To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Entry: PS00122

General information about the entry

Entry name [info] CARBOXYLESTERASE_B_1
Accession [info] PS00122
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED; 01-NOV-1995 DATA UPDATE; 27-SEP-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC00112
Associated ProRule [info] PRU10039

Name and characterization of the entry

Description [info] Carboxylesterases type-B serine active site.
Pattern [info]
F-[GR]-G-x(4)-[LIVM]-x-[LIV]-x-G-x-S-[STAG]-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_09 which contains 555'594 sequence entries.


Total number of hits 118 in 118 different sequences
Number of true positive hits 116 in 116 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 4
Number of 'partial' sequences 14
Precision (true positives / (true positives + false positives)) 98.31 %
Recall (true positives / (true positives + false negatives)) 96.67 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 11
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
116 sequences

ACE1_CAEBR  (Q27459    ), ACE1_CAEEL  (P38433    ), ACE4_CAEBR  (Q9NDG8    ), 
ACES_ANOGA  (Q869C3    ), ACES_ANOST  (P56161    ), ACES_BOVIN  (P23795    ), 
ACES_BUNFA  (Q92035    ), ACES_CHICK  (P36196    ), ACES_CULPI  (Q86GC8    ), 
ACES_DANRE  (Q9DDE3    ), ACES_DROME  (P07140    ), ACES_ELEEL  (O42275    ), 
ACES_FELCA  (O62763    ), ACES_HUMAN  (P22303    ), ACES_LEPDE  (Q27677    ), 
ACES_MOUSE  (P21836    ), ACES_MYXGL  (Q92081    ), ACES_RABIT  (Q29499    ), 
ACES_RAT    (P37136    ), ACES_TETCF  (P04058    ), ACES_TORMA  (P07692    ), 
CEL_BOVIN   (P30122    ), CEL_HUMAN   (P19835    ), CEL_MOUSE   (Q64285    ), 
CEL_RAT     (P07882    ), CES1D_MOUSE (Q8VCT4    ), CES1D_RAT   (P16303    ), 
CES1F_MOUSE (Q91WU0    ), CHLE1_BRALA (Q95000    ), CHLE2_BRALA (Q95001    ), 
CHLE_BOVIN  (P32749    ), CHLE_CANLF  (P32750    ), CHLE_FELCA  (O62760    ), 
CHLE_HORSE  (P81908    ), CHLE_HUMAN  (P06276    ), CHLE_MACMU  (P32751    ), 
CHLE_MIMIV  (Q5UR02    ), CHLE_MOUSE  (Q03311    ), CHLE_PANTT  (O62761    ), 
CHLE_PIG    (P32752    ), CHLE_RABIT  (P21927    ), CHLE_SHEEP  (P32753    ), 
CRYS_DICDI  (P21837    ), D2_DICDI    (P18142    ), EST1C_MOUSE (P23953    ), 
EST1C_RAT   (P10959    ), EST1E_MOUSE (Q64176    ), EST1E_RAT   (Q63108    ), 
EST1_CAEBR  (Q04456    ), EST1_CAEEL  (Q04457    ), EST1_CULPI  (P16854    ), 
EST1_HUMAN  (P23141    ), EST1_MACFA  (O46421    ), EST1_MESAU  (Q64419    ), 
EST1_MOUSE  (Q8VCC2    ), EST1_PIG    (Q29550    ), EST1_RABIT  (P12337    ), 
EST1_THEFU  (P86325    ), EST1_THEFY  (Q47M62    ), EST2A_MOUSE (Q8QZR3    ), 
EST2C_MOUSE (Q91WG0    ), EST2E_MOUSE (Q8BK48    ), EST2_CAEEL  (Q07085    ), 
EST2_HUMAN  (O00748    ), EST2_RABIT  (P14943    ), EST3A_MOUSE (Q63880    ), 
EST3B_MOUSE (Q8VCU1    ), EST3_HUMAN  (Q6UWW8    ), EST3_PONAB  (Q5RCL7    ), 
EST4A_BOVIN (P0C6R3    ), EST4A_HUMAN (Q5XG92    ), EST4A_MOUSE (Q8R0W5    ), 
EST4_RAT    (Q64573    ), EST5A_CANLF (Q6AW47    ), EST5A_DROMI (O16168    ), 
EST5A_DROPE (O16173    ), EST5A_DROPS (P25727    ), EST5A_FELCA (Q8I034    ), 
EST5A_HUMAN (Q6NT32    ), EST5A_MOUSE (Q6AW46    ), EST5A_RAT   (Q5GRG2    ), 
EST5A_SHEEP (Q3T930    ), EST5B_DROMI (O16170    ), EST5B_DROPE (O16172    ), 
EST5B_DROPS (P25726    ), EST5C_DROMI (O16169    ), EST5C_DROPE (O16171    ), 
EST5C_DROPS (P25725    ), EST5_RAT    (Q63010    ), EST6_APIME  (B2D0J5    ), 
EST6_DROMA  (P47982    ), EST6_DROME  (P08171    ), EST6_DROSI  (Q08662    ), 
ESTE_MYZPE  (P35501    ), ESTF_MYZPE  (P35502    ), ESTJ_HELVI  (P12992    ), 
ESTP_DROME  (P18167    ), ESTS_DROVI  (Q05487    ), FUMD_SPHMC  (D2D3B6    ), 
LIP1_ARTBC  (D4ASH1    ), LIP1_DIURU  (P20261    ), LIP1_GEOCN  (P17573    ), 
LIP1_GEOFE  (P79066    ), LIP1_YARLI  (Q99156    ), LIP2_DIURU  (P32946    ), 
LIP2_GEOCN  (P22394    ), LIP3_ARTBC  (D4B1N9    ), LIP3_DIURU  (P32947    ), 
LIP3_YARLI  (Q96VC9    ), LIP4_DIURU  (P32948    ), LIP5_DIURU  (P32949    ), 
PATB_ASPCL  (A1CFK9    ), PCD_PSEOX   (Q01470    ), PNBA_BACSU  (P37967    ), 
SASB_ANAPL  (Q04791    ), YC7C_SCHPO  (O94493    )
» more

UniProtKB/Swiss-Prot
False negative sequences
4 sequences

ACES_TRILK  (W4VSJ0    ), CES1P_HUMAN (Q9UKY3    ), ESTE_HVAVE  (A4KX74    ), 
ESTE_SFAVA  (Q0E588    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
14 sequences

ACES_CULPP  (Q867X3    ), ACES_CULQU  (Q867X2    ), ACES_CULTO  (Q86GC9    ), 
ACES_NAJOX  (Q7LZG1    ), EST1_SCHGA  (P81429    ), EST2_CULPI  (P21370    ), 
EST4_DROMO  (P10094    ), EST5_DROMO  (P10095    ), ESTA_SCHGA  (P81012    ), 
ESTB_SCHGA  (P81011    ), ESTJ_MANSE  (P19985    ), JHEA_TRINI  (P30809    ), 
JHEB_TRINI  (P30810    ), PMCH_RAT    (P80250    )
» more

UniProtKB/Swiss-Prot
False positive sequences
2 sequences

ICME_ARATH  (Q94AS5    ), ICML2_ARATH (Q1PET6    )

		
PDB
[Detailed view]
235 PDB

1ACJ; 1ACL; 1AKN; 1AMN; 1AQL; 1AX9; 1B41; 1C2B; 1C2O; 1C7I; 1C7J; 1CFJ; 1CLE; 1CRL; 1DX4; 1DX6; 1E3Q; 1E66; 1EA5; 1EEA; 1EVE; 1F6W; 1F8U; 1FSS; 1GPK; 1GPN; 1GQR; 1GQS; 1GZ7; 1H22; 1H23; 1HBJ; 1J06; 1J07; 1JJB; 1JMY; 1K4Y; 1KU6; 1LLF; 1LPM; 1LPN; 1LPO; 1LPP; 1LPS; 1MAA; 1MAH; 1MX1; 1MX5; 1MX9; 1N5M; 1N5R; 1OCE; 1ODC; 1P0I; 1P0M; 1P0P; 1P0Q; 1Q83; 1Q84; 1QE3; 1QID; 1QIE; 1QIF; 1QIG; 1QIH; 1QII; 1QIJ; 1QIK; 1QIM; 1QO9; 1QON; 1QTI; 1SOM; 1THG; 1TRH; 1U65; 1UT6; 1VOT; 1VXO; 1VXR; 1W4L; 1W6R; 1W75; 1W76; 1XLU; 1XLV; 1XLW; 1YA4; 1YA8; 1YAH; 1YAJ; 1ZGB; 1ZGC; 2ACE; 2ACK; 2BAG; 2BCE; 2C0P; 2C0Q; 2C4H; 2C5F; 2C5G; 2CEK; 2CKM; 2CMF; 2DQY; 2DQZ; 2DR0; 2GYU; 2GYV; 2GYW; 2H7C; 2H9Y; 2HA0; 2HA2; 2HA3; 2HRQ; 2HRR; 2J3D; 2J3Q; 2J4C; 2J4F; 2JEY; 2PM8; 2V96; 2V97; 2V98; 2VA9; 2VJA; 2VJB; 2VJC; 2VJD; 2VQ6; 2VT6; 2VT7; 2W6C; 2WFZ; 2WG0; 2WG1; 2WG2; 2WHR; 2WID; 2WIF; 2WIG; 2WIJ; 2WIK; 2WIL; 2WLS; 2WSL; 2XI4; 2XMB; 2XMC; 2XMD; 2XMG; 2XQF; 2XQG; 2XQI; 2XQJ; 2XQK; 2XUD; 2XUF; 2XUG; 2XUH; 2XUI; 2XUJ; 2XUK; 2XUO; 2XUP; 2XUQ; 3I6M; 3I6Z; 3K9B; 3LII; 3M3D; 3O9M; 3RAR; 3ZV7; 4A16; 4A23; 4AB1; 4AQD; 4ARA; 4ARB; 4B7Z; 4B80; 4B81; 4B82; 4B83; 4B84; 4B85; 4BBZ; 4BC0; 4BC1; 4BDS; 4BDT; 4BTL; 4EY4; 4EY5; 4EY6; 4EY7; 4EY8; 4M0E; 4M0F; 4PQE; 4QWW; 4TPK; 4TVK; 4W63; 4X3C; 4XII; 5A7F; 5A7H; 5BWB; 5BWC; 5DLP; 5DTI; 5DYT; 5E2I; 5E4J; 5E4T; 5EHN; 5EHQ; 5EHZ; 5EIA; 5EIE; 5EIH; 5FKJ; 5FOQ; 5FUM; 5HF5; 5HF6; 5HF8; 5HF9; 5HFA; 5K5E
» more

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission