Entry: PS00099

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General information about the entry

Entry name [info] THIOLASE_3
Accession [info] PS00099
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); APR-2006 (DATA UPDATE); JUN-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00092
Associated ProRule [info] PRU10020

Name and characterization of the entry

Description [info] Thiolases active site.
Pattern [info]
[AG]-[LIVMA]-[STAGCLIVM]-[STAG]-[LIVMA]-C-{Q}-[AG]-x-[AG]-x-[AG]-x-[SAG].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_07 which contains 546'000 sequence entries.


Total number of hits 292 in 292 different sequences
Number of true positive hits 253 in 253 different sequences
Number of 'unknown' hits
Number of false positive hits 39 in 39 different sequences
Number of false negative sequences 39
Number of 'partial' sequences 3
Precision (true positives / (true positives + false positives)) 86.64 %
Recall (true positives / (true positives + false negatives)) 86.64 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 6
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
253 sequences

ATOB_ECOLI  (P76461), ATOB_HAEIN  (P44873), ATOB_PSEAE  (Q9I2A8), 
BKTB_CUPNH  (Q0KBP1), CATF_ACIAD  (Q43935), ECHB_BOVIN  (O46629), 
ECHB_HUMAN  (P55084), ECHB_MACFA  (Q8HXX4), ECHB_MOUSE  (Q99JY0), 
ECHB_PANTR  (Q5R1W7), ECHB_RAT    (Q60587), FADA4_MYCBO (P66927), 
FADA4_MYCLE (P46707), FADA4_MYCS2 (A0R1Y7), FADA4_MYCTO (P9WG68), 
FADA4_MYCTU (P9WG69), FADA_ACIAD  (Q6FF69), FADA_ACIB3  (B7H1I1), 
FADA_ACIB5  (B7I3P0), FADA_ACIBC  (B2I2J8), FADA_ACIBS  (B0VLX5), 
FADA_ACIBT  (A3M1H9), FADA_ACIBY  (B0VE46), FADA_AERHH  (A0KEL0), 
FADA_AERS4  (A4STF3), FADA_ALCBS  (Q0VNZ7), FADA_ALISL  (B6EGU1), 
FADA_BACSU  (O32177), FADA_CHRSD  (Q1QUW9), FADA_CITK8  (A8ACZ3), 
FADA_COLP3  (Q489W4), FADA_CROS8  (A7MQM5), FADA_ECO24  (A7ZU50), 
FADA_ECO57  (Q8X8J4), FADA_ECOHS  (A8A6V0), FADA_ECOK1  (A1AI32), 
FADA_ECOL5  (Q0TAL1), FADA_ECOL6  (Q8FBI3), FADA_ECOLI  (P21151), 
FADA_ECOUT  (Q1R467), FADA_ENT38  (A4WFX5), FADA_ENTCL  (Q9F0Y6), 
FADA_ERWT9  (B2VFE0), FADA_ESCF3  (B7LTZ0), FADA_HAHCH  (Q2SD23), 
FADA_IDILO  (Q5QXH8), FADA_KLEP7  (A6TGM3), FADA_MARAV  (A1TZR8), 
FADA_MARMS  (A6VVM8), FADA_PECAS  (Q6DAP6), FADA_PECCP  (C6DI66), 
FADA_PHOLL  (Q7MZ91), FADA_PHOPR  (Q6LW07), FADA_PSE14  (Q48GW4), 
FADA_PSEA6  (Q15ZF4), FADA_PSEF5  (Q4KFC3), FADA_PSEFR  (P28790), 
FADA_PSEHT  (Q3IJ24), FADA_PSEPF  (Q3K9D9), FADA_PSESM  (Q87ZB3), 
FADA_PSEU2  (Q4ZRA1), FADA_PSEU5  (A4VKA4), FADA_PSYA2  (Q4FQC7), 
FADA_PSYCK  (Q1Q8K0), FADA_PSYWF  (A5WH98), FADA_SALCH  (Q57HM7), 
FADA_SALPA  (Q5PKQ3), FADA_SALTI  (P0A2H8), FADA_SALTY  (P0A2H7), 
FADA_SERP5  (A8G8D0), FADA_SHEAM  (A1S1I7), FADA_SHEB5  (A3CYJ3), 
FADA_SHEB8  (A6WH99), FADA_SHEDO  (Q12TB5), FADA_SHEFN  (Q08A40), 
FADA_SHELP  (A3Q8U3), FADA_SHEON  (Q8EKS0), FADA_SHEPC  (A4Y1B5), 
FADA_SHESA  (A0KR49), FADA_SHESM  (Q0HPB8), FADA_SHESR  (Q0I0T4), 
FADA_SHESW  (A1RDW3), FADA_SHIBS  (Q31UE3), FADA_SHIDS  (Q32A20), 
FADA_SHIF8  (Q0SZ35), FADA_SHIFL  (Q83PG2), FADA_SHISS  (Q3YVC2), 
FADA_VIBC3  (A5F464), FADA_VIBCH  (Q9KNI0), FADA_VIBF1  (Q5E8X7), 
FADA_VIBFM  (B5FEW7), FADA_VIBPA  (Q87TP0), FADA_VIBVU  (Q8DDK5), 
FADA_VIBVY  (Q7MQI0), FADA_YERE8  (A1JIG3), FADA_YERP3  (A7FDF1), 
FADA_YERPA  (Q1C2C3), FADA_YERPE  (Q8ZAM9), FADA_YERPN  (Q1CNA0), 
FADA_YERPP  (A4TR28), FADA_YERPS  (Q66FR9), FADI_ALTMD  (B4RTU9), 
FADI_CITK8  (A8ADP1), FADI_COLP3  (Q47ZB6), FADI_CROS8  (A7MH80), 
FADI_ECO24  (A7ZPF9), FADI_ECO27  (B7UFZ9), FADI_ECO45  (B7MGV8), 
FADI_ECO55  (B7LBJ6), FADI_ECO57  (Q8XCN9), FADI_ECO5E  (B5YXY5), 
FADI_ECO7I  (B7NP25), FADI_ECO81  (B7MY17), FADI_ECO8A  (B7M6M3), 
FADI_ECOBW  (C4ZVN3), FADI_ECODH  (B1X9L5), FADI_ECOHS  (A8A2L1), 
FADI_ECOK1  (A1ADI9), FADI_ECOL5  (Q0TFA5), FADI_ECOL6  (Q8FFG3), 
FADI_ECOLC  (B1IXA4), FADI_ECOLI  (P76503), FADI_ECOLU  (B7N5V3), 
FADI_ECOSE  (B6I6Q5), FADI_ECOSM  (B1LME8), FADI_ECOUT  (Q1R971), 
FADI_ENT38  (A4WCW7), FADI_ERWT9  (B2VJ10), FADI_ESCF3  (B7LLC9), 
FADI_IDILO  (Q5QXN5), FADI_KLEP3  (B5XVW1), FADI_KLEP7  (A6TC20), 
FADI_PECAS  (Q6D2L6), FADI_PECCP  (C6DAL8), FADI_PHOLL  (Q7N287), 
FADI_PSEA6  (Q15VA3), FADI_PSEHT  (Q3IEE3), FADI_SALA4  (B5EZS0), 
FADI_SALAR  (A9MJ36), FADI_SALCH  (Q57LW5), FADI_SALDC  (B5FPN2), 
FADI_SALEP  (B5R3S0), FADI_SALHS  (B4TCA9), FADI_SALNS  (B4SZR1), 
FADI_SALPA  (Q5PCX7), FADI_SALPB  (A9N452), FADI_SALPC  (C0PZX5), 
FADI_SALPK  (B5BBA0), FADI_SALSV  (B4TQC3), FADI_SALTI  (Q8Z4Y9), 
FADI_SALTY  (Q8ZNA6), FADI_SERP5  (A8GH87), FADI_SHEAM  (A1S7L7), 
FADI_SHEB2  (B8EE97), FADI_SHEB5  (A3D685), FADI_SHEB8  (A6WQ26), 
FADI_SHEB9  (A9KTW7), FADI_SHEDO  (Q12P12), FADI_SHEFN  (Q07ZP7), 
FADI_SHEHH  (B0TL22), FADI_SHELP  (A3QFP4), FADI_SHEON  (Q8ECP6), 
FADI_SHEPA  (A8H5T2), FADI_SHEPC  (A4Y898), FADI_SHEPW  (B8CPY7), 
FADI_SHESA  (A0KV75), FADI_SHESH  (A8FTR6), FADI_SHESM  (Q0HKD2), 
FADI_SHESR  (Q0HWN4), FADI_SHESW  (A1RI91), FADI_SHEWM  (B1KKT1), 
FADI_SHIB3  (B2TWV5), FADI_SHIBS  (Q31YB6), FADI_SHIDS  (Q32DJ3), 
FADI_SHIF8  (Q0T2E5), FADI_SHIFL  (Q83K95), FADI_SHISS  (Q3YZM1), 
FADI_YERE8  (A1JK23), FADI_YERP3  (A7FGK0), FADI_YERPA  (Q1C659), 
FADI_YERPB  (B2K8J6), FADI_YERPE  (Q8ZD46), FADI_YERPG  (A9R7W9), 
FADI_YERPN  (Q1CHK1), FADI_YERPP  (A4TM83), FADI_YERPS  (Q668V0), 
FADI_YERPY  (B1JGG1), PAAJ_ECOLI  (P0C7L2), PAAJ_ECOLX  (P0C7L3), 
PCAF_ACIAD  (Q43974), PCAF_PSEAE  (Q9I6R0), PCAF_PSEPU  (Q51956), 
PCAF_PSESB  (Q8VPF1), THIA_CANTR  (Q12598), THIB_CANTR  (Q04677), 
THIC1_ARATH (Q8S4Y1), THIC2_ARATH (Q9FIK7), THIC_HUMAN  (Q9BWD1), 
THIC_MOUSE  (Q8CAY6), THIC_RAT    (Q5XI22), THIK1_ARATH (Q8LF48), 
THIK2_ARATH (Q56WD9), THIK5_ARATH (Q570C8), THIKA_CANTR (P33290), 
THIKA_MOUSE (Q921H8), THIKA_RAT   (P21775), THIKB_CANTR (P33291), 
THIKB_MOUSE (Q8VCH0), THIKB_RAT   (P07871), THIK_ENCCU  (Q8SVA6), 
THIK_HUMAN  (P09110), THIK_YARLI  (Q05493), THIK_YEAST  (P27796), 
THILA_XENLA (Q6NU46), THILB_XENLA (Q6GN02), THIL_ALLVD  (P45369), 
THIL_BOVIN  (Q29RZ0), THIL_CHRVO  (Q9ZHI1), THIL_CUPNH  (P14611), 
THIL_DANRE  (Q6AZA0), THIL_HUMAN  (P24752), THIL_MACFA  (Q8HXY6), 
THIL_MOUSE  (Q8QZT1), THIL_PARDE  (P54810), THIL_RAT    (P17764), 
THIL_RHIME  (P50174), THIL_SACMO  (P10551), THIL_SCHPO  (Q9UQW6), 
THIL_THIVI  (P45363), THIL_XENTR  (Q5BKN8), THIL_YEAST  (P41338), 
THIL_ZOORA  (P07097), THIM_BOVIN  (Q3T0R7), THIM_HUMAN  (P42765), 
THIM_MOUSE  (Q8BWT1), THIM_PONAB  (Q5RES5), THIM_RAT    (P13437), 
THLA_CLOAB  (P45359), THLA_STAA3  (Q2FJQ9), THLA_STAA8  (Q2G124), 
THLA_STAAB  (Q2YVF5), THLA_STAAC  (Q5HIU0), THLA_STAAM  (Q99WM3), 
THLA_STAAN  (Q7A7L2), THLA_STAAR  (Q6GJW4), THLA_STAAS  (Q6GCB8), 
THLA_STAAW  (Q8NY95), THLA_STAEQ  (Q5HS07), THLA_STAES  (Q8CQN7), 
THL_BACSU   (P45855), Y0859_MYCTU (O53871), YKA3_CAEEL  (P34255), 
YQEF_ECOLI  (Q46939)
» More

UniProtKB/Swiss-Prot
False negative sequences
39 sequences

FADA_PSEA7  (A6V383), FADA_PSEAB  (Q02PH7), FADA_PSEAE  (Q9HZJ3), 
FADA_PSEE4  (Q1I7D5), FADA_PSEMY  (A4XSM9), FADA_PSEOL  (Q93Q11), 
FADA_PSEP1  (A5W6G9), FADA_PSEPK  (Q88L01), FADA_PSEPU  (Q9R9W0), 
FADA_SACD2  (Q21KB1), FADI_AERHH  (A0KK76), FADI_AERS4  (A4SMT9), 
FADI_PHOPR  (Q6LTK4), FADI_VIBC3  (A5F2P1), FADI_VIBCH  (Q9KT59), 
FADI_VIBF1  (Q5E3U0), FADI_VIBFM  (B5FGB5), FADI_VIBPA  (Q87MM2), 
FADI_VIBVU  (Q8DB48), FADI_VIBVY  (Q7MIS4), NLTP_BOVIN  (P07857), 
NLTP_CHICK  (Q07598), NLTP_HUMAN  (P22307), NLTP_MOUSE  (P32020), 
NLTP_RABIT  (O62742), NLTP_RAT    (P11915), THIL1_DICDI (Q86AD9), 
THIL_YARLI  (Q6L8K7), VRAB_STAA1  (Q9KWK4), VRAB_STAAC  (Q5HIA0), 
VRAB_STAAM  (Q7A2W9), VRAB_STAAN  (Q7A768), VRAB_STAAR  (Q6GJ93), 
VRAB_STAAS  (Q6GBR1), VRAB_STAAW  (Q7A1P9), VRAB_STAEQ  (Q5HRH3), 
VRAB_STAES  (Q8CTR0), VRAB_STAHJ  (Q4L3Q1), YHFS_BACSU  (O07618)
» More

UniProtKB/Swiss-Prot
'Partial' sequences
3 sequences

THIL_PIG    (P14610), THL_CLOPA   (P81347), THL_PEPDI   (P45362)

		
UniProtKB/Swiss-Prot
False positive sequences
39 sequences

ACON_BOVIN  (P20004), ACON_CAEEL  (P34455), ACON_HUMAN  (Q99798), 
ACON_MOUSE  (Q99KI0), ACON_PIG    (P16276), ACON_RAT    (Q9ER34), 
ARGJ_OSTLU  (A4S1K1), J1I_HCMVA   (P09711), MYCN_MOUSE  (P03966), 
MYST1_ORYSJ (Q8LI34), PER1_VOLCA  (P81131), SSTT_CAMFF  (A0RNW2), 
SSTT_DESPS  (Q6AS08), SSTT_ENTFA  (Q82ZN5), SSTT_PHOPR  (Q6LG82), 
SSTT_PSYIN  (A1SS94), SSTT_SHEAM  (A1S7P9), SSTT_SHELP  (A3QCX7), 
SSTT_SHEON  (Q8ECL5), SSTT_SHESA  (A0KV41), SSTT_SHESM  (Q0HKG6), 
SSTT_SHESR  (Q0HWR8), SSTT_SHESW  (A1RI59), SSTT_STRP1  (Q9A1E0), 
SSTT_STRP3  (P0DF78), SSTT_STRP6  (Q5XDS5), SSTT_STRP8  (Q8P2K3), 
SSTT_STRPB  (Q1JDG4), SSTT_STRPC  (Q1JND7), SSTT_STRPD  (Q1JII6), 
SSTT_STRPF  (Q1J8E1), SSTT_STRPG  (A2RGC2), SSTT_STRPM  (Q48V75), 
SSTT_STRPQ  (P0DF79), SSTT_VIBCH  (Q9KNC9), SSTT_VIBF1  (Q5DZC3), 
SSTT_VIBPA  (Q87FP8), SSTT_VIBVU  (Q8D4Q1), SSTT_VIBVY  (Q7MGA3)
» More

PDB
[Detailed view]
44 PDB

1AFW; 1DLU; 1DLV; 1DM3; 1M1O; 1M1T; 1M3K; 1M3Z; 1M4S; 1M4T; 1NL7; 1OU6; 1PXT; 1QFL; 1WDK; 1WDL; 1WDM; 1WL4; 1WL5; 2C7Y; 2C7Z; 2D3T; 2F2S; 2IB7; 2IB8; 2IB9; 2IBU; 2IBW; 2IBY; 2IIK; 2VTZ; 2VU0; 2VU1; 2VU2; 2WKT; 2WKU; 2WKV; 2WL4; 2WL5; 2WL6; 2WU9; 4B3H; 4B3I; 4B3J
» More

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