Entry: PS00139

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General information about the entry

Entry name [info] THIOL_PROTEASE_CYS
Accession [info] PS00139
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); APR-2006 (DATA UPDATE); JUN-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00126
Associated ProRule [info] PRU10088

Name and characterization of the entry

Description [info] Eukaryotic thiol (cysteine) proteases cysteine active site.
Pattern [info]
Q-{V}-x-{DE}-[GE]-{F}-C-[YW]-{DN}-x-[STAGC]-[STAGCV].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_07 which contains 546'000 sequence entries.


Total number of hits 266 in 266 different sequences
Number of true positive hits 255 in 255 different sequences
Number of 'unknown' hits
Number of false positive hits 11 in 11 different sequences
Number of false negative sequences 54
Number of 'partial' sequences 22
Precision (true positives / (true positives + false positives)) 95.86 %
Recall (true positives / (true positives + false negatives)) 82.52 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 7
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
255 sequences

361L_IIV6   (Q91FG3), A494_ARATH  (P43295), ACP1_ENTHI  (P36184), 
ACP2_ENTHI  (P36185), ACTN_ACTCH  (P00785), ACTN_ACTDE  (A5HII1), 
ALEUL_ARATH (Q8RWQ9), ALEU_ARATH  (Q8H166), ALEU_HORVU  (P05167), 
ANAN_ANACO  (P80884), BLH1_YEAS1  (B3LP78), BLH1_YEAS2  (C7GPC1), 
BLH1_YEAS6  (B5VQH0), BLH1_YEAS7  (A6ZRK4), BLH1_YEAS8  (C8ZFZ7), 
BLH1_YEAST  (Q01532), BLMH_CHICK  (P87362), BLMH_HUMAN  (Q13867), 
BLMH_MOUSE  (Q8R016), BLMH_RABIT  (P13019), BLMH_RAT    (P70645), 
BROM1_ANACO (O23791), BROM2_ANACO (P14518), CAN10_HUMAN (Q9HC96), 
CAN10_MACFA (Q95LP4), CAN10_MOUSE (Q9ESK3), CAN10_RAT   (Q9ES66), 
CAN11_HUMAN (Q9UMQ6), CAN11_MOUSE (Q6J756), CAN11_RAT   (Q4V8Q1), 
CAN12_HUMAN (Q6ZSI9), CAN12_MOUSE (Q9ER56), CAN13_MOUSE (Q3UW68), 
CAN13_RAT   (Q5BK10), CAN14_HUMAN (A8MX76), CAN15_HUMAN (O75808), 
CAN15_MOUSE (Q9JLG8), CAN1_BOVIN  (Q27970), CAN1_HUMAN  (P07384), 
CAN1_MACFA  (Q9GLG2), CAN1_MOUSE  (O35350), CAN1_PIG    (P35750), 
CAN1_PONAB  (Q5NVS7), CAN1_RAT    (P97571), CAN2_BOVIN  (Q27971), 
CAN2_CHICK  (Q92178), CAN2_HUMAN  (P17655), CAN2_MACFA  (Q9GLG1), 
CAN2_MOUSE  (O08529), CAN2_RAT    (Q07009), CAN3_BOVIN  (P51186), 
CAN3_CHICK  (Q92177), CAN3_HUMAN  (P20807), CAN3_MACFA  (Q9GLG7), 
CAN3_MOUSE  (Q64691), CAN3_PIG    (P43368), CAN3_RAT    (P16259), 
CAN3_SHEEP  (Q9TTH8), CAN5_CAEEL  (Q22036), CAN5_HUMAN  (O15484), 
CAN5_MOUSE  (O08688), CAN5_RAT    (Q8R4C0), CAN8_HUMAN  (A6NHC0), 
CAN8_MOUSE  (Q91VA3), CAN8_RAT    (Q78EJ9), CAN9_HUMAN  (O14815), 
CAN9_MOUSE  (Q9D805), CAN9_RAT    (O35920), CANA_DROME  (Q11002), 
CANB_DROME  (Q9VT65), CAND_DROME  (P27398), CANX_CHICK  (P00789), 
CAN_CAEEL   (P34308), CAN_SCHMA   (P27730), CAT7_MOUSE  (Q91ZF2), 
CAT7_RAT    (D3ZZ07), CATB1_GIAIN (P92131), CATB2_GIAIN (P92132), 
CATB3_GIAIN (P92133), CATB_BOVIN  (P07688), CATB_CHICK  (P43233), 
CATB_HUMAN  (P07858), CATB_MACFA  (Q4R5M2), CATB_MOUSE  (P10605), 
CATB_PIG    (A1E295), CATB_PONAB  (Q5R6D1), CATB_RAT    (P00787), 
CATC_BOVIN  (Q3ZCJ8), CATC_CANFA  (O97578), CATC_HUMAN  (P53634), 
CATC_MACFA  (Q60HG6), CATC_MOUSE  (P97821), CATC_PONAB  (Q5RB02), 
CATC_RAT    (P80067), CATF_HUMAN  (Q9UBX1), CATF_MOUSE  (Q9R013), 
CATH_BOVIN  (Q3T0I2), CATH_HUMAN  (P09668), CATH_MOUSE  (P49935), 
CATH_PIG    (O46427), CATH_RAT    (P00786), CATJ_MOUSE  (Q9R014), 
CATJ_RAT    (Q63088), CATK_BOVIN  (Q5E968), CATK_CANFA  (Q3ZKN1), 
CATK_CHICK  (Q90686), CATK_HUMAN  (P43235), CATK_MACFA  (P61276), 
CATK_MACMU  (P61277), CATK_MOUSE  (P55097), CATK_PIG    (Q9GLE3), 
CATK_RABIT  (P43236), CATK_RAT    (O35186), CATL1_BOVIN (P25975), 
CATL1_CANFA (Q9GL24), CATL1_CHICK (P09648), CATL1_CHLAE (Q9GKL8), 
CATL1_HUMAN (P07711), CATL1_MOUSE (P06797), CATL1_PARTE (Q94714), 
CATL1_PIG   (Q28944), CATL1_RAT   (P07154), CATL1_SHEEP (Q10991), 
CATL2_BOVIN (Q5E998), CATL2_HUMAN (O60911), CATL2_PARTE (A0E358), 
CATLL_FASHE (Q24940), CATLL_PHACE (O97397), CATL_BRUPA  (O17473), 
CATL_DROME  (Q95029), CATL_SARPE  (Q26636), CATL_SCHMA  (Q26534), 
CATO_HUMAN  (P43234), CATO_MOUSE  (Q8BM88), CATS_BOVIN  (P25326), 
CATS_CANFA  (Q8HY81), CATS_HUMAN  (P25774), CATS_MOUSE  (O70370), 
CATS_RAT    (Q02765), CATS_SAIBB  (Q8HY82), CATV_GVCPM  (O91466), 
CATV_GVXN   (Q9PYY5), CATV_NPVAC  (P25783), CATV_NPVAH  (Q80LP4), 
CATV_NPVAP  (Q91CL9), CATV_NPVBM  (P41721), CATV_NPVBS  (Q9YWK4), 
CATV_NPVCD  (Q6VTL7), CATV_NPVCF  (P41715), CATV_NPVEP  (Q91GE3), 
CATV_NPVHC  (Q9WGE0), CATV_NPVLD  (Q9YMP9), CATV_NPVMC  (Q8QLK1), 
CATV_NPVOP  (O10364), CATV_NPVR1  (Q8B9D5), CATV_NPVSE  (Q9J8B9), 
CATV_NPVST  (Q91BH1), CEP1_ARATH  (Q9FGR9), CEP2_ARATH  (Q9STL4), 
CEP3_ARATH  (Q9STL5), CFAD_DICDI  (Q54TR1), CPGP2_ZINOF (P82474), 
CPP1_ENTHI  (Q01957), CPP2_ENTHI  (Q01958), CPP3_ENTHI  (Q06964), 
CPR1_ARATH  (Q9LT77), CPR1_CAEEL  (P25807), CPR1_DROME  (Q9VN93), 
CPR2_ARATH  (Q9LXW3), CPR3_CAEEL  (P43507), CPR4_CAEEL  (P43508), 
CPR5_CAEEL  (P43509), CPR6_CAEEL  (P43510), CRUST_PANBO (Q86GF7), 
CTSB_DICDI  (Q54QD9), CYSEP_PHAVU (P25803), CYSEP_RICCO (O65039), 
CYSEP_VIGMU (P12412), CYSP1_CARCN (P32954), CYSP1_DICDI (P04988), 
CYSP1_HAECO (P19092), CYSP1_HOMAM (P13277), CYSP1_HORVU (P25249), 
CYSP1_LEIPI (P35591), CYSP1_MAIZE (Q10716), CYSP1_ORYSJ (Q7XR52), 
CYSP1_OSTOS (P25802), CYSP2_CARCN (P32955), CYSP2_DICDI (P04989), 
CYSP2_HAECO (P25793), CYSP2_HOMAM (P25782), CYSP2_HORVU (P25250), 
CYSP2_LEIPI (Q05094), CYSP2_MAIZE (Q10717), CYSP3_CARCN (P32956), 
CYSP3_DICDI (Q23894), CYSP3_HOMAM (P25784), CYSP3_SOLLC (Q40143), 
CYSP4_BRANA (P25251), CYSP4_CARCN (P32957), CYSP4_DICDI (P54639), 
CYSP5_DICDI (P54640), CYSP6_DICDI (Q94503), CYSP7_DICDI (Q94504), 
CYSPL_SOLLC (P20721), CYSP_HEMSP  (P43156), CYSP_PEA    (P25804), 
CYSP_PLAFA  (P25805), CYSP_PLAVN  (P46102), CYSP_PLAVS  (P42666), 
CYSP_SCHJA  (P43157), CYSP_SCHMA  (P25792), CYSP_THEPA  (P22497), 
CYSP_TRYBB  (P14658), CYSP_TRYCR  (P25779), DEK1_ARATH  (Q8RVL2), 
DEK1_MAIZE  (Q8RVL1), DEK1_ORYSJ  (Q6ZFZ4), ERVB_TABDI  (P60994), 
ERVC_TABDI  (P83654), GCP1_ARATH  (Q94B08), GMSA_DICDI  (Q54ME1), 
LMCPA_LEIME (P25775), LMCPB_LEIME (P36400), MDO1_PSEMR  (P83443), 
MEX1_JACME  (P84346), MEX2_JACME  (P84347), ORYA_ORYSJ  (P25776), 
ORYB_ORYSJ  (P25777), ORYC_ORYSJ  (P25778), PAPA1_CARPA (P00784), 
PAPA2_CARPA (P14080), PAPA3_CARPA (P10056), PAPA4_CARPA (P05994), 
PEPC_LACDL  (Q48543), PEPC_LACHE  (Q10744), PEPC_LACLA  (Q9CEG3), 
PEPC_LACLC  (Q04723), PEPC_LISIN  (Q928V0), PEPC_LISMO  (O69192), 
PEPC_STRTR  (Q56115), PEPE_LACHE  (P94870), PEPG_LACDL  (P94869), 
PEPT1_DERFA (P16311), PEPT1_DERPT (P08176), PEPT1_EURMA (P25780), 
PEPW_LACDL  (P94868), RD19A_ARATH (P43296), RD21A_ARATH (P43297), 
THPA_THADA  (P21381), TPR_PORGI   (P25806), VF224_IIV3  (Q197D6), 
VF224_IIV6  (Q91FU7), XCP1_ARATH  (O65493), XCP2_ARATH  (Q9LM66)
» More

UniProtKB/Swiss-Prot
False negative sequences
54 sequences

CAN13_HUMAN (Q6MZZ7), CAN6_HUMAN  (Q9Y6Q1), CAN6_MOUSE  (O35646), 
CAN6_RAT    (O88501), CAN7_HUMAN  (Q9Y6W3), CAN7_MOUSE  (Q9R1S8), 
CAN7_PIG    (A0FKG7), CANC_DROME  (Q9VXH6), CATC_PLAF7  (Q8IIJ9), 
CATC_SCHMA  (Q26563), CATL3_PARTE (Q94715), CATM_MOUSE  (Q9JL96), 
CATQ_RAT    (Q9QZE3), CATR_MOUSE  (Q9JIA9), CATV_NPVHZ  (Q8V5U0), 
CATW_FELCA  (Q9TST1), CATW_HUMAN  (P56202), CATW_MOUSE  (P56203), 
CATZ_BOVIN  (P05689), CATZ_HUMAN  (Q9UBR2), CATZ_MOUSE  (Q9WUU7), 
CATZ_RAT    (Q9R1T3), CPGP1_ZINOF (P82473), CPR3_ARATH  (Q9SUT0), 
CPR4_ARATH  (Q9SUS9), CYSP_THEAN  (P25781), ECPA_STAEP  (P0C0P9), 
ECPA_STAEQ  (Q5HKF6), ECPA_STAES  (P0C0Q0), P34_SOYBN   (P22895), 
PEPT1_PSOOV (Q1EIQ3), SERA_PLAF7  (Q9TY95), SERA_PLAFD  (P69193), 
SERA_PLAFG  (P69192), SILIC_PETFI (Q6YD92), SSPB_STAA8  (Q2FZL3), 
SSPB_STAAC  (Q5HH36), SSPB_STAAM  (Q99V46), SSPB_STAAN  (Q7A6A7), 
SSPB_STAAR  (Q6GI35), SSPB_STAAS  (Q6GAG5), SSPB_STAAU  (P0C1S6), 
SSPB_STAAW  (Q8NX99), SSPP_STAA8  (Q2G2R8), SSPP_STAAC  (Q5HEL3), 
SSPP_STAAM  (P65825), SSPP_STAAN  (P65826), SSPP_STAAR  (Q6GFE8), 
SSPP_STAAS  (Q6G824), SSPP_STAAU  (P81297), SSPP_STAAW  (Q8NVS9), 
TEST2_MOUSE (Q80UB0), TEST2_RAT   (P15242), YCF2E_CAEEL (P90850)
» More

UniProtKB/Swiss-Prot
'Partial' sequences
22 sequences

CAL1_CALGI  (P20728), CAN1_RABIT  (P06815), CAN2_PIG    (P43367), 
CAN2_RABIT  (P06814), CATB_COTJA  (P81494), CATB_SHEEP  (P83205), 
CATL1_FASHE (Q09093), CATL1_FELCA (P25773), CATL2_FASHE (P80342), 
CATL3_FASHE (P80532), CATL4_FASHE (P80528), CATL9_FASHE (P80533), 
CYSB_FASHE  (P80529), CYSP3_OSTOS (Q06544), CYSP_TRIFO  (P33403), 
CYSP_TRIVA  (P33404), HP29_SARPE  (P29184), KARA_BROPL  (P22442), 
MDO2_PSEMR  (P83447), PAPA5_CARPA (P05993), PEPT1_DERMI (P16312), 
PHIG1_PHIGI (P84789)
» More

UniProtKB/Swiss-Prot
False positive sequences
11 sequences

CB042_BOVIN (Q3SYX3), CB042_HUMAN (Q9NWW7), CB042_MACFA (Q4R907), 
CB042_MOUSE (Q8R3C1), CCM2L_HUMAN (Q9NUG4), COBD_MYCBO  (Q7VEN1), 
CRIM1_HUMAN (Q9NZV1), HEPA_HHV6U  (P52375), IF172_CHLRE (Q5DM57), 
KIT_TAKRU   (Q8AXC6), VM3VA_MACLB (Q4VM08)
» More

PDB
[Detailed view]
195 PDB

1AEC; 1AIM; 1ATK; 1AU0; 1AU2; 1AU3; 1AU4; 1AYU; 1AYV; 1AYW; 1BGO; 1BP4; 1BQI; 1BY8; 1CB5; 1CPJ; 1CQD; 1CSB; 1CTE; 1CVZ; 1EWL; 1EWM; 1EWO; 1EWP; 1F29; 1F2A; 1F2B; 1F2C; 1FH0; 1GCB; 1GEC; 1GMY; 1HUC; 1ICF; 1ITO; 1IWD; 1JQP; 1K3B; 1KFU; 1KFX; 1KHP; 1KHQ; 1M6D; 1ME3; 1ME4; 1MEG; 1MEM; 1MS6; 1NB3; 1NB5; 1NL6; 1NLJ; 1NPZ; 1NQC; 1O0E; 1PAD; 1PBH; 1PCI; 1PE6; 1PIP; 1POP; 1PPD; 1PPN; 1PPO; 1PPP; 1Q6K; 1QDQ; 1S4V; 1SNK; 1SP4; 1THE; 1TL9; 1TLO; 1TU6; 1U9Q; 1U9V; 1U9W; 1U9X; 1VSN; 1YK7; 1YK8; 1YT7; 1ZCM; 1ZIV; 2AIM; 2ARY; 2AS8; 2ATO; 2AUX; 2AUZ; 2BDL; 2BDZ; 2DC6; 2DC7; 2DC8; 2DC9; 2DCA; 2DCB; 2DCC; 2DCD; 2DJF; 2DJG; 2DZY; 2E00; 2F1G; 2F7D; 2FO5; 2FQ9; 2FRA; 2FRQ; 2FT2; 2FTD; 2FUD; 2FYE; 2G6D; 2G7Y; 2G8E; 2G8J; 2H7J; 2HH5; 2HHN; 2HXZ; 2IPP; 2NQA; 2NQG; 2NQI; 2OP3; 2OZ2; 2P0R; 2PAD; 2PBH; 2PNS; 2R6N; 2R9C; 2R9F; 2R9M; 2R9N; 2R9O; 2XU1; 2XU3; 2XU4; 2XU5; 2YJ2; 2YJ8; 2YJ9; 2YJB; 2YJC; 3AI8; 3C9E; 3D6S; 3E1Z; 3H7D; 3H89; 3H8B; 3HD3; 3HHA; 3HWN; 3I06; 3IUT; 3K9M; 3KKU; 3KW9; 3KWB; 3KWZ; 3KX1; 3LXS; 3N3G; 3N4C; 3O0U; 3O1G; 3OF8; 3OF9; 3OVX; 3OVZ; 3PBH; 3PDF; 3RVV; 3RVW; 3RVX; 4AXL; 4AXM; 4BS5; 4BSQ; 4CDC; 4CDD; 4CDE; 4CDF; 4DMX; 4DMY; 4KLB; 4PAD; 5PAD; 6PAD; 7PCK; 8PCH
» More

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