Entry: PS00120

General information about the entry

Entry name [info] LIPASE_SER
Accession [info] PS00120
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED; 01-DEC-2004 DATA UPDATE; 07-JUN-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC00110
Associated ProRule [info] PRU10037

Name and characterization of the entry

Description [info] Lipases, serine active site.
Pattern [info]
[LIV]-{KG}-[LIVFY]-[LIVMST]-G-[HYWV]-S-{YAG}-G-[GSTAC].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_06 which contains 554'860 sequence entries.


Total number of hits 333 in 333 different sequences
Number of true positive hits 228 in 228 different sequences
Number of 'unknown' hits 27 in 27 different sequences
Number of false positive hits 78 in 78 different sequences
Number of false negative sequences 51
Number of 'partial' sequences 7
Precision (true positives / (true positives + false positives)) 74.51 %
Recall (true positives / (true positives + false negatives)) 81.72 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
228 sequences

ATG15_AJECN (A6REI4    ), ATG15_ASHGO (Q75EN3    ), ATG15_ASPFU (Q4X180    ), 
ATG15_ASPNC (A2QGD9    ), ATG15_ASPTN (Q0CXU6    ), ATG15_CANAL (Q5A4N0    ), 
ATG15_CANGA (Q6FPI6    ), ATG15_CRYNB (P0CO61    ), ATG15_CRYNJ (P0CO60    ), 
ATG15_DEBHA (Q6BLM0    ), ATG15_EMENI (Q5B0L1    ), ATG15_KLULA (Q6CU02    ), 
ATG15_LODEL (A5E567    ), ATG15_NEUCR (Q7RYY1    ), ATG15_PASFU (O13444    ), 
ATG15_PICAN (A7KAJ9    ), ATG15_PICGU (A5DC90    ), ATG15_PICST (A3LV34    ), 
ATG15_SCHPO (O13934    ), ATG15_USTMA (Q4PHZ2    ), ATG15_VANPO (A7TG13    ), 
ATG15_YARLI (Q6C2N7    ), ATG15_YEAS7 (A6ZTP2    ), ATG15_YEAST (P25641    ), 
BPHL_HUMAN  (Q86WA6    ), BPHL_MOUSE  (Q8R164    ), CLH0_CHEAL  (Q9LE89    ), 
CLH1_CITSI  (Q9MV14    ), CLH1_CITUN  (Q94LX1    ), DGLA_HUMAN  (Q9Y4D2    ), 
DGLA_MOUSE  (Q6WQJ1    ), DGLA_RAT    (Q5YLM1    ), DGLB_HUMAN  (Q8NCG7    ), 
DGLB_MOUSE  (Q91WC9    ), DGLB_RAT    (P0C1S9    ), ESTD_THEMA  (Q9WYH1    ), 
FAEA_ASPAW  (Q9P979    ), FAEA_ASPFN  (B8NIB8    ), FAEA_ASPNC  (A2QSY5    ), 
FAEA_ASPNG  (O42807    ), FAEA_ASPOR  (Q2UNW5    ), FAEA_ASPTN  (Q0CBM7    ), 
FAEA_ASPTU  (O42815    ), KRAK_DROME  (O18391    ), LCAT_GERGM  (O35840    ), 
LCAT_HUMAN  (P04180    ), LCAT_MOUSE  (P16301    ), LCAT_MYOGA  (O35502    ), 
LCAT_PAPAN  (Q08758    ), LCAT_RABIT  (P53761    ), LCAT_RAT    (P18424    ), 
LDAH_HUMAN  (Q9H6V9    ), LDAH_MOUSE  (Q8BVA5    ), LDAH_PONAB  (Q5R7E8    ), 
LDAH_RAT    (Q5HZX7    ), LDH1_YEAST  (P38139    ), LICH_CROAD  (J3SDX8    ), 
LICH_HUMAN  (P38571    ), LICH_MACFA  (Q4R4S5    ), LICH_MOUSE  (Q9Z0M5    ), 
LIP1_ARATH  (Q71DJ5    ), LIP1_CAEEL  (Q9XTR8    ), LIP1_STAA8  (Q2FUU5    ), 
LIP1_STAAC  (Q5HCM7    ), LIP1_STAAM  (P65288    ), LIP1_STAAN  (P65289    ), 
LIP1_STAAR  (Q6GDD3    ), LIP1_STAAS  (Q6G604    ), LIP1_STAAW  (Q8NUI5    ), 
LIP2_ARATH  (Q67ZU1    ), LIP2_STAA8  (Q2G155    ), LIP2_STAAC  (Q5HJ48    ), 
LIP2_STAAM  (Q99WQ6    ), LIP2_STAAN  (Q7A7P2    ), LIP2_STAAR  (Q6GJZ6    ), 
LIP2_STAAS  (Q6GCF1    ), LIP2_STAAU  (P10335    ), LIP2_STAAW  (Q8NYC2    ), 
LIP3_DROME  (O46108    ), LIPA_ACRAM  (P0CT91    ), LIPA_PSEFL  (P26504    ), 
LIPB_PSEFL  (P41773    ), LIPC_BOVIN  (Q3SZ79    ), LIPC_HUMAN  (P11150    ), 
LIPC_MOUSE  (P27656    ), LIPC_RABIT  (O46559    ), LIPC_RAT    (P07867    ), 
LIPE_AERHY  (P40600    ), LIPE_CROAD  (J3RZ81    ), LIPE_HUMAN  (Q9Y5X9    ), 
LIPE_MOUSE  (Q9WVG5    ), LIPE_RAT    (Q8VBX1    ), LIPG_BOVIN  (Q29458    ), 
LIPG_CANLF  (P80035    ), LIPG_HUMAN  (P07098    ), LIPG_MOUSE  (Q9CPP7    ), 
LIPG_RAT    (P04634    ), LIPJ_HUMAN  (Q5W064    ), LIPK_HUMAN  (Q5VXJ0    ), 
LIPK_MOUSE  (Q8BM14    ), LIPL_BOVIN  (P11151    ), LIPL_CAVPO  (P11153    ), 
LIPL_CHICK  (P11602    ), LIPL_FELCA  (P55031    ), LIPL_HUMAN  (P06858    ), 
LIPL_MOUSE  (P11152    ), LIPL_NEOVI  (O46647    ), LIPL_PAPAN  (P49060    ), 
LIPL_PIG    (P49923    ), LIPL_RAT    (Q06000    ), LIPL_SHEEP  (Q29524    ), 
LIPM_HUMAN  (Q5VYY2    ), LIPM_MOUSE  (Q8K2A6    ), LIPN_HUMAN  (Q5VXI9    ), 
LIPN_MOUSE  (Q3U4B4    ), LIPP_CAVPO  (P50903    ), LIPP_HORSE  (P29183    ), 
LIPP_HUMAN  (P16233    ), LIPP_ICTTR  (O88354    ), LIPP_MOUSE  (Q6P8U6    ), 
LIPP_MYOCO  (Q64425    ), LIPP_PIG    (P00591    ), LIPP_RABIT  (Q02157    ), 
LIPP_RAT    (P27657    ), LIPR1_CANLF (P06857    ), LIPR1_HUMAN (P54315    ), 
LIPR1_MOUSE (Q5BKQ4    ), LIPR1_RAT   (P54316    ), LIPR2_BOVIN (A5PK46    ), 
LIPR2_CAVPO (P81139    ), LIPR2_HUMAN (P54317    ), LIPR2_RAT   (P54318    ), 
LIPR3_HUMAN (Q17RR3    ), LIPV_MYCTU  (L0TC47    ), LIP_BURCE   (P22088    ), 
LIP_BURGL   (Q05489    ), LIP_PSEAE   (P26876    ), LIP_PSES5   (P25275    ), 
LIP_PSEU0   (P26877    ), LIP_RHIMI   (P19515    ), LIP_RHINI   (P61871    ), 
LIP_RHIOR   (P61872    ), LIP_STAEP   (P0C0R3    ), LIP_STAEQ   (Q5HKP6    ), 
LIP_STAES   (P0C0R4    ), LIP_STAHY   (P04635    ), LIP_THELA   (O59952    ), 
LIP_VIBCH   (P15493    ), MDLA_PENCA  (P61870    ), MDLA_PENCY  (P61869    ), 
MES14_ARATH (Q9FVW3    ), MGLL_HUMAN  (Q99685    ), MGLL_MOUSE  (O35678    ), 
MGLL_RAT    (Q8R431    ), PA11_DOLMA  (Q06478    ), PA11_POLDO  (Q6Q252    ), 
PA11_VESAF  (P0DMB4    ), PA12_DOLMA  (P53357    ), PA12_POLDO  (Q6Q251    ), 
PA12_VESAF  (P0DMB5    ), PA13_POLDO  (Q6Q250    ), PA14_POLDO  (Q6Q249    ), 
PA1_POLAN   (Q9U6W0    ), PA1_POLPI   (A2VBC4    ), PA1_SOLIN   (Q68KK0    ), 
PA1_VESCR   (P0CH87    ), PA1_VESGE   (Q3ZU95    ), PA1_VESMC   (P51528    ), 
PA1_VESMG   (P0CH47    ), PA1_VESSQ   (P0CH86    ), PA1_VESVU   (P49369    ), 
PAFA2_BOVIN (P79106    ), PAFA2_HUMAN (Q99487    ), PAFA2_MOUSE (Q8VDG7    ), 
PAFA2_RAT   (P83006    ), PAFA_BOVIN  (Q28017    ), PAFA_CANLF  (Q28262    ), 
PAFA_CAVPO  (P70683    ), PAFA_CHICK  (Q90678    ), PAFA_HUMAN  (Q13093    ), 
PAFA_MOUSE  (Q60963    ), PHAZ_PSEOL  (P26495    ), PIR7A_ORYSI (A2WYS8    ), 
PIR7A_ORYSJ (Q0JG98    ), PIR7B_ORYSI (A2WYS7    ), PIR7B_ORYSJ (Q0JG99    ), 
PLA11_ARATH (Q948R1    ), PLA14_ARATH (O23522    ), PLA15_ARATH (Q941F1    ), 
PLA16_ARATH (Q3EBR6    ), PLA17_ARATH (Q9C8J6    ), PLA18_ARATH (Q9LNC2    ), 
PLA19_ARATH (O82274    ), PLA1A_HUMAN (Q53H76    ), PLA1A_MOUSE (Q8VI78    ), 
PLA1A_PONAB (Q5RBQ5    ), PLA1A_RAT   (P97535    ), PLA1_ORYSI  (A2WT95    ), 
PLA1_ORYSJ  (A2ZW16    ), PLA20_ARATH (Q9SJI7    ), PLA2_ORYSI  (A2WT96    ), 
PLA2_ORYSJ  (Q0JKT4    ), PLA3_ORYSI  (A2WTA0    ), PLA3_ORYSJ  (Q8RZ40    ), 
PLA4_ORYSJ  (B9EYD3    ), PLA6_ORYSJ  (Q6F358    ), PLA7_ORYSI  (A2Y7R2    ), 
PLA7_ORYSJ  (Q6F357    ), PLBAC_BACSU (O34705    ), PPD_ARATH   (O23512    ), 
PPD_RAPSA   (Q2V0W1    ), PPME1_BOVIN (Q58DN4    ), PPME1_CAEEL (Q9BIB3    ), 
PPME1_DICDI (Q54TN3    ), PPME1_HUMAN (Q9Y570    ), PPME1_MOUSE (Q8BVQ5    ), 
PPME1_PONAB (Q5R4F9    ), PPT2_DROME  (Q9VKH6    ), ROG1_YEAST  (P53118    ), 
SABP2_TOBAC (Q6RYA0    ), TALLP_MESAU (Q3YBN2    ), YD109_YEAST (Q12103    ), 
YD444_YEAST (Q04093    ), YDK2_SCHPO  (P87109    ), YJ77_YEAST  (P47145    ), 
YJMD_SCHPO  (Q7LKZ6    ), YO059_YEAST (Q08448    ), YOR22_YEAST (Q12204    )
» more

UniProtKB/Swiss-Prot
False negative sequences
51 sequences

AT151_PHANO (Q0V1P1    ), ATG15_ASPCL (A1C6D6    ), ATG15_CHAGB (Q2H6M8    ), 
ATG15_COCIM (Q1DZE0    ), ATG15_NEOFI (A1DH10    ), ATG15_PENRW (A7KAM5    ), 
CSE_ARATH   (Q9C942    ), DSEL_ARATH  (O49523    ), EG1_ORYSI   (A2WY00    ), 
EG1_ORYSJ   (Q8S1D9    ), ESTA_BACSU  (P37957    ), ESTB_BACSU  (Q79F14    ), 
LCAT_CHICK  (P53760    ), LCAT_ELIQU  (O35573    ), LCAT_MICMN  (O35724    ), 
LDAH_CHICK  (Q5F477    ), LDAH_DICDI  (Q54LL8    ), LICH_RAT    (Q64194    ), 
LIP1_DROME  (O46107    ), LIP1_MORS1  (P19833    ), LIP1_PSYIM  (Q02104    ), 
LIPHA_XENLA (Q6PA23    ), LIPHB_XENLA (Q641F6    ), LIPH_DANRE  (Q6DBU8    ), 
LIPH_HUMAN  (Q8WWY8    ), LIPH_MOUSE  (Q8CIV3    ), LIPH_RABIT  (Q9BDJ4    ), 
LIPH_RAT    (Q32PY2    ), LIPH_XENTR  (Q5XGE9    ), LIPI_HUMAN  (Q6XZB0    ), 
LIPR2_MOUSE (P17892    ), LIPR2_MYOCO (Q64424    ), LIP_BACSP   (Q5U780    ), 
LIP_PSEFR   (P08658    ), PAD4_ARATH  (Q9S745    ), PAFA_CAEEL  (Q22943    ), 
PETH_IDESA  (A0A0K8P6T7), PLA12_ARATH (Q9MA46    ), PLA13_ARATH (Q9SIN9    ), 
PLA1A_BOVIN (Q5E9H0    ), PLA1A_DANRE (Q6NYZ4    ), PLA5_ORYSI  (B8A8C9    ), 
PLA5_ORYSJ  (Q5NAI4    ), PLG7_SCHPO  (Q9URV1    ), TGCE1_SCHPO (O74430    ), 
TGCE2_SCHPO (P78898    ), TGCE3_SCHPO (O60095    ), TGL1_YEAST  (P34163    ), 
YE7A_SCHPO  (O14162    ), YEH1_YEAST  (Q07804    ), YEH2_YEAST  (Q07950    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
7 sequences

LCAT_PIG    (P30930    ), LIPP_FELCA  (P83629    ), LIPT_BURCE  (P29605    ), 
PA11_VESVE  (P0DMB6    ), PA12A_VESVE (P0DMB7    ), PA12B_VESVE (P0DMB8    ), 
PA1_POLGA   (P83542    )
» more

UniProtKB/Swiss-Prot
'Unknown' sequences
27 sequences

AED3_ARATH  (O04496    ), AXE1_HYPJE  (Q99034    ), BST1A_YARLI (Q6C2Z2    ), 
BST1B_YARLI (Q6BZU7    ), BST1C_YARLI (Q6CF60    ), BST1_ASHGO  (Q752Q2    ), 
BST1_ASPFU  (Q4WGM4    ), BST1_ASPOR  (Q2USI0    ), BST1_ASPTN  (Q0CIV4    ), 
BST1_CANAL  (Q59VP0    ), BST1_CHAGB  (Q2H102    ), BST1_COCIM  (Q1DWP9    ), 
BST1_DEBHA  (Q6BRG1    ), BST1_EMENI  (Q5AYC8    ), BST1_KLULA  (Q6CIN9    ), 
BST1_NEUCR  (Q7SAM0    ), BST1_PHANO  (Q0UQV6    ), BST1_SCHPO  (Q9UT41    ), 
BST1_YEAST  (P43571    ), PGAP1_DROME (Q9W495    ), PGAP1_HUMAN (Q75T13    ), 
PGAP1_MOUSE (Q3UUQ7    ), PGAP1_RAT   (Q765A7    ), PGAP1_XENLA (Q66J01    ), 
YL4M_CAEEL  (Q8WT51    ), YP147_YEAST (Q06522    ), YR843_MIMIV (Q5URB6    )
» more

UniProtKB/Swiss-Prot
False positive sequences
78 sequences

ALTH1_PLAF7 (C6KTB7    ), ARGJ_DECAR  (Q47AB5    ), AXE2_TALPU  (O59893    ), 
CHEB2_CARHZ (Q3ADA6    ), CHEB3_RHORT (Q2RRX2    ), CHEB3_VIBCH (Q9KS59    ), 
CHEB_CALS4  (Q8RAZ3    ), CHEB_SALRD  (Q2RZD2    ), CUTI_BOTFU  (Q00298    ), 
CUTI_MONFR  (Q8TGB8    ), ESL2_MYCGE  (Q49418    ), ESL2_MYCPN  (P75311    ), 
ESL3_MYCGE  (Q49421    ), ESL3_MYCPN  (P75268    ), F135B_XENLA (Q641I1    ), 
GLU2A_ORYSJ (B9F676    ), ICT1_YEAST  (Q12385    ), KANL3_RAT   (Q3KR73    ), 
KFA_ASHGO   (Q759T3    ), KFA_CANAL   (Q59ZV4    ), KFA_PICST   (A3GGU3    ), 
KFA_VANPO   (A7TJ85    ), KR231_HUMAN (A1A580    ), MCLN1_HUMAN (Q9GZU1    ), 
MCLN1_MACFA (Q60HE8    ), MCLN1_MOUSE (Q99J21    ), MEX67_SCHPO (Q9Y8G3    ), 
NUOH_FRAAA  (Q0RRW1    ), NUOH_FRACC  (Q2JFL3    ), PDAT_YEAST  (P40345    ), 
PDXD1_BOVIN (A7MBC2    ), PDXD2_HUMAN (Q6P474    ), PHYLO_ARATH (Q15KI9    ), 
PIP_BACCO   (P46541    ), PIP_BREBN   (C0ZKI1    ), PLSX_PSEHT  (Q3IHD8    ), 
PNAE_RAUSE  (Q9SE93    ), PPME1_ASHGO (Q74Z47    ), PPME1_ASPFU (Q4WKB2    ), 
PPME1_ASPOR (Q2URJ0    ), PPME1_CANAL (Q5ALW7    ), PPME1_CANGA (Q6FNL6    ), 
PPME1_CRYNB (P0CO63    ), PPME1_CRYNJ (P0CO62    ), PPME1_DEBHA (Q6BZG3    ), 
PPME1_EMENI (Q5BGN7    ), PPME1_GIBZE (Q4IQC1    ), PPME1_KLULA (Q6CQZ5    ), 
PPME1_NEUCR (Q7SGG8    ), PPME1_RAT   (Q4FZT2    ), PPME1_SCHPO (Q9P7D2    ), 
PPME1_YARLI (Q6CGE1    ), PPME1_YEAST (P38796    ), RPOB_COXB2  (B6J270    ), 
RPOB_COXBN  (A9KD39    ), RPOB_COXBR  (A9NAL4    ), RPOB_COXBU  (P0C8S4    ), 
SFGH_YEAST  (P40363    ), SYE_AMOA5   (B3ERQ7    ), SYE_CARHZ   (Q3A9N9    ), 
SYE_DESAP   (B1I4Z1    ), SYE_DESRM   (A4J0Y7    ), SYE_HELMI   (B0TBU3    ), 
SYE_PELTS   (A5D5L8    ), SYE_SALRD   (Q2S1L8    ), TNR16_HUMAN (P08138    ), 
TNR16_MOUSE (Q9Z0W1    ), TNR16_RAT   (P07174    ), UBE11_ARATH (P93028    ), 
UBE12_ARATH (P92974    ), Y193_HAEIN  (Q57427    ), Y2412_DICDI (Q54DA4    ), 
Y2715_MYCTO (P9WNH2    ), Y2715_MYCTU (P9WNH3    ), Y2734_MYCBO (P0A573    ), 
Y4KF_SINFN  (P55526    ), YELD_SCHPO  (O14244    ), YKM6_SCHPO  (Q9C0Y8    )
» more

PDB
[Detailed view]
95 PDB

1BU8; 1CVL; 1DT3; 1DT5; 1DTE; 1DU4; 1EIN; 1ETH; 1EX9; 1GPL; 1HLG; 1HPL; 1HQD; 1K8Q; 1LGY; 1LPA; 1LPB; 1N8S; 1OIL; 1QGE; 1QOZ; 1RP1; 1TAH; 1TGL; 1TIA; 1TIB; 1TIC; 1USW; 1UWC; 1UZA; 1XKL; 1Y7H; 1Y7I; 1YS1; 1YS2; 2ES4; 2HIH; 2HL6; 2IX9; 2LIP; 2NW6; 2OCG; 2OCI; 2OCK; 2OXE; 2PPL; 2PVS; 3C5V; 3D59; 3D5E; 3F97; 3F98; 3F9C; 3HJU; 3JW8; 3JWE; 3LIP; 3PE6; 3TGL; 4DYH; 4EA6; 4FLF; 4GBG; 4GHW; 4GI1; 4GLB; 4GWL; 4KJX; 4LIP; 4N8S; 4S0X; 4TGL; 4UUQ; 4X96; 4XWG; 4XX1; 4ZGB; 5AP9; 5BV7; 5CH8; 5HK8; 5I8P; 5I9I; 5JAD; 5JAH; 5JAL; 5JAN; 5JAO; 5JAP; 5JAR; 5JAS; 5JAT; 5JAU; 5LIP; 5TGL
» more

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission