Entry: PS00287

General information about the entry

Entry name [info] CYSTATIN
Accession [info] PS00287
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); APR-2006 (DATA UPDATE); MAY-2015 (INFO UPDATE).
PROSITE Doc. [info] PDOC00259

Name and characterization of the entry

Description [info] Cysteine proteases inhibitors signature.
Pattern [info]
[GSTEQKRV]-Q-[LIVT]-[VAF]-[SAGQ]-G-{DG}-[LIVMNK]-{TK}-x-[LIVMFY]-{S}-
[LIVMFYA]-[DENQKRHSIV].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2015_07 which contains 548'872 sequence entries.


Total number of hits 110 in 102 different sequences
Number of true positive hits 94 in 86 different sequences
Number of 'unknown' hits 0
Number of false positive hits 16 in 16 different sequences
Number of false negative sequences 41
Number of 'partial' sequences 6
Precision (true positives / (true positives + false positives)) 85.45 %
Recall (true positives / (true positives + false negatives)) 69.63 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
86 sequences

CPI1_PIG    (P35479), CYT11_ORYSJ (Q6K309), CYT12_ORYSJ (Q0JNR2), 
CYT1_ARATH  (Q945Q1), CYT1_CROAD  (J3RYX9), CYT1_HORVU  (Q9LEI7), 
CYT1_MAIZE  (P31726), CYT1_MOUSE  (P35175), CYT1_ORYSJ  (P09229), 
CYT2_ARATH  (Q8L5T9), CYT2_CROAD  (J3SE80), CYT2_MOUSE  (P35174), 
CYT2_ORYSJ  (P20907), CYT3_ARATH  (Q41906), CYT3_MOUSE  (P35173), 
CYT6_ARATH  (Q8H0X6), CYT6_ORYSJ  (Q10Q46), CYT7_ARATH  (Q8LC76), 
CYT7_ORYSJ  (Q10Q47), CYT8_ORYSJ  (Q10J94), CYTA1_DICDI (Q65YR8), 
CYTA1_PIG   (Q28988), CYTA5_PIG   (Q28986), CYTA8_PIG   (Q28987), 
CYTA_BOVIN  (P80416), CYTA_FELCA  (Q8WNR9), CYTA_HELAN  (Q10992), 
CYTA_HUMAN  (P01040), CYTA_MOUSE  (P56567), CYTA_RAT    (P01039), 
CYTA_SARPE  (P31727), CYTB_BOVIN  (P25417), CYTB_GORGO  (Q76LA0), 
CYTB_HELAN  (Q10993), CYTB_HUMAN  (P04080), CYTB_MACFU  (Q862Z5), 
CYTB_MOUSE  (Q62426), CYTB_PANPA  (P60575), CYTB_PANTR  (Q8I030), 
CYTB_PIG    (Q29290), CYTB_PONPY  (P60576), CYTB_RAT    (P01041), 
CYTB_SHEEP  (Q10994), CYTC_BOVIN  (P01035), CYTC_HUMAN  (P01034), 
CYTC_MACMU  (O19092), CYTC_MOUSE  (P21460), CYTC_RAT    (P14841), 
CYTC_SAISC  (O19093), CYTD_HUMAN  (P28325), CYTI_VIGUN  (Q06445), 
CYTL_DROME  (P23779), CYTL_TACTR  (Q7M429), CYTM_HUMAN  (Q15828), 
CYTM_SOLTU  (P37842), CYTN_HUMAN  (P01037), CYTS_HUMAN  (P01036), 
CYTS_RAT    (P19313), CYTT_HUMAN  (P09228), CYTX_BOVIN  (P35478), 
CYTX_ONCVO  (P22085), CYT_BITAR   (P08935), CYT_BITGA   (Q6T6T4), 
CYT_CHICK   (P01038), CYT_CHIGU   (B1P1J3), CYT_COTJA   (P81061), 
CYT_CYPCA   (P35481), CYT_MICIK   (E3P6P3), CYT_NAJKA   (E3P6P4), 
CYT_NOTSC   (E3P6P2), CYT_ONCKE   (Q98967), CYT_ONCMY   (Q91195), 
CYT_OXYMI   (E3P6N5), CYT_OXYSC   (E3P6N6), CYT_PSEAU   (E3P6N8), 
CYT_PSEPO   (E3P6N7), CYT_PSETE   (E3P6N4), CYT_RHING   (E3P6P1), 
CYT_SOLTU   (Q03196), KNG1_BOVIN  (P01044), KNG1_HUMAN  (P01042), 
KNG1_MOUSE  (O08677), KNG1_RAT    (P08934), KNG2_BOVIN  (P01045), 
KNT1_RAT    (P01048), KNT2_RAT    (P08932)
» More

UniProtKB/Swiss-Prot
False negative sequences
41 sequences

22P1_RAT    (P22282), 22P2_RAT    (P22283), CST11_HUMAN (Q9H112), 
CST11_MOUSE (Q9D269), CST11_RAT   (Q8K5A3), CST12_MOUSE (Q9DAN8), 
CST12_RAT   (Q8VII2), CST13_MOUSE (Q80ZN5), CST14_MOUSE (Q8VII3), 
CST14_RAT   (Q8VIH8), CST15_BOVIN (Q2NKZ5), CST16_BOVIN (Q32KQ9), 
CST1L_HUMAN (Q9H114), CST8_HUMAN  (O60676), CST8_MOUSE  (P32766), 
CST8_RAT    (O88969), CST9L_HUMAN (Q9H4G1), CST9P_HUMAN (Q5W188), 
CST9_BOVIN  (Q29RH0), CST9_HUMAN  (Q5W186), CST9_MOUSE  (Q9Z0H6), 
CYT10_ORYSI (A2XS65), CYT10_ORYSJ (P0C579), CYT1_ACTDE  (Q6TPK4), 
CYT3_ORYSJ  (Q6I570), CYT4_ARATH  (Q84WT8), CYT4_ORYSJ  (Q5N806), 
CYT5_ARATH  (Q41916), CYT5_ORYSJ  (Q0JGM8), CYT9_ORYSJ  (Q10Q48), 
CYTA2_DICDI (Q65YR7), CYTA3_DICDI (Q5R1U3), CYTC_RABIT  (O97862), 
CYTF_HUMAN  (O76096), CYTF_MOUSE  (O89098), CYT_AUSSU   (E3P6N3), 
CYT_NAJAT   (P81714), HRG_HUMAN   (P04196), HRG_MOUSE   (Q9ESB3), 
HRG_RABIT   (Q28640), HRG_RAT     (Q99PS8)
» More

UniProtKB/Swiss-Prot
'Partial' sequences
6 sequences

CPI2_PIG    (P80736), CYT1_ACTCH  (P86472), CYT1_CAPHI  (P84911), 
CYT2_CAPHI  (P84910), CYT3_WISFL  (P19864), CYT_SOYBN   (P25973)
» More

UniProtKB/Swiss-Prot
False positive sequences
16 sequences

ABCB4_DICDI (Q54W24), ADPP_BACSU  (P54570), ATPE_ALCBS  (Q0VKX5), 
HEM1_CAMC5  (A7GYU7), KGUA_BACFN  (Q5L9N9), KGUA_BACFR  (Q64PY1), 
MRAY_ENTFA  (O07107), OADC_PSEMY  (A4XQ41), PP4R2_MOUSE (Q0VGB7), 
SASA_PROMP  (Q7V113), SIP5_COCIM  (Q1DZ34), SYM_METM5   (A4FZL1), 
SYM_METM7   (A6VIW5), SYM_METMP   (Q6M0E5), TICRR_DANRE (Q6DRL4), 
Y1217_OCEIH (Q8ERT3)
» More

PDB
[Detailed view]
34 PDB

1A67; 1A90; 1CEW; 1CYU; 1CYV; 1DVC; 1DVD; 1EQK; 1G96; 1GD3; 1GD4; 1N9J; 1NB3; 1NB5; 1R4C; 1RN7; 1ROA; 1STF; 1TIJ; 1YVB; 2OCT; 3GAX; 3K9M; 3KFQ; 3KSE; 3PS8; 3QRD; 4LZI; 4N6L; 4N6M; 4N6N; 4N6O; 4N6V; 4N6V0
» More

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