Entry: PS00143

General information about the entry

Entry name [info] INSULINASE
Accession [info] PS00143
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); NOV-1997 (DATA UPDATE); MAR-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC00130
Associated ProRule [info] PRU10096

Name and characterization of the entry

Description [info] Insulinase family, zinc-binding region signature.
Pattern [info]
G-x(8,9)-G-x-[STA]-H-[LIVMFY]-[LIVMC]-[DERN]-[HRKL]-[LMFAT]-x-[LFSTH]-x-
[GSTAN]-[GST].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_04 which contains 550'960 sequence entries.


Total number of hits 73 in 73 different sequences
Number of true positive hits 73 in 73 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 40
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 64.60 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] zinc at position 6
Site [info] active_site at position 9
Site [info] zinc at position 10
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
73 sequences

AXL1_YEAST  (P40851), IDE1_ARATH  (O22941), IDE2_ARATH  (F4J3D9), 
IDE_BOVIN   (Q24K02), IDE_DICDI   (Q54JQ2), IDE_DROME   (P22817), 
IDE_HUMAN   (P14735), IDE_MOUSE   (Q9JHR7), IDE_RAT     (P35559), 
MPPA1_ARATH (Q9ZU25), MPPA2_ARATH (O04308), MPPA_BOVIN  (Q0P5M8), 
MPPA_HUMAN  (Q10713), MPPA_MOUSE  (Q9DC61), MPPA_NEUCR  (P23955), 
MPPA_PONAB  (Q5R513), MPPA_RAT    (P20069), MPPA_SCHPO  (O94745), 
MPPA_SOLTU  (P29677), MPPA_YEAST  (P11914), MPPB_ARATH  (Q42290), 
MPPB_BOVIN  (Q3SZ71), MPPB_DICDI  (Q4W6B5), MPPB_HUMAN  (O75439), 
MPPB_LENED  (Q9Y8B5), MPPB_MOUSE  (Q9CXT8), MPPB_NEUCR  (P11913), 
MPPB_PONAB  (Q5REK3), MPPB_RAT    (Q03346), MPPB_SCHPO  (Q9P7X1), 
MPPB_YEAST  (P10507), MU138_SCHPO (O14077), NRDC_ARATH  (F4HNU6), 
NRDC_HUMAN  (O43847), NRDC_MOUSE  (Q8BHG1), NRDC_PONAB  (Q5R4H6), 
NRDC_RAT    (P47245), PQQF_KLEPN  (P27508), PQQF_PSEAE  (Q9I2D2), 
PQQF_PSEPH  (P55174), PQQF_PSEPK  (Q88QV3), PQQF_PSESM  (Q88A79), 
PQQL_ARATH  (Q9FJT9), PQQL_ECOLI  (P31828), PQQL_HAEIN  (P45181), 
PTRA_ECO57  (Q8X6M8), PTRA_ECOL6  (Q8CVS2), PTRA_ECOLI  (P05458), 
PTRA_SALTY  (Q8ZMB5), PTRA_SHIFL  (Q83QC3), QCR1_EUGGR  (P43264), 
QCR2_BOVIN  (P23004), QCR2_HUMAN  (P22695), QCR2_MOUSE  (Q9DB77), 
QCR2_RAT    (P32551), QCR2_YARLI  (Q6C2E3), QCR2_YEAST  (P07257), 
SDP_EIMBO   (P42789), STE23_YEAST (Q06010), UCR1_CAEEL  (P98080), 
Y210_RICTY  (Q68XF0), Y219_RICPR  (O05945), Y2782_MYCTO (P9WHT4), 
Y2782_MYCTU (P9WHT5), Y2805_MYCBO (P0A5S9), Y293_RICCN  (Q92IX7), 
Y338_RICFE  (Q4UML9), Y4WA_RHISN  (P55679), Y522_RICBR  (Q1RJ61), 
Y5738_STRCO (O86835), Y855_MYCLE  (O32965), YMXG_BACSU  (Q04805), 
YQA4_CAEEL  (Q10040)
» more

UniProtKB/Swiss-Prot
False negative sequences
40 sequences

ALBF_BACIU  (Q8RKH2), ALBF_BACSU  (P71006), CYM1_ASHGO  (Q759T9), 
CYM1_ASPFU  (Q4WP38), CYM1_ASPOR  (Q2UGN1), CYM1_CANAL  (Q5A301), 
CYM1_CANGA  (Q6FUI7), CYM1_DEBHA  (Q6BTC0), CYM1_EMENI  (Q5B6H7), 
CYM1_GIBZE  (Q4IA56), CYM1_KLULA  (Q6CWW6), CYM1_NEUCR  (Q7S7C0), 
CYM1_SCHPO  (O42908), CYM1_YARLI  (Q6C0U8), CYM1_YEAST  (P32898), 
MPPA_BLAEM  (P97997), PREP1_ARATH (Q9LJL3), PREP2_ARATH (Q8VY06), 
PREP_DANRE  (Q7ZVZ6), PREP_DROME  (Q9V9E3), PREP_HUMAN  (Q5JRX3), 
PREP_MOUSE  (Q8K411), PREP_PONAB  (Q5RDG3), PREP_XENLA  (Q6PF24), 
PREP_XENTR  (Q28BR5), PTRA_SALTI  (Q8Z418), QCR1_BOVIN  (P31800), 
QCR1_HUMAN  (P31930), QCR1_MOUSE  (Q9CZ13), QCR1_YEAST  (P07256), 
QCR2_EUGGR  (P43265), SPP_ARATH   (Q9FIH8), SPP_ORYSI   (B8B0E2), 
SPP_ORYSJ   (Q69TY5), SPP_PEA     (Q40983), Y4WB_RHISN  (P55680), 
YHJJ_ECOLI  (P37648), YHJJ_SALTI  (Q8Z286), YHJJ_SALTY  (P50335), 
YMFH_BACSU  (O31766)
» more

PDB
[Detailed view]
45 PDB

1BCC; 1BE3; 1BGY; 1EZV; 1HR6; 1HR7; 1HR8; 1HR9; 1KB9; 1KYO; 1L0L; 1L0N; 1NTK; 1NTM; 1NTZ; 1NU1; 1P84; 1PP9; 1PPJ; 1Q2L; 1QCR; 1SQB; 1SQP; 1SQQ; 1SQV; 1SQX; 2A06; 2BCC; 2FYU; 2IBZ; 2JG4; 2YBB; 3BCC; 3CX5; 3CXH; 3P7L; 3QZ2; 3TUV; 4D6T; 4D6U; 4DTT; 4IFH; 4IOF; 4PD4; 4RE9
» more

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