PROSITE logo

PROSITE entry PS00098


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] THIOLASE_1
Accession [info] PS00098
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00092

Name and characterization of the entry

Description [info] Thiolases acyl-enzyme intermediate signature.
Pattern [info]
[LIVM]-[NST]-{T}-x-C-[SAGLI]-[ST]-[SAG]-[LIVMFYNS]-x-[STAG]-[LIVM]-x(6)-
[LIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.


Total number of hits 277 in 277 different sequences
Number of true positive hits 263 in 263 different sequences
Number of 'unknown' hits 1
Number of false positive hits 13 in 13 different sequences
Number of false negative sequences 48
Number of 'partial' sequences 3
Precision (true positives / (true positives + false positives)) 95.29 %
Recall (true positives / (true positives + false negatives)) 84.57 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] involved_formation_acyl-enzyme_intermediate at position 5
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
263 sequences

ACCT2_ARATH (Q8S4Y1), ATOB_ECOLI  (P76461), ATOB_HAEIN  (P44873), 
ATOB_PSEAE  (Q9I2A8), BKTB_CUPNH  (Q0KBP1), CATF_ACIAD  (Q43935), 
CLE1_ASPVE  (A0A3T0ZHJ0), ECHB_BOVIN  (O46629), ECHB_HUMAN  (P55084), 
ECHB_MACFA  (Q8HXX4), ECHB_MOUSE  (Q99JY0), ECHB_PANTR  (Q5R1W7), 
ECHB_RAT(Q60587), ECHH_CAEEL  (P34255), ER10A_ASPFC (B0XMC1), 
ER10A_ASPFU (Q4WLA8), ER10A_GIBZE (I1RMA2), ER10B_ASPFC (B0YA65), 
ER10B_ASPFU (Q4WCL5), ER10B_GIBZE (I1RY81), ERG10_CANAL (A0A1D8PH52), 
ERG10_SACMO (P10551), ERG10_YEAST (P41338), FADA4_MYCBO (P66927), 
FADA4_MYCLE (P46707), FADA4_MYCS2 (A0R1Y7), FADA4_MYCTO (P9WG68), 
FADA4_MYCTU (P9WG69), FADA_ACIAD  (Q6FF69), FADA_ACIB3  (B7H1I1), 
FADA_ACIB5  (B7I3P0), FADA_ACIBC  (B2I2J8), FADA_ACIBS  (B0VLX5), 
FADA_ACIBT  (A3M1H9), FADA_ACIBY  (B0VE46), FADA_AERHH  (A0KEL0), 
FADA_AERS4  (A4STF3), FADA_ALCBS  (Q0VNZ7), FADA_ALIF1  (Q5E8X7), 
FADA_ALIFM  (B5FEW7), FADA_ALISL  (B6EGU1), FADA_BACSU  (O32177), 
FADA_CHRSD  (Q1QUW9), FADA_CITK8  (A8ACZ3), FADA_COLP3  (Q489W4), 
FADA_CROS8  (A7MQM5), FADA_ECO24  (A7ZU50), FADA_ECO57  (Q8X8J4), 
FADA_ECOHS  (A8A6V0), FADA_ECOK1  (A1AI32), FADA_ECOL5  (Q0TAL1), 
FADA_ECOL6  (Q8FBI3), FADA_ECOLI  (P21151), FADA_ECOUT  (Q1R467), 
FADA_ENT38  (A4WFX5), FADA_ENTCL  (Q9F0Y6), FADA_ERWT9  (B2VFE0), 
FADA_ESCF3  (B7LTZ0), FADA_HAHCH  (Q2SD23), FADA_IDILO  (Q5QXH8), 
FADA_KLEP7  (A6TGM3), FADA_MARMS  (A6VVM8), FADA_MARN8  (A1TZR8), 
FADA_PECAS  (Q6DAP6), FADA_PECCP  (C6DI66), FADA_PHOLL  (Q7MZ91), 
FADA_PHOPR  (Q6LW07), FADA_PSE14  (Q48GW4), FADA_PSEA6  (Q15ZF4), 
FADA_PSEA7  (A6V383), FADA_PSEAB  (Q02PH7), FADA_PSEAE  (Q9HZJ3), 
FADA_PSEE4  (Q1I7D5), FADA_PSEF5  (Q4KFC3), FADA_PSEFR  (P28790), 
FADA_PSEMY  (A4XSM9), FADA_PSEOL  (Q93Q11), FADA_PSEP1  (A5W6G9), 
FADA_PSEPF  (Q3K9D9), FADA_PSEPK  (Q88L01), FADA_PSEPU  (Q9R9W0), 
FADA_PSESM  (Q87ZB3), FADA_PSET1  (Q3IJ24), FADA_PSEU2  (Q4ZRA1), 
FADA_PSYA2  (Q4FQC7), FADA_PSYCK  (Q1Q8K0), FADA_PSYWF  (A5WH98), 
FADA_SACD2  (Q21KB1), FADA_SALCH  (Q57HM7), FADA_SALPA  (Q5PKQ3), 
FADA_SALTI  (P0A2H8), FADA_SALTY  (P0A2H7), FADA_SERP5  (A8G8D0), 
FADA_SHEAM  (A1S1I7), FADA_SHEB5  (A3CYJ3), FADA_SHEB8  (A6WH99), 
FADA_SHEDO  (Q12TB5), FADA_SHEFN  (Q08A40), FADA_SHELP  (A3Q8U3), 
FADA_SHEON  (Q8EKS0), FADA_SHEPC  (A4Y1B5), FADA_SHESA  (A0KR49), 
FADA_SHESM  (Q0HPB8), FADA_SHESR  (Q0I0T4), FADA_SHESW  (A1RDW3), 
FADA_SHIBS  (Q31UE3), FADA_SHIDS  (Q32A20), FADA_SHIF8  (Q0SZ35), 
FADA_SHIFL  (Q83PG2), FADA_SHISS  (Q3YVC2), FADA_STUS1  (A4VKA4), 
FADA_VIBC3  (A5F464), FADA_VIBCH  (Q9KNI0), FADA_VIBPA  (Q87TP0), 
FADA_VIBVU  (Q8DDK5), FADA_VIBVY  (Q7MQI0), FADA_YERE8  (A1JIG3), 
FADA_YERP3  (A7FDF1), FADA_YERPA  (Q1C2C3), FADA_YERPE  (Q8ZAM9), 
FADA_YERPN  (Q1CNA0), FADA_YERPP  (A4TR28), FADA_YERPS  (Q66FR9), 
FADI_AERHH  (A0KK76), FADI_AERS4  (A4SMT9), FADI_CITK8  (A8ADP1), 
FADI_CROS8  (A7MH80), FADI_ECO24  (A7ZPF9), FADI_ECO27  (B7UFZ9), 
FADI_ECO45  (B7MGV8), FADI_ECO55  (B7LBJ6), FADI_ECO57  (Q8XCN9), 
FADI_ECO5E  (B5YXY5), FADI_ECO7I  (B7NP25), FADI_ECO81  (B7MY17), 
FADI_ECO8A  (B7M6M3), FADI_ECOBW  (C4ZVN3), FADI_ECODH  (B1X9L5), 
FADI_ECOHS  (A8A2L1), FADI_ECOK1  (A1ADI9), FADI_ECOL5  (Q0TFA5), 
FADI_ECOL6  (Q8FFG3), FADI_ECOLC  (B1IXA4), FADI_ECOLI  (P76503), 
FADI_ECOLU  (B7N5V3), FADI_ECOSE  (B6I6Q5), FADI_ECOSM  (B1LME8), 
FADI_ECOUT  (Q1R971), FADI_ENT38  (A4WCW7), FADI_ERWT9  (B2VJ10), 
FADI_ESCF3  (B7LLC9), FADI_KLEP3  (B5XVW1), FADI_KLEP7  (A6TC20), 
FADI_PECAS  (Q6D2L6), FADI_PECCP  (C6DAL8), FADI_PHOLL  (Q7N287), 
FADI_PSET1  (Q3IEE3), FADI_SALA4  (B5EZS0), FADI_SALAR  (A9MJ36), 
FADI_SALCH  (Q57LW5), FADI_SALDC  (B5FPN2), FADI_SALEP  (B5R3S0), 
FADI_SALHS  (B4TCA9), FADI_SALNS  (B4SZR1), FADI_SALPA  (Q5PCX7), 
FADI_SALPB  (A9N452), FADI_SALPC  (C0PZX5), FADI_SALPK  (B5BBA0), 
FADI_SALSV  (B4TQC3), FADI_SALTI  (Q8Z4Y9), FADI_SALTY  (Q8ZNA6), 
FADI_SERP5  (A8GH87), FADI_SHIB3  (B2TWV5), FADI_SHIBS  (Q31YB6), 
FADI_SHIDS  (Q32DJ3), FADI_SHIF8  (Q0T2E5), FADI_SHIFL  (Q83K95), 
FADI_SHISS  (Q3YZM1), FADI_YERE8  (A1JK23), FADI_YERP3  (A7FGK0), 
FADI_YERPA  (Q1C659), FADI_YERPB  (B2K8J6), FADI_YERPE  (Q8ZD46), 
FADI_YERPG  (A9R7W9), FADI_YERPN  (Q1CHK1), FADI_YERPP  (A4TM83), 
FADI_YERPS  (Q668V0), FADI_YERPY  (B1JGG1), KAT1_PETHY  (C8YNG6), 
NLTP2_CAEEL (G5EDP2), PAAJ_ECOLI  (P0C7L2), PAAJ_ECOLX  (P0C7L3), 
PCAF_ACIAD  (Q43974), PCAF_PSEAE  (Q9I6R0), PCAF_PSEKB  (Q8VPF1), 
PCAF_PSEPU  (Q51956), PIGA_MONRU  (A0A0S2CHA9), PKS11_TALMA (D7RJN5), 
PKSM_BACSU  (P40872), PKSR_BACSU  (O31784), SCP2_BOVIN  (P07857), 
SCP2_CHICK  (Q07598), SCP2_HUMAN  (P22307), SCP2_MOUSE  (P32020), 
SCP2_RABIT  (O62742), SCP2_RAT(P11915), TAS1_CORMM  (G3J9P0), 
THIA_CANTR  (Q12598), THIB_CANTR  (Q04677), THIK1_ARATH (Q8LF48), 
THIK2_ARATH (Q56WD9), THIK5_ARATH (Q570C8), THIKA_CANTR (P33290), 
THIKA_MOUSE (Q921H8), THIKA_RAT   (P21775), THIKB_CANTR (P33291), 
THIKB_MOUSE (Q8VCH0), THIKB_RAT   (P07871), THIK_ENCCU  (Q8SVA6), 
THIK_HUMAN  (P09110), THIK_YARLI  (Q05493), THIK_YEAST  (P27796), 
THIL1_DICDI (Q86AD9), THILA_XENLA (Q6NU46), THILB_XENLA (Q6GN02), 
THILH_CAEEL (Q22100), THIL_ALLVD  (P45369), THIL_BOVIN  (Q29RZ0), 
THIL_CHRVO  (Q9ZHI1), THIL_CUPNH  (P14611), THIL_DANRE  (Q6AZA0), 
THIL_HUMAN  (P24752), THIL_MACFA  (Q8HXY6), THIL_MOUSE  (Q8QZT1), 
THIL_PARDE  (P54810), THIL_RAT(P17764), THIL_RHIME  (P50174), 
THIL_SHIZO  (P07097), THIL_THIVI  (P45363), THIL_XENTR  (Q5BKN8), 
THIL_YARLI  (Q6L8K7), THIM_BOVIN  (Q3T0R7), THIM_HUMAN  (P42765), 
THIM_MOUSE  (Q8BWT1), THIM_PONAB  (Q5RES5), THIM_RAT(P13437), 
THLA_CLOAB  (P45359), THLA_CLOD6  (Q18AR0), THLA_STAA3  (Q2FJQ9), 
THLA_STAA8  (Q2G124), THLA_STAAB  (Q2YVF5), THLA_STAAC  (Q5HIU0), 
THLA_STAAM  (Q99WM3), THLA_STAAN  (Q7A7L2), THLA_STAAR  (Q6GJW4), 
THLA_STAAS  (Q6GCB8), THLA_STAAW  (Q8NY95), THLA_STAEQ  (Q5HS07), 
THLA_STAES  (Q8CQN7), THLA_SYNWW  (Q0AVM3), THL_BACSU   (P45855), 
Y0859_MYCTU (O53871), YQEF_ECOLI  (Q46939)
» more

UniProtKB/Swiss-Prot
False negative sequences
48 sequences

AACT1_ARATH (Q9FIK7), FADA5_MYCTU (I6XHI4), FADA6_MYCTU (I6XHJ3), 
FADI_ALIF1  (Q5E3U0), FADI_ALIFM  (B5FGB5), FADI_ALTMD  (B4RTU9), 
FADI_COLP3  (Q47ZB6), FADI_IDILO  (Q5QXN5), FADI_PHOPR  (Q6LTK4), 
FADI_PSEA6  (Q15VA3), FADI_SHEAM  (A1S7L7), FADI_SHEB2  (B8EE97), 
FADI_SHEB5  (A3D685), FADI_SHEB8  (A6WQ26), FADI_SHEB9  (A9KTW7), 
FADI_SHEDO  (Q12P12), FADI_SHEFN  (Q07ZP7), FADI_SHEHH  (B0TL22), 
FADI_SHELP  (A3QFP4), FADI_SHEON  (Q8ECP6), FADI_SHEPA  (A8H5T2), 
FADI_SHEPC  (A4Y898), FADI_SHEPW  (B8CPY7), FADI_SHESA  (A0KV75), 
FADI_SHESH  (A8FTR6), FADI_SHESM  (Q0HKD2), FADI_SHESR  (Q0HWN4), 
FADI_SHESW  (A1RI91), FADI_SHEWM  (B1KKT1), FADI_VIBC3  (A5F2P1), 
FADI_VIBCH  (Q9KT59), FADI_VIBPA  (Q87MM2), FADI_VIBVU  (Q8DB48), 
FADI_VIBVY  (Q7MIS4), THIC_HUMAN  (Q9BWD1), THIC_MOUSE  (Q8CAY6), 
THIC_RAT(Q5XI22), VRAB_STAA1  (Q9KWK4), VRAB_STAAC  (Q5HIA0), 
VRAB_STAAM  (Q7A2W9), VRAB_STAAN  (Q7A768), VRAB_STAAR  (Q6GJ93), 
VRAB_STAAS  (Q6GBR1), VRAB_STAAW  (Q7A1P9), VRAB_STAEQ  (Q5HRH3), 
VRAB_STAES  (Q8CTR0), VRAB_STAHJ  (Q4L3Q1), YHFS_BACSU  (O07618)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
3 sequences

THIL_PIG(P14610), THLA_CLODI  (P45362), THLA_CLOPA  (P81347)

		
UniProtKB/Swiss-Prot
'Unknown' sequences
1 sequence

PKS11_TALMQ (B6QK76)

		
UniProtKB/Swiss-Prot
False positive sequences
13 sequences

C9B51_TRIFG (A0A517FNC6), DPASA_APISA (P9WEX0), DPMAA_METAN (P9WEX6), 
EPAA_ASPNC  (A2QTE9), NODE_RHIME  (P06230), NODE_RHIS3  (P72331), 
NOE4_RHIML  (P06231), PKS1_SARSH  (A5PHD6), POMT2_DANRE (F1Q8R9), 
SERB2_ARATH (Q9SHP0), SORB_HYPJQ  (G0R6S9), STRU3_BPPAJ (P85503), 
SUBA_METRA  (E9F5E7)
» more

PDB
[Detailed view]
102 PDB

1AFW; 1DLU; 1DLV; 1DM3; 1M1T; 1M4S; 1M4T; 1NL7; 1OU6; 1PXT; 1QFL; 1WDK; 1WDL; 1WDM; 2C7Y; 2C7Z; 2D3T; 2F2S; 2IB7; 2IB8; 2IB9; 2IBU; 2IBW; 2IBY; 2IIK; 2VU0; 2VU1; 2VU2; 2WKT; 2WKU; 2WKV; 2WL4; 2WL5; 2WL6; 2WU9; 3GOA; 4B3H; 4B3I; 4B3J; 4C2J; 4C2K; 4DD5; 4NZS; 4O99; 4W61; 4WYR; 4WYS; 4XL2; 5F0V; 5F38; 5LP7; 5XZ5; 5ZQZ; 5ZRV; 6AQP; 6ARE; 6ARF; 6ARG; 6ARL; 6ARR; 6ART; 6DV2; 6L2C; 6L2G; 7LBZ; 7LCA; 7LCL; 7LD2; 7LDC; 7LDT; 7LDU; 7LDV; 7LDW; 7O1I; 7O1L; 7O4Q; 7O4R; 7O4S; 7O4T; 7O4V; 8BNR; 8BNU; 8BRJ; 8GQH; 8GQJ; 8OPU; 8OPV; 8OPW; 8OPX; 8OPY; 8OQL; 8OQM; 8OQN; 8OQO; 8OQP; 8OQQ; 8OQR; 8OQS; 8OQT; 8OQU; 8OQV; 8PF8
» more