Entry: PS00250

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General information about the entry

Entry name [info] TGF_BETA_1
Accession [info] PS00250
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); APR-1990 (DATA UPDATE); MAR-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00223

Name and characterization of the entry

Description [info] TGF-beta family signature.
Pattern [info]
[LIVM]-x(2)-P-x(2)-[FY]-x(4)-C-x-G-x-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_04 which contains 544'996 sequence entries.


Total number of hits 202 in 202 different sequences
Number of true positive hits 200 in 200 different sequences
Number of 'unknown' hits
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 23
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 99.01 %
Recall (true positives / (true positives + false negatives)) 89.69 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 7
Site [info] disulfide at position 11
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
200 sequences

60A_DROME   (P27091), 60A_DROVI   (Q24735), BMP10_HUMAN (O95393), 
BMP10_MOUSE (Q9R229), BMP10_RAT   (Q4AEG6), BMP15_BOVIN (Q6PX77), 
BMP15_HUMAN (O95972), BMP15_MOUSE (Q9Z0L4), BMP15_SHEEP (Q9MZE2), 
BMP2A_XENLA (P25703), BMP2B_XENLA (P30884), BMP2_CHICK  (Q90751), 
BMP2_DAMDA  (O19006), BMP2_HUMAN  (P12643), BMP2_MOUSE  (P21274), 
BMP2_RABIT  (O46564), BMP2_RAT    (P49001), BMP2_TETNG  (Q804S2), 
BMP3B_BOVIN (Q08DX6), BMP3B_HUMAN (P55107), BMP3B_MOUSE (P97737), 
BMP3B_RAT   (P55108), BMP3B_XENLA (Q7T2X6), BMP3_BOVIN  (P22444), 
BMP3_HUMAN  (P12645), BMP3_MOUSE  (Q8BHE5), BMP3_RAT    (P49002), 
BMP3_XENLA  (Q7T2X7), BMP4_BOVIN  (Q2KJH1), BMP4_CHICK  (Q90752), 
BMP4_DAMDA  (Q29607), BMP4_HUMAN  (P12644), BMP4_MOUSE  (P21275), 
BMP4_RABIT  (O46576), BMP4_RAT    (Q06826), BMP4_SUNMU  (Q8MJV5), 
BMP4_XENLA  (P30885), BMP5_HUMAN  (P22003), BMP5_MOUSE  (P49003), 
BMP6_HUMAN  (P22004), BMP6_MOUSE  (P20722), BMP6_RAT    (Q04906), 
BMP7_HUMAN  (P18075), BMP7_MOUSE  (P23359), BMP7_XENLA  (P30886), 
BMP8A_HUMAN (Q7Z5Y6), BMP8A_MOUSE (P34821), BMP8B_HUMAN (P34820), 
BMP8B_MOUSE (P55105), DAF7_CAEEL  (P92172), DECA_DROME  (P07713), 
DECA_DROPS  (P91699), DECA_DROSI  (P91706), DECA_TRICA  (Q26974), 
DERR_XENLA  (Q9YGV1), DERR_XENTR  (Q66KL4), DSL1_CHICK  (P34822), 
DVR1_DANRE  (P35621), DVR1_STRPU  (P48969), DVR1_XENLA  (P09534), 
GDF11_HUMAN (O95390), GDF11_MOUSE (Q9Z1W4), GDF11_RAT   (Q9Z217), 
GDF1_HUMAN  (P27539), GDF1_MOUSE  (P20863), GDF2_DANRE  (F1QWZ4), 
GDF2_HUMAN  (Q9UK05), GDF2_MOUSE  (Q9WV56), GDF3_HUMAN  (Q9NR23), 
GDF3_MOUSE  (Q07104), GDF5_HUMAN  (P43026), GDF5_MOUSE  (P43027), 
GDF6A_DANRE (P85857), GDF6B_DANRE (A8E7N9), GDF6_BOVIN  (P55106), 
GDF6_HUMAN  (Q6KF10), GDF6_MOUSE  (P43028), GDF6_RAT    (Q6HA10), 
GDF7_CHLAE  (Q9BDW8), GDF7_HUMAN  (Q7Z4P5), GDF7_MOUSE  (P43029), 
GDF8_AEPME  (Q5USV7), GDF8_ANSAN  (Q8UWD9), GDF8_ANTAM  (Q5USV5), 
GDF8_BOSGA  (Q5USW1), GDF8_BOSIN  (Q5RZV4), GDF8_BOVIN  (O18836), 
GDF8_BUBBU  (Q6X5V1), GDF8_CANFA  (Q6UKZ8), GDF8_CAPHI  (Q6T5B8), 
GDF8_CAPIB  (Q5USV9), GDF8_CHICK  (O42220), GDF8_COLLI  (Q8UWD8), 
GDF8_COTCH  (Q8UWD7), GDF8_COTCO  (Q8AVB2), GDF8_DANRE  (O42222), 
GDF8_GORGO  (A1C2V5), GDF8_HEMJE  (Q5USV8), GDF8_HORSE  (Q9GM97), 
GDF8_HUMAN  (O14793), GDF8_LEPCA  (Q8HY52), GDF8_MACFA  (Q95J86), 
GDF8_MACMU  (A1C2U6), GDF8_MELGA  (O42221), GDF8_MOUSE  (O08689), 
GDF8_PANPA  (A1C2U7), GDF8_PANTR  (A1C2V0), GDF8_PAPHA  (O18828), 
GDF8_PIG    (O18831), GDF8_PONPY  (A1C2U3), GDF8_RAT    (O35312), 
GDF8_SHEEP  (O18830), GDF8_SYLGR  (Q5USV6), GDF8_TAUDE  (Q5USW0), 
GDF8_VULLA  (Q6J1J2), GDF8_VULVU  (Q6DTL9), GDF9_BOVIN  (Q9GK68), 
GDF9_CAPHI  (Q66NC0), GDF9_HUMAN  (O60383), GDF9_MOUSE  (Q07105), 
GDF9_PAPAN  (A9CB18), GDF9_SHEEP  (O77681), INHA_BOVIN  (P07994), 
INHA_CHICK  (P43031), INHA_HORSE  (P55101), INHA_HUMAN  (P05111), 
INHA_MOUSE  (Q04997), INHA_PIG    (P04087), INHA_RAT    (P17490), 
INHA_SHEEP  (P38440), INHA_TRIVU  (O77755), INHBA_BOVIN (P07995), 
INHBA_FELCA (Q6X2S4), INHBA_HORSE (P55102), INHBA_HUMAN (P08476), 
INHBA_MOUSE (Q04998), INHBA_PIG   (P03970), INHBA_RAT   (P18331), 
INHBA_SHEEP (P43032), INHBB_BOVIN (P42917), INHBB_CHICK (P27093), 
INHBB_HUMAN (P09529), INHBB_MOUSE (Q04999), INHBB_PIG   (P04088), 
INHBB_RAT   (P17491), INHBC_HUMAN (P55103), INHBC_MOUSE (P55104), 
INHBC_RAT   (Q9WUK5), INHBE_HUMAN (P58166), INHBE_MOUSE (O08717), 
INHBE_RAT   (O88959), INHB_DROME  (O61643), LFTY1_HUMAN (O75610), 
LFTY1_MOUSE (Q64280), LFTY2_HUMAN (O00292), LFTY2_MOUSE (P57785), 
MIS_BOVIN   (P03972), MIS_HUMAN   (P03971), MIS_MOUSE   (P27106), 
MIS_PIG     (P79295), MIS_RAT     (P49000), NOD2A_XENLA (Q91620), 
NOD2B_XENLA (Q90XB7), NOD4A_XENLA (O13048), NOD4B_XENLA (Q90XB8), 
NODAL_HUMAN (Q96S42), NODAL_MOUSE (P43021), NODAL_XENLA (Q91619), 
NODAL_XENTR (Q28GB8), SCW_DROME   (P54631), TGFB1_BOVIN (P18341), 
TGFB1_CANFA (P54831), TGFB1_CAVPO (Q9Z1Y6), TGFB1_CHICK (P09531), 
TGFB1_CHLAE (P09533), TGFB1_CYPCA (Q9PTQ2), TGFB1_HORSE (O19011), 
TGFB1_HUMAN (P01137), TGFB1_MOUSE (P04202), TGFB1_MUSPF (Q38HS2), 
TGFB1_ONCMY (O93449), TGFB1_PIG   (P07200), TGFB1_RAT   (P17246), 
TGFB1_SHEEP (P50414), TGFB1_XENLA (P16176), TGFB2_BOVIN (P21214), 
TGFB2_CHICK (P30371), TGFB2_CHLAE (P61811), TGFB2_HUMAN (P61812), 
TGFB2_MOUSE (P27090), TGFB2_MUSPF (Q38L25), TGFB2_PIG   (P09858), 
TGFB2_RAT   (Q07257), TGFB2_XENLA (P17247), TGFB3_CHICK (P16047), 
TGFB3_HUMAN (P10600), TGFB3_MOUSE (P17125), TGFB3_PIG   (P15203), 
TGFB3_RAT   (Q07258), UNIV_STRPU  (P48970)
» More

UniProtKB/Swiss-Prot
False negative sequences
23 sequences

ARTN_HUMAN  (Q5T4W7), ARTN_MOUSE  (Q9Z0L2), ARTN_RAT    (Q6AYE8), 
GDF15_HUMAN (Q99988), GDF15_MOUSE (Q9Z0J7), GDF15_RAT   (Q9Z0J6), 
GDF8_ANAPL  (Q8UWE0), GDNF_DANRE  (Q98TU0), GDNF_HUMAN  (P39905), 
GDNF_MOUSE  (P48540), GDNF_RAT    (Q07731), GDNF_XENLA  (Q06PM8), 
INHBA_CHICK (P27092), NOD3A_XENLA (Q91609), NOD3A_XENTR (Q800C0), 
NOD3B_XENLA (Q91621), NOD3B_XENTR (Q800B9), NOD3C_XENTR (Q800B8), 
NRTN_HUMAN  (Q99748), NRTN_MOUSE  (P97463), PSPN_HUMAN  (O60542), 
PSPN_MOUSE  (O70300), PSPN_RAT    (O70301)
» More

UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

BMP7_CANFA  (P34819)

		
UniProtKB/Swiss-Prot
False positive sequences
2 sequences

ACOXL_MOUSE (Q9DBS4), CLPX_MYXXA  (Q9X5N1)

		
PDB
[Detailed view]
48 PDB

1BMP; 1ES7; 1KLA; 1KLC; 1KLD; 1KTZ; 1LX5; 1LXI; 1M4U; 1NYS; 1NYU; 1REU; 1REW; 1S4Y; 1TFG; 1TGJ; 1TGK; 1WAQ; 1ZKZ; 2ARP; 2ARV; 2B0U; 2BHK; 2GOO; 2H62; 2H64; 2P6A; 2PJY; 2QCQ; 2QCW; 2QJ9; 2QJA; 2QJB; 2R52; 2R53; 2TGI; 3B4V; 3BK3; 3BMP; 3EO1; 3EVS; 3HH2; 3KFD; 3QB4; 3RJR; 3SEK; 4FAO; 4N1D
» More

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