Entry: PS00251

General information about the entry

Entry name [info] TNF_1
Accession [info] PS00251
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); DEC-2004 (DATA UPDATE); MAY-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC00224

Name and characterization of the entry

Description [info] TNF family signature.
Pattern [info]
[LV]-x-[LIVM]-{V}-x-{L}-G-[LIVMF]-Y-[LIVMFY](2)-x(2)-[QEKHL]-[LIVMGT]-x-
[LIVMFY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_06 which contains 551'385 sequence entries.


Total number of hits 93 in 93 different sequences
Number of true positive hits 88 in 88 different sequences
Number of 'unknown' hits 0
Number of false positive hits 5 in 5 different sequences
Number of false negative sequences 16
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 94.62 %
Recall (true positives / (true positives + false negatives)) 84.62 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
88 sequences

CD40L_AOTTR (Q9BDM3    ), CD40L_BOVIN (P51749    ), CD40L_CALJA (Q9BDN3    ), 
CD40L_CANLF (O97626    ), CD40L_CERAT (P63305    ), CD40L_CHICK (Q9I8D8    ), 
CD40L_FELCA (O97605    ), CD40L_HUMAN (P29965    ), CD40L_MACMU (P63304    ), 
CD40L_MACNE (Q9BDM7    ), CD40L_MOUSE (P27548    ), CD40L_PIG   (Q95MQ5    ), 
CD40L_RAT   (Q9Z2V2    ), CD70_HUMAN  (P32970    ), EIGER_DROME (Q8MUJ1    ), 
TNF10_HUMAN (P50591    ), TNF10_MOUSE (P50592    ), TNF13_HUMAN (O75888    ), 
TNF13_MOUSE (Q9D777    ), TNFA_BOSIN  (P59684    ), TNFA_BOSTR  (Q1G1A2    ), 
TNFA_BOVIN  (Q06599    ), TNFA_BUBBU  (P59693    ), TNFA_BUBCA  (Q2MH05    ), 
TNFA_CALJA  (Q19LH4    ), TNFA_CAMBA  (Q75N23    ), TNFA_CANLF  (P51742    ), 
TNFA_CAPHI  (P13296    ), TNFA_CAVPO  (P51435    ), TNFA_CEREL  (P51743    ), 
TNFA_DASNO  (Q1WM27    ), TNFA_DELLE  (Q8WNR1    ), TNFA_FELCA  (P19101    ), 
TNFA_HORSE  (P29553    ), TNFA_HUMAN  (P01375    ), TNFA_LAMGL  (P59694    ), 
TNFA_MACEU  (O77764    ), TNFA_MACFA  (P79337    ), TNFA_MACMU  (P48094    ), 
TNFA_MARMO  (O35734    ), TNFA_MOUSE  (P06804    ), TNFA_PANTR  (Q8HZD9    ), 
TNFA_PAPAN  (P59695    ), TNFA_PAPHU  (O77510    ), TNFA_PAPSP  (P33620    ), 
TNFA_PERLE  (P36939    ), TNFA_PIG    (P23563    ), TNFA_RABIT  (P04924    ), 
TNFA_RAT    (P16599    ), TNFA_SAISC  (Q8MKG8    ), TNFA_SHEEP  (P23383    ), 
TNFA_TRIVU  (P79374    ), TNFA_TUPTA  (Q539C2    ), TNFA_TURTR  (Q9BEA1    ), 
TNFB_BOVIN  (Q06600    ), TNFB_CANLF  (Q5WR07    ), TNFB_HUMAN  (P01374    ), 
TNFB_MACEU  (Q9XT48    ), TNFB_MACMU  (Q5TM20    ), TNFB_MARMO  (Q9JM09    ), 
TNFB_MOUSE  (P09225    ), TNFB_PANTR  (P61125    ), TNFB_PIG    (P26445    ), 
TNFB_RABIT  (P10154    ), TNFB_RAT    (Q06332    ), TNFC_HUMAN  (Q06643    ), 
TNFC_MACEU  (Q9XT47    ), TNFC_MACMU  (Q5TM22    ), TNFC_MOUSE  (P41155    ), 
TNFC_PANTR  (Q862Z7    ), TNFC_PIG    (Q9TSV8    ), TNFL4_HUMAN (P23510    ), 
TNFL4_MOUSE (P43488    ), TNFL4_RABIT (O02765    ), TNFL4_RAT   (Q9Z2P3    ), 
TNFL6_CERAT (Q9BDN1    ), TNFL6_FELCA (Q861W5    ), TNFL6_HUMAN (P48023    ), 
TNFL6_MACFA (P63308    ), TNFL6_MACMU (P63307    ), TNFL6_MACNE (P63306    ), 
TNFL6_MOUSE (P41047    ), TNFL6_PIG   (Q9BEA8    ), TNFL6_RAT   (P36940    ), 
TNFL8_HUMAN (P32971    ), TNFL8_MOUSE (P32972    ), TNFL9_HUMAN (P41273    ), 
TNFL9_MOUSE (P41274    )
» more

UniProtKB/Swiss-Prot
False negative sequences
16 sequences

EDA_BOVIN   (Q9BEG5    ), EDA_HUMAN   (Q92838    ), EDA_MOUSE   (O54693    ), 
TN13B_HUMAN (Q9Y275    ), TN13B_MOUSE (Q9WU72    ), TNF11_HUMAN (O14788    ), 
TNF11_MOUSE (O35235    ), TNF11_RAT   (Q9ESE2    ), TNF12_HUMAN (O43508    ), 
TNF12_MOUSE (O54907    ), TNF14_HUMAN (O43557    ), TNF14_MOUSE (Q9QYH9    ), 
TNF18_HUMAN (Q9UNG2    ), TNF18_MOUSE (Q7TS55    ), TNFA_SPAAU  (Q8JFG3    ), 
TNFC_MARMO  (Q9JM10    )
» more

UniProtKB/Swiss-Prot
False positive sequences
5 sequences

ATP6_VANPO  (A6H4Q8    ), LIVH_METJA  (Q58665    ), LNT2_LEPIC  (Q72MD8    ), 
LNT2_LEPIN  (Q8EYY4    ), PCID2_DROME (Q9VTL1    )
» more

PDB
[Detailed view]
38 PDB

1A8M; 1ALY; 1D0G; 1D2Q; 1D4V; 1DG6; 1DU3; 1I9R; 1TNF; 1TNR; 1U5X; 1U5Y; 1U5Z; 1XU1; 1XU2; 2AZ5; 2E7A; 2HEV; 2HEW; 2HEY; 2TNF; 2TUN; 2ZJC; 2ZPX; 3ALQ; 3IT8; 3K48; 3L9J; 3LKJ; 3QD6; 3WD5; 4G3Y; 4MSV; 4MXV; 4MXW; 4N90; 4TWT; 4ZCH
» more

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