Entry: PS00139

General information about the entry

Entry name [info] THIOL_PROTEASE_CYS
Accession [info] PS00139
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); APR-2006 (DATA UPDATE); JUN-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC00126
Associated ProRule [info] PRU10088

Name and characterization of the entry

Description [info] Eukaryotic thiol (cysteine) proteases cysteine active site.
Pattern [info]
Q-{V}-x-{DE}-[GE]-{F}-C-[YW]-{DN}-x-[STAGC]-[STAGCV].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_07 which contains 551'705 sequence entries.


Total number of hits 273 in 273 different sequences
Number of true positive hits 262 in 262 different sequences
Number of 'unknown' hits 0
Number of false positive hits 11 in 11 different sequences
Number of false negative sequences 55
Number of 'partial' sequences 22
Precision (true positives / (true positives + false positives)) 95.97 %
Recall (true positives / (true positives + false negatives)) 82.65 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 7
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
262 sequences

361L_IIV6   (Q91FG3    ), ACP1_ENTHI  (P36184    ), ACP2_ENTHI  (P36185    ), 
ACTN_ACTCH  (P00785    ), ACTN_ACTDE  (A5HII1    ), ALEUL_ARATH (Q8RWQ9    ), 
ALEU_ARATH  (Q8H166    ), ALEU_HORVU  (P05167    ), ANAN_ANACO  (P80884    ), 
BLH1_YEAS1  (B3LP78    ), BLH1_YEAS2  (C7GPC1    ), BLH1_YEAS6  (B5VQH0    ), 
BLH1_YEAS7  (A6ZRK4    ), BLH1_YEAS8  (C8ZFZ7    ), BLH1_YEAST  (Q01532    ), 
BLMH_CHICK  (P87362    ), BLMH_HUMAN  (Q13867    ), BLMH_MOUSE  (Q8R016    ), 
BLMH_RABIT  (P13019    ), BLMH_RAT    (P70645    ), BROM1_ANACO (O23791    ), 
BROM2_ANACO (P14518    ), CAN10_HUMAN (Q9HC96    ), CAN10_MACFA (Q95LP4    ), 
CAN10_MOUSE (Q9ESK3    ), CAN10_RAT   (Q9ES66    ), CAN11_HUMAN (Q9UMQ6    ), 
CAN11_MOUSE (Q6J756    ), CAN11_RAT   (Q4V8Q1    ), CAN12_HUMAN (Q6ZSI9    ), 
CAN12_MOUSE (Q9ER56    ), CAN13_MOUSE (Q3UW68    ), CAN13_RAT   (Q5BK10    ), 
CAN14_HUMAN (A8MX76    ), CAN15_HUMAN (O75808    ), CAN15_MOUSE (Q9JLG8    ), 
CAN1_BOVIN  (Q27970    ), CAN1_HUMAN  (P07384    ), CAN1_MACFA  (Q9GLG2    ), 
CAN1_MOUSE  (O35350    ), CAN1_PIG    (P35750    ), CAN1_PONAB  (Q5NVS7    ), 
CAN1_RAT    (P97571    ), CAN2_BOVIN  (Q27971    ), CAN2_CHICK  (Q92178    ), 
CAN2_HUMAN  (P17655    ), CAN2_MACFA  (Q9GLG1    ), CAN2_MOUSE  (O08529    ), 
CAN2_RAT    (Q07009    ), CAN3_BOVIN  (P51186    ), CAN3_CHICK  (Q92177    ), 
CAN3_HUMAN  (P20807    ), CAN3_MACFA  (Q9GLG7    ), CAN3_MOUSE  (Q64691    ), 
CAN3_PIG    (P43368    ), CAN3_RAT    (P16259    ), CAN3_SHEEP  (Q9TTH8    ), 
CAN5_CAEEL  (Q22036    ), CAN5_HUMAN  (O15484    ), CAN5_MOUSE  (O08688    ), 
CAN5_RAT    (Q8R4C0    ), CAN8_HUMAN  (A6NHC0    ), CAN8_MOUSE  (Q91VA3    ), 
CAN8_RAT    (Q78EJ9    ), CAN9_HUMAN  (O14815    ), CAN9_MOUSE  (Q9D805    ), 
CAN9_RAT    (O35920    ), CANA_DROME  (Q11002    ), CANB_DROME  (Q9VT65    ), 
CAND_DROME  (P27398    ), CANX_CHICK  (P00789    ), CAN_CAEEL   (P34308    ), 
CAN_SCHMA   (P27730    ), CAT7_MOUSE  (Q91ZF2    ), CAT7_RAT    (D3ZZ07    ), 
CATB1_GIAIN (P92131    ), CATB2_GIAIN (P92132    ), CATB3_GIAIN (P92133    ), 
CATB_BOVIN  (P07688    ), CATB_CHICK  (P43233    ), CATB_HUMAN  (P07858    ), 
CATB_MACFA  (Q4R5M2    ), CATB_MOUSE  (P10605    ), CATB_PIG    (A1E295    ), 
CATB_PONAB  (Q5R6D1    ), CATB_RAT    (P00787    ), CATC_BOVIN  (Q3ZCJ8    ), 
CATC_CANLF  (O97578    ), CATC_HUMAN  (P53634    ), CATC_MACFA  (Q60HG6    ), 
CATC_MOUSE  (P97821    ), CATC_PONAB  (Q5RB02    ), CATC_RAT    (P80067    ), 
CATF_HUMAN  (Q9UBX1    ), CATF_MOUSE  (Q9R013    ), CATH_BOVIN  (Q3T0I2    ), 
CATH_HUMAN  (P09668    ), CATH_MOUSE  (P49935    ), CATH_PIG    (O46427    ), 
CATH_RAT    (P00786    ), CATJ_MOUSE  (Q9R014    ), CATJ_RAT    (Q63088    ), 
CATK_BOVIN  (Q5E968    ), CATK_CANLF  (Q3ZKN1    ), CATK_CHICK  (Q90686    ), 
CATK_HUMAN  (P43235    ), CATK_MACFA  (P61276    ), CATK_MACMU  (P61277    ), 
CATK_MOUSE  (P55097    ), CATK_PIG    (Q9GLE3    ), CATK_RABIT  (P43236    ), 
CATK_RAT    (O35186    ), CATL1_BOVIN (P25975    ), CATL1_CANLF (Q9GL24    ), 
CATL1_CHICK (P09648    ), CATL1_CHLAE (Q9GKL8    ), CATL1_HUMAN (P07711    ), 
CATL1_MOUSE (P06797    ), CATL1_PARTE (Q94714    ), CATL1_PIG   (Q28944    ), 
CATL1_RAT   (P07154    ), CATL1_SHEEP (Q10991    ), CATL2_BOVIN (Q5E998    ), 
CATL2_HUMAN (O60911    ), CATL2_PARTE (A0E358    ), CATLL_FASHE (Q24940    ), 
CATLL_PHACE (O97397    ), CATL_BRUPA  (O17473    ), CATL_DROME  (Q95029    ), 
CATL_SARPE  (Q26636    ), CATL_SCHMA  (Q26534    ), CATO_HUMAN  (P43234    ), 
CATO_MOUSE  (Q8BM88    ), CATS_BOVIN  (P25326    ), CATS_CANLF  (Q8HY81    ), 
CATS_HUMAN  (P25774    ), CATS_MOUSE  (O70370    ), CATS_RAT    (Q02765    ), 
CATS_SAIBB  (Q8HY82    ), CATV_GVCPM  (O91466    ), CATV_GVXN   (Q9PYY5    ), 
CATV_NPVAC  (P25783    ), CATV_NPVAH  (Q80LP4    ), CATV_NPVAP  (Q91CL9    ), 
CATV_NPVBM  (P41721    ), CATV_NPVBS  (Q9YWK4    ), CATV_NPVCD  (Q6VTL7    ), 
CATV_NPVCF  (P41715    ), CATV_NPVEP  (Q91GE3    ), CATV_NPVHC  (Q9WGE0    ), 
CATV_NPVLD  (Q9YMP9    ), CATV_NPVMC  (Q8QLK1    ), CATV_NPVOP  (O10364    ), 
CATV_NPVR1  (Q8B9D5    ), CATV_NPVSE  (Q9J8B9    ), CATV_NPVST  (Q91BH1    ), 
CEP1_ARATH  (Q9FGR9    ), CEP2_ARATH  (Q9STL4    ), CEP3_ARATH  (Q9STL5    ), 
CFAD_DICDI  (Q54TR1    ), CPGP2_ZINOF (P82474    ), CPP1_ENTHI  (Q01957    ), 
CPP2_ENTHI  (Q01958    ), CPP3_ENTHI  (Q06964    ), CPR1_CAEEL  (P25807    ), 
CPR1_DROME  (Q9VN93    ), CPR3_CAEEL  (P43507    ), CPR4_CAEEL  (P43508    ), 
CPR5_CAEEL  (P43509    ), CPR6_CAEEL  (P43510    ), CRUST_PANBO (Q86GF7    ), 
CTSB_DICDI  (Q54QD9    ), CYSEP_PHAVU (P25803    ), CYSEP_RICCO (O65039    ), 
CYSEP_VIGMU (P12412    ), CYSP1_DICDI (P04988    ), CYSP1_HAECO (P19092    ), 
CYSP1_HOMAM (P13277    ), CYSP1_HORVU (P25249    ), CYSP1_LEIPI (P35591    ), 
CYSP1_MAIZE (Q10716    ), CYSP1_ORYSJ (Q7XR52    ), CYSP1_OSTOS (P25802    ), 
CYSP1_VASCU (P32954    ), CYSP2_DICDI (P04989    ), CYSP2_HAECO (P25793    ), 
CYSP2_HOMAM (P25782    ), CYSP2_HORVU (P25250    ), CYSP2_LEIPI (Q05094    ), 
CYSP2_MAIZE (Q10717    ), CYSP2_VASCU (P32955    ), CYSP3_DICDI (Q23894    ), 
CYSP3_HOMAM (P25784    ), CYSP3_SOLLC (Q40143    ), CYSP3_VASCU (P32956    ), 
CYSP4_BRANA (P25251    ), CYSP4_DICDI (P54639    ), CYSP4_VASCU (P32957    ), 
CYSP5_DICDI (P54640    ), CYSP6_DICDI (Q94503    ), CYSP7_DICDI (Q94504    ), 
CYSPL_SOLLC (P20721    ), CYSP_HEMSP  (P43156    ), CYSP_PEA    (P25804    ), 
CYSP_PLAFA  (P25805    ), CYSP_PLAVN  (P46102    ), CYSP_PLAVS  (P42666    ), 
CYSP_SCHJA  (P43157    ), CYSP_SCHMA  (P25792    ), CYSP_THEPA  (P22497    ), 
CYSP_TRYBB  (P14658    ), CYSP_TRYCR  (P25779    ), DEK1_ARATH  (Q8RVL2    ), 
DEK1_MAIZE  (Q8RVL1    ), DEK1_ORYSJ  (Q6ZFZ4    ), ERVB_TABDI  (P60994    ), 
ERVC_TABDI  (P83654    ), GMSA_DICDI  (Q54ME1    ), LMCPA_LEIME (P25775    ), 
LMCPB_LEIME (P36400    ), MDO1_PSEMR  (P83443    ), MEX1_JACME  (P84346    ), 
MEX2_JACME  (P84347    ), ORYA_ORYSJ  (P25776    ), ORYB_ORYSJ  (P25777    ), 
ORYC_ORYSJ  (P25778    ), PAPA1_CARPA (P00784    ), PAPA2_CARPA (P14080    ), 
PAPA3_CARPA (P10056    ), PAPA4_CARPA (P05994    ), PEPC_LACDL  (Q48543    ), 
PEPC_LACHE  (Q10744    ), PEPC_LACLA  (Q9CEG3    ), PEPC_LACLC  (Q04723    ), 
PEPC_LISIN  (Q928V0    ), PEPC_LISMO  (O69192    ), PEPC_STRTR  (Q56115    ), 
PEPE_LACHE  (P94870    ), PEPG_LACDL  (P94869    ), PEPT1_DERFA (P16311    ), 
PEPT1_DERPT (P08176    ), PEPT1_EURMA (P25780    ), PEPW_LACDL  (P94868    ), 
RD19A_ARATH (P43296    ), RD19B_ARATH (P43295    ), RD19C_ARATH (Q9SUL1    ), 
RD19D_ARATH (Q8VYS0    ), RD21A_ARATH (P43297    ), RD21B_ARATH (Q9FMH8    ), 
RD21C_ARATH (Q9LT78    ), RDL1_ARATH  (Q94B08    ), RDL2_ARATH  (Q9LT77    ), 
RDL3_ARATH  (Q9LXW3    ), SAG12_ARATH (Q9FJ47    ), SAG39_ORYSI (A2XQE8    ), 
SAG39_ORYSJ (Q7XWK5    ), THPA_THADA  (P21381    ), TPR_PORGI   (P25806    ), 
VF224_IIV3  (Q197D6    ), VF224_IIV6  (Q91FU7    ), XCP1_ARATH  (O65493    ), 
XCP2_ARATH  (Q9LM66    )
» more

UniProtKB/Swiss-Prot
False negative sequences
55 sequences

CAN13_HUMAN (Q6MZZ7    ), CAN6_HUMAN  (Q9Y6Q1    ), CAN6_MOUSE  (O35646    ), 
CAN6_RAT    (O88501    ), CAN7_HUMAN  (Q9Y6W3    ), CAN7_MOUSE  (Q9R1S8    ), 
CAN7_PIG    (A0FKG7    ), CANC_DROME  (Q9VXH6    ), CATC_PLAF7  (Q8IIJ9    ), 
CATC_SCHMA  (Q26563    ), CATL3_PARTE (Q94715    ), CATM_MOUSE  (Q9JL96    ), 
CATQ_RAT    (Q9QZE3    ), CATR_MOUSE  (Q9JIA9    ), CATV_NPVHZ  (Q8V5U0    ), 
CATW_FELCA  (Q9TST1    ), CATW_HUMAN  (P56202    ), CATW_MOUSE  (P56203    ), 
CATZ_BOVIN  (P05689    ), CATZ_HUMAN  (Q9UBR2    ), CATZ_MOUSE  (Q9WUU7    ), 
CATZ_RAT    (Q9R1T3    ), CPGP1_ZINOF (P82473    ), CYSP_THEAN  (P25781    ), 
ECPA_STAEP  (P0C0P9    ), ECPA_STAEQ  (Q5HKF6    ), ECPA_STAES  (P0C0Q0    ), 
P34_SOYBN   (P22895    ), PEPT1_PSOOV (Q1EIQ3    ), RDL4_ARATH  (Q9SUT0    ), 
RDL5_ARATH  (Q9SUS9    ), RDL6_ARATH  (F4JNL3    ), SERA_PLAF7  (Q9TY95    ), 
SERA_PLAFD  (P69193    ), SERA_PLAFG  (P69192    ), SILIC_PETFI (Q6YD92    ), 
SSPB_STAA8  (Q2FZL3    ), SSPB_STAAC  (Q5HH36    ), SSPB_STAAM  (Q99V46    ), 
SSPB_STAAN  (Q7A6A7    ), SSPB_STAAR  (Q6GI35    ), SSPB_STAAS  (Q6GAG5    ), 
SSPB_STAAU  (P0C1S6    ), SSPB_STAAW  (Q8NX99    ), SSPP_STAA8  (Q2G2R8    ), 
SSPP_STAAC  (Q5HEL3    ), SSPP_STAAM  (P65825    ), SSPP_STAAN  (P65826    ), 
SSPP_STAAR  (Q6GFE8    ), SSPP_STAAS  (Q6G824    ), SSPP_STAAU  (P81297    ), 
SSPP_STAAW  (Q8NVS9    ), TEST2_MOUSE (Q80UB0    ), TEST2_RAT   (P15242    ), 
YCF2E_CAEEL (P90850    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
22 sequences

CAL1_CALGI  (P20728    ), CAN1_RABIT  (P06815    ), CAN2_PIG    (P43367    ), 
CAN2_RABIT  (P06814    ), CATB_COTJA  (P81494    ), CATB_SHEEP  (P83205    ), 
CATL1_FASHE (Q09093    ), CATL1_FELCA (P25773    ), CATL2_FASHE (P80342    ), 
CATL3_FASHE (P80532    ), CATL4_FASHE (P80528    ), CATL9_FASHE (P80533    ), 
CYSB_FASHE  (P80529    ), CYSP3_OSTOS (Q06544    ), CYSP_TRIFO  (P33403    ), 
CYSP_TRIVA  (P33404    ), HP29_SARPE  (P29184    ), KARA_BROPL  (P22442    ), 
MDO2_PSEMR  (P83447    ), PAPA5_CARPA (P05993    ), PEPT1_DERMI (P16312    ), 
PHIG1_PHIGI (P84789    )
» more

UniProtKB/Swiss-Prot
False positive sequences
11 sequences

CB042_BOVIN (Q3SYX3    ), CB042_HUMAN (Q9NWW7    ), CB042_MACFA (Q4R907    ), 
CB042_MOUSE (Q8R3C1    ), CCM2L_HUMAN (Q9NUG4    ), COBD_MYCBO  (Q7VEN1    ), 
CRIM1_HUMAN (Q9NZV1    ), HEPA_HHV6U  (P52375    ), IF172_CHLRE (Q5DM57    ), 
KIT_TAKRU   (Q8AXC6    ), VM3VA_MACLB (Q4VM08    )
» more

PDB
[Detailed view]
218 PDB

1AEC; 1AIM; 1ATK; 1AU0; 1AU2; 1AU3; 1AU4; 1AYU; 1AYV; 1AYW; 1BGO; 1BP4; 1BQI; 1BY8; 1CB5; 1CPJ; 1CQD; 1CSB; 1CTE; 1CVZ; 1EWL; 1EWM; 1EWO; 1EWP; 1F29; 1F2A; 1F2B; 1F2C; 1FH0; 1GCB; 1GEC; 1GMY; 1HUC; 1ICF; 1ITO; 1IWD; 1JQP; 1K3B; 1KFU; 1KFX; 1KHP; 1KHQ; 1M6D; 1ME3; 1ME4; 1MEG; 1MEM; 1MS6; 1NB3; 1NB5; 1NL6; 1NLJ; 1NPZ; 1NQC; 1O0E; 1PAD; 1PBH; 1PCI; 1PE6; 1PIP; 1POP; 1PPD; 1PPN; 1PPO; 1PPP; 1Q6K; 1QDQ; 1S4V; 1SNK; 1SP4; 1THE; 1TL9; 1TLO; 1TU6; 1U9Q; 1U9V; 1U9W; 1U9X; 1VSN; 1YK7; 1YK8; 1YT7; 1ZCM; 1ZIV; 2AIM; 2ARY; 2AS8; 2ATO; 2AUX; 2AUZ; 2BDL; 2BDZ; 2DC6; 2DC7; 2DC8; 2DC9; 2DCA; 2DCB; 2DCC; 2DCD; 2DJF; 2DJG; 2DZY; 2E00; 2F1G; 2F7D; 2FO5; 2FQ9; 2FRA; 2FRQ; 2FT2; 2FTD; 2FUD; 2FYE; 2G6D; 2G7Y; 2G8E; 2G8J; 2H7J; 2HH5; 2HHN; 2HXZ; 2IPP; 2NQA; 2NQG; 2NQI; 2OP3; 2OZ2; 2P0R; 2PAD; 2PBH; 2PNS; 2R6N; 2R9C; 2R9F; 2R9M; 2R9N; 2R9O; 2XU1; 2XU3; 2XU4; 2XU5; 2YJ2; 2YJ8; 2YJ9; 2YJB; 2YJC; 3AI8; 3C9E; 3D6S; 3E1Z; 3H7D; 3H89; 3H8B; 3HD3; 3HHA; 3HWN; 3I06; 3IUT; 3K9M; 3KKU; 3KW9; 3KWB; 3KWZ; 3KX1; 3LXS; 3N3G; 3N4C; 3O0U; 3O1G; 3OF8; 3OF9; 3OVX; 3OVZ; 3PBH; 3PDF; 3RVV; 3RVW; 3RVX; 4AXL; 4AXM; 4BPV; 4BQV; 4BS5; 4BS6; 4BSQ; 4CDC; 4CDD; 4CDE; 4CDF; 4DMX; 4DMY; 4KLB; 4KP9; 4MZO; 4MZS; 4N79; 4N8W; 4OEL; 4OEM; 4P6E; 4P6G; 4PAD; 4PI3; 4PP1; 4PP2; 4QH6; 4X6H; 4X6I; 4X6J; 4XUI; 4YV8; 4YVA; 5F02; 5PAD; 6PAD; 7PCK; 8PCH
» more

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