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Entry: PS00137

General information about the entry

Entry name [info] SUBTILASE_HIS
Accession [info] PS00137
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED; 01-NOV-1997 DATA UPDATE; 27-SEP-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC00125
Associated ProRule [info] PRU10081

Name and characterization of the entry

Description [info] Serine proteases, subtilase family, histidine active site.
Pattern [info]
H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-[SAGM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_09 which contains 555'594 sequence entries.


Total number of hits 228 in 228 different sequences
Number of true positive hits 213 in 213 different sequences
Number of 'unknown' hits 0
Number of false positive hits 15 in 15 different sequences
Number of false negative sequences 98
Number of 'partial' sequences 11
Precision (true positives / (true positives + false positives)) 93.42 %
Recall (true positives / (true positives + false negatives)) 68.49 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
213 sequences

AEP_YARLI   (P09230    ), AEX5_CAEEL  (P91863    ), ALP2_ASPFC  (B0Y473    ), 
ALP2_ASPFU  (P87184    ), ALP_ACRCH   (P29118    ), ALP_HYPAT   (Q03420    ), 
ALP_LECPS   (Q68GV9    ), APRX_BACSU  (O31788    ), AQL1_THEAQ  (P08594    ), 
BLI4_CAEEL  (P51559    ), BLI_ONCVO   (A0A044RE18), BPRV_DICNO  (P42779    ), 
BPRX_DICNO  (P42780    ), C5AP_STRP1  (P58099    ), C5AP_STRP3  (P0DD34    ), 
C5AP_STRP6  (Q5X9R0    ), C5AP_STRP8  (Q8NZ80    ), C5AP_STRPQ  (P0DD35    ), 
C5AP_STRPY  (P15926    ), CRSP_ARATH  (Q9LNU1    ), CUDP_METAN  (P29138    ), 
ELYA_BACAO  (P27693    ), ELYA_BACCS  (P41362    ), ELYA_BACHD  (P41363    ), 
ELYA_BACYA  (P20724    ), EPIP_STAEP  (P30199    ), EXPR_XANCP  (P23314    ), 
FKPC1_CAEEL (O17798    ), FLS_FERPE   (Q93LQ6    ), FUR11_DROME (P26016    ), 
FUR1C_DROME (P30430    ), FUR2_DROME  (P30432    ), FURI1_XENLA (P29119    ), 
FURIN_BOVIN (Q28193    ), FURIN_HUMAN (P09958    ), FURIN_MOUSE (P23188    ), 
FURIN_RAT   (P23377    ), HLY_HALMT   (I3R794    ), HLY_NATA1   (P29143    ), 
ISP1_BACSU  (P11018    ), ISP6_SCHPO  (P40903    ), ISP_BACCS   (P29140    ), 
ISP_PAEPO   (P29139    ), KEX1A_KLULA (P09231    ), KEX2_CANAW  (O13359    ), 
KEX2_YEAST  (P13134    ), KRP1_SCHPO  (Q09175    ), MBTP1_CRIGR (Q9Z2A8    ), 
MBTP1_HUMAN (Q14703    ), MBTP1_MOUSE (Q9WTZ2    ), MBTP1_RAT   (Q9WTZ3    ), 
MYCP2_MYCTU (O05458    ), MYCP3_MYCTU (O53695    ), MYCP4_MYCTU (I6YC58    ), 
MYCP5_MYCTU (O53945    ), NEC1_BOVIN  (Q9GLR1    ), NEC1_HUMAN  (P29120    ), 
NEC1_MOUSE  (P63239    ), NEC1_MUSCO  (P63240    ), NEC1_RAT    (P28840    ), 
NEC2_BOVIN  (Q9GLR0    ), NEC2_CAEEL  (G5ECN9    ), NEC2_HUMAN  (P16519    ), 
NEC2_MOUSE  (P21661    ), NEC2_PIG    (Q03333    ), NEC2_PONAB  (Q5REC2    ), 
NEC2_RAT    (P28841    ), NECA_HYDVU  (P29146    ), NECB_HYDVU  (P29145    ), 
NEP_NATMA   (Q5RLZ1    ), NISP_LACLL  (Q07596    ), ORYZ_ASPCL  (A1CIA7    ), 
ORYZ_ASPFC  (B0Y708    ), ORYZ_ASPFL  (P35211    ), ORYZ_ASPFN  (B8N106    ), 
ORYZ_ASPFU  (P28296    ), ORYZ_ASPOR  (P12547    ), ORYZ_EMENI  (Q00208    ), 
ORYZ_NEOFI  (A1CWF3    ), P1P_LACLC   (P16271    ), P2P_LACLC   (P15293    ), 
P2P_LACPA   (Q02470    ), P3P_LACLS   (P15292    ), PCSK4_HUMAN (Q6UW60    ), 
PCSK4_MOUSE (P29121    ), PCSK4_RAT   (Q78EH2    ), PCSK5_BRACL (Q9NJ15    ), 
PCSK5_HUMAN (Q92824    ), PCSK5_MOUSE (Q04592    ), PCSK5_RAT   (P41413    ), 
PCSK6_HUMAN (P29122    ), PCSK6_RAT   (Q63415    ), PCSK7_HUMAN (Q16549    ), 
PCSK7_MOUSE (Q61139    ), PCSK7_RAT   (Q62849    ), PEPC_ASPNG  (P33295    ), 
PLS_PYRFU   (P72186    ), PRCA_ANAVT  (P23916    ), PRCA_NOSS1  (Q59149    ), 
PROA_VIBAL  (P16588    ), PRTB_YEAST  (P09232    ), PRTK_PARAQ  (P06873    ), 
PRTM_BACSK  (Q99405    ), PRTR_PARAQ  (P23653    ), PRTS_SERMA  (P09489    ), 
PRTT_PARAQ  (P20015    ), PRTT_SERMA  (P29805    ), PSP3_SCHPO  (Q9UTS0    ), 
RRT12_YEAST (P25381    ), SBT24_ARATH (F4HYR6    ), SBT31_ARATH (F4JJH4    ), 
SBT33_ARATH (Q9MAP5    ), SBT34_ARATH (F4HPF1    ), SBT39_ARATH (Q9ZSB0    ), 
SBT3A_ARATH (Q9ZSB1    ), SBT3B_ARATH (Q1PDX5    ), SBT3G_ARATH (Q8GWX9    ), 
SBT41_ARATH (F4IG09    ), SBT51_ARATH (F4HSQ2    ), SBT61_ARATH (Q0WUG6    ), 
SEPR_THESR  (P80146    ), SMP1_MAGPO  (Q9Y778    ), SPAZ_ARTOA  (G1X8P8    ), 
SPAZ_ARTOL  (G3FNQ9    ), SPL1_ENCCU  (Q8SQJ3    ), SPM1_MAGO7  (P58371    ), 
SUB10_ARTBC (D4AQG0    ), SUB10_TRIVH (D4DIS6    ), SUB1_PSED2  (L8G6I7    ), 
SUB2A_COCP7 (C5P6D1    ), SUB2C_COCP7 (C5NZ70    ), SUB2_ARTBC  (D4AZ75    ), 
SUB2_ARTBE  (Q64K35    ), SUB2_ARTGP  (E4UZP9    ), SUB2_ARTOC  (C5G168    ), 
SUB2_ARTOT  (Q8J0D8    ), SUB2_DEIRA  (Q9RYM8    ), SUB2_PSED2  (L8FSM5    ), 
SUB2_TRIEQ  (B6VA85    ), SUB2_TRIRU  (Q69F57    ), SUB2_TRITO  (B8XGQ5    ), 
SUB2_TRIVC  (Q5VJ76    ), SUB2_TRIVH  (D4DLI5    ), SUB3_PSED2  (L8GD75    ), 
SUB4B_COCP7 (C5NZT2    ), SUB5_ARTBC  (D4B194    ), SUB5_ARTBE  (Q64K32    ), 
SUB5_ARTGP  (E4V2L6    ), SUB5_ARTOC  (C5G1D1    ), SUB5_TRIEQ  (B6VA87    ), 
SUB5_TRIRU  (Q69F34    ), SUB5_TRITO  (B8XGQ8    ), SUB5_TRIVC  (Q5VJ73    ), 
SUB5_TRIVH  (D4D0F5    ), SUB6_ARTBC  (D4ALV9    ), SUB6_ARTBE  (Q64K31    ), 
SUB6_ARTGP  (E4V4J8    ), SUB6_ARTOC  (C5FQI3    ), SUB6_TRIEQ  (A1XIH0    ), 
SUB6_TRIRU  (Q9UW97    ), SUB6_TRISD  (A1XIH1    ), SUB6_TRISH  (Q8J077    ), 
SUB6_TRITO  (Q3ZEJ8    ), SUB6_TRIVC  (Q5VJ72    ), SUB6_TRIVH  (D4D5H3    ), 
SUB7B_COCP7 (C5PCX1    ), SUB7C_COCP7 (C5NZ69    ), SUB7_ARTBC  (D4APA9    ), 
SUB7_ARTBE  (Q64K36    ), SUB7_ARTGP  (E4V2V9    ), SUB7_ARTOC  (C5FJA5    ), 
SUB7_TRIEQ  (A1XIH3    ), SUB7_TRIRU  (Q8NID9    ), SUB7_TRISD  (A1XIH5    ), 
SUB7_TRITO  (A1XIH4    ), SUB7_TRIVC  (Q5VJ71    ), SUB7_TRIVH  (D4CZQ4    ), 
SUB7_TRIVO  (A1XIH6    ), SUB8_ARTBC  (D4AX50    ), SUB8_ARTOC  (C5FII2    ), 
SUB8_COCP7  (C5P4Z8    ), SUB8_TRIVH  (D4DKQ4    ), SUBB_BACLE  (P29599    ), 
SUBD_BACLI  (P00781    ), SUBE_BACSU  (P16396    ), SUBF_BACSU  (P16397    ), 
SUBN_BACNA  (P35835    ), SUBS_BACLE  (P29600    ), SUBT_BACAM  (P00782    ), 
SUBT_BACLI  (P00780    ), SUBT_BACPU  (P07518    ), SUBT_BACS9  (P28842    ), 
SUBT_BACSA  (P00783    ), SUBT_BACSU  (P04189    ), SUBT_GEOSE  (P29142    ), 
SUBV_BACSU  (P29141    ), TAGB_DICDI  (P54683    ), TAGC_DICDI  (Q23868    ), 
TAGD_DICDI  (Q8T9W1    ), THES_BACSJ  (Q45670    ), THET_THEVU  (P04072    ), 
TKSP_THEKO  (Q5JIZ5    ), TPP2_BOVIN  (A5PK39    ), TPP2_CAEEL  (Q09541    ), 
TPP2_DROME  (Q9V6K1    ), TPP2_HUMAN  (P29144    ), TPP2_MOUSE  (Q64514    ), 
TPP2_RAT    (Q64560    ), TPP2_SCHPO  (Q9UT05    ), TPPII_ARATH (F4JVN6    ), 
WPRA_BACSU  (P54423    ), XPR6_YARLI  (P42781    ), YSP3_YEAST  (P25036    )
» more

UniProtKB/Swiss-Prot
False negative sequences
98 sequences

ASPA_AERSA  (P31339    ), CUCM1_CUCME (Q39547    ), MYCP1_MYCS2 (A0QNL1    ), 
MYCP1_MYCTU (O05461    ), PCSK9_ATEGE (A8T6A1    ), PCSK9_CALJA (A8T688    ), 
PCSK9_COLGU (A8T672    ), PCSK9_GORGO (A8T650    ), PCSK9_HUMAN (Q8NBP7    ), 
PCSK9_LAGLA (A8T6A6    ), PCSK9_MACMU (A8T666    ), PCSK9_MACNE (A8T662    ), 
PCSK9_MOUSE (Q80W65    ), PCSK9_PANPA (A8T655    ), PCSK9_PANTR (A8T644    ), 
PCSK9_PLEMO (A8T677    ), PCSK9_PONPY (A8T658    ), PCSK9_RAT   (P59996    ), 
PCSK9_SAGLB (A8T682    ), PCSK9_SAIBB (A8T695    ), SBT11_ARATH (Q84WS0    ), 
SBT12_ARATH (O64495    ), SBT13_ARATH (Q9FLI4    ), SBT14_ARATH (Q9LVJ1    ), 
SBT15_ARATH (Q9LUM3    ), SBT16_ARATH (O49607    ), SBT17_ARATH (O65351    ), 
SBT18_ARATH (Q9ZUF6    ), SBT19_ARATH (Q9FHA4    ), SBT21_ARATH (Q9SA75    ), 
SBT22_ARATH (Q9SUN6    ), SBT23_ARATH (Q9FI12    ), SBT25_ARATH (O64481    ), 
SBT26_ARATH (Q9SZV5    ), SBT32_ARATH (Q9MAP4    ), SBT35_ARATH (Q9MAP7    ), 
SBT36_ARATH (Q8L7I2    ), SBT37_ARATH (Q9SZY2    ), SBT38_ARATH (Q9SZY3    ), 
SBT3C_ARATH (F4JJH5    ), SBT3D_ARATH (Q8GUK4    ), SBT3E_ARATH (Q9SVT4    ), 
SBT3F_ARATH (F4JJL8    ), SBT3H_ARATH (Q9C7U8    ), SBT3I_ARATH (Q9STQ2    ), 
SBT42_ARATH (O23357    ), SBT43_ARATH (Q9FIF8    ), SBT44_ARATH (Q9FGU3    ), 
SBT45_ARATH (F4JA91    ), SBT46_ARATH (Q9STF7    ), SBT47_ARATH (F4KGD4    ), 
SBT48_ARATH (Q9FIM6    ), SBT49_ARATH (Q9FIM5    ), SBT4A_ARATH (Q9FIM8    ), 
SBT4B_ARATH (Q9FIG1    ), SBT4C_ARATH (Q8L7D2    ), SBT4D_ARATH (Q9FIG2    ), 
SBT4E_ARATH (Q9LLL8    ), SBT4F_ARATH (Q9LZS6    ), SBT54_ARATH (F4JXC5    ), 
SBT55_ARATH (F4KEL0    ), SBT56_ARATH (Q9FK76    ), SSA1_MANHA  (P31631    ), 
SU11A_COCP7 (C5P1W9    ), SU11B_COCP7 (C5PFR5    ), SUB10_ARTOC (C5FX37    ), 
SUB11_ARTBC (D4APE3    ), SUB11_ARTGP (E4V5C5    ), SUB11_ARTOC (C5FZ39    ), 
SUB11_TRIVH (D4CZ60    ), SUB12_ARTBC (D4AQA9    ), SUB12_ARTGP (E4UY04    ), 
SUB12_TRIVH (D4D1U5    ), SUB1_ARTBC  (D4AKU9    ), SUB1_ARTGP  (E4UPZ4    ), 
SUB1_ARTOC  (C5FPS1    ), SUB1_TRIVH  (D4DIW9    ), SUB2B_COCP7 (C5P906    ), 
SUB3_ARTBC  (D4AWY5    ), SUB3_ARTGP  (E4UN97    ), SUB3_ARTOC  (C5FMY5    ), 
SUB3_TRIVH  (D4DLA2    ), SUB4A_COCP7 (C5PCB1    ), SUB4C_COCP7 (C5P6L5    ), 
SUB4_ARTBC  (D4AXW3    ), SUB4_ARTGP  (E4UWA4    ), SUB4_ARTOC  (C5FXZ6    ), 
SUB4_TRIVH  (D4D6Q4    ), SUB7A_COCP7 (C5PGK9    ), SUB7D_COCP7 (C5P9H3    ), 
SUB9_ARTBC  (D4B5N1    ), SUB9_ARTGP  (E4UTU7    ), SUB9_ARTOC  (C5FH27    ), 
SUB9_COCP7  (C5P5Q3    ), SUB9_TRIVH  (D4D674    ), TAGA_DICDI  (Q9GTN7    ), 
TPPII_ORYSJ (Q6ESI7    ), VG47_ICHVA  (Q00139    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
11 sequences

ALP_FUSCU   (P83610    ), APGR3_BIOOC (P83492    ), ASE1_ACRSP  (P85156    ), 
ASE2_ACRSP  (P85157    ), CUDP_METCM  (P80406    ), FIBR2_NEAJA (P86876    ), 
NCP3_COPCM  (P83454    ), NVSP_ALIVI  (P83433    ), PRTE_HALME  (P28308    ), 
SP01_PSEBO  (Q10721    ), THEM_MALCI  (P13858    )
» more

UniProtKB/Swiss-Prot
False positive sequences
15 sequences

ADCY8_HUMAN (P40145    ), ADCY8_MOUSE (P97490    ), ADCY8_RAT   (P40146    ), 
DGGGP_METTH (O27170    ), KTNB1_XENTR (Q6NVM2    ), PSBA3_GLOVI (Q7NH81    ), 
PSBA_ALETA  (Q9TM69    ), PSBA_AMPCA  (Q9BBC1    ), PSBA_AMPOP  (Q7HP56    ), 
PSBA_HETNI  (Q9MSC0    ), PSBA_HETPY  (Q9MSC1    ), PSBA_HETRO  (Q9MSC2    ), 
PSBA_HETTR  (Q9XQV1    ), PSBA_PROMC  (Q9TM72    ), TM241_MOUSE (Q3UME2    )
» more

PDB
[Detailed view]
204 PDB

1A2Q; 1AF4; 1AH2; 1AK9; 1AQN; 1AU9; 1AV7; 1AVT; 1BE6; 1BE8; 1BFK; 1BFU; 1BH6; 1BJR; 1C3L; 1C9J; 1C9M; 1C9N; 1CNM; 1CSE; 1DBI; 1DUI; 1EGQ; 1GCI; 1GNS; 1GNV; 1HT3; 1IAV; 1IC6; 1JEA; 1LW6; 1MEE; 1MPT; 1NDQ; 1NDU; 1OT5; 1OYO; 1OYV; 1P7V; 1P7W; 1P8J; 1PEK; 1PFG; 1PJ8; 1PTK; 1Q5P; 1R0R; 1R64; 1S01; 1S02; 1SBC; 1SBH; 1SBI; 1SBN; 1SBT; 1SCA; 1SCB; 1SCD; 1SCJ; 1SCN; 1SEL; 1SIB; 1SPB; 1ST2; 1ST3; 1SUA; 1SUB; 1SUC; 1SUD; 1SUE; 1SUP; 1SVN; 1TEC; 1THM; 1TK2; 1TM1; 1TM3; 1TM4; 1TM5; 1TM7; 1TMG; 1TO1; 1TO2; 1UBN; 1V5I; 1VSB; 1WSD; 1XF1; 1Y1K; 1Y33; 1Y34; 1Y3B; 1Y3C; 1Y3D; 1Y3F; 1Y48; 1Y4A; 1Y4D; 1YJA; 1YJB; 1YJC; 1YU6; 2DP4; 2DQK; 2DUJ; 2G4V; 2HD4; 2HPZ; 2ID4; 2ID8; 2PKC; 2PQ2; 2PRK; 2PWA; 2PWB; 2PYZ; 2SBT; 2SEC; 2SIC; 2SNI; 2ST1; 2TEC; 2V8B; 2WUV; 2WUW; 3AFG; 3AJ8; 3AJ9; 3BGO; 3BX1; 3CNQ; 3CO0; 3D9Q; 3DDZ; 3DE0; 3DE1; 3DE2; 3DE3; 3DE4; 3DE5; 3DE6; 3DE7; 3DVQ; 3DVR; 3DVS; 3DW1; 3DW3; 3DWE; 3DYB; 3EIF; 3F49; 3F7M; 3GT3; 3GT4; 3I2Y; 3I30; 3I34; 3I37; 3L1K; 3LXU; 3OSZ; 3PRK; 3PTL; 3Q40; 3Q5G; 3QMP; 3SIC; 3TEC; 3UNX; 3VSB; 3VYV; 3WHI; 4B5L; 4C3U; 4C3V; 4CFY; 4CFZ; 4CG0; 4DJ5; 4DWW; 4DZT; 4FON; 4MZD; 4OMC; 4OMD; 4RYD; 4WOB; 4WOC; 4Z2A; 4ZAR; 5AMX; 5AQE; 5ARB; 5ARC; 5ARD; 5AVJ; 5AVK; 5CW1; 5I9S; 5JXG; 5JXH; 5JXI; 5JXJ; 5SIC
» more

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