMA   (Q62AG8), 
MDH_BURMS   (A1UZ10), MDH_BURP0   (A3P7Q9), MDH_BURP1   (Q3JKE9), 
MDH_BURP6   (A3NM97), MDH_BURP8   (B2JQD2), MDH_BURPP   (B2T9P8), 
MDH_BURPS   (P80536), MDH_BURS3   (Q393V1), MDH_BURXL   (Q13S42), 
MDH_CHLAB   (Q5L5E3), MDH_CHLCV   (Q822E9), MDH_CHLFF   (Q255I4), 
MDH_CHLMU   (Q9PK18), MDH_CHLPN   (Q9Z6N1), MDH_CHLT2   (B0B7U5), 
MDH_CHLTA   (Q3KLX8), MDH_CHLTB   (B0BC10), MDH_CHLTR   (O84381), 
MDH_CHRVO   (Q7NZ60), MDH_CORDI   (P61974), MDH_COREF   (Q8FN62), 
MDH_CORGB   (A4QGA0), MDH_CORGL   (Q8NN33), MDH_CORJK   (Q4JWV0), 
MDH_CUPNH   (Q0K8F5), MDH_CUPPJ   (Q46YU4), MDH_CUPTR   (B3R570), 
MDH_DECAR   (Q47C34), MDH_DEIDV   (C1CY73), MDH_DEIGD   (Q1IWC9), 
MDH_DEIRA   (Q9RXI8), MDH_DELAS   (A9BVK0), MDH_DESPS   (Q6AQI3), 
MDH_EHRRG   (Q5FGT9), MDH_HAEPS   (B8F5K4), MDH_HERAR   (A4G5Z9), 
MDH_JANMA   (A6SY47), MDH_LARHH   (C1DB66), MDH_LEPBA   (B0SF41), 
MDH_LEPBP   (B0SN74), MDH_LEPCP   (B1Y8A3), MDH_MAGSM   (A0L5T9), 
MDH_METPP   (A2SHT9), MDH_MYCVP   (A1T9L9), MDH_NITEC   (Q0AFK6), 
MDH_NITEU   (Q82WB9), MDH_NITMU   (Q2YAQ4), MDH_POLNA   (A1VRQ1), 
MDH_POLNS   (B1XV63), MDH_POLSJ   (Q126N9), MDH_POLSQ   (A4SWW0), 
MDH_PSYWF   (A5WGM2), MDH_RALME   (Q1LKG0), MDH_RALPJ   (B2U705), 
MDH_RALSO   (Q8XXW5), MDH_SACD2   (Q21K60), MDH_SERP5   (A8G8Y7), 
MDH_STRM5   (B4SLI5), MDH_STRMK   (B2FQL8), MDH_SYNFM   (A0LFF8), 
MDH_TERTT   (C5BU70), MDH_VARPS   (C5CSI5), MDH_VEREI   (A1WR02), 
MDH_WOLTR   (Q5GT41), MDH_XANAC   (Q8PNP8), MDH_XANC5   (Q3BWU8), 
MDH_XANC8   (Q4URH2), MDH_XANCB   (B0RU49), MDH_XANCP   (Q8PC25), 
MDH_XANOM   (Q2P736), MDH_XANOP   (B2SMP6), MDH_XANOR   (Q5H496), 
MDH_XYLF2   (B2I8M1), MDH_XYLFA   (Q9PE17), MDH_XYLFM   (B0U5Q1), 
MDH_XYLFT   (Q87E35)
» More

UniProtKB/Swiss-Prot
'Partial' sequences
21 sequences

MDHM_CAPAA  (P86074), MDHM_IMPCY  (P84209), MDHM_SCHMA  (P37227), 
MDHM_TOBAC  (P82816), MDH_ACIDE   (P80540), MDH_ACTMI   (P19977), 
MDH_BURCE   (P80537), MDH_DELAC   (P80539), MDH_KIBAR   (P19978), 
MDH_KLEPN   (P0C1G4), MDH_KLEPR   (P0C1G5), MDH_MICGL   (P19979), 
MDH_NITAL   (P10887), MDH_PHEIM   (P19980), MDH_PLAVE   (P19981), 
MDH_PSEIN   (P80538), MDH_PSEMZ   (P85920), MDH_STEMA   (P80541), 
MDH_STRAR   (P19982), MDH_STRRS   (P19983), MDH_THEAL   (P33163)
» More

UniProtKB/Swiss-Prot
False positive sequences
4 sequences

HIS4_CHRVO  (Q7P0F0), HIS4_THICR  (Q31E65), PX11E_ARATH (Q84JW1), 
TLR3_BOSTR  (Q0PV50)
» More

PDB
[Detailed view]
22 PDB

1BDM; 1BMD; 1CIV; 1EMD; 1IZ9; 1MLD; 1SEV; 1SMK; 1WZE; 1WZI; 1Y7T; 2CMD; 2CVQ; 2DFD; 2PWZ; 3HHP; 4E0B; 4KDE; 4KDF; 4MDH; 5MDH; 7MDH
» More

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