Entry: PS00143

General information about the entry
Entry name INSULINASE
Accession number PS00143
Entry type PATTERN
Date APR-1990 (CREATED); NOV-1997 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation PDOC00130
Associated ProRule PRU10096
Name and characterization of the entry
DescriptionInsulinase family, zinc-binding region signature.
Pattern G-x(8,9)-G-x-[STA]-H-[LIVMFY]-[LIVMC]-[DERN]-[HRKL]-[LMFAT]-x-[LFSTH]-x- [GSTAN]-[GST].
Numerical results
  • UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052.
  • Total number of hits in UniProtKB/Swiss-Prot: 69 hits in 69 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 69 hits in 69 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 0 hits in 0 different sequences
  • Number of known missed hits: 36
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0
  • Precision (true hits / (true hits + false positives)): 100.00 %
  • Recall (true hits / (true hits + false negatives)): 65.71 %
Comments
  • Taxonomic range: Eukaryotes, Prokaryotes (Bacteria)
  • Maximum known number of repetitions of the pattern in a single protein: 1
  • `Interesting' site in the pattern: 6,zinc
  • `Interesting' site in the pattern: 9,active_site
  • `Interesting' site in the pattern: 10,zinc
  • VERSION: 1
Cross-references
UniProtKB/Swiss-Prot True positive hits:
AXL1_YEAST  (P40851), IDE_BOVIN   (Q24K02), IDE_DICDI   (Q54JQ2), 
IDE_DROME   (P22817), IDE_HUMAN   (P14735), IDE_MOUSE   (Q9JHR7), 
IDE_RAT     (P35559), MPPA1_ARATH (Q9ZU25), MPPA2_ARATH (O04308), 
MPPA_BOVIN  (Q0P5M8), MPPA_HUMAN  (Q10713), MPPA_MOUSE  (Q9DC61), 
MPPA_NEUCR  (P23955), MPPA_PONAB  (Q5R513), MPPA_RAT    (P20069), 
MPPA_SCHPO  (O94745), MPPA_SOLTU  (P29677), MPPA_YEAST  (P11914), 
MPPB_ARATH  (Q42290), MPPB_BOVIN  (Q3SZ71), MPPB_DICDI  (Q4W6B5), 
MPPB_HUMAN  (O75439), MPPB_LENED  (Q9Y8B5), MPPB_MOUSE  (Q9CXT8), 
MPPB_NEUCR  (P11913), MPPB_PONAB  (Q5REK3), MPPB_RAT    (Q03346), 
MPPB_SCHPO  (Q9P7X1), MPPB_YEAST  (P10507), MU138_SCHPO (O14077), 
NRDC_HUMAN  (O43847), NRDC_MOUSE  (Q8BHG1), NRDC_PONAB  (Q5R4H6), 
NRDC_RAT    (P47245), PQQF_KLEPN  (P27508), PQQF_PSEAE  (Q9I2D2), 
PQQF_PSEFL  (P55174), PQQF_PSEPK  (Q88QV3), PQQF_PSESM  (Q88A79), 
PQQL_ECOLI  (P31828), PQQL_HAEIN  (P45181), PTRA_ECO57  (Q8X6M8), 
PTRA_ECOL6  (Q8CVS2), PTRA_ECOLI  (P05458), PTRA_SALTY  (Q8ZMB5), 
PTRA_SHIFL  (Q83QC3), PXM16_ARATH (O22941), QCR1_EUGGR  (P43264), 
QCR2_BOVIN  (P23004), QCR2_HUMAN  (P22695), QCR2_MOUSE  (Q9DB77), 
QCR2_RAT    (P32551), QCR2_YARLI  (Q6C2E3), QCR2_YEAST  (P07257), 
SDP_EIMBO   (P42789), STE23_YEAST (Q06010), UCR1_CAEEL  (P98080), 
Y210_RICTY  (Q68XF0), Y219_RICPR  (O05945), Y2782_MYCTU (P0A5S8), 
Y2805_MYCBO (P0A5S9), Y293_RICCN  (Q92IX7), Y338_RICFE  (Q4UML9), 
Y4WA_RHISN  (P55679), Y522_RICBR  (Q1RJ61), Y5738_STRCO (O86835), 
Y855_MYCLE  (O32965), YMXG_BACSU  (Q04805), YQA4_CAEEL  (Q10040)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
ALBF_BACIU  (Q8RKH2), ALBF_BACSU  (P71006), CYM1_ASHGO  (Q759T9), 
CYM1_ASPFU  (Q4WP38), CYM1_ASPOR  (Q2UGN1), CYM1_CANAL  (Q5A301), 
CYM1_CANGA  (Q6FUI7), CYM1_DEBHA  (Q6BTC0), CYM1_EMENI  (Q5B6H7), 
CYM1_GIBZE  (Q4IA56), CYM1_KLULA  (Q6CWW6), CYM1_NEUCR  (Q7S7C0), 
CYM1_SCHPO  (O42908), CYM1_YARLI  (Q6C0U8), CYM1_YEAST  (P32898), 
MPPA_BLAEM  (P97997), PREP1_ARATH (Q9LJL3), PREP2_ARATH (Q8VY06), 
PREP_DANRE  (Q7ZVZ6), PREP_DROME  (Q9V9E3), PREP_HUMAN  (Q5JRX3), 
PREP_MOUSE  (Q8K411), PREP_PONAB  (Q5RDG3), PREP_XENLA  (Q6PF24), 
PREP_XENTR  (Q28BR5), PTRA_SALTI  (Q8Z418), QCR1_BOVIN  (P31800), 
QCR1_HUMAN  (P31930), QCR1_MOUSE  (Q9CZ13), QCR1_YEAST  (P07256), 
QCR2_EUGGR  (P43265), Y4WB_RHISN  (P55680), YHJJ_ECOLI  (P37648), 
YHJJ_SALTI  (Q8Z286), YHJJ_SALTY  (P50335), YMFH_BACSU  (O31766)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

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Retrieve the sequence logo from the alignment

PDB
[Detailed view]		 1BCC; 1BE3; 1BGY; 1EZV; 1HR6; 1HR7; 1HR8; 1HR9; 1KB9; 1KYO; 1L0L; 1L0N; 1NTK; 1NTM; 1NTZ; 1NU1; 1P84; 1PP9; 1PPJ; 1Q2L; 1QCR; 1SQB; 1SQP; 1SQQ; 1SQV; 1SQX; 2A06; 2BCC; 2FYU; 2IBZ; 2JG4; 2YBB; 3BCC; 3CX5; 3CXH; 3P7L; 3QZ2; 3TUV; 4DTT;

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