Entry: PS00287

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General information about the entry

Entry name [info] CYSTATIN
Accession [info] PS00287
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); APR-2006 (DATA UPDATE); JUL-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00259

Name and characterization of the entry

Description [info] Cysteine proteases inhibitors signature.
Pattern [info]
[GSTEQKRV]-Q-[LIVT]-[VAF]-[SAGQ]-G-{DG}-[LIVMNK]-{TK}-x-[LIVMFY]-{S}-
[LIVMFYA]-[DENQKRHSIV].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_08 which contains 546'238 sequence entries.


Total number of hits 110 in 102 different sequences
Number of true positive hits 94 in 86 different sequences
Number of 'unknown' hits
Number of false positive hits 16 in 16 different sequences
Number of false negative sequences 41
Number of 'partial' sequences 6
Precision (true positives / (true positives + false positives)) 85.45 %
Recall (true positives / (true positives + false negatives)) 69.63 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
86 sequences

CPI1_PIG    (P35479), CYT11_ORYSJ (Q6K309), CYT12_ORYSJ (Q0JNR2), 
CYT1_ARATH  (Q945Q1), CYT1_CROAD  (J3RYX9), CYT1_HORVU  (Q9LEI7), 
CYT1_MAIZE  (P31726), CYT1_MOUSE  (P35175), CYT1_ORYSJ  (P09229), 
CYT2_ARATH  (Q8L5T9), CYT2_CROAD  (J3SE80), CYT2_MOUSE  (P35174), 
CYT2_ORYSJ  (P20907), CYT3_ARATH  (Q41906), CYT3_MOUSE  (P35173), 
CYT6_ARATH  (Q8H0X6), CYT6_ORYSJ  (Q10Q46), CYT7_ARATH  (Q8LC76), 
CYT7_ORYSJ  (Q10Q47), CYT8_ORYSJ  (Q10J94), CYTA1_DICDI (Q65YR8), 
CYTA1_PIG   (Q28988), CYTA5_PIG   (Q28986), CYTA8_PIG   (Q28987), 
CYTA_BOVIN  (P80416), CYTA_FELCA  (Q8WNR9), CYTA_HELAN  (Q10992), 
CYTA_HUMAN  (P01040), CYTA_MOUSE  (P56567), CYTA_RAT    (P01039), 
CYTA_SARPE  (P31727), CYTB_BOVIN  (P25417), CYTB_GORGO  (Q76LA0), 
CYTB_HELAN  (Q10993), CYTB_HUMAN  (P04080), CYTB_MACFU  (Q862Z5), 
CYTB_MOUSE  (Q62426), CYTB_PANPA  (P60575), CYTB_PANTR  (Q8I030), 
CYTB_PIG    (Q29290), CYTB_PONPY  (P60576), CYTB_RAT    (P01041), 
CYTB_SHEEP  (Q10994), CYTC_BOVIN  (P01035), CYTC_HUMAN  (P01034), 
CYTC_MACMU  (O19092), CYTC_MOUSE  (P21460), CYTC_RAT    (P14841), 
CYTC_SAISC  (O19093), CYTD_HUMAN  (P28325), CYTI_VIGUN  (Q06445), 
CYTL_DROME  (P23779), CYTL_TACTR  (Q7M429), CYTM_HUMAN  (Q15828), 
CYTM_SOLTU  (P37842), CYTN_HUMAN  (P01037), CYTS_HUMAN  (P01036), 
CYTS_RAT    (P19313), CYTT_HUMAN  (P09228), CYTX_BOVIN  (P35478), 
CYTX_ONCVO  (P22085), CYT_BITAR   (P08935), CYT_BITGA   (Q6T6T4), 
CYT_CHICK   (P01038), CYT_CHIGU   (B1P1J3), CYT_COTJA   (P81061), 
CYT_CYPCA   (P35481), CYT_MICIK   (E3P6P3), CYT_NAJKA   (E3P6P4), 
CYT_NOTSC   (E3P6P2), CYT_ONCKE   (Q98967), CYT_ONCMY   (Q91195), 
CYT_OXYMI   (E3P6N5), CYT_OXYSC   (E3P6N6), CYT_PSEAU   (E3P6N8), 
CYT_PSEPO   (E3P6N7), CYT_PSETE   (E3P6N4), CYT_RHING   (E3P6P1), 
CYT_SOLTU   (Q03196), KNG1_BOVIN  (P01044), KNG1_HUMAN  (P01042), 
KNG1_MOUSE  (O08677), KNG1_RAT    (P08934), KNG2_BOVIN  (P01045), 
KNT1_RAT    (P01048), KNT2_RAT    (P08932)
» More

UniProtKB/Swiss-Prot
False negative sequences
41 sequences

22P1_RAT    (P22282), 22P2_RAT    (P22283), CST11_HUMAN (Q9H112), 
CST11_MOUSE (Q9D269), CST11_RAT   (Q8K5A3), CST12_MOUSE (Q9DAN8), 
CST12_RAT   (Q8VII2), CST13_MOUSE (Q80ZN5), CST14_MOUSE (Q8VII3), 
CST14_RAT   (Q8VIH8), CST15_BOVIN (Q2NKZ5), CST16_BOVIN (Q32KQ9), 
CST1L_HUMAN (Q9H114), CST8_HUMAN  (O60676), CST8_MOUSE  (P32766), 
CST8_RAT    (O88969), CST9L_HUMAN (Q9H4G1), CST9P_HUMAN (Q5W188), 
CST9_BOVIN  (Q29RH0), CST9_HUMAN  (Q5W186), CST9_MOUSE  (Q9Z0H6), 
CYT10_ORYSI (A2XS65), CYT10_ORYSJ (P0C579), CYT1_ACTDE  (Q6TPK4), 
CYT3_ORYSJ  (Q6I570), CYT4_ARATH  (Q84WT8), CYT4_ORYSJ  (Q5N806), 
CYT5_ARATH  (Q41916), CYT5_ORYSJ  (Q0JGM8), CYT9_ORYSJ  (Q10Q48), 
CYTA2_DICDI (Q65YR7), CYTA3_DICDI (Q5R1U3), CYTC_RABIT  (O97862), 
CYTF_HUMAN  (O76096), CYTF_MOUSE  (O89098), CYT_AUSSU   (E3P6N3), 
CYT_NAJAT   (P81714), HRG_HUMAN   (P04196), HRG_MOUSE   (Q9ESB3), 
HRG_RABIT   (Q28640), HRG_RAT     (Q99PS8)
» More

UniProtKB/Swiss-Prot
'Partial' sequences
6 sequences

CPI2_PIG    (P80736), CYT1_ACTCH  (P86472), CYT1_CAPHI  (P84911), 
CYT2_CAPHI  (P84910), CYT3_WISFL  (P19864), CYT_SOYBN   (P25973)
» More

UniProtKB/Swiss-Prot
False positive sequences
16 sequences

ABCB4_DICDI (Q54W24), ADPP_BACSU  (P54570), ATPE_ALCBS  (Q0VKX5), 
HEM1_CAMC5  (A7GYU7), KGUA_BACFN  (Q5L9N9), KGUA_BACFR  (Q64PY1), 
MRAY_ENTFA  (O07107), OADC_PSEMY  (A4XQ41), PP4R2_MOUSE (Q0VGB7), 
SASA_PROMP  (Q7V113), SIP5_COCIM  (Q1DZ34), SYM_METM5   (A4FZL1), 
SYM_METM7   (A6VIW5), SYM_METMP   (Q6M0E5), TICRR_DANRE (Q6DRL4), 
Y1217_OCEIH (Q8ERT3)
» More

PDB
[Detailed view]
30 PDB

1A67; 1A90; 1CEW; 1CYU; 1CYV; 1DVC; 1DVD; 1EQK; 1G96; 1GD3; 1GD4; 1N9J; 1NB3; 1NB5; 1R4C; 1RN7; 1ROA; 1STF; 1TIJ; 1YVB; 2OCT; 3GAX; 3K9M; 3KFQ; 3KSE; 3PS8; 3QRD; 4LZI; 4N6V; 4N6V0
» More

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