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Entry: PS00318
General information about the entry
Entry nameHMG_COA_REDUCTASE_2
Accession numberPS00318
Entry typePATTERN
DateAPR-1990 (CREATED); APR-1990 (DATA UPDATE); DEC-2011 (INFO UPDATE).
PROSITE DocumentationPDOC00064
Name and characterization of the entry
DescriptionHydroxymethylglutaryl-coenzyme A reductases signature 2.
Pattern[LIVM]-G-x-[LIVM]-G-G-[AG]-T.
Numerical results
  • UniProtKB/Swiss-Prot release number: 01, total number of sequence entries in that release: 534242.
  • Total number of hits in UniProtKB/Swiss-Prot: 74 hits in 74 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 51 hits in 51 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 23 hits in 23 different sequences
  • Number of known missed hits: 2
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0
  • Precision (true hits / (true hits + false positives)): 68.92 %
  • Recall (true hits / (true hits + false negatives)): 96.23 %
Comments
  • Taxonomic range: Archaebacteria, Eukaryotes, Prokaryotes (Bacteria)
  • Maximum known number of repetitions of the pattern in a single protein: 1
  • VERSION: 1
Cross-references
UniProtKB/Swiss-ProtTrue positive hits:
HMDH1_ARATH (P14891), HMDH1_DICDI (P34135), HMDH1_GOSHI (O64966), 
HMDH1_HEVBR (P29057), HMDH1_ORYSI (A2X8W3), HMDH1_ORYSJ (Q0DY59), 
HMDH1_SOLTU (P48020), HMDH1_YEAST (P12683), HMDH2_ARATH (P43256), 
HMDH2_CAPAN (Q9XEL8), HMDH2_DICDI (P34136), HMDH2_GOSHI (O64967), 
HMDH2_HEVBR (P29058), HMDH2_SOLLC (P48022), HMDH2_SOLTU (Q41437), 
HMDH2_YEAST (P12684), HMDH3_HEVBR (Q00583), HMDH3_ORYSJ (Q9XHL5), 
HMDH3_SOLTU (Q41438), HMDH_AERPE  (Q9YAS4), HMDH_AGRIP  (O76819), 
HMDH_ARCFU  (O28538), HMDH_ASPTE  (Q9Y7D2), HMDH_ASPTN  (Q0C8L9), 
HMDH_BLAGE  (P54960), HMDH_CAMAC  (P48021), HMDH_CATRO  (Q03163), 
HMDH_CRIGR  (P00347), HMDH_CYBJA  (O74164), HMDH_DROME  (P14773), 
HMDH_GIBFU  (Q12577), HMDH_HALVD  (Q59468), HMDH_HUMAN  (P04035), 
HMDH_MAIZE  (O24594), HMDH_MESAU  (P09610), HMDH_METJA  (Q58116), 
HMDH_MOUSE  (Q01237), HMDH_NICSY  (Q01559), HMDH_PHYBL  (Q12649), 
HMDH_PIG    (Q1W675), HMDH_PONAB  (Q5R6N3), HMDH_PYRAB  (Q9V1R3), 
HMDH_PYRHO  (O59469), HMDH_RABIT  (Q29512), HMDH_RAT    (P51639), 
HMDH_SCHMA  (P16237), HMDH_SCHPO  (Q10283), HMDH_STRPU  (P16393), 
HMDH_SULSO  (O08424), HMDH_XENLA  (P20715), MVAA_PSEMV  (P13702)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
HMDH_BORBU  (O51628), HMDH_METTH  (O26662)
False positive hits (sequences which do not belong to the set under consideration):
AMIC_STRPN  (P0A4M7), AMIC_STRR6  (P0A4M8), ARO1_SCLS1  (A7F7H0), 
ARO1_SCLSC  (Q5XNP0), C3390_DROME (Q7KT91), CDX4_HUMAN  (O14627), 
CND1_MOUSE  (Q8K2Z4), DHOM_METGL  (P37143), DHOM_PSEAE  (P29365), 
DHON_METGL  (P37144), GBA2_HUMAN  (Q9HCG7), GBA2_MOUSE  (Q69ZF3), 
GBA2_RAT    (Q5M868), INIB_MYCTU  (O06292), MSRA_LACSA  (Q9SEC2), 
MURC_ERYLH  (Q2NCY9), NU4C_SYNPW  (A5GP41), SECY_METJA  (Q60175), 
SIGJ_DICDI  (Q6TMJ3), SYY_MESFL   (Q6F0M8), SYY_STRAW   (Q829F2), 
THIM_DESDA  (B8J4C1), Y3023_ACIAD (P70736)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]		1DQ8; 1DQ9; 1DQA; 1HW8; 1HW9; 1HWI; 1HWJ; 1HWK; 1HWL; 1QAX; 1QAY; 1R31; 1R7I; 1T02; 2Q1L; 2Q6B; 2Q6C; 2R4F; 3BGL; 3CCT; 3CCW; 3CCZ; 3CD0; 3CD5; 3CD7; 3CDA; 3CDB;

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