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| Entry: PS00068 |
| General information about the entry | |
|---|---|
| Entry name | MDH |
| Accession number | PS00068 |
| Entry type | PATTERN |
| Date | APR-1990 (CREATED); OCT-1993 (DATA UPDATE); MAR-2013 (INFO UPDATE). |
| PROSITE Documentation | PDOC00066 |
| Associated ProRule | PRU10004 |
| Name and characterization of the entry | |
| Description | Malate dehydrogenase active site signature. |
| Pattern | [LIVM]-T-[TRKMN]-L-D-x(2)-R-[STA]-x(3)-[LIVMFY]. |
| Numerical results | |
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| Comments | |
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| Cross-references | |
| UniProtKB/Swiss-Prot | True positive hits:MDHA_DICDI (Q54GE6), MDHC1_ARATH (P93819), MDHC2_ARATH (P57106), MDHC_BETVU (Q9SML8), MDHC_BOVIN (Q3T145), MDHC_CANAL (P83778), MDHC_CHICK (Q5ZME2), MDHC_DICDI (Q54VM2), MDHC_ECHGR (Q04820), MDHC_FELCA (Q7YRU4), MDHC_HUMAN (P40925), MDHC_MAIZE (Q08062), MDHC_MEDSA (O48905), MDHC_MESCR (O24047), MDHC_MOUSE (P14152), MDHC_ORYSJ (Q7XDC8), MDHC_PIG (P11708), MDHC_RAT (O88989), MDHC_XENLA (Q6PAB3), MDHC_XENTR (Q6DIY9), MDHC_YEAST (P22133), MDHG1_ARATH (Q9ZP05), MDHG1_BRANA (Q43743), MDHG2_ARATH (O82399), MDHG2_BRANA (Q9XFW3), MDHG_CITLA (P19446), MDHG_CUCSA (P46488), MDHG_ORYSJ (Q42972), MDHG_SOYBN (P37228), MDHM1_ARATH (Q9ZP06), MDHM2_ARATH (Q9LKA3), MDHM_BOVIN (Q32LG3), MDHM_CAEEL (O02640), MDHM_CHLRE (Q42686), MDHM_CITLA (P17783), MDHM_EUCGU (P46487), MDHM_FRAAN (P83373), MDHM_HUMAN (P40926), MDHM_MACFA (Q4R568), MDHM_MOUSE (P08249), MDHM_PIG (P00346), MDHM_PONAB (Q5NVR2), MDHM_RAT (P04636), MDHM_YEAST (P17505), MDHP1_SORBI (P17606), MDHP2_SORBI (P37229), MDHP_ARATH (Q9SN86), MDHP_FLABI (P46489), MDHP_MAIZE (P15719), MDHP_MEDSA (O48902), MDHP_MESCR (Q05145), MDHP_PEA (P21528), MDHP_SPIOL (P52426), MDHP_YEAST (P32419), MDH_ACTSZ (Q5U907), MDH_AERHH (A0KG16), MDH_AERS4 (A4SIV0), MDH_AKKM8 (B2UKY5), MDH_ALCBS (Q0VQ52), MDH_ALHEH (Q0ABE6), MDH_ALISL (B6EL39), MDH_ARTAT (A1R2B5), MDH_CELJU (B3PHI3), MDH_CITK8 (A8AQC8), MDH_COLP3 (Q47VL0), MDH_COXB1 (B6J7Q0), MDH_COXB2 (B6IZN7), MDH_COXBN (A9KFT9), MDH_COXBR (A9NDV1), MDH_COXBU (Q83C87), MDH_CROS8 (A7MNR3), MDH_ECO24 (A7ZSD0), MDH_ECO27 (B7UJW8), MDH_ECO45 (B7MBZ7), MDH_ECO55 (B7LHU4), MDH_ECO57 (P61891), MDH_ECO5E (B5YSW2), MDH_ECO7I (B7NKU9), MDH_ECO81 (B7N0M1), MDH_ECO8A (B7M0U8), MDH_ECOBW (C4ZSX4), MDH_ECODH (B1XHK9), MDH_ECOHS (A8A545), MDH_ECOK1 (A1AGC9), MDH_ECOL5 (Q0TCN0), MDH_ECOL6 (P61890), MDH_ECOLC (B1IQP3), MDH_ECOLI (P61889), MDH_ECOLU (B7NDL4), MDH_ECOSE (B6I1V4), MDH_ECOSM (B1LGK2), MDH_ECOUT (Q1R6A3), MDH_EDWI9 (C5BF98), MDH_ENT38 (A4WF48), MDH_ERWCT (Q6D9D1), MDH_ERWT9 (B2VGW7), MDH_ESCF3 (B7LRL0), MDH_FRAAA (Q0RE66), MDH_FRASC (Q2J7E7), MDH_HAEDU (Q7VP41), MDH_HAEI8 (Q4QL89), MDH_HAEIE (A5UCQ1), MDH_HAEIG (A5UIX3), MDH_HAEIN (P44427), MDH_HAES1 (Q0I491), MDH_HAES2 (B0UUR6), MDH_HALHL (A1WV94), MDH_IDILO (Q5R030), MDH_KLEOX (P61894), MDH_KLEP3 (B5XSQ7), MDH_KLEP7 (A6TEQ3), MDH_KLEVA (P61896), MDH_KOCRD (B2GKC8), MDH_LEGPA (Q5X2T6), MDH_LEGPC (A5IEF4), MDH_LEGPH (Q5ZT13), MDH_LEGPL (Q5WU94), MDH_LEPBJ (Q04RS5), MDH_LEPBL (Q051U6), MDH_LEPIC (P61975), MDH_LEPIN (Q8F4A2), MDH_MANSM (Q65T37), MDH_METCA (Q60B71), MDH_MORJA (Q6AW21), MDH_MORS2 (Q7X3X5), MDH_MORS5 (P48364), MDH_MYCA1 (A0QCI6), MDH_MYCBO (P0A5J7), MDH_MYCBP (A1KI28), MDH_MYCBT (C1AMN4), MDH_MYCLE (P50917), MDH_MYCMM (B2HRH5), MDH_MYCPA (P61976), MDH_MYCTA (A5U1T8), MDH_MYCTU (P0A5J6), MDH_MYCUA (A0PVV1), MDH_NOCFA (Q5YTI1), MDH_NOCSJ (A1SMP3), MDH_PARUW (Q6MAA3), MDH_PASMU (Q9CN86), MDH_PECCC (P61897), MDH_PECCP (C6DKH1), MDH_PHOLL (Q7MYW9), MDH_PHOPR (P37226), MDH_PROAC (Q6A6Z5), MDH_PROMH (B4F2A1), MDH_PSEA6 (Q15YH0), MDH_PSEHT (Q3IFH4), MDH_PSYA2 (Q4FQU7), MDH_PSYCK (Q1Q932), MDH_PSYIN (A1SRP8), MDH_RAOTE (P61895), MDH_RHOOB (C1B155), MDH_RHOSR (Q0S365), MDH_RUBXD (Q1AWH4), MDH_SACEN (A4FFX3), MDH_SALA4 (B5F7L9), MDH_SALAR (A9MNX5), MDH_SALCH (Q57JA9), MDH_SALDC (B5FIT7), MDH_SALEP (B5R0N2), MDH_SALG2 (B5REV7), MDH_SALHS (B4TJT3), MDH_SALMU (Q59838), MDH_SALNS (B4T769), MDH_SALPA (Q7WS85), MDH_SALPB (A9N855), MDH_SALPC (C0PZQ4), MDH_SALPK (B5BGR3), MDH_SALSV (B4TWK9), MDH_SALTI (Q8Z3E0), MDH_SALTY (P25077), MDH_SHEAM (A1S3C4), MDH_SHEB2 (B8EB55), MDH_SHEB5 (A3D075), MDH_SHEB8 (A6WSM1), MDH_SHEB9 (A9L340), MDH_SHEDO (Q12R11), MDH_SHEFN (Q07YA5), MDH_SHEHH (B0TUH8), MDH_SHELP (A3QB91), MDH_SHEON (P82177), MDH_SHEPA (A8H0U0), MDH_SHEPC (A4YAE8), MDH_SHEPW (B8CSY7), MDH_SHESA (A0L113), MDH_SHESH (A8FRU0), MDH_SHESM (Q0HEW2), MDH_SHESR (Q0HZ38), MDH_SHESW (A1RFX8), MDH_SHEWM (B1KGG7), MDH_SHIB3 (B2U1U9), MDH_SHIBS (Q31WA4), MDH_SHIDS (Q32BA3), MDH_SHIF8 (Q0T052), MDH_SHIFL (Q83Q04), MDH_SHISS (Q3YX11), MDH_STRAW (Q82HS2), MDH_STRCO (Q9K3J3), MDH_STRGG (B1W3N4), MDH_THEFY (Q47TT4), MDH_THET2 (P61977), MDH_THET8 (Q5SKV7), MDH_THETH (P10584), MDH_VIBCH (Q9KUT3), MDH_VIBF1 (Q5E875), MDH_VIBFM (B5FGF5), MDH_VIBHB (A7MWD3), MDH_VIBMA (Q6AW23), MDH_VIBMI (Q9L8F6), MDH_VIBPA (Q87SU7), MDH_VIBSL (B7VID0), MDH_VIBVU (Q8DEC2), MDH_VIBVY (Q7MP97), MDH_YERE8 (A1JIV0), MDH_YERP3 (A7FMU2), MDH_YERPA (Q1CBY7), MDH_YERPB (B2K2N5), MDH_YERPE (P61892), MDH_YERPG (A9R584), MDH_YERPN (Q1CEJ3), MDH_YERPP (A4TRK3), MDH_YERPS (P0C7R5), MDH_YERPY (B1JMK1)False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile): MDH1_BURTA (Q2T7J2), MDH1_BURVG (A4JKE6), MDH1_RHOFD (Q21XH1), MDH2_BURTA (Q2T4T8), MDH2_BURVG (A4JM71), MDH2_RHOFD (Q21VT3), MDHM_BRANA (Q43744), MDH_ACIAC (A1TP96), MDH_ACIAD (Q6F7X1), MDH_ACIB3 (B7GW58), MDH_ACIB5 (B7I9D2), MDH_ACIBC (B2HZ52), MDH_ACIBS (B0VQX5), MDH_ACIBT (A3M928), MDH_ACIBY (B0V6R7), MDH_ACICJ (A5G320), MDH_ACIET (B9MBP0), MDH_ACISJ (A1W9K7), MDH_ACTP2 (A3N1U6), MDH_ACTP7 (B3H269), MDH_ACTPJ (B0BQN0), MDH_AQUAR (Q9ZF99), MDH_AROAE (Q5NYA9), MDH_AZOSB (A1K5Q9), MDH_BDEBA (P61973), MDH_BORA1 (Q2L068), MDH_BORBR (Q7WD94), MDH_BORPA (Q7W5Q8), MDH_BORPD (A9IIS3), MDH_BORPE (Q7VW97), MDH_BURCA (Q1BM38), MDH_BURCC (B1K394), MDH_BURCH (A0AZ43), MDH_BURCJ (B4EFB0), MDH_BURCM (Q0BAF9), MDH_BURM1 (A9AMD5), MDH_BURM7 (A3MBR2), MDH_BURM9 (A2S105), MDH_BURMA (Q62AG8), MDH_BURMS (A1UZ10), MDH_BURP0 (A3P7Q9), MDH_BURP1 (Q3JKE9), MDH_BURP6 (A3NM97), MDH_BURP8 (B2JQD2), MDH_BURPP (B2T9P8), MDH_BURPS (P80536), MDH_BURS3 (Q393V1), MDH_BURXL (Q13S42), MDH_CHLAB (Q5L5E3), MDH_CHLCV (Q822E9), MDH_CHLFF (Q255I4), MDH_CHLMU (Q9PK18), MDH_CHLPN (Q9Z6N1), MDH_CHLT2 (B0B7U5), MDH_CHLTA (Q3KLX8), MDH_CHLTB (B0BC10), MDH_CHLTR (O84381), MDH_CHRVO (Q7NZ60), MDH_CORDI (P61974), MDH_COREF (Q8FN62), MDH_CORGB (A4QGA0), MDH_CORGL (Q8NN33), MDH_CORJK (Q4JWV0), MDH_CUPNH (Q0K8F5), MDH_CUPPJ (Q46YU4), MDH_CUPTR (B3R570), MDH_DECAR (Q47C34), MDH_DEIDV (C1CY73), MDH_DEIGD (Q1IWC9), MDH_DEIRA (Q9RXI8), MDH_DELAS (A9BVK0), MDH_DESPS (Q6AQI3), MDH_EHRRG (Q5FGT9), MDH_HAEPS (B8F5K4), MDH_HERAR (A4G5Z9), MDH_JANMA (A6SY47), MDH_LARHH (C1DB66), MDH_LEPBA (B0SF41), MDH_LEPBP (B0SN74), MDH_LEPCP (B1Y8A3), MDH_MAGSM (A0L5T9), MDH_METPP (A2SHT9), MDH_MYCVP (A1T9L9), MDH_NITEC (Q0AFK6), MDH_NITEU (Q82WB9), MDH_NITMU (Q2YAQ4), MDH_POLNA (A1VRQ1), MDH_POLNS (B1XV63), MDH_POLSJ (Q126N9), MDH_POLSQ (A4SWW0), MDH_PSYWF (A5WGM2), MDH_RALME (Q1LKG0), MDH_RALPJ (B2U705), MDH_RALSO (Q8XXW5), MDH_SACD2 (Q21K60), MDH_SERP5 (A8G8Y7), MDH_STRM5 (B4SLI5), MDH_STRMK (B2FQL8), MDH_SYNFM (A0LFF8), MDH_TERTT (C5BU70), MDH_VARPS (C5CSI5), MDH_VEREI (A1WR02), MDH_WOLTR (Q5GT41), MDH_XANAC (Q8PNP8), MDH_XANC5 (Q3BWU8), MDH_XANC8 (Q4URH2), MDH_XANCB (B0RU49), MDH_XANCP (Q8PC25), MDH_XANOM (Q2P736), MDH_XANOP (B2SMP6), MDH_XANOR (Q5H496), MDH_XYLF2 (B2I8M1), MDH_XYLFA (Q9PE17), MDH_XYLFM (B0U5Q1), MDH_XYLFT (Q87E35)`Potential' hits (partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences): MDHM_CAPAA (P86074), MDHM_IMPCY (P84209), MDHM_SCHMA (P37227), MDHM_TOBAC (P82816), MDH_ACIDE (P80540), MDH_ACTMI (P19977), MDH_BURCE (P80537), MDH_DELAC (P80539), MDH_KIBAR (P19978), MDH_KLEPN (P0C1G4), MDH_KLEPR (P0C1G5), MDH_MICGL (P19979), MDH_NITAL (P10887), MDH_PHEIM (P19980), MDH_PLAVE (P19981), MDH_PSEIN (P80538), MDH_PSEMZ (P85920), MDH_STEMA (P80541), MDH_STRAR (P19982), MDH_STRRS (P19983), MDH_THEAL (P33163)False positive hits (sequences which do not belong to the set under consideration): HIS4_CHRVO (Q7P0F0), HIS4_THICR (Q31E65), PX11E_ARATH (Q84JW1), TLR3_BOSTR (Q0PV50)Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view]
[Clustal format, color]
[Clustal format, plain text]
[Fasta format]
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| PDB [Detailed view] |
1BDM; 1BMD; 1CIV; 1CME; 1EMD; 1IZ9; 1MLD; 1SEV; 1SMK; 1WZE; 1WZI; 1Y7T; 2CMD; 2CVQ; 2DFD; 2PWZ; 3HHP; 4E0B; 4MDH; 5MDH; 7MDH; |
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