Entry: PS00136

Forthcoming changes to the profile format
General information about the entry

Entry name [info] SUBTILASE_ASP
Accession [info] PS00136
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); DEC-2004 (DATA UPDATE); MAR-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00125
Associated ProRule [info] PRU10080

Name and characterization of the entry

Description [info] Serine proteases, subtilase family, aspartic acid active site.
Pattern [info]
[STAIV]-{ERDL}-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-[DNH].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_04 which contains 544'996 sequence entries.


Total number of hits 330 in 330 different sequences
Number of true positive hits 148 in 148 different sequences
Number of 'unknown' hits
Number of false positive hits 182 in 182 different sequences
Number of false negative sequences 90
Number of 'partial' sequences 9
Precision (true positives / (true positives + false positives)) 44.85 %
Recall (true positives / (true positives + false negatives)) 62.18 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 5
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
148 sequences

AEP_YARLI   (P09230), ALP_ACRCH   (P29118), ALP_FUSCU   (P83610), 
ALP_HYPAT   (Q03420), ALP_LECPS   (Q68GV9), APRX_BACSU  (O31788), 
AQL1_THEAQ  (P08594), ASPA_AERSA  (P31339), BLI4_CAEEL  (P51559), 
BPRV_DICNO  (P42779), BPRX_DICNO  (P42780), C5AP_STRP1  (P58099), 
C5AP_STRP3  (P0DD34), C5AP_STRP6  (Q5X9R0), C5AP_STRP8  (Q8NZ80), 
C5AP_STRPQ  (P0DD35), C5AP_STRPY  (P15926), CUDP_METAN  (P29138), 
ELYA_BACAO  (P27693), ELYA_BACCS  (P41362), ELYA_BACHD  (P41363), 
ELYA_BACYA  (P20724), EPIP_STAEP  (P30199), EXPR_XANCP  (P23314), 
FUR11_DROME (P26016), FUR1C_DROME (P30430), FUR2_DROME  (P30432), 
FURI1_XENLA (P29119), FURIN_BOVIN (Q28193), FURIN_HUMAN (P09958), 
FURIN_MOUSE (P23188), FURIN_RAT   (P23377), ISP1_BACSU  (P11018), 
ISP6_SCHPO  (P40903), ISP_BACCS   (P29140), ISP_PAEPO   (P29139), 
KEX1A_KLULA (P09231), KEX2_YEAST  (P13134), KRP1_SCHPO  (Q09175), 
NEC1_BOVIN  (Q9GLR1), NEC1_HUMAN  (P29120), NEC1_MOUSE  (P63239), 
NEC1_MUSCO  (P63240), NEC1_RAT    (P28840), NEC2_BOVIN  (Q9GLR0), 
NEC2_HUMAN  (P16519), NEC2_MOUSE  (P21661), NEC2_PIG    (Q03333), 
NEC2_PONAB  (Q5REC2), NEC2_RAT    (P28841), NECA_HYDVU  (P29146), 
NECB_HYDVU  (P29145), NISP_LACLL  (Q07596), NVSP_ALIVI  (P83433), 
ORYZ_ASPCL  (A1CIA7), ORYZ_ASPFC  (B0Y708), ORYZ_ASPFN  (B8N106), 
ORYZ_ASPFU  (P28296), ORYZ_ASPOR  (P12547), ORYZ_EMENI  (Q00208), 
ORYZ_NEOFI  (A1CWF3), P1P_LACLC   (P16271), P2P_LACLC   (P15293), 
P2P_LACPA   (Q02470), P3P_LACLS   (P15292), PCSK4_HUMAN (Q6UW60), 
PCSK4_MOUSE (P29121), PCSK4_RAT   (Q78EH2), PCSK5_HUMAN (Q92824), 
PCSK5_MOUSE (Q04592), PCSK5_RAT   (P41413), PCSK6_HUMAN (P29122), 
PCSK6_RAT   (Q63415), PIIS_ACHLY  (P81719), PLS_PYRFU   (P72186), 
PRCA_ANAVT  (P23916), PRCA_NOSS1  (Q59149), PROA_VIBAL  (P16588), 
PRTB_YEAST  (P09232), PRTK_ENGAL  (P06873), PRTM_BACSK  (Q99405), 
PRTR_ENGAL  (P23653), PRTT_ENGAL  (P20015), PSP3_SCHPO  (Q9UTS0), 
RRT12_YEAST (P25381), SEPR_THESR  (P80146), SMP1_MAGPO  (Q9Y778), 
SPAZ_ARTOA  (G1X8P8), SPAZ_ARTOL  (G3FNQ9), SPL1_ENCCU  (Q8SQJ3), 
SUB10_ARTBC (D4AQG0), SUB10_TRIVH (D4DIS6), SUB2A_COCP7 (C5P6D1), 
SUB2B_COCP7 (C5P906), SUB2C_COCP7 (C5NZ70), SUB2_ARTBC  (D4AZ75), 
SUB2_ARTBE  (Q64K35), SUB2_ARTGP  (E4UZP9), SUB2_ARTOC  (C5G168), 
SUB2_ARTOT  (Q8J0D8), SUB2_TRIEQ  (B6VA85), SUB2_TRIRU  (Q69F57), 
SUB2_TRITO  (B8XGQ5), SUB2_TRIVC  (Q5VJ76), SUB2_TRIVH  (D4DLI5), 
SUB4B_COCP7 (C5NZT2), SUB5_ARTBC  (D4B194), SUB5_ARTBE  (Q64K32), 
SUB5_ARTGP  (E4V2L6), SUB5_ARTOC  (C5G1D1), SUB5_TRIEQ  (B6VA87), 
SUB5_TRIRU  (Q69F34), SUB5_TRITO  (B8XGQ8), SUB5_TRIVC  (Q5VJ73), 
SUB5_TRIVH  (D4D0F5), SUB6_ARTBC  (D4ALV9), SUB6_ARTBE  (Q64K31), 
SUB6_ARTGP  (E4V4J8), SUB6_ARTOC  (C5FQI3), SUB6_TRIEQ  (A1XIH0), 
SUB6_TRIRU  (Q9UW97), SUB6_TRISD  (A1XIH1), SUB6_TRISH  (Q8J077), 
SUB6_TRITO  (Q3ZEJ8), SUB6_TRIVC  (Q5VJ72), SUB6_TRIVH  (D4D5H3), 
SUB7A_COCP7 (C5PGK9), SUB7C_COCP7 (C5NZ69), SUB7D_COCP7 (C5P9H3), 
SUBB_BACLE  (P29599), SUBD_BACLI  (P00781), SUBE_BACSU  (P16396), 
SUBN_BACNA  (P35835), SUBS_BACLE  (P29600), SUBT_BACAM  (P00782), 
SUBT_BACLI  (P00780), SUBT_BACPU  (P07518), SUBT_BACS9  (P28842), 
SUBT_BACSA  (P00783), SUBT_BACSU  (P04189), SUBT_GEOSE  (P29142), 
SUBV_BACSU  (P29141), THES_BACSJ  (Q45670), THET_THEVU  (P04072), 
TKSU_THEKO  (P58502), XPR6_YARLI  (P42781), XSP1_ARATH  (Q9LLL8), 
YSP3_YEAST  (P25036)
» More

UniProtKB/Swiss-Prot
False negative sequences
90 sequences

ALP2_ASPFC  (B0Y473), ALP2_ASPFU  (P87184), CUCM1_CUCME (Q39547), 
HLY_NATA1   (P29143), KEX2_CANAW  (O13359), MBTP1_CRIGR (Q9Z2A8), 
MBTP1_HUMAN (Q14703), MBTP1_MOUSE (Q9WTZ2), MBTP1_RAT   (Q9WTZ3), 
ORYZ_ASPFL  (P35211), PCSK5_BRACL (Q9NJ15), PCSK7_HUMAN (Q16549), 
PCSK7_MOUSE (Q61139), PCSK7_RAT   (Q62849), PCSK9_ATEGE (A8T6A1), 
PCSK9_CALJA (A8T688), PCSK9_CALMO (A8T677), PCSK9_COLGU (A8T672), 
PCSK9_GORGO (A8T650), PCSK9_HUMAN (Q8NBP7), PCSK9_LAGLA (A8T6A6), 
PCSK9_MACMU (A8T666), PCSK9_MACNE (A8T662), PCSK9_MOUSE (Q80W65), 
PCSK9_PANPA (A8T655), PCSK9_PANTR (A8T644), PCSK9_PONPY (A8T658), 
PCSK9_RAT   (P59996), PCSK9_SAGLB (A8T682), PCSK9_SAIBB (A8T695), 
PEPC_ASPNG  (P33295), PRTS_SERMA  (P09489), PRTT_SERMA  (P29805), 
SDD1_ARATH  (O64495), SPM1_MAGO7  (P58371), SSA1_PASHA  (P31631), 
SU11A_COCP7 (C5P1W9), SU11B_COCP7 (C5PFR5), SUB10_ARTOC (C5FX37), 
SUB11_ARTBC (D4APE3), SUB11_ARTGP (E4V5C5), SUB11_ARTOC (C5FZ39), 
SUB11_TRIVH (D4CZ60), SUB12_ARTBC (D4AQA9), SUB12_ARTGP (E4UY04), 
SUB12_TRIVH (D4D1U5), SUB1_ARTBC  (D4AKU9), SUB1_ARTGP  (E4UPZ4), 
SUB1_ARTOC  (C5FPS1), SUB1_TRIVH  (D4DIW9), SUB2_DEIRA  (Q9RYM8), 
SUB3_ARTBC  (D4AWY5), SUB3_ARTGP  (E4UN97), SUB3_ARTOC  (C5FMY5), 
SUB3_TRIVH  (D4DLA2), SUB4A_COCP7 (C5PCB1), SUB4C_COCP7 (C5P6L5), 
SUB4_ARTBC  (D4AXW3), SUB4_ARTGP  (E4UWA4), SUB4_ARTOC  (C5FXZ6), 
SUB4_TRIVH  (D4D6Q4), SUB7B_COCP7 (C5PCX1), SUB7_ARTBC  (D4APA9), 
SUB7_ARTGP  (E4V2V9), SUB7_ARTOC  (C5FJA5), SUB7_TRIVH  (D4CZQ4), 
SUB8_ARTBC  (D4AX50), SUB8_ARTOC  (C5FII2), SUB8_COCP7  (C5P4Z8), 
SUB8_TRIVH  (D4DKQ4), SUB9_ARTBC  (D4B5N1), SUB9_ARTGP  (E4UTU7), 
SUB9_ARTOC  (C5FH27), SUB9_COCP7  (C5P5Q3), SUB9_TRIVH  (D4D674), 
SUBF_BACSU  (P16397), SUBL_ARATH  (O65351), TAGA_DICDI  (Q9GTN7), 
TAGB_DICDI  (P54683), TAGC_DICDI  (Q23868), TAGD_DICDI  (Q8T9W1), 
TPP2_BOVIN  (A5PK39), TPP2_DROME  (Q9V6K1), TPP2_HUMAN  (P29144), 
TPP2_MOUSE  (Q64514), TPP2_RAT    (Q64560), TPP2_SCHPO  (Q9UT05), 
VG47_ICHVA  (Q00139), WPRA_BACSU  (P54423), YQS6_CAEEL  (Q09541)
» More

UniProtKB/Swiss-Prot
'Partial' sequences
9 sequences

APGR3_BIOOC (P83492), ASE1_ACRSP  (P85156), ASE2_ACRSP  (P85157), 
CUDP_METCM  (P80406), FIBR2_NEAJA (P86876), NCP3_COPCM  (P83454), 
PRTE_HALME  (P28308), SP01_PSEBO  (Q10721), THEM_MALSU  (P13858)
» More

UniProtKB/Swiss-Prot
False positive sequences
182 sequences

ACDA1_ARCFU (O29165), AGLU_TETPY  (O00906), ALDO3_ARATH (Q7G9P4), 
AP1_KLULA   (P56095), ARGC_CHRVO  (Q7NRT5), BAR_RHOER   (Q8RSQ2), 
BTUB_PHOLL  (Q7MYE3), CBID_PROMP  (Q7V3N8), CHS1_CRYNH  (O13356), 
CLS2_STAAC  (Q5HEB2), CLS2_STAAR  (Q6GEY7), CLS_STAAM   (P63800), 
CLS_STAAN   (P63801), CLS_STAAS   (Q6G7M2), CLS_STAAW   (P63802), 
COBT_DEIRA  (Q9RYR8), DCL4_ORYSJ  (A7LFZ6), DMXL1_HUMAN (Q9Y485), 
DMXL1_MOUSE (Q6PNC0), DNAG_NEIMA  (P57028), DNAG_NEIMB  (P57029), 
DNLJ1_STRGG (B1VUC2), DNLJ_FERNB  (A7HJG6), DRD1_CARAU  (P35406), 
EXOC1_DICDI (Q54NV1), FIXJ_AZOC5  (P26487), FLII_BUCBP  (Q89AZ7), 
FMT_GEOSL   (Q74GW4), FOLD2_ACIAD (Q6F8N7), FOLD_ACIBT  (A3M846), 
FOLD_MYCPE  (Q8EV80), FOLD_PSYA2  (Q4FTX6), FOLD_PSYCK  (Q1QD30), 
FOLD_RUTMC  (A1AXA0), FOLD_THETN  (Q8RAD0), GLUQ_PROAC  (Q6A7Y1), 
GLYA_MYCS2  (A0R2V7), GLYA_PROAC  (Q6AAU3), GUAAB_PICTO (Q6L1Q1), 
GUAA_ASPOR  (Q2UFN0), HEM1_RHORT  (Q2RWE2), HIS5_ECOL6  (P60596), 
HIS5_ECOLI  (P60595), HIS5_SHIBS  (Q323I9), HIS5_SHIDS  (Q32EF2), 
HIS5_SHIFL  (Q83KJ5), HIS5_SHISS  (Q3Z0G2), HLYE_ECO57  (Q9REB3), 
HLYE_ECOLI  (P77335), HN1BA_DANRE (A1L1N5), HN1BB_DANRE (Q8UW00), 
HOA_BURPP   (B2T2S2), HOY1_YARLI  (Q99160), KATG2_ALKMQ (A6TV07), 
KATG_PHEZH  (B4R8U3), KATG_SACD2  (Q21DT6), KUP3_RHIL3  (Q1M651), 
LCAP_HUMAN  (Q9UIQ6), LEC2_CYTSE  (P22971), LEU3_BRUA2  (Q2YL58), 
LEU3_BRUAB  (Q579B1), LEU3_BRUME  (Q8YCX4), LEU3_BRUSU  (Q8FVF3), 
LPXK_HELAH  (Q17X64), LPXK_HELPH  (Q1CUH3), LPXK_HELPJ  (Q9ZMB1), 
LPXK_HELPY  (O25095), LRC14_BOVIN (A5PJJ5), LRC14_HUMAN (Q15048), 
LRC14_MOUSE (Q8VC16), LRC14_RAT   (Q569B5), LRRC3_DANRE (A8WHP9), 
MATK_GAGLU  (Q9TMC8), MATK_ILLOL  (A6MMS5), METL2_ARATH (Q8LFA9), 
METN1_PSEU2 (Q4ZZR8), MSTO1_BOVIN (A5D9D4), MSTO1_HUMAN (Q9BUK6), 
MSTO1_MACFA (Q4R681), MSTO1_MOUSE (Q2YDW2), MSTO1_PONPY (Q5RF82), 
MYO2_CAEEL  (P12845), MZT1B_ARATH (Q9M0N8), NADE_SHEON  (Q8EFF2), 
NADO2_ORYSJ (Q7G765), NCAP_CVM1   (P18446), NCAP_CVM2   (Q9PY96), 
NCAP_CVM3   (P18447), NCAP_CVMA5  (P03416), NCAP_CVMDV  (Q83360), 
NCAP_CVMJH  (P03417), NCAP_CVMS   (P18448), NCAP_CVPV   (P59713), 
NCAP_CVRNJ  (Q9WCD0), NCAP_CVRSD  (Q02915), NEMS_APIME  (P85527), 
NOL6_DROME  (Q8IH00), NOL6_DROSE  (B4IBY3), NOL6_DROSI  (B4QX57), 
NOL6_DROYA  (B4PR18), NR2C1_BOVIN (A0JNE3), NR2C1_HUMAN (P13056), 
NR2C1_MACFA (Q95K90), NR2C1_MOUSE (Q505F1), NR2C1_PONAB (Q5RCZ5), 
NR2C1_RAT   (Q8VIJ4), NR2C1_XENTR (Q28CK1), NUS1_ASPOR  (P24021), 
PA24A_BOVIN (A4IFJ5), PA24A_CHICK (P49147), PA24A_DANRE (P50392), 
PA24A_HORSE (O77793), PA24A_HUMAN (P47712), PA24A_MOUSE (P47713), 
PA24A_PONAB (Q5R8A5), PA24A_RABIT (Q9TT38), PA24A_RAT   (P50393), 
PA24A_XENLA (Q7T0T9), PA24A_XENTR (B1WAZ6), PDAD_METKA  (Q8TXD4), 
PEPQ_AERHH  (A0KEL3), PEPQ_AERS4  (A4STF0), PGP_ARCFU   (O29805), 
PNP_FRAT1   (Q14IC9), PNP_FRATF   (A7NDP3), PNP_FRATH   (Q2A269), 
PNP_FRATM   (B2SDK7), PNP_FRATN   (A0Q5I9), PNP_FRATO   (Q0BKU1), 
PNP_FRATT   (Q5NGX7), PNP_FRATW   (A4IZA6), PP263_ARATH (Q9M2A1), 
PPOC_ARATH  (P55826), PURA_LEIDO  (A7LBL2), PURA_LEIIN  (A4HVP7), 
PURA_LEIMA  (Q4QG35), PYRE_PHOLL  (Q7MY25), PYRE_SHEON  (Q8E9L5), 
PYRE_VIBCH  (Q9KVD5), RNJ1_STAA3  (Q2FHZ1), RNJ1_STAA8  (Q2FZG9), 
RNJ1_STAAB  (Q2YX35), RNJ1_STAAC  (Q5HGZ5), RNJ1_STAAM  (Q99V09), 
RNJ1_STAAN  (Q7A682), RNJ1_STAAR  (Q6GHZ6), RNJ1_STAAS  (Q6GAC5), 
RNJ1_STAAW  (Q7A171), RNJ1_STAEQ  (Q5HQ80), RNJ1_STAES  (Q8CT16), 
RNJ1_STAHJ  (Q4L5A3), RNJ1_STAS1  (Q49WL3), RPOB_KORVE  (Q1IHH4), 
RR2_THAPS   (A0T0Q8), SC6_SCHCO   (O74300), SECA_MYCPU  (Q98RA6), 
SEY1_SCHPO  (Q9UTE0), SMI1_SCHPO  (O14362), STE13_YEAST (P33894), 
SYFB_THIDA  (Q3SK29), T2S1_LACLC  (O34104), TEN1_HUMAN  (Q9UKZ4), 
TEN1_MOUSE  (Q9WTS4), TRP3_ARATH  (Q9C7B1), VL2_HPV42   (P27235), 
XERS_LACLA  (Q9CG78), XERS_LACLM  (A2RKP9), XERS_LACLS  (Q02YZ4), 
XOL1_CAEEL  (Q23229), Y072_CHLTR  (O84075), Y1273_MYCTO (P9WQJ0), 
Y1273_MYCTU (P9WQJ1), Y1304_MYCBO (P0A4W5), Y1776_COREF (Q8FPK2), 
Y344_CHLMU  (Q9PKW7), Y4KK_RHISN  (P55529), Y5194_MYCGI (A4T1E2), 
Y973_METJA  (Q58383), YFIB_BACSU  (P54718), YQ02_CAEEL  (Q17405), 
YSH1_ASHGO  (Q74ZC0), YSH1_YARLI  (Q6C2Z7)
» More

PDB
[Detailed view]
188 PDB

1A2Q; 1AF4; 1AH2; 1AK9; 1AQN; 1AU9; 1AV7; 1AVT; 1BE6; 1BE8; 1BFK; 1BFU; 1BH6; 1BJR; 1C3L; 1C9J; 1C9M; 1C9N; 1CNM; 1CSE; 1DBI; 1DUI; 1EGQ; 1GCI; 1GNS; 1GNV; 1HT3; 1IAV; 1IC6; 1JEA; 1LW6; 1MEE; 1MPT; 1NDQ; 1NDU; 1OT5; 1OYO; 1OYV; 1P7V; 1P7W; 1P8J; 1PEK; 1PFG; 1PJ8; 1PTK; 1Q5P; 1R0R; 1R64; 1S01; 1S02; 1SBC; 1SBH; 1SBI; 1SBN; 1SBT; 1SCA; 1SCB; 1SCD; 1SCJ; 1SCN; 1SEL; 1SIB; 1ST2; 1ST3; 1SUA; 1SUB; 1SUC; 1SUD; 1SUE; 1SUP; 1SVN; 1TEC; 1THM; 1TK2; 1TM1; 1TM3; 1TM4; 1TM5; 1TM7; 1TMG; 1TO1; 1TO2; 1UBN; 1V5I; 1VSB; 1WSD; 1XF1; 1Y1K; 1Y33; 1Y34; 1Y3B; 1Y3C; 1Y3D; 1Y3F; 1Y48; 1Y4A; 1Y4D; 1YJA; 1YJB; 1YJC; 1YU6; 2DP4; 2DQK; 2DUJ; 2E1P; 2G4V; 2HD4; 2HPZ; 2ID4; 2ID8; 2PKC; 2PQ2; 2PRK; 2PWA; 2PWB; 2PYZ; 2SBT; 2SEC; 2SIC; 2SNI; 2ST1; 2TEC; 2V8B; 2WUV; 2WUW; 2Z2X; 2Z2Y; 2Z2Z; 2Z30; 2Z56; 2Z57; 2Z58; 2ZRQ; 2ZWO; 2ZWP; 3A3N; 3A3O; 3A3P; 3AJ8; 3AJ9; 3BX1; 3D9Q; 3DDZ; 3DE0; 3DE1; 3DE2; 3DE3; 3DE4; 3DE5; 3DE6; 3DE7; 3DVQ; 3DVR; 3DVS; 3DW1; 3DW3; 3DWE; 3DYB; 3EIF; 3F7M; 3GT3; 3GT4; 3I2Y; 3I30; 3I34; 3I37; 3L1K; 3OSZ; 3PRK; 3PTL; 3Q40; 3Q5G; 3QMP; 3SIC; 3TEC; 3UNX; 3VHQ; 3VSB; 3VV2; 3VYV; 3WHI; 4B5L; 4DJ5; 4DWW; 4DZT; 4FON; 4JP8; 5SIC
» More

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