To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Entry: PS00250

General information about the entry

Entry name [info] TGF_BETA_1
Accession [info] PS00250
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED; 01-APR-1990 DATA UPDATE; 22-NOV-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC00223

Name and characterization of the entry

Description [info] TGF-beta family signature.
Pattern [info]
[LIVM]-x(2)-P-x(2)-[FY]-x(4)-C-x-G-x-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_11 which contains 556'196 sequence entries.


Total number of hits 204 in 204 different sequences
Number of true positive hits 202 in 202 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 23
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 99.02 %
Recall (true positives / (true positives + false negatives)) 89.78 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 7
Site [info] disulfide at position 11
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
202 sequences

60A_DROME   (P27091    ), 60A_DROVI   (Q24735    ), BMP10_HUMAN (O95393    ), 
BMP10_MOUSE (Q9R229    ), BMP10_RAT   (Q4AEG6    ), BMP15_BOVIN (Q6PX77    ), 
BMP15_HUMAN (O95972    ), BMP15_MOUSE (Q9Z0L4    ), BMP15_SHEEP (Q9MZE2    ), 
BMP2A_XENLA (P25703    ), BMP2B_XENLA (P30884    ), BMP2_CHICK  (Q90751    ), 
BMP2_DAMDA  (O19006    ), BMP2_HUMAN  (P12643    ), BMP2_MOUSE  (P21274    ), 
BMP2_RABIT  (O46564    ), BMP2_RAT    (P49001    ), BMP2_TETNG  (Q804S2    ), 
BMP3_BOVIN  (P22444    ), BMP3_HUMAN  (P12645    ), BMP3_MOUSE  (Q8BHE5    ), 
BMP3_RAT    (P49002    ), BMP3_XENLA  (Q7T2X7    ), BMP4_BOVIN  (Q2KJH1    ), 
BMP4_CHICK  (Q90752    ), BMP4_DAMDA  (Q29607    ), BMP4_HUMAN  (P12644    ), 
BMP4_MOUSE  (P21275    ), BMP4_RABIT  (O46576    ), BMP4_RAT    (Q06826    ), 
BMP4_SUNMU  (Q8MJV5    ), BMP4_XENLA  (P30885    ), BMP5_HUMAN  (P22003    ), 
BMP5_MOUSE  (P49003    ), BMP6_HUMAN  (P22004    ), BMP6_MOUSE  (P20722    ), 
BMP6_RAT    (Q04906    ), BMP7_HUMAN  (P18075    ), BMP7_MOUSE  (P23359    ), 
BMP7_XENLA  (P30886    ), BMP8A_HUMAN (Q7Z5Y6    ), BMP8A_MOUSE (P34821    ), 
BMP8B_HUMAN (P34820    ), BMP8B_MOUSE (P55105    ), DAF7_CAEEL  (P92172    ), 
DECA_DROME  (P07713    ), DECA_DROPS  (P91699    ), DECA_DROSI  (P91706    ), 
DECA_TRICA  (Q26974    ), DERR_XENTR  (Q66KL4    ), DSL1_CHICK  (P34822    ), 
DVR1_DANRE  (P35621    ), DVR1_STRPU  (P48969    ), DVR1_XENLA  (P09534    ), 
GDF10_BOVIN (Q08DX6    ), GDF10_HUMAN (P55107    ), GDF10_MOUSE (P97737    ), 
GDF10_RAT   (P55108    ), GDF10_XENLA (Q7T2X6    ), GDF11_HUMAN (O95390    ), 
GDF11_MOUSE (Q9Z1W4    ), GDF11_RAT   (Q9Z217    ), GDF1_HUMAN  (P27539    ), 
GDF1_MOUSE  (P20863    ), GDF2_DANRE  (F1QWZ4    ), GDF2_HUMAN  (Q9UK05    ), 
GDF2_MOUSE  (Q9WV56    ), GDF3_HUMAN  (Q9NR23    ), GDF3_MOUSE  (Q07104    ), 
GDF3_XENLA  (Q9YGV1    ), GDF5_HUMAN  (P43026    ), GDF5_MOUSE  (P43027    ), 
GDF6A_DANRE (P85857    ), GDF6B_DANRE (A8E7N9    ), GDF6_BOVIN  (P55106    ), 
GDF6_HUMAN  (Q6KF10    ), GDF6_MOUSE  (P43028    ), GDF6_RAT    (Q6HA10    ), 
GDF7_CHLAE  (Q9BDW8    ), GDF7_HUMAN  (Q7Z4P5    ), GDF7_MOUSE  (P43029    ), 
GDF8_AEPME  (Q5USV7    ), GDF8_ANSAN  (Q8UWD9    ), GDF8_ANTAM  (Q5USV5    ), 
GDF8_BOSGA  (Q5USW1    ), GDF8_BOSIN  (Q5RZV4    ), GDF8_BOVIN  (O18836    ), 
GDF8_BUBBU  (Q6X5V1    ), GDF8_CANLF  (Q6UKZ8    ), GDF8_CAPHI  (Q6T5B8    ), 
GDF8_CAPIB  (Q5USV9    ), GDF8_CHICK  (O42220    ), GDF8_COLLI  (Q8UWD8    ), 
GDF8_COTCO  (Q8AVB2    ), GDF8_DANRE  (O42222    ), GDF8_EPICO  (Q5I3Q2    ), 
GDF8_GORGO  (A1C2V5    ), GDF8_HEMJE  (Q5USV8    ), GDF8_HORSE  (Q9GM97    ), 
GDF8_HUMAN  (O14793    ), GDF8_LEPCA  (Q8HY52    ), GDF8_MACFA  (Q95J86    ), 
GDF8_MACMU  (A1C2U6    ), GDF8_MELGA  (O42221    ), GDF8_MOUSE  (O08689    ), 
GDF8_OREMO  (Q98TB4    ), GDF8_PANPA  (A1C2U7    ), GDF8_PANTR  (A1C2V0    ), 
GDF8_PAPHA  (O18828    ), GDF8_PIG    (O18831    ), GDF8_PONPY  (A1C2U3    ), 
GDF8_RAT    (O35312    ), GDF8_SHEEP  (O18830    ), GDF8_SYLGR  (Q5USV6    ), 
GDF8_SYNCH  (Q8UWD7    ), GDF8_TAUDE  (Q5USW0    ), GDF8_VULLA  (Q6J1J2    ), 
GDF8_VULVU  (Q6DTL9    ), GDF9_BOVIN  (Q9GK68    ), GDF9_CAPHI  (Q66NC0    ), 
GDF9_HUMAN  (O60383    ), GDF9_MOUSE  (Q07105    ), GDF9_PAPAN  (A9CB18    ), 
GDF9_SHEEP  (O77681    ), INHA_BOVIN  (P07994    ), INHA_CHICK  (P43031    ), 
INHA_HORSE  (P55101    ), INHA_HUMAN  (P05111    ), INHA_MOUSE  (Q04997    ), 
INHA_PIG    (P04087    ), INHA_RAT    (P17490    ), INHA_SHEEP  (P38440    ), 
INHA_TRIVU  (O77755    ), INHBA_BOVIN (P07995    ), INHBA_FELCA (Q6X2S4    ), 
INHBA_HORSE (P55102    ), INHBA_HUMAN (P08476    ), INHBA_MOUSE (Q04998    ), 
INHBA_PIG   (P03970    ), INHBA_RAT   (P18331    ), INHBA_SHEEP (P43032    ), 
INHBB_BOVIN (P42917    ), INHBB_CHICK (P27093    ), INHBB_HUMAN (P09529    ), 
INHBB_MOUSE (Q04999    ), INHBB_PIG   (P04088    ), INHBB_RAT   (P17491    ), 
INHBC_HUMAN (P55103    ), INHBC_MOUSE (P55104    ), INHBC_RAT   (Q9WUK5    ), 
INHBE_HUMAN (P58166    ), INHBE_MOUSE (O08717    ), INHBE_RAT   (O88959    ), 
INHB_DROME  (O61643    ), LFTY1_HUMAN (O75610    ), LFTY1_MOUSE (Q64280    ), 
LFTY2_HUMAN (O00292    ), LFTY2_MOUSE (P57785    ), MIS_BOVIN   (P03972    ), 
MIS_HUMAN   (P03971    ), MIS_MOUSE   (P27106    ), MIS_PIG     (P79295    ), 
MIS_RAT     (P49000    ), NOD2A_XENLA (Q91620    ), NOD2B_XENLA (Q90XB7    ), 
NOD4A_XENLA (O13048    ), NOD4B_XENLA (Q90XB8    ), NODAL_HUMAN (Q96S42    ), 
NODAL_MOUSE (P43021    ), NODAL_XENLA (Q91619    ), NODAL_XENTR (Q28GB8    ), 
SCW_DROME   (P54631    ), TGFB1_BOVIN (P18341    ), TGFB1_CANLF (P54831    ), 
TGFB1_CAVPO (Q9Z1Y6    ), TGFB1_CHICK (P09531    ), TGFB1_CHLAE (P09533    ), 
TGFB1_CYPCA (Q9PTQ2    ), TGFB1_HORSE (O19011    ), TGFB1_HUMAN (P01137    ), 
TGFB1_MOUSE (P04202    ), TGFB1_MUSPF (Q38HS2    ), TGFB1_ONCMY (O93449    ), 
TGFB1_PIG   (P07200    ), TGFB1_RAT   (P17246    ), TGFB1_SHEEP (P50414    ), 
TGFB1_XENLA (P16176    ), TGFB2_BOVIN (P21214    ), TGFB2_CHICK (P30371    ), 
TGFB2_CHLAE (P61811    ), TGFB2_HUMAN (P61812    ), TGFB2_MOUSE (P27090    ), 
TGFB2_MUSPF (Q38L25    ), TGFB2_PIG   (P09858    ), TGFB2_RAT   (Q07257    ), 
TGFB2_XENLA (P17247    ), TGFB3_CHICK (P16047    ), TGFB3_HUMAN (P10600    ), 
TGFB3_MOUSE (P17125    ), TGFB3_PIG   (P15203    ), TGFB3_RAT   (Q07258    ), 
UNIV_STRPU  (P48970    )
» more

UniProtKB/Swiss-Prot
False negative sequences
23 sequences

ARTN_HUMAN  (Q5T4W7    ), ARTN_MOUSE  (Q9Z0L2    ), ARTN_RAT    (Q6AYE8    ), 
GDF15_HUMAN (Q99988    ), GDF15_MOUSE (Q9Z0J7    ), GDF15_RAT   (Q9Z0J6    ), 
GDF8_ANAPL  (Q8UWE0    ), GDNF_DANRE  (Q98TU0    ), GDNF_HUMAN  (P39905    ), 
GDNF_MOUSE  (P48540    ), GDNF_RAT    (Q07731    ), GDNF_XENLA  (Q06PM8    ), 
INHBA_CHICK (P27092    ), NOD3A_XENLA (Q91609    ), NOD3A_XENTR (Q800C0    ), 
NOD3B_XENLA (Q91621    ), NOD3B_XENTR (Q800B9    ), NOD3C_XENTR (Q800B8    ), 
NRTN_HUMAN  (Q99748    ), NRTN_MOUSE  (P97463    ), PSPN_HUMAN  (O60542    ), 
PSPN_MOUSE  (O70300    ), PSPN_RAT    (O70301    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

BMP7_CANLF  (P34819    )

		
UniProtKB/Swiss-Prot
False positive sequences
2 sequences

ACOXL_MOUSE (Q9DBS4    ), CLPX_MYXXA  (Q9X5N1    )

		
PDB
[Detailed view]
65 PDB

1BMP; 1ES7; 1KLA; 1KLC; 1KLD; 1KTZ; 1LX5; 1LXI; 1M4U; 1NYS; 1NYU; 1REU; 1REW; 1S4Y; 1TFG; 1TGJ; 1TGK; 1WAQ; 1ZKZ; 2ARP; 2ARV; 2B0U; 2BHK; 2GOO; 2H62; 2H64; 2P6A; 2PJY; 2QCQ; 2QCW; 2QJ9; 2QJA; 2QJB; 2R52; 2R53; 2TGI; 3B4V; 3BK3; 3BMP; 3EO1; 3EVS; 3HH2; 3KFD; 3QB4; 3RJR; 3SEK; 4FAO; 4KV5; 4KXZ; 4MID; 4MPL; 4N1D; 4UHY; 4UHZ; 4UI0; 4UI1; 4UI2; 4YCG; 4YCI; 5E4G; 5F3B; 5F3H; 5HK5; 5HLY; 5HLZ
» more

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission