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Entry: PS00287

General information about the entry

Entry name [info] CYSTATIN
Accession [info] PS00287
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED; 01-APR-2006 DATA UPDATE; 22-NOV-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC00259

Name and characterization of the entry

Description [info] Cysteine proteases inhibitors signature.
Pattern [info]
[GSTEQKRV]-Q-[LIVT]-[VAF]-[SAGQ]-G-{DG}-[LIVMNK]-{TK}-x-[LIVMFY]-{S}-
[LIVMFYA]-[DENQKRHSIV].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_11 which contains 556'196 sequence entries.


Total number of hits 116 in 108 different sequences
Number of true positive hits 100 in 92 different sequences
Number of 'unknown' hits 0
Number of false positive hits 16 in 16 different sequences
Number of false negative sequences 43
Number of 'partial' sequences 6
Precision (true positives / (true positives + false positives)) 86.21 %
Recall (true positives / (true positives + false negatives)) 69.93 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
92 sequences

CPI1_PIG    (P35479    ), CST10_MOUSE (Q9JM84    ), CYT11_ORYSJ (Q6K309    ), 
CYT12_ORYSJ (Q0JNR2    ), CYT1_ARATH  (Q945Q1    ), CYT1_CROAD  (J3RYX9    ), 
CYT1_HORVU  (Q9LEI7    ), CYT1_MAIZE  (P31726    ), CYT1_MOUSE  (P35175    ), 
CYT1_ORYSJ  (P09229    ), CYT2_ARATH  (Q8L5T9    ), CYT2_CROAD  (J3SE80    ), 
CYT2_MOUSE  (P35174    ), CYT2_ORYSJ  (P20907    ), CYT3_ARATH  (Q41906    ), 
CYT3_MOUSE  (P35173    ), CYT6_ARATH  (Q8H0X6    ), CYT6_ORYSJ  (Q10Q46    ), 
CYT7_ARATH  (Q8LC76    ), CYT7_ORYSJ  (Q10Q47    ), CYT8_ORYSJ  (Q10J94    ), 
CYTA1_DICDI (Q65YR8    ), CYTA1_PIG   (Q28988    ), CYTA5_PIG   (Q28986    ), 
CYTA8_PIG   (Q28987    ), CYTA_BOVIN  (P80416    ), CYTA_FELCA  (Q8WNR9    ), 
CYTA_HELAN  (Q10992    ), CYTA_HUMAN  (P01040    ), CYTA_MOUSE  (P56567    ), 
CYTA_RAT    (P01039    ), CYTA_SARPE  (P31727    ), CYTB_BOVIN  (P25417    ), 
CYTB_GORGO  (Q76LA0    ), CYTB_HELAN  (Q10993    ), CYTB_HUMAN  (P04080    ), 
CYTB_MACFU  (Q862Z5    ), CYTB_MOUSE  (Q62426    ), CYTB_OPLFA  (J7FQE8    ), 
CYTB_PANPA  (P60575    ), CYTB_PANTR  (Q8I030    ), CYTB_PIG    (Q29290    ), 
CYTB_PONPY  (P60576    ), CYTB_RAT    (P01041    ), CYTB_SHEEP  (Q10994    ), 
CYTC_BOVIN  (P01035    ), CYTC_HUMAN  (P01034    ), CYTC_MACMU  (O19092    ), 
CYTC_MOUSE  (P21460    ), CYTC_PAROL  (B2Z450    ), CYTC_RAT    (P14841    ), 
CYTC_SAISC  (O19093    ), CYTD_HUMAN  (P28325    ), CYTI_VIGUN  (Q06445    ), 
CYTL2_IXOSC (B7PKZ1    ), CYTLG_IXOSC (B7PKZ2    ), CYTL_DROME  (P23779    ), 
CYTL_IXOSC  (Q8MVB6    ), CYTL_TACTR  (Q7M429    ), CYTM_HUMAN  (Q15828    ), 
CYTM_SOLTU  (P37842    ), CYTN_HUMAN  (P01037    ), CYTS_HUMAN  (P01036    ), 
CYTS_RAT    (P19313    ), CYTT_HUMAN  (P09228    ), CYTX_BOVIN  (P35478    ), 
CYTX_ONCVO  (P22085    ), CYT_BITAR   (P08935    ), CYT_BITGA   (Q6T6T4    ), 
CYT_CHICK   (P01038    ), CYT_CHIGU   (B1P1J3    ), CYT_COTJA   (P81061    ), 
CYT_CRYNI   (E3P6P1    ), CYT_CYPCA   (P35481    ), CYT_MICIK   (E3P6P3    ), 
CYT_NAJKA   (E3P6P4    ), CYT_NOTSC   (E3P6P2    ), CYT_ONCKE   (Q98967    ), 
CYT_ONCMY   (Q91195    ), CYT_OXYMI   (E3P6N5    ), CYT_OXYSC   (E3P6N6    ), 
CYT_PSEAU   (E3P6N8    ), CYT_PSEPO   (E3P6N7    ), CYT_PSETE   (E3P6N4    ), 
CYT_SOLTU   (Q03196    ), KNG1_BOVIN  (P01044    ), KNG1_HUMAN  (P01042    ), 
KNG1_MOUSE  (O08677    ), KNG1_RAT    (P08934    ), KNG2_BOVIN  (P01045    ), 
KNT1_RAT    (P01048    ), KNT2_RAT    (P08932    )
» more

UniProtKB/Swiss-Prot
False negative sequences
43 sequences

22P1_RAT    (P22282    ), 22P2_RAT    (P22283    ), CST11_HUMAN (Q9H112    ), 
CST11_MOUSE (Q9D269    ), CST11_RAT   (Q8K5A3    ), CST12_MOUSE (Q9DAN8    ), 
CST12_RAT   (Q8VII2    ), CST13_MOUSE (Q80ZN5    ), CST14_MOUSE (Q8VII3    ), 
CST14_RAT   (Q8VIH8    ), CST15_BOVIN (Q2NKZ5    ), CST16_BOVIN (Q32KQ9    ), 
CST8_HUMAN  (O60676    ), CST8_MOUSE  (P32766    ), CST8_RAT    (O88969    ), 
CST9L_HUMAN (Q9H4G1    ), CST9P_HUMAN (Q5W188    ), CST9_BOVIN  (Q29RH0    ), 
CST9_HUMAN  (Q5W186    ), CST9_MOUSE  (Q9Z0H6    ), CSTL1_HUMAN (Q9H114    ), 
CSTL1_MOUSE (Q80Y72    ), CYT10_ORYSI (A2XS65    ), CYT10_ORYSJ (P0C579    ), 
CYT1_ACTDE  (Q6TPK4    ), CYT3_ORYSJ  (Q6I570    ), CYT4_ARATH  (Q84WT8    ), 
CYT4_ORYSJ  (Q5N806    ), CYT5_ARATH  (Q41916    ), CYT5_ORYSJ  (Q0JGM8    ), 
CYT9_ORYSJ  (Q10Q48    ), CYTA2_DICDI (Q65YR7    ), CYTA3_DICDI (Q5R1U3    ), 
CYTB_PAROL  (B2Z449    ), CYTC_RABIT  (O97862    ), CYTF_HUMAN  (O76096    ), 
CYTF_MOUSE  (O89098    ), CYT_AUSSU   (E3P6N3    ), CYT_NAJAT   (P81714    ), 
HRG_HUMAN   (P04196    ), HRG_MOUSE   (Q9ESB3    ), HRG_RABIT   (Q28640    ), 
HRG_RAT     (Q99PS8    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
6 sequences

CPI2_PIG    (P80736    ), CYT1_ACTCH  (P86472    ), CYT1_CAPHI  (P84911    ), 
CYT2_CAPHI  (P84910    ), CYT3_WISFL  (P19864    ), CYT_SOYBN   (P25973    )
» more

UniProtKB/Swiss-Prot
False positive sequences
16 sequences

ABCB4_DICDI (Q54W24    ), ADPP_BACSU  (P54570    ), ATPE_ALCBS  (Q0VKX5    ), 
HEM1_CAMC5  (A7GYU7    ), KGUA_BACFN  (Q5L9N9    ), KGUA_BACFR  (Q64PY1    ), 
MRAY_ENTFA  (O07107    ), OADC_PSEMY  (A4XQ41    ), PP4R2_MOUSE (Q0VGB7    ), 
SASA_PROMP  (Q7V113    ), SIP5_COCIM  (Q1DZ34    ), SYM_METM5   (A4FZL1    ), 
SYM_METM7   (A6VIW5    ), SYM_METMP   (Q6M0E5    ), TICRR_DANRE (Q6DRL4    ), 
Y1217_OCEIH (Q8ERT3    )
» more

PDB
[Detailed view]
37 PDB

1A67; 1A90; 1CEW; 1CYU; 1CYV; 1DVC; 1DVD; 1EQK; 1G96; 1GD3; 1GD4; 1N9J; 1NB3; 1NB5; 1R4C; 1RN7; 1ROA; 1STF; 1TIJ; 1YVB; 2OCT; 3GAX; 3K9M; 3KFQ; 3KSE; 3LH4; 3MWZ; 3PS8; 3QRD; 4LZI; 4N6L; 4N6M; 4N6N; 4N6O; 4N6V; 4TX4; 4ZM8
» more

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission