Entry: PS00288

General information about the entry
Entry name TIMP
Accession number PS00288
Entry type PATTERN
Date APR-1990 (CREATED); JUL-1999 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation PDOC00260
Name and characterization of the entry
DescriptionTissue inhibitors of metalloproteinases signature.
Pattern C-x-C-x-P-x-H-P-Q-x(2)-[FIV]-C.
Numerical results
  • UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052.
  • Total number of hits in UniProtKB/Swiss-Prot: 33 hits in 33 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 33 hits in 33 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 0 hits in 0 different sequences
  • Number of known missed hits: 4
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 2
  • Precision (true hits / (true hits + false positives)): 100.00 %
  • Recall (true hits / (true hits + false negatives)): 89.19 %
Comments
  • Taxonomic range: Eukaryotes
  • Maximum known number of repetitions of the pattern in a single protein: 1
  • `Interesting' site in the pattern: 1,disulfide
  • `Interesting' site in the pattern: 3,disulfide
  • `Interesting' site in the pattern: 12,disulfide
  • VERSION: 1
Cross-references
UniProtKB/Swiss-Prot True positive hits:
TIMP1_BOVIN (P20414), TIMP1_HORSE (O02722), TIMP1_HUMAN (P01033), 
TIMP1_MOUSE (P12032), TIMP1_PAPCY (P49061), TIMP1_PIG   (P35624), 
TIMP1_PONAB (Q5RC60), TIMP1_RABIT (P20614), TIMP1_RAT   (P30120), 
TIMP1_SHEEP (P50122), TIMP2_BOVIN (P16368), TIMP2_CANFA (Q9TTY1), 
TIMP2_CAVPO (Q9WUC6), TIMP2_CHICK (O42146), TIMP2_CRILO (Q60453), 
TIMP2_HUMAN (P16035), TIMP2_MOUSE (P25785), TIMP2_RABIT (Q9TRZ7), 
TIMP2_RAT   (P30121), TIMP3_BOVIN (P79121), TIMP3_CHICK (P26652), 
TIMP3_HORSE (Q9TUL9), TIMP3_HUMAN (P35625), TIMP3_MACFA (P61269), 
TIMP3_MACMU (Q5PXZ9), TIMP3_MOUSE (P39876), TIMP3_RAT   (P48032), 
TIMP3_SCYTO (Q9W6B4), TIMP3_XENLA (O73746), TIMP4_BOVIN (O97563), 
TIMP4_HUMAN (Q99727), TIMP4_MOUSE (Q9JHB3), TIMP4_RAT   (P81556)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
TIMP1_CANFA (P81546), TIMP1_MACMU (Q95KL9), TIMPL_CAEEL (Q21265), 
TIMP_DROME  (Q9VH14)
`Potential' hits (partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences):
TIMP3_RABIT (O97590), TIMP4_RABIT (O97591)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]		 1BQQ; 1BR9; 1BUV; 1D2B; 1GXD; 1LQN; 1OO9; 1UEA; 2E2D; 2J0T; 2TMP; 3CKI; 3MA2; 3V96;

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