Entry: PS00269

General information about the entry
Entry name DEFENSIN
Accession number PS00269
Entry type PATTERN
Date APR-1990 (CREATED); OCT-1993 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation PDOC00242
Name and characterization of the entry
DescriptionMammalian defensins signature.
Pattern C-x-C-x(3,5)-C-x(7)-G-x-C-x(9)-C-C.
Numerical results
  • UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052.
  • Total number of hits in UniProtKB/Swiss-Prot: 60 hits in 60 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 59 hits in 59 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 1 hits in 1 different sequences
  • Number of known missed hits: 11
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 2
  • Precision (true hits / (true hits + false positives)): 98.33 %
  • Recall (true hits / (true hits + false negatives)): 84.29 %
Comments
  • Taxonomic range: Eukaryotes
  • Maximum known number of repetitions of the pattern in a single protein: 1
  • `Interesting' site in the pattern: 1,disulfide
  • `Interesting' site in the pattern: 3,disulfide
  • `Interesting' site in the pattern: 5,disulfide
  • `Interesting' site in the pattern: 9,disulfide
  • `Interesting' site in the pattern: 11,disulfide
  • `Interesting' site in the pattern: 12,disulfide
  • VERSION: 1
Cross-references
UniProtKB/Swiss-Prot True positive hits:
DEF1A_CAVPO (P11478), DEF1B_CAVPO (Q64365), DEF1_HUMAN  (P59665), 
DEF1_MACMU  (P60030), DEF1_MESAU  (P81465), DEF1_PANTR  (Q5G863), 
DEF1_PAPHA  (P84757), DEF1_RABIT  (P07469), DEF1_RAT    (Q62716), 
DEF2_CAVPO  (P49112), DEF2_MACMU  (P82317), DEF2_MESAU  (P81466), 
DEF2_RABIT  (P07468), DEF2_RAT    (Q62715), DEF3A_RAT   (Q62713), 
DEF3B_RAT   (Q9Z1F1), DEF3_HUMAN  (P59666), DEF3_MACMU  (P60031), 
DEF3_MESAU  (P81467), DEF3_PAPHA  (P84758), DEF3_RABIT  (P01376), 
DEF4_HUMAN  (P12838), DEF4_MACMU  (P82319), DEF4_MESAU  (P81468), 
DEF4_PANTR  (Q5G862), DEF4_PAPHA  (P86724), DEF4_RABIT  (P01377), 
DEF4_RAT    (Q62714), DEF5_HUMAN  (Q01523), DEF5_PANTR  (Q5G861), 
DEF5_RABIT  (P07467), DEF5_RAT    (P82106), DEF6_HUMAN  (Q01524), 
DEF6_MACMU  (P82320), DEF6_PANTR  (Q5G860), DEF6_RABIT  (P07466), 
DEF7_RABIT  (P80223), DEF8_MACMU  (P60032), DEFA1_MOUSE (P11477), 
DEFA1_ORNAN (P0C8A1), DEFA2_MOUSE (P28309), DEFA2_ORNAN (P0C8A2), 
DEFA3_MOUSE (P28310), DEFA3_ORNAN (P0C8A3), DEFA5_MOUSE (P28312), 
DEFA6_MOUSE (P50704), DEFA7_MOUSE (P50705), DEFA8_MOUSE (P50706), 
DEFA9_MOUSE (P50707), DFA10_MOUSE (P50708), DFA11_MOUSE (P50709), 
DFA13_MOUSE (P50711), DFA14_MOUSE (P50712), DFA15_MOUSE (P50713), 
DFA16_MOUSE (P50714), DFA17_MOUSE (Q64016), DFA23_MOUSE (Q5G866), 
DFA24_MOUSE (Q5G865), DFA26_MOUSE (Q3L180)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
BTDA_PAPAN  (B6ULW4), BTDB_PAPAN  (B6ULW5), BTDC_PAPAN  (B6ULW6), 
BTDD_PAPAN  (B6ULW7), DEF7_PANTR  (Q5G859), DEFA4_MOUSE (P28311), 
DEFA4_ORNAN (P0C8A4), RK1_RABIT   (P81655), RTD1A_MACMU (P82270), 
RTD1B_MACMU (P82271), RTD3_MACMU  (Q9GLR2)
`Potential' hits (partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences):
BTDA_PAPHA  (P86722), BTDB_PAPHA  (P86723)
False positive hits (sequences which do not belong to the set under consideration):
KRUC_SHEEP  (P26372)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]		 1DFN; 1ZMM; 1ZMP; 1ZMQ; 2KHT; 2LXZ; 2PM1; 2PM4; 2PM5; 3GNY; 3H6C; 3HJ2; 3HJD; 3I5W; 3LO1; 3LO2; 3LO4; 3LO6; 3LO9; 3LOE; 3LVX; 3QTE; 4E82; 4E83; 4E86;

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