Entry: PS00262

Forthcoming changes to the profile format
General information about the entry

Entry name [info] INSULIN
Accession [info] PS00262
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); DEC-2004 (DATA UPDATE); SEP-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00235

Name and characterization of the entry

Description [info] Insulin family signature.
Pattern [info]
C-C-{P}-{P}-x-C-[STDNEKPI]-x(3)-[LIVMFS]-x(3)-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_10 which contains 546'790 sequence entries.


Total number of hits 230 in 230 different sequences
Number of true positive hits 222 in 222 different sequences
Number of 'unknown' hits
Number of false positive hits 8 in 8 different sequences
Number of false negative sequences 10
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 96.52 %
Recall (true positives / (true positives + false negatives)) 95.69 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 1
Site [info] disulfide at position 2
Site [info] disulfide at position 6
Site [info] disulfide at position 11
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
222 sequences

BXA1_BOMMO  (Q17192), BXA1_SAMCY  (P33718), BXA2_BOMMO  (P15411), 
BXA2_SAMCY  (P33719), BXA3_BOMMO  (P26726), BXA3_SAMCY  (P33720), 
BXA4_BOMMO  (P26727), BXA5_BOMMO  (P26728), BXA6_BOMMO  (P26729), 
BXA7_BOMMO  (P26730), BXA8_BOMMO  (P26731), BXA9_BOMMO  (P26732), 
BXB10_BOMMO (Q17194), BXB12_BOMMO (P29519), BXB1_BOMMO  (P26733), 
BXB1_SAMCY  (P33721), BXB2_BOMMO  (P26734), BXB2_SAMCY  (P33722), 
BXB3_BOMMO  (P26737), BXB4_BOMMO  (P26738), BXB5_BOMMO  (P26739), 
BXB6_BOMMO  (P26740), BXB7_BOMMO  (P26741), BXB8_BOMMO  (P26742), 
BXB9_BOMMO  (P26743), BXC1_BOMMO  (P15410), BXC2_BOMMO  (P26735), 
BXD1_BOMMO  (P26736), BXE1_BOMMO  (P21808), BXF1_BOMMO  (P91896), 
BXG1_BOMMO  (O61271), BXRA_AGRCO  (O09209), BXRB_AGRCO  (O09210), 
IGF1A_CYPCA (Q90325), IGF1A_XENLA (P16501), IGF1B_CYPCA (Q90326), 
IGF1B_XENLA (P84775), IGF1_AILFU  (Q6IVA5), IGF1_AILME  (Q6JLX1), 
IGF1_BOVIN  (P07455), IGF1_CANFA  (P33712), IGF1_CAPHI  (P51457), 
IGF1_CAVPO  (P17647), IGF1_CHICK  (P18254), IGF1_COTJA  (P51462), 
IGF1_HORSE  (P51458), IGF1_HUMAN  (P05019), IGF1_MOUSE  (P05017), 
IGF1_ONCKI  (P17085), IGF1_ONCMY  (Q02815), IGF1_PANTA  (Q6GUL6), 
IGF1_PIG    (P16545), IGF1_RABIT  (Q95222), IGF1_RAT    (P08025), 
IGF1_RHIRO  (Q68LC0), IGF1_SHEEP  (P10763), IGF1_SUNMU  (Q28933), 
IGF2A_XENLA (Q90WW4), IGF2B_XENLA (Q6INW9), IGF2_BOVIN  (P07456), 
IGF2_CAVPO  (Q08279), IGF2_CHICK  (P33717), IGF2_HORSE  (P51459), 
IGF2_HUMAN  (P01344), IGF2_MOUSE  (P09535), IGF2_NEOVI  (P41694), 
IGF2_ONCMY  (Q02816), IGF2_PIG    (P23695), IGF2_RAT    (P01346), 
IGF2_SHEEP  (P10764), IGF3_XENLA  (Q90WX8), IGF_MYXGL   (P22618), 
ILB1_CAEEL  (Q09626), ILB2_CAEEL  (Q09627), ILB3_CAEEL  (Q09628), 
ILB4_CAEEL  (Q23430), ILB5_CAEEL  (P56174), ILB6_CAEEL  (P56173), 
ILG1_CAEEL  (Q18060), ILP_BRACL   (P22334), INS1_BATSP  (P01337), 
INS1_HUSDA  (C0HJI7), INS1_KATPE  (C0HJI2), INS1_MOUSE  (P01325), 
INS1_RAT    (P01322), INS1_THUOR  (C0HJI5), INS1_XENLA  (P12706), 
INS2_BATSP  (P01338), INS2_HUSDA  (C0HJI8), INS2_KATPE  (C0HJI3), 
INS2_MOUSE  (P01326), INS2_RAT    (P01323), INS2_THUOR  (C0HJI6), 
INS2_XENLA  (P12707), INSL1_DROME (Q9VT50), INSL2_DROME (Q9VT51), 
INSL3_BOVIN (O77801), INSL3_CALJA (O97937), INSL3_CANFA (Q6X7V3), 
INSL3_DROME (Q9VT52), INSL3_HUMAN (P51460), INSL3_MOUSE (O09107), 
INSL3_PANTR (Q5CZK3), INSL3_PIG   (P51461), INSL3_RAT   (Q9WUK0), 
INSL4_DROME (Q9VT53), INSL4_HUMAN (Q14641), INSL4_PANTR (Q5CZK6), 
INSL5_DROME (Q7KUD5), INSL5_HUMAN (Q9Y5Q6), INSL5_MOUSE (Q9WUG6), 
INSL5_PANTR (Q5CZK5), INSL6_BOVIN (Q32L79), INSL6_HUMAN (Q9Y581), 
INSL6_MOUSE (Q9QY05), INSL6_RAT   (Q9WV41), INS_ACIGU   (P81423), 
INS_ACOCA   (P01324), INS_ALLMI   (P12703), INS_AMICA   (P29335), 
INS_ANAPL   (P01333), INS_ANGAN   (P41522), INS_ANGRO   (P42633), 
INS_ANSAN   (P68245), INS_AOTTR   (P67972), INS_ATRSP   (P09476), 
INS_BALBO   (P01314), INS_BALPH   (P67973), INS_BOVIN   (P01317), 
INS_CAIMO   (P68243), INS_CALMI   (P13190), INS_CAMDR   (P01320), 
INS_CANFA   (P01321), INS_CAPHI   (P01319), INS_CARSE   (C0HJI1), 
INS_CAVPO   (P01329), INS_CHICH   (P01327), INS_CHICK   (P67970), 
INS_CHIMO   (P68991), INS_CHLAE   (P30407), INS_CRILO   (P01313), 
INS_CROAT   (P01334), INS_CYPCA   (P01335), INS_DANRE   (O73727), 
INS_DIDVI   (P18109), INS_ELEMA   (P01316), INS_FELCA   (P06306), 
INS_GADMC   (P01336), INS_GORGO   (Q6YK33), INS_HORSE   (P01310), 
INS_HUMAN   (P01308), INS_HYDCO   (P68992), INS_HYSCR   (P01328), 
INS_KATPE   (P01340), INS_LAMFL   (P68988), INS_LOPAM   (P69045), 
INS_LOPPI   (P69046), INS_MACFA   (P30406), INS_MELGA   (P67968), 
INS_MYOCO   (P01330), INS_MYOSC   (P07453), INS_MYXGL   (P01342), 
INS_OCTDE   (P17715), INS_ONCGO   (P68989), INS_ONCKE   (P04667), 
INS_ONCKI   (P68990), INS_ORENI   (P81025), INS_ORNAN   (Q9TQY7), 
INS_PAGMA   (C0HJI4), INS_PANBU   (Q98TA8), INS_PANTR   (P30410), 
INS_PETMA   (P68987), INS_PHYCD   (P67974), INS_PIAME   (P81881), 
INS_PIG     (P01315), INS_PLAFE   (P09477), INS_PONPY   (Q8HXV2), 
INS_PROGU   (P01331), INS_PSAOB   (Q62587), INS_PTYDH   (P12708), 
INS_RABIT   (P01311), INS_SAISC   (P67971), INS_SELRF   (P51463), 
INS_SHEEP   (P01318), INS_SPETR   (Q91XI3), INS_SQUAC   (P12704), 
INS_STRCA   (P67969), INS_THUTH   (P01339), INS_TORMA   (P12705), 
INS_TRADO   (P69047), INS_TRASC   (P69048), INS_VERMO   (Q9W7R2), 
LIRP_LOCMI  (P15131), MPI1_LYMST  (P07223), MPI2_LYMST  (P25289), 
MPI3_LYMST  (P80090), MPI5_LYMST  (P31241), MPI7_LYMST  (P91797), 
REL1_HUMAN  (P04808), REL1_PANTR  (P51454), REL1_RAT    (P01347), 
REL2_HUMAN  (P04090), REL2_PANTR  (P51455), REL3_HUMAN  (Q8WXF3), 
REL3_MOUSE  (Q8CHK2), REL3_PANTR  (Q5CZK2), REL3_PIG    (Q8HY17), 
REL3_RAT    (Q8BFS3), RELH_RABIT  (P51456), RELX_BALAC  (P11184), 
RELX_BALED  (P11185), RELX_CANFA  (Q9TRM8), RELX_CARTA  (P01349), 
RELX_CAVPO  (P51453), RELX_DASSA  (P81191), RELX_FELCA  (Q9MYK8), 
RELX_HORSE  (P22969), RELX_LEUER  (P11952), RELX_MACMU  (P19884), 
RELX_MESAU  (Q64171), RELX_PIG    (P01348), RELX_SQUAC  (P11953)
» More

UniProtKB/Swiss-Prot
False negative sequences
10 sequences

BXB11_BOMMO (Q17196), ILA1_CAEEL  (Q21507), ILA2_CAEEL  (Q21508), 
ILA3_CAEEL  (Q21506), INSL6_DROME (Q9W4Z4), INSL7_DROME (Q9W4Q9), 
INSL_VIGUN  (P83770), INS_POLSE   (P0C236), INS_RODSP   (P21563), 
REL1_MOUSE  (P47932)
» More

UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

RELX_PHODA  (Q7M3C4)

		
UniProtKB/Swiss-Prot
False positive sequences
8 sequences

ADA18_MACFA (Q95194), ADAM5_RAT   (Q5BK84), CO195_CONLI (Q3YEE6), 
CO1A_CONCE  (Q5K0C4), F256_CTEON  (P85032), GG3_ARATH   (Q6AWT8), 
PRMC_CHLT2  (B0B9D1), PRMC_CHLTR  (O84027)
» More

PDB
[Detailed view]
285 PDB

1A7F; 1AI0; 1AIY; 1APH; 1B17; 1B18; 1B19; 1B2A; 1B2B; 1B2C; 1B2D; 1B2E; 1B2F; 1B2G; 1B9E; 1B9G; 1BEN; 1BOM; 1BON; 1BPH; 1BQT; 1BZV; 1CPH; 1DEI; 1DPH; 1EFE; 1EV3; 1EV6; 1EVR; 1FU2; 1FUB; 1G7A; 1G7B; 1GUJ; 1GZR; 1GZY; 1GZZ; 1H02; 1H59; 1HIQ; 1HIS; 1HIT; 1HLS; 1HTV; 1HUI; 1IGL; 1IMX; 1IOG; 1IOH; 1IZA; 1IZB; 1J73; 1JCA; 1JCO; 1K3M; 1KMF; 1LKQ; 1LPH; 1M5A; 1MHI; 1MHJ; 1MPJ; 1MSO; 1OS3; 1OS4; 1PID; 1PMX; 1Q4V; 1QIY; 1QIZ; 1QJ0; 1RWE; 1SDB; 1SF1; 1SJT; 1SJU; 1T1K; 1T1P; 1T1Q; 1TGR; 1TRZ; 1TYL; 1TYM; 1UZ9; 1W8P; 1WAV; 1WQJ; 1XDA; 1XGL; 1XW7; 1ZEG; 1ZEH; 1ZEI; 1ZNI; 1ZNJ; 2A3G; 2AIY; 2BN1; 2BN3; 2C8Q; 2C8R; 2CEU; 2DSP; 2DSQ; 2DSR; 2EFA; 2FHW; 2G4M; 2GF1; 2H67; 2H8B; 2HH4; 2HHO; 2HIU; 2INS; 2JMN; 2JUM; 2JUU; 2JUV; 2JV1; 2JZQ; 2K1V; 2K6T; 2K6U; 2K91; 2K9R; 2KBC; 2KJI; 2KJJ; 2KJU; 2KQP; 2KQQ; 2KXK; 2L1Y; 2L1Z; 2L29; 2LGB; 2LWZ; 2M1D; 2M1E; 2M2M; 2M2N; 2M2O; 2M2P; 2MLI; 2MPG; 2OLY; 2OLZ; 2OM0; 2OM1; 2OMG; 2OMH; 2OMI; 2QIU; 2R34; 2R35; 2R36; 2RN5; 2TCI; 2V5P; 2VJZ; 2VK0; 2W44; 2WBY; 2WC0; 2WFU; 2WFV; 2WRU; 2WRV; 2WRW; 2WRX; 2WS0; 2WS1; 2WS4; 2WS6; 2WS7; 2ZP6; 2ZPP; 3AIY; 3BRR; 3BXQ; 3E7Y; 3E7Z; 3EXX; 3FHP; 3FQ9; 3GF1; 3GKY; 3I3Z; 3I40; 3ILG; 3INC; 3INS; 3IR0; 3JSD; 3KQ6; 3KR3; 3LRI; 3MTH; 3P2X; 3P33; 3Q6E; 3ROV; 3RTO; 3T2A; 3TT8; 3U4N; 3V19; 3V1G; 3W11; 3W12; 3W13; 3W14; 3W7Y; 3W7Z; 3W80; 3ZI3; 3ZQR; 3ZS2; 3ZU1; 4A7E; 4AIY; 4AJX; 4AJZ; 4AK0; 4AKJ; 4BS3; 4CXL; 4CXN; 4CY7; 4E7T; 4E7U; 4E7V; 4EFX; 4EWW; 4EWX; 4EWZ; 4EX0; 4EX1; 4EXX; 4EY1; 4EY9; 4EYD; 4EYN; 4EYP; 4F0N; 4F0O; 4F1A; 4F1B; 4F1C; 4F1D; 4F1F; 4F1G; 4F4T; 4F4V; 4F51; 4F8F; 4FG3; 4FKA; 4GBC; 4GBI; 4GBK; 4GBL; 4GBN; 4I5Y; 4I5Z; 4IDW; 4IHN; 4INS; 4IUZ; 4IYD; 4IYF; 4M4F; 4M4H; 4M4I; 4M4J; 4M4L; 4M4M; 4NIB; 4OGA; 5AIY; 6INS; 6RLX; 7INS; 9INS
» More

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