Entry: PS00138

General information about the entry

Entry name [info] SUBTILASE_SER
Accession [info] PS00138
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); APR-2006 (DATA UPDATE); JUN-2015 (INFO UPDATE).
PROSITE Doc. [info] PDOC00125
Associated ProRule [info] PRU10082

Name and characterization of the entry

Description [info] Serine proteases, subtilase family, serine active site.
Pattern [info]
G-T-S-x-[SA]-x-P-x-{L}-[STAVC]-[AG].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2015_08 which contains 320'201 sequence entries.


Total number of hits 278 in 275 different sequences
Number of true positive hits 247 in 247 different sequences
Number of 'unknown' hits 0
Number of false positive hits 31 in 28 different sequences
Number of false negative sequences 29
Number of 'partial' sequences 10
Precision (true positives / (true positives + false positives)) 88.85 %
Recall (true positives / (true positives + false negatives)) 89.49 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 4
Site [info] active_site at position 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
247 sequences

AEP_YARLI   (P09230), AIR3_ARATH  (Q9ZSP5), ALP2_ASPFC  (B0Y473), 
ALP2_ASPFU  (P87184), ALP_ACRCH   (P29118), ALP_HYPAT   (Q03420), 
ALP_LECPS   (Q68GV9), APRX_BACSU  (O31788), AQL1_THEAQ  (P08594), 
ASPA_AERSA  (P31339), BLI4_CAEEL  (P51559), BPRV_DICNO  (P42779), 
BPRX_DICNO  (P42780), C5AP_STRP1  (P58099), C5AP_STRP3  (P0DD34), 
C5AP_STRP6  (Q5X9R0), C5AP_STRP8  (Q8NZ80), C5AP_STRPQ  (P0DD35), 
C5AP_STRPY  (P15926), CRSP_ARATH  (Q9LNU1), CUCM1_CUCME (Q39547), 
CUDP_METAN  (P29138), ELYA_BACAO  (P27693), ELYA_BACCS  (P41362), 
ELYA_BACHD  (P41363), ELYA_BACYA  (P20724), EPIP_STAEP  (P30199), 
EXPR_XANCP  (P23314), FIBR2_NEAJA (P86876), FKPC1_CAEEL (O17798), 
FUR11_DROME (P26016), FUR1C_DROME (P30430), FUR2_DROME  (P30432), 
FURI1_XENLA (P29119), FURIN_HUMAN (P09958), FURIN_MOUSE (P23188), 
FURIN_RAT   (P23377), HLY_HALMT   (I3R794), HLY_NATA1   (P29143), 
ISP1_BACSU  (P11018), ISP6_SCHPO  (P40903), ISP_BACCS   (P29140), 
ISP_PAEPO   (P29139), KEX1A_KLULA (P09231), KEX2_CANAW  (O13359), 
KEX2_YEAST  (P13134), KRP1_SCHPO  (Q09175), MBTP1_CRIGR (Q9Z2A8), 
MBTP1_HUMAN (Q14703), MBTP1_MOUSE (Q9WTZ2), MBTP1_RAT   (Q9WTZ3), 
NEC1_BOVIN  (Q9GLR1), NEC1_HUMAN  (P29120), NEC1_MOUSE  (P63239), 
NEC1_MUSCO  (P63240), NEC1_RAT    (P28840), NEC2_BOVIN  (Q9GLR0), 
NEC2_HUMAN  (P16519), NEC2_MOUSE  (P21661), NEC2_PIG    (Q03333), 
NEC2_PONAB  (Q5REC2), NEC2_RAT    (P28841), NECA_HYDVU  (P29146), 
NECB_HYDVU  (P29145), NEP_NATMA   (Q5RLZ1), ORYZ_ASPCL  (A1CIA7), 
ORYZ_ASPFC  (B0Y708), ORYZ_ASPFL  (P35211), ORYZ_ASPFN  (B8N106), 
ORYZ_ASPFU  (P28296), ORYZ_ASPOR  (P12547), ORYZ_EMENI  (Q00208), 
ORYZ_NEOFI  (A1CWF3), P1P_LACLC   (P16271), P2P_LACLC   (P15293), 
P2P_LACPA   (Q02470), P3P_LACLS   (P15292), PCSK4_HUMAN (Q6UW60), 
PCSK4_MOUSE (P29121), PCSK4_RAT   (Q78EH2), PCSK5_BRACL (Q9NJ15), 
PCSK5_HUMAN (Q92824), PCSK5_MOUSE (Q04592), PCSK5_RAT   (P41413), 
PCSK6_HUMAN (P29122), PCSK6_RAT   (Q63415), PCSK7_HUMAN (Q16549), 
PCSK7_MOUSE (Q61139), PCSK7_RAT   (Q62849), PEPC_ASPNG  (P33295), 
PLS_PYRFU   (P72186), PRCA_ANAVT  (P23916), PRCA_NOSS1  (Q59149), 
PROA_VIBAL  (P16588), PRTB_YEAST  (P09232), PRTK_ENGAL  (P06873), 
PRTM_BACSK  (Q99405), PRTR_ENGAL  (P23653), PRTS_SERMA  (P09489), 
PRTT_ENGAL  (P20015), PSP3_SCHPO  (Q9UTS0), RRT12_YEAST (P25381), 
SBT11_ARATH (Q84WS0), SBT12_ARATH (O64495), SBT16_ARATH (O49607), 
SBT17_ARATH (O65351), SBT1_SOYBN  (I1N462), SBT24_ARATH (F4HYR6), 
SBT25_ARATH (O64481), SBT33_ARATH (Q9MAP5), SBT35_ARATH (Q9MAP7), 
SBT4E_ARATH (Q9LLL8), SBT54_ARATH (F4JXC5), SBT61_ARATH (Q0WUG6), 
SEPR_THESR  (P80146), SMP1_MAGPO  (Q9Y778), SPAZ_ARTOA  (G1X8P8), 
SPAZ_ARTOL  (G3FNQ9), SPL1_ENCCU  (Q8SQJ3), SPM1_MAGO7  (P58371), 
SSA1_MANHA  (P31631), SU11A_COCP7 (C5P1W9), SU11B_COCP7 (C5PFR5), 
SUB10_ARTBC (D4AQG0), SUB10_ARTOC (C5FX37), SUB10_TRIVH (D4DIS6), 
SUB12_ARTBC (D4AQA9), SUB12_ARTGP (E4UY04), SUB12_TRIVH (D4D1U5), 
SUB1_ARTBC  (D4AKU9), SUB1_ARTBE  (Q64K30), SUB1_ARTGP  (E4UPZ4), 
SUB1_ARTOC  (C5FPS1), SUB1_ARTOT  (Q8J0D9), SUB1_TRIEQ  (B6VA84), 
SUB1_TRIRU  (Q69F58), SUB1_TRITO  (B8XGQ4), SUB1_TRIVC  (Q5VJ77), 
SUB1_TRIVH  (D4DIW9), SUB2A_COCP7 (C5P6D1), SUB2B_COCP7 (C5P906), 
SUB2C_COCP7 (C5NZ70), SUB2_ARTBC  (D4AZ75), SUB2_ARTBE  (Q64K35), 
SUB2_ARTGP  (E4UZP9), SUB2_ARTOC  (C5G168), SUB2_ARTOT  (Q8J0D8), 
SUB2_DEIRA  (Q9RYM8), SUB2_TRIEQ  (B6VA85), SUB2_TRIRU  (Q69F57), 
SUB2_TRITO  (B8XGQ5), SUB2_TRIVC  (Q5VJ76), SUB2_TRIVH  (D4DLI5), 
SUB3_ARTBC  (D4AWY5), SUB3_ARTBE  (Q64K34), SUB3_ARTGP  (E4UN97), 
SUB3_ARTOC  (C5FMY5), SUB3_ARTOT  (Q8J0D7), SUB3_TRIEQ  (B6VA86), 
SUB3_TRIRU  (Q69F56), SUB3_TRITO  (B8XGQ6), SUB3_TRIVC  (Q5VJ75), 
SUB3_TRIVH  (D4DLA2), SUB4A_COCP7 (C5PCB1), SUB4C_COCP7 (C5P6L5), 
SUB4_ARTBC  (D4AXW3), SUB4_ARTBE  (Q64K33), SUB4_ARTGP  (E4UWA4), 
SUB4_ARTOC  (C5FXZ6), SUB4_TRIEQ  (A7UKV6), SUB4_TRIRU  (Q69F35), 
SUB4_TRITO  (B8XGQ7), SUB4_TRIVC  (Q5VJ74), SUB4_TRIVH  (D4D6Q4), 
SUB5_ARTBC  (D4B194), SUB5_ARTBE  (Q64K32), SUB5_ARTGP  (E4V2L6), 
SUB5_ARTOC  (C5G1D1), SUB5_TRIEQ  (B6VA87), SUB5_TRIRU  (Q69F34), 
SUB5_TRITO  (B8XGQ8), SUB5_TRIVC  (Q5VJ73), SUB5_TRIVH  (D4D0F5), 
SUB6_ARTBC  (D4ALV9), SUB6_ARTBE  (Q64K31), SUB6_ARTGP  (E4V4J8), 
SUB6_ARTOC  (C5FQI3), SUB6_TRIEQ  (A1XIH0), SUB6_TRIRU  (Q9UW97), 
SUB6_TRISD  (A1XIH1), SUB6_TRISH  (Q8J077), SUB6_TRITO  (Q3ZEJ8), 
SUB6_TRIVC  (Q5VJ72), SUB6_TRIVH  (D4D5H3), SUB7A_COCP7 (C5PGK9), 
SUB7B_COCP7 (C5PCX1), SUB7_ARTBC  (D4APA9), SUB7_ARTBE  (Q64K36), 
SUB7_ARTGP  (E4V2V9), SUB7_ARTOC  (C5FJA5), SUB7_TRIEQ  (A1XIH3), 
SUB7_TRIRU  (Q8NID9), SUB7_TRITO  (A1XIH4), SUB7_TRIVC  (Q5VJ71), 
SUB7_TRIVH  (D4CZQ4), SUB7_TRIVO  (A1XIH6), SUB8_ARTBC  (D4AX50), 
SUB8_ARTOC  (C5FII2), SUB8_COCP7  (C5P4Z8), SUB8_TRIVH  (D4DKQ4), 
SUB9_ARTBC  (D4B5N1), SUB9_ARTGP  (E4UTU7), SUB9_ARTOC  (C5FH27), 
SUB9_COCP7  (C5P5Q3), SUB9_TRIVH  (D4D674), SUBB_BACLE  (P29599), 
SUBD_BACLI  (P00781), SUBE_BACSU  (P16396), SUBF_BACSU  (P16397), 
SUBN_BACNA  (P35835), SUBS_BACLE  (P29600), SUBT_BACAM  (P00782), 
SUBT_BACLI  (P00780), SUBT_BACPU  (P07518), SUBT_BACS9  (P28842), 
SUBT_BACSA  (P00783), SUBT_BACSU  (P04189), SUBT_GEOSE  (P29142), 
SUBV_BACSU  (P29141), TAGB_DICDI  (P54683), TAGD_DICDI  (Q8T9W1), 
THES_BACSJ  (Q45670), THET_THEVU  (P04072), TKSP_THEKO  (Q5JIZ5), 
TKSU_THEKO  (P58502), TPP2_BOVIN  (A5PK39), TPP2_CAEEL  (Q09541), 
TPP2_DROME  (Q9V6K1), TPP2_HUMAN  (P29144), TPP2_MOUSE  (Q64514), 
TPP2_RAT    (Q64560), TPP2_SCHPO  (Q9UT05), TPPII_ARATH (F4JVN6), 
TPPII_ORYSJ (Q6ESI7), WPRA_BACSU  (P54423), XPR6_YARLI  (P42781), 
YSP3_YEAST  (P25036)
» More

UniProtKB/Swiss-Prot
False negative sequences
29 sequences

FURIN_BOVIN (Q28193), NISP_LACLL  (Q07596), PCSK9_ATEGE (A8T6A1), 
PCSK9_CALJA (A8T688), PCSK9_CALMO (A8T677), PCSK9_COLGU (A8T672), 
PCSK9_GORGO (A8T650), PCSK9_HUMAN (Q8NBP7), PCSK9_LAGLA (A8T6A6), 
PCSK9_MACMU (A8T666), PCSK9_MACNE (A8T662), PCSK9_MOUSE (Q80W65), 
PCSK9_PANPA (A8T655), PCSK9_PANTR (A8T644), PCSK9_PONPY (A8T658), 
PCSK9_RAT   (P59996), PCSK9_SAGLB (A8T682), PCSK9_SAIBB (A8T695), 
PRTT_SERMA  (P29805), SUB11_ARTBC (D4APE3), SUB11_ARTGP (E4V5C5), 
SUB11_ARTOC (C5FZ39), SUB11_TRIVH (D4CZ60), SUB4B_COCP7 (C5NZT2), 
SUB7C_COCP7 (C5NZ69), SUB7D_COCP7 (C5P9H3), TAGA_DICDI  (Q9GTN7), 
TAGC_DICDI  (Q23868), VG47_ICHVA  (Q00139)
» More

UniProtKB/Swiss-Prot
'Partial' sequences
10 sequences

ALP_FUSCU   (P83610), APGR3_BIOOC (P83492), ASE1_ACRSP  (P85156), 
ASE2_ACRSP  (P85157), CUDP_METCM  (P80406), NCP3_COPCM  (P83454), 
NVSP_ALIVI  (P83433), PRTE_HALME  (P28308), SP01_PSEBO  (Q10721), 
THEM_MALCI  (P13858)
» More

UniProtKB/Swiss-Prot
False positive sequences
28 sequences

DCA11_CAEEL (P90794), FOSB_CANFA  (Q9TUB3), FOSB_HUMAN  (P53539), 
LIMD_DICDI  (Q9BIW4), MUCAP_PIG   (P12021), PAND_ALCBS  (Q0VSR5), 
PHYSA_PHYPO (Q8MZS4), PICP_PSESR  (P42790), SED1_ASPFU  (Q70DX9), 
SED2_ARTBC  (D4ANG0), SED2_ARTOC  (C5FBW2), SED2_ASPFU  (Q70J59), 
SED2_TRIVH  (D4DBH6), SED3_ARTBC  (D4AK75), SED3_ARTOC  (C5FTQ5), 
SED3_ASPFU  (Q70GH4), SED3_TRIVH  (D4D7N6), SED4_ARTBC  (D4AIK6), 
SED4_ARTOC  (C5FRX4), SED4_ASPFU  (Q4WQU0), SED4_TRIVH  (D4D9U2), 
SED5_ASPFU  (Q4WGU1), SPAST_DROWI (B4NBP4), TENS1_HUMAN (Q9HBL0), 
TPP1_DICDI  (Q55CT0), UCR1_CAEEL  (P98080), XANP_XANS2  (Q60106), 
YL139_YARLI (P0C8L8)
» More

PDB
[Detailed view]
162 PDB

1AF4; 1AH2; 1AK9; 1AQN; 1AU9; 1BE6; 1BE8; 1BFK; 1BFU; 1BH6; 1BJR; 1C3L; 1C9J; 1CNM; 1CSE; 1DBI; 1DUI; 1EGQ; 1GCI; 1HT3; 1IC6; 1JEA; 1LW6; 1MEE; 1MPT; 1NDQ; 1NDU; 1OT5; 1OYO; 1OYV; 1P7V; 1P7W; 1P8J; 1PEK; 1PFG; 1PJ8; 1PTK; 1R0R; 1R64; 1S01; 1S02; 1SBC; 1SBH; 1SBI; 1SBN; 1SBT; 1SCA; 1SCB; 1SCD; 1SCN; 1SIB; 1ST2; 1ST3; 1SUE; 1SUP; 1SVN; 1TEC; 1THM; 1TK2; 1TM1; 1TM3; 1TM4; 1TM5; 1TM7; 1TMG; 1TO1; 1TO2; 1WSD; 1XF1; 1Y1K; 1Y33; 1Y34; 1Y3B; 1Y3C; 1Y3D; 1Y3F; 1Y48; 1Y4A; 1Y4D; 1YJA; 1YJB; 1YJC; 1YU6; 2DP4; 2DQK; 2DUJ; 2G4V; 2HD4; 2HPZ; 2ID4; 2ID8; 2PKC; 2PQ2; 2PRK; 2PWA; 2PWB; 2PYZ; 2SBT; 2SEC; 2SIC; 2SNI; 2ST1; 2TEC; 2V8B; 2WUV; 2WUW; 3AJ8; 3AJ9; 3BX1; 3D9Q; 3DDZ; 3DE0; 3DE1; 3DE2; 3DE3; 3DE4; 3DE5; 3DE6; 3DE7; 3DVQ; 3DVR; 3DVS; 3DW1; 3DW3; 3DWE; 3DYB; 3EIF; 3F49; 3F7M; 3GT3; 3GT4; 3I2Y; 3I30; 3I34; 3I37; 3L1K; 3LXU; 3OSZ; 3PRK; 3PTL; 3Q40; 3Q5G; 3QMP; 3SIC; 3TEC; 3UNX; 3VTA; 4B5L; 4C3U; 4C3V; 4CFY; 4CFZ; 4CG0; 4DJ5; 4DZT; 4FON; 4OMC; 4OMD; 4WOB; 4WOC; 4ZAR; 5SIC
» More

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