Entry: PS00138

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General information about the entry

Entry name [info] SUBTILASE_SER
Accession [info] PS00138
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); APR-2006 (DATA UPDATE); SEP-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00125
Associated ProRule [info] PRU10082

Name and characterization of the entry

Description [info] Serine proteases, subtilase family, serine active site.
Pattern [info]
G-T-S-x-[SA]-x-P-x-{L}-[STAVC]-[AG].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_10 which contains 546'790 sequence entries.


Total number of hits 272 in 269 different sequences
Number of true positive hits 241 in 241 different sequences
Number of 'unknown' hits
Number of false positive hits 31 in 28 different sequences
Number of false negative sequences 29
Number of 'partial' sequences 10
Precision (true positives / (true positives + false positives)) 88.60 %
Recall (true positives / (true positives + false negatives)) 89.26 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 4
Site [info] active_site at position 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
241 sequences

AEP_YARLI   (P09230), AIR3_ARATH  (Q9ZSP5), ALP2_ASPFC  (B0Y473), 
ALP2_ASPFU  (P87184), ALP_ACRCH   (P29118), ALP_HYPAT   (Q03420), 
ALP_LECPS   (Q68GV9), APRX_BACSU  (O31788), AQL1_THEAQ  (P08594), 
ASPA_AERSA  (P31339), BLI4_CAEEL  (P51559), BPRV_DICNO  (P42779), 
BPRX_DICNO  (P42780), C5AP_STRP1  (P58099), C5AP_STRP3  (P0DD34), 
C5AP_STRP6  (Q5X9R0), C5AP_STRP8  (Q8NZ80), C5AP_STRPQ  (P0DD35), 
C5AP_STRPY  (P15926), CRSP_ARATH  (Q9LNU1), CUCM1_CUCME (Q39547), 
CUDP_METAN  (P29138), ELYA_BACAO  (P27693), ELYA_BACCS  (P41362), 
ELYA_BACHD  (P41363), ELYA_BACYA  (P20724), EPIP_STAEP  (P30199), 
EXPR_XANCP  (P23314), FIBR2_NEAJA (P86876), FKPC1_CAEEL (O17798), 
FUR11_DROME (P26016), FUR1C_DROME (P30430), FUR2_DROME  (P30432), 
FURI1_XENLA (P29119), FURIN_HUMAN (P09958), FURIN_MOUSE (P23188), 
FURIN_RAT   (P23377), HLY_HALMT   (I3R794), HLY_NATA1   (P29143), 
ISP1_BACSU  (P11018), ISP6_SCHPO  (P40903), ISP_BACCS   (P29140), 
ISP_PAEPO   (P29139), KEX1A_KLULA (P09231), KEX2_CANAW  (O13359), 
KEX2_YEAST  (P13134), KRP1_SCHPO  (Q09175), MBTP1_CRIGR (Q9Z2A8), 
MBTP1_HUMAN (Q14703), MBTP1_MOUSE (Q9WTZ2), MBTP1_RAT   (Q9WTZ3), 
NEC1_BOVIN  (Q9GLR1), NEC1_HUMAN  (P29120), NEC1_MOUSE  (P63239), 
NEC1_MUSCO  (P63240), NEC1_RAT    (P28840), NEC2_BOVIN  (Q9GLR0), 
NEC2_HUMAN  (P16519), NEC2_MOUSE  (P21661), NEC2_PIG    (Q03333), 
NEC2_PONAB  (Q5REC2), NEC2_RAT    (P28841), NECA_HYDVU  (P29146), 
NECB_HYDVU  (P29145), NEP_NATMA   (Q5RLZ1), ORYZ_ASPCL  (A1CIA7), 
ORYZ_ASPFC  (B0Y708), ORYZ_ASPFL  (P35211), ORYZ_ASPFN  (B8N106), 
ORYZ_ASPFU  (P28296), ORYZ_ASPOR  (P12547), ORYZ_EMENI  (Q00208), 
ORYZ_NEOFI  (A1CWF3), P1P_LACLC   (P16271), P2P_LACLC   (P15293), 
P2P_LACPA   (Q02470), P3P_LACLS   (P15292), PCSK4_HUMAN (Q6UW60), 
PCSK4_MOUSE (P29121), PCSK4_RAT   (Q78EH2), PCSK5_BRACL (Q9NJ15), 
PCSK5_HUMAN (Q92824), PCSK5_MOUSE (Q04592), PCSK5_RAT   (P41413), 
PCSK6_HUMAN (P29122), PCSK6_RAT   (Q63415), PCSK7_HUMAN (Q16549), 
PCSK7_MOUSE (Q61139), PCSK7_RAT   (Q62849), PEPC_ASPNG  (P33295), 
PLS_PYRFU   (P72186), PRCA_ANAVT  (P23916), PRCA_NOSS1  (Q59149), 
PROA_VIBAL  (P16588), PRTB_YEAST  (P09232), PRTK_ENGAL  (P06873), 
PRTM_BACSK  (Q99405), PRTR_ENGAL  (P23653), PRTS_SERMA  (P09489), 
PRTT_ENGAL  (P20015), PSP3_SCHPO  (Q9UTS0), RRT12_YEAST (P25381), 
SBT1_SOYBN  (I1N462), SBT33_ARATH (Q9MAP5), SBT35_ARATH (Q9MAP7), 
SBT54_ARATH (F4JXC5), SDD1_ARATH  (O64495), SEPR_THESR  (P80146), 
SMP1_MAGPO  (Q9Y778), SPAZ_ARTOA  (G1X8P8), SPAZ_ARTOL  (G3FNQ9), 
SPL1_ENCCU  (Q8SQJ3), SPM1_MAGO7  (P58371), SSA1_PASHA  (P31631), 
SU11A_COCP7 (C5P1W9), SU11B_COCP7 (C5PFR5), SUB10_ARTBC (D4AQG0), 
SUB10_ARTOC (C5FX37), SUB10_TRIVH (D4DIS6), SUB12_ARTBC (D4AQA9), 
SUB12_ARTGP (E4UY04), SUB12_TRIVH (D4D1U5), SUB1_ARTBC  (D4AKU9), 
SUB1_ARTBE  (Q64K30), SUB1_ARTGP  (E4UPZ4), SUB1_ARTOC  (C5FPS1), 
SUB1_ARTOT  (Q8J0D9), SUB1_TRIEQ  (B6VA84), SUB1_TRIRU  (Q69F58), 
SUB1_TRITO  (B8XGQ4), SUB1_TRIVC  (Q5VJ77), SUB1_TRIVH  (D4DIW9), 
SUB2A_COCP7 (C5P6D1), SUB2B_COCP7 (C5P906), SUB2C_COCP7 (C5NZ70), 
SUB2_ARTBC  (D4AZ75), SUB2_ARTBE  (Q64K35), SUB2_ARTGP  (E4UZP9), 
SUB2_ARTOC  (C5G168), SUB2_ARTOT  (Q8J0D8), SUB2_DEIRA  (Q9RYM8), 
SUB2_TRIEQ  (B6VA85), SUB2_TRIRU  (Q69F57), SUB2_TRITO  (B8XGQ5), 
SUB2_TRIVC  (Q5VJ76), SUB2_TRIVH  (D4DLI5), SUB3_ARTBC  (D4AWY5), 
SUB3_ARTBE  (Q64K34), SUB3_ARTGP  (E4UN97), SUB3_ARTOC  (C5FMY5), 
SUB3_ARTOT  (Q8J0D7), SUB3_TRIEQ  (B6VA86), SUB3_TRIRU  (Q69F56), 
SUB3_TRITO  (B8XGQ6), SUB3_TRIVC  (Q5VJ75), SUB3_TRIVH  (D4DLA2), 
SUB4A_COCP7 (C5PCB1), SUB4C_COCP7 (C5P6L5), SUB4_ARTBC  (D4AXW3), 
SUB4_ARTBE  (Q64K33), SUB4_ARTGP  (E4UWA4), SUB4_ARTOC  (C5FXZ6), 
SUB4_TRIEQ  (A7UKV6), SUB4_TRIRU  (Q69F35), SUB4_TRITO  (B8XGQ7), 
SUB4_TRIVC  (Q5VJ74), SUB4_TRIVH  (D4D6Q4), SUB5_ARTBC  (D4B194), 
SUB5_ARTBE  (Q64K32), SUB5_ARTGP  (E4V2L6), SUB5_ARTOC  (C5G1D1), 
SUB5_TRIEQ  (B6VA87), SUB5_TRIRU  (Q69F34), SUB5_TRITO  (B8XGQ8), 
SUB5_TRIVC  (Q5VJ73), SUB5_TRIVH  (D4D0F5), SUB6_ARTBC  (D4ALV9), 
SUB6_ARTBE  (Q64K31), SUB6_ARTGP  (E4V4J8), SUB6_ARTOC  (C5FQI3), 
SUB6_TRIEQ  (A1XIH0), SUB6_TRIRU  (Q9UW97), SUB6_TRISD  (A1XIH1), 
SUB6_TRISH  (Q8J077), SUB6_TRITO  (Q3ZEJ8), SUB6_TRIVC  (Q5VJ72), 
SUB6_TRIVH  (D4D5H3), SUB7A_COCP7 (C5PGK9), SUB7B_COCP7 (C5PCX1), 
SUB7_ARTBC  (D4APA9), SUB7_ARTBE  (Q64K36), SUB7_ARTGP  (E4V2V9), 
SUB7_ARTOC  (C5FJA5), SUB7_TRIEQ  (A1XIH3), SUB7_TRIRU  (Q8NID9), 
SUB7_TRITO  (A1XIH4), SUB7_TRIVC  (Q5VJ71), SUB7_TRIVH  (D4CZQ4), 
SUB7_TRIVO  (A1XIH6), SUB8_ARTBC  (D4AX50), SUB8_ARTOC  (C5FII2), 
SUB8_COCP7  (C5P4Z8), SUB8_TRIVH  (D4DKQ4), SUB9_ARTBC  (D4B5N1), 
SUB9_ARTGP  (E4UTU7), SUB9_ARTOC  (C5FH27), SUB9_COCP7  (C5P5Q3), 
SUB9_TRIVH  (D4D674), SUBB_BACLE  (P29599), SUBD_BACLI  (P00781), 
SUBE_BACSU  (P16396), SUBF_BACSU  (P16397), SUBL_ARATH  (O65351), 
SUBN_BACNA  (P35835), SUBS_BACLE  (P29600), SUBT_BACAM  (P00782), 
SUBT_BACLI  (P00780), SUBT_BACPU  (P07518), SUBT_BACS9  (P28842), 
SUBT_BACSA  (P00783), SUBT_BACSU  (P04189), SUBT_GEOSE  (P29142), 
SUBV_BACSU  (P29141), TAGB_DICDI  (P54683), TAGD_DICDI  (Q8T9W1), 
THES_BACSJ  (Q45670), THET_THEVU  (P04072), TKSU_THEKO  (P58502), 
TPP2_BOVIN  (A5PK39), TPP2_CAEEL  (Q09541), TPP2_DROME  (Q9V6K1), 
TPP2_HUMAN  (P29144), TPP2_MOUSE  (Q64514), TPP2_RAT    (Q64560), 
TPP2_SCHPO  (Q9UT05), TPPII_ARATH (F4JVN6), TPPII_ORYSJ (Q6ESI7), 
WPRA_BACSU  (P54423), XPR6_YARLI  (P42781), XSP1_ARATH  (Q9LLL8), 
YSP3_YEAST  (P25036)
» More

UniProtKB/Swiss-Prot
False negative sequences
29 sequences

FURIN_BOVIN (Q28193), NISP_LACLL  (Q07596), PCSK9_ATEGE (A8T6A1), 
PCSK9_CALJA (A8T688), PCSK9_CALMO (A8T677), PCSK9_COLGU (A8T672), 
PCSK9_GORGO (A8T650), PCSK9_HUMAN (Q8NBP7), PCSK9_LAGLA (A8T6A6), 
PCSK9_MACMU (A8T666), PCSK9_MACNE (A8T662), PCSK9_MOUSE (Q80W65), 
PCSK9_PANPA (A8T655), PCSK9_PANTR (A8T644), PCSK9_PONPY (A8T658), 
PCSK9_RAT   (P59996), PCSK9_SAGLB (A8T682), PCSK9_SAIBB (A8T695), 
PRTT_SERMA  (P29805), SUB11_ARTBC (D4APE3), SUB11_ARTGP (E4V5C5), 
SUB11_ARTOC (C5FZ39), SUB11_TRIVH (D4CZ60), SUB4B_COCP7 (C5NZT2), 
SUB7C_COCP7 (C5NZ69), SUB7D_COCP7 (C5P9H3), TAGA_DICDI  (Q9GTN7), 
TAGC_DICDI  (Q23868), VG47_ICHVA  (Q00139)
» More

UniProtKB/Swiss-Prot
'Partial' sequences
10 sequences

ALP_FUSCU   (P83610), APGR3_BIOOC (P83492), ASE1_ACRSP  (P85156), 
ASE2_ACRSP  (P85157), CUDP_METCM  (P80406), NCP3_COPCM  (P83454), 
NVSP_ALIVI  (P83433), PRTE_HALME  (P28308), SP01_PSEBO  (Q10721), 
THEM_MALSU  (P13858)
» More

UniProtKB/Swiss-Prot
False positive sequences
28 sequences

DCA11_CAEEL (P90794), FOSB_CANFA  (Q9TUB3), FOSB_HUMAN  (P53539), 
LIMD_DICDI  (Q9BIW4), MUCAP_PIG   (P12021), PAND_ALCBS  (Q0VSR5), 
PHYSA_PHYPO (Q8MZS4), PICP_PSESR  (P42790), SED1_ASPFU  (Q70DX9), 
SED2_ARTBC  (D4ANG0), SED2_ARTOC  (C5FBW2), SED2_ASPFU  (Q70J59), 
SED2_TRIVH  (D4DBH6), SED3_ARTBC  (D4AK75), SED3_ARTOC  (C5FTQ5), 
SED3_ASPFU  (Q70GH4), SED3_TRIVH  (D4D7N6), SED4_ARTBC  (D4AIK6), 
SED4_ARTOC  (C5FRX4), SED4_ASPFU  (Q4WQU0), SED4_TRIVH  (D4D9U2), 
SED5_ASPFU  (Q4WGU1), SPAST_DROWI (B4NBP4), TENS1_HUMAN (Q9HBL0), 
TPP1_DICDI  (Q55CT0), UCR1_CAEEL  (P98080), XANP_XANS2  (Q60106), 
YL139_YARLI (P0C8L8)
» More

PDB
[Detailed view]
159 PDB

1AF4; 1AH2; 1AK9; 1AQN; 1AU9; 1BE6; 1BE8; 1BFK; 1BFU; 1BH6; 1BJR; 1C3L; 1C9J; 1CNM; 1CSE; 1DBI; 1DUI; 1EGQ; 1GCI; 1HT3; 1IC6; 1JEA; 1LW6; 1MEE; 1MPT; 1NDQ; 1NDU; 1OT5; 1OYO; 1OYV; 1P7V; 1P7W; 1P8J; 1PEK; 1PFG; 1PJ8; 1PTK; 1R0R; 1R64; 1S01; 1S02; 1SBC; 1SBH; 1SBI; 1SBN; 1SBT; 1SCA; 1SCB; 1SCD; 1SCN; 1SIB; 1ST2; 1ST3; 1SUE; 1SUP; 1SVN; 1TEC; 1THM; 1TK2; 1TM1; 1TM3; 1TM4; 1TM5; 1TM7; 1TMG; 1TO1; 1TO2; 1WSD; 1XF1; 1Y1K; 1Y33; 1Y34; 1Y3B; 1Y3C; 1Y3D; 1Y3F; 1Y48; 1Y4A; 1Y4D; 1YJA; 1YJB; 1YJC; 1YU6; 2DP4; 2DQK; 2DUJ; 2G4V; 2HD4; 2HPZ; 2ID4; 2ID8; 2PKC; 2PQ2; 2PRK; 2PWA; 2PWB; 2PYZ; 2SBT; 2SEC; 2SIC; 2SNI; 2ST1; 2TEC; 2V8B; 2WUV; 2WUW; 3AJ8; 3AJ9; 3BX1; 3D9Q; 3DDZ; 3DE0; 3DE1; 3DE2; 3DE3; 3DE4; 3DE5; 3DE6; 3DE7; 3DVQ; 3DVR; 3DVS; 3DW1; 3DW3; 3DWE; 3DYB; 3EIF; 3F49; 3F7M; 3GT3; 3GT4; 3I2Y; 3I30; 3I34; 3I37; 3L1K; 3LXU; 3OSZ; 3PRK; 3PTL; 3Q40; 3Q5G; 3QMP; 3SIC; 3TEC; 3UNX; 3VTA; 4B5L; 4C3U; 4C3V; 4CFY; 4CFZ; 4CG0; 4DJ5; 4DZT; 4FON; 4OMC; 4OMD; 5SIC
» More

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