Entry: PS00250

General information about the entry

Entry name [info] TGF_BETA_1
Accession [info] PS00250
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); APR-1990 (DATA UPDATE); MAY-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC00223

Name and characterization of the entry

Description [info] TGF-beta family signature.
Pattern [info]
[LIVM]-x(2)-P-x(2)-[FY]-x(4)-C-x-G-x-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_06 which contains 551'385 sequence entries.


Total number of hits 202 in 202 different sequences
Number of true positive hits 200 in 200 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 23
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 99.01 %
Recall (true positives / (true positives + false negatives)) 89.69 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 7
Site [info] disulfide at position 11
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
200 sequences

60A_DROME   (P27091    ), 60A_DROVI   (Q24735    ), BMP10_HUMAN (O95393    ), 
BMP10_MOUSE (Q9R229    ), BMP10_RAT   (Q4AEG6    ), BMP15_BOVIN (Q6PX77    ), 
BMP15_HUMAN (O95972    ), BMP15_MOUSE (Q9Z0L4    ), BMP15_SHEEP (Q9MZE2    ), 
BMP2A_XENLA (P25703    ), BMP2B_XENLA (P30884    ), BMP2_CHICK  (Q90751    ), 
BMP2_DAMDA  (O19006    ), BMP2_HUMAN  (P12643    ), BMP2_MOUSE  (P21274    ), 
BMP2_RABIT  (O46564    ), BMP2_RAT    (P49001    ), BMP2_TETNG  (Q804S2    ), 
BMP3_BOVIN  (P22444    ), BMP3_HUMAN  (P12645    ), BMP3_MOUSE  (Q8BHE5    ), 
BMP3_RAT    (P49002    ), BMP3_XENLA  (Q7T2X7    ), BMP4_BOVIN  (Q2KJH1    ), 
BMP4_CHICK  (Q90752    ), BMP4_DAMDA  (Q29607    ), BMP4_HUMAN  (P12644    ), 
BMP4_MOUSE  (P21275    ), BMP4_RABIT  (O46576    ), BMP4_RAT    (Q06826    ), 
BMP4_SUNMU  (Q8MJV5    ), BMP4_XENLA  (P30885    ), BMP5_HUMAN  (P22003    ), 
BMP5_MOUSE  (P49003    ), BMP6_HUMAN  (P22004    ), BMP6_MOUSE  (P20722    ), 
BMP6_RAT    (Q04906    ), BMP7_HUMAN  (P18075    ), BMP7_MOUSE  (P23359    ), 
BMP7_XENLA  (P30886    ), BMP8A_HUMAN (Q7Z5Y6    ), BMP8A_MOUSE (P34821    ), 
BMP8B_HUMAN (P34820    ), BMP8B_MOUSE (P55105    ), DAF7_CAEEL  (P92172    ), 
DECA_DROME  (P07713    ), DECA_DROPS  (P91699    ), DECA_DROSI  (P91706    ), 
DECA_TRICA  (Q26974    ), DERR_XENLA  (Q9YGV1    ), DERR_XENTR  (Q66KL4    ), 
DSL1_CHICK  (P34822    ), DVR1_DANRE  (P35621    ), DVR1_STRPU  (P48969    ), 
DVR1_XENLA  (P09534    ), GDF10_BOVIN (Q08DX6    ), GDF10_HUMAN (P55107    ), 
GDF10_MOUSE (P97737    ), GDF10_RAT   (P55108    ), GDF10_XENLA (Q7T2X6    ), 
GDF11_HUMAN (O95390    ), GDF11_MOUSE (Q9Z1W4    ), GDF11_RAT   (Q9Z217    ), 
GDF1_HUMAN  (P27539    ), GDF1_MOUSE  (P20863    ), GDF2_DANRE  (F1QWZ4    ), 
GDF2_HUMAN  (Q9UK05    ), GDF2_MOUSE  (Q9WV56    ), GDF3_HUMAN  (Q9NR23    ), 
GDF3_MOUSE  (Q07104    ), GDF5_HUMAN  (P43026    ), GDF5_MOUSE  (P43027    ), 
GDF6A_DANRE (P85857    ), GDF6B_DANRE (A8E7N9    ), GDF6_BOVIN  (P55106    ), 
GDF6_HUMAN  (Q6KF10    ), GDF6_MOUSE  (P43028    ), GDF6_RAT    (Q6HA10    ), 
GDF7_CHLAE  (Q9BDW8    ), GDF7_HUMAN  (Q7Z4P5    ), GDF7_MOUSE  (P43029    ), 
GDF8_AEPME  (Q5USV7    ), GDF8_ANSAN  (Q8UWD9    ), GDF8_ANTAM  (Q5USV5    ), 
GDF8_BOSGA  (Q5USW1    ), GDF8_BOSIN  (Q5RZV4    ), GDF8_BOVIN  (O18836    ), 
GDF8_BUBBU  (Q6X5V1    ), GDF8_CANLF  (Q6UKZ8    ), GDF8_CAPHI  (Q6T5B8    ), 
GDF8_CAPIB  (Q5USV9    ), GDF8_CHICK  (O42220    ), GDF8_COLLI  (Q8UWD8    ), 
GDF8_COTCO  (Q8AVB2    ), GDF8_DANRE  (O42222    ), GDF8_GORGO  (A1C2V5    ), 
GDF8_HEMJE  (Q5USV8    ), GDF8_HORSE  (Q9GM97    ), GDF8_HUMAN  (O14793    ), 
GDF8_LEPCA  (Q8HY52    ), GDF8_MACFA  (Q95J86    ), GDF8_MACMU  (A1C2U6    ), 
GDF8_MELGA  (O42221    ), GDF8_MOUSE  (O08689    ), GDF8_PANPA  (A1C2U7    ), 
GDF8_PANTR  (A1C2V0    ), GDF8_PAPHA  (O18828    ), GDF8_PIG    (O18831    ), 
GDF8_PONPY  (A1C2U3    ), GDF8_RAT    (O35312    ), GDF8_SHEEP  (O18830    ), 
GDF8_SYLGR  (Q5USV6    ), GDF8_SYNCH  (Q8UWD7    ), GDF8_TAUDE  (Q5USW0    ), 
GDF8_VULLA  (Q6J1J2    ), GDF8_VULVU  (Q6DTL9    ), GDF9_BOVIN  (Q9GK68    ), 
GDF9_CAPHI  (Q66NC0    ), GDF9_HUMAN  (O60383    ), GDF9_MOUSE  (Q07105    ), 
GDF9_PAPAN  (A9CB18    ), GDF9_SHEEP  (O77681    ), INHA_BOVIN  (P07994    ), 
INHA_CHICK  (P43031    ), INHA_HORSE  (P55101    ), INHA_HUMAN  (P05111    ), 
INHA_MOUSE  (Q04997    ), INHA_PIG    (P04087    ), INHA_RAT    (P17490    ), 
INHA_SHEEP  (P38440    ), INHA_TRIVU  (O77755    ), INHBA_BOVIN (P07995    ), 
INHBA_FELCA (Q6X2S4    ), INHBA_HORSE (P55102    ), INHBA_HUMAN (P08476    ), 
INHBA_MOUSE (Q04998    ), INHBA_PIG   (P03970    ), INHBA_RAT   (P18331    ), 
INHBA_SHEEP (P43032    ), INHBB_BOVIN (P42917    ), INHBB_CHICK (P27093    ), 
INHBB_HUMAN (P09529    ), INHBB_MOUSE (Q04999    ), INHBB_PIG   (P04088    ), 
INHBB_RAT   (P17491    ), INHBC_HUMAN (P55103    ), INHBC_MOUSE (P55104    ), 
INHBC_RAT   (Q9WUK5    ), INHBE_HUMAN (P58166    ), INHBE_MOUSE (O08717    ), 
INHBE_RAT   (O88959    ), INHB_DROME  (O61643    ), LFTY1_HUMAN (O75610    ), 
LFTY1_MOUSE (Q64280    ), LFTY2_HUMAN (O00292    ), LFTY2_MOUSE (P57785    ), 
MIS_BOVIN   (P03972    ), MIS_HUMAN   (P03971    ), MIS_MOUSE   (P27106    ), 
MIS_PIG     (P79295    ), MIS_RAT     (P49000    ), NOD2A_XENLA (Q91620    ), 
NOD2B_XENLA (Q90XB7    ), NOD4A_XENLA (O13048    ), NOD4B_XENLA (Q90XB8    ), 
NODAL_HUMAN (Q96S42    ), NODAL_MOUSE (P43021    ), NODAL_XENLA (Q91619    ), 
NODAL_XENTR (Q28GB8    ), SCW_DROME   (P54631    ), TGFB1_BOVIN (P18341    ), 
TGFB1_CANLF (P54831    ), TGFB1_CAVPO (Q9Z1Y6    ), TGFB1_CHICK (P09531    ), 
TGFB1_CHLAE (P09533    ), TGFB1_CYPCA (Q9PTQ2    ), TGFB1_HORSE (O19011    ), 
TGFB1_HUMAN (P01137    ), TGFB1_MOUSE (P04202    ), TGFB1_MUSPF (Q38HS2    ), 
TGFB1_ONCMY (O93449    ), TGFB1_PIG   (P07200    ), TGFB1_RAT   (P17246    ), 
TGFB1_SHEEP (P50414    ), TGFB1_XENLA (P16176    ), TGFB2_BOVIN (P21214    ), 
TGFB2_CHICK (P30371    ), TGFB2_CHLAE (P61811    ), TGFB2_HUMAN (P61812    ), 
TGFB2_MOUSE (P27090    ), TGFB2_MUSPF (Q38L25    ), TGFB2_PIG   (P09858    ), 
TGFB2_RAT   (Q07257    ), TGFB2_XENLA (P17247    ), TGFB3_CHICK (P16047    ), 
TGFB3_HUMAN (P10600    ), TGFB3_MOUSE (P17125    ), TGFB3_PIG   (P15203    ), 
TGFB3_RAT   (Q07258    ), UNIV_STRPU  (P48970    )
» more

UniProtKB/Swiss-Prot
False negative sequences
23 sequences

ARTN_HUMAN  (Q5T4W7    ), ARTN_MOUSE  (Q9Z0L2    ), ARTN_RAT    (Q6AYE8    ), 
GDF15_HUMAN (Q99988    ), GDF15_MOUSE (Q9Z0J7    ), GDF15_RAT   (Q9Z0J6    ), 
GDF8_ANAPL  (Q8UWE0    ), GDNF_DANRE  (Q98TU0    ), GDNF_HUMAN  (P39905    ), 
GDNF_MOUSE  (P48540    ), GDNF_RAT    (Q07731    ), GDNF_XENLA  (Q06PM8    ), 
INHBA_CHICK (P27092    ), NOD3A_XENLA (Q91609    ), NOD3A_XENTR (Q800C0    ), 
NOD3B_XENLA (Q91621    ), NOD3B_XENTR (Q800B9    ), NOD3C_XENTR (Q800B8    ), 
NRTN_HUMAN  (Q99748    ), NRTN_MOUSE  (P97463    ), PSPN_HUMAN  (O60542    ), 
PSPN_MOUSE  (O70300    ), PSPN_RAT    (O70301    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

BMP7_CANLF  (P34819    )

		
UniProtKB/Swiss-Prot
False positive sequences
2 sequences

ACOXL_MOUSE (Q9DBS4    ), CLPX_MYXXA  (Q9X5N1    )

		
PDB
[Detailed view]
60 PDB

1BMP; 1ES7; 1KLA; 1KLC; 1KLD; 1KTZ; 1LX5; 1LXI; 1M4U; 1NYS; 1NYU; 1REU; 1REW; 1S4Y; 1TFG; 1TGJ; 1TGK; 1WAQ; 1ZKZ; 2ARP; 2ARV; 2B0U; 2BHK; 2GOO; 2H62; 2H64; 2P6A; 2PJY; 2QCQ; 2QCW; 2QJ9; 2QJA; 2QJB; 2R52; 2R53; 2TGI; 3B4V; 3BK3; 3BMP; 3EO1; 3EVS; 3HH2; 3KFD; 3QB4; 3RJR; 3SEK; 4FAO; 4KV5; 4KXZ; 4MID; 4MPL; 4N1D; 4UHY; 4UHZ; 4UI0; 4UI1; 4UI2; 4YCG; 4YCI; 5E4G
» more

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission