Entry: PS00383

General information about the entry

Entry name [info] TYR_PHOSPHATASE_1
Accession [info] PS00383
Entry type [info] PATTERN
Date [info] NOV-1990 (CREATED); AUG-2007 (DATA UPDATE); FEB-2015 (INFO UPDATE).
PROSITE Doc. [info] PDOC00323
Associated ProRule [info] PRU10044

Name and characterization of the entry

Description [info] Tyrosine specific protein phosphatases active site.
Pattern [info]
[LIVMF]-H-C-x(2)-G-x(2)-R-[STC]-[STAGP].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2015_04 which contains 548'208 sequence entries.


Total number of hits 355 in 326 different sequences
Number of true positive hits 343 in 314 different sequences
Number of 'unknown' hits
Number of false positive hits 12 in 12 different sequences
Number of false negative sequences 81
Number of 'partial' sequences 27
Precision (true positives / (true positives + false positives)) 96.62 %
Recall (true positives / (true positives + false negatives)) 80.90 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 2
Site [info] active_site at position 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
314 sequences

123R_IIV6   (O55737), CC14A_HUMAN (Q9UNH5), CC14A_MOUSE (Q6GQT0), 
CC14B_HUMAN (O60729), CC14B_MOUSE (Q6PFY9), CC14C_HUMAN (A4D256), 
CC14C_HYLSY (A6N3Q4), CDC14_CAEEL (P81299), CDC14_CANAL (Q59NH8), 
CDC14_EMENI (Q5B323), CDC14_YEAST (Q00684), CNRN_DICDI  (Q54JL7), 
CPP1_CANAL  (Q5APU2), CSW_DROME   (P29349), CSW_DROSI   (Q8ISC9), 
CSW_DROVI   (Q24708), DPHS1_ARATH (Q75QN6), DS13A_HUMAN (Q6B8I1), 
DS13A_MOUSE (Q6B8I0), DS13B_HUMAN (Q9UII6), DS13B_MOUSE (Q9QYJ7), 
DS22A_DANRE (Q1LWL2), DSP8_ARATH  (Q9ZQP1), DUPD1_ANOCA (P0C598), 
DUPD1_BOVIN (P0C591), DUPD1_CALMI (P0C5A2), DUPD1_CHICK (P0C597), 
DUPD1_DANRE (Q29RA3), DUPD1_GASAC (P0C5A0), DUPD1_HORSE (P0C592), 
DUPD1_HUMAN (Q68J44), DUPD1_MONDO (P0C593), DUPD1_MOUSE (Q8BK84), 
DUPD1_ORYLA (P0C5A1), DUPD1_PANTR (P0C594), DUPD1_PIG   (P0C596), 
DUPD1_RAT   (P0C595), DUPD1_TAKRU (P0C599), DUPD1_TETNG (Q4RQD3), 
DUS10_BOVIN (Q0IID7), DUS10_HUMAN (Q9Y6W6), DUS10_MOUSE (Q9ESS0), 
DUS11_BOVIN (Q5E999), DUS11_HUMAN (O75319), DUS11_MOUSE (Q6NXK5), 
DUS11_RAT   (Q4KM79), DUS14_BOVIN (Q17QM8), DUS14_HUMAN (O95147), 
DUS14_MOUSE (Q9JLY7), DUS15_HUMAN (Q9H1R2), DUS15_MOUSE (Q8R4V2), 
DUS16_HUMAN (Q9BY84), DUS18_BOVIN (Q5BIP9), DUS18_HUMAN (Q8NEJ0), 
DUS18_MOUSE (Q8VE01), DUS18_PONAB (Q5R8X2), DUS18_RAT   (Q6AXW7), 
DUS1A_XENLA (Q91790), DUS1B_XENLA (Q90W58), DUS1_HUMAN  (P28562), 
DUS1_MOUSE  (P28563), DUS1_RAT    (Q64623), DUS21_HUMAN (Q9H596), 
DUS21_MOUSE (Q9D9D8), DUS23_HUMAN (Q9BVJ7), DUS23_MOUSE (Q6NT99), 
DUS26_BOVIN (Q17QJ3), DUS26_HUMAN (Q9BV47), DUS26_MOUSE (Q9D700), 
DUS26_PONAB (Q5R6H6), DUS26_RAT   (Q5FVI9), DUS2_HUMAN  (Q05923), 
DUS2_MOUSE  (Q05922), DUS3_HUMAN  (P51452), DUS3_MOUSE  (Q9D7X3), 
DUS3_PONAB  (Q5RD73), DUS4_CHICK  (Q9PW71), DUS4_HUMAN  (Q13115), 
DUS4_MOUSE  (Q8BFV3), DUS4_RAT    (Q62767), DUS5_HUMAN  (Q16690), 
DUS5_RAT    (O54838), DUS8_HUMAN  (Q13202), DUS8_MOUSE  (O09112), 
DUSP1_DICDI (Q55E39), DUSP2_DICDI (Q54R42), DUSP3_DICDI (Q55BI8), 
DUSP4_DICDI (Q54T76), DUSPR_DICDI (Q556Y8), DUSP_FOWPN  (Q9J592), 
DUSP_MYXVL  (Q85297), DUSP_RACVI  (P80994), DUSP_VACCC  (P20495), 
DUSP_VACCW  (P07239), DUSP_VAR67  (P33064), EPM2A_CANFA (Q1M199), 
EPM2A_HUMAN (O95278), EPM2A_MOUSE (Q9WUA5), EPM2A_RAT   (Q91XQ2), 
FLP1_SCHPO  (Q9P7H1), HOPD2_PSESM (Q79LY0), IBR5_ARATH  (Q84JU4), 
IPHP_NOSCO  (Q05918), LAR_CAEEL   (Q9BMN8), LAR_DROME   (P16621), 
MCE1_CAEEL  (Q17607), MCE1_DANRE  (Q6NY98), MCE1_HUMAN  (O60942), 
MCE1_MOUSE  (O55236), MKP1_ARATH  (Q9C5S1), MPL1_DICDI  (Q55CS7), 
MPL2_DICDI  (Q55CS8), MPL3_DICDI  (Q54Y32), MSG5_YEAST  (P38590), 
MTM1_BOVIN  (A6QLT4), MTM1_HUMAN  (Q13496), MTM1_MOUSE  (Q9Z2C5), 
MTM1_PONAB  (Q5R9S3), MTM1_RAT    (Q6AXQ4), MTM1_XENLA  (Q52KU6), 
MTM1_XENTR  (Q5EB32), MTMR1_HUMAN (Q13613), MTMR1_MOUSE (Q9Z2C4), 
MTMR2_BOVIN (A6QLT2), MTMR2_CHICK (Q5ZIV1), MTMR2_DANRE (A0JMK5), 
MTMR2_HUMAN (Q13614), MTMR2_MOUSE (Q9Z2D1), MTMR2_PONAB (Q5REB9), 
MTMR3_CAEEL (Q22712), MTMR3_HUMAN (Q13615), MTMR3_MOUSE (Q8K296), 
MTMR3_RAT   (Q5PQT2), MTMR4_HUMAN (Q9NYA4), MTMR4_MOUSE (Q91XS1), 
MTMR4_XENLA (Q7ZXF1), MTMR6_HUMAN (Q9Y217), MTMR6_MOUSE (Q8VE11), 
MTMR7_HUMAN (Q9Y216), MTMR7_MOUSE (Q9Z2C9), MTMR7_PONAB (Q5R6F6), 
MTMR8_CHICK (Q5F452), MTMR8_DANRE (Q6TEL0), MTMR8_HUMAN (Q96EF0), 
MYTM1_ARATH (F4J3T8), MYTM2_ARATH (F4JWB3), PPS1_YEAST  (P38148), 
PRPTZ_MOUSE (B9EKR1), PTEN_DICDI  (Q8T9S7), PTN11_CHICK (Q90687), 
PTN11_HUMAN (Q06124), PTN11_MOUSE (P35235), PTN11_RAT   (P41499), 
PTN12_HUMAN (Q05209), PTN12_MOUSE (P35831), PTN14_HUMAN (Q15678), 
PTN14_MOUSE (Q62130), PTN18_HUMAN (Q99952), PTN18_MOUSE (Q61152), 
PTN1_CHICK  (O13016), PTN1_HUMAN  (P18031), PTN1_MOUSE  (P35821), 
PTN1_RAT    (P20417), PTN20_HUMAN (Q4JDL3), PTN20_MOUSE (O55082), 
PTN20_RAT   (A1L1L3), PTN21_HUMAN (Q16825), PTN21_MOUSE (Q62136), 
PTN21_RAT   (Q62728), PTN22_HUMAN (Q9Y2R2), PTN22_MOUSE (P29352), 
PTN23_HUMAN (Q9H3S7), PTN23_MOUSE (Q6PB44), PTN23_RAT   (O88902), 
PTN2_HUMAN  (P17706), PTN2_MOUSE  (Q06180), PTN2_RAT    (P35233), 
PTN3_HUMAN  (P26045), PTN3_MOUSE  (A2ALK8), PTN4_HUMAN  (P29074), 
PTN4_MOUSE  (Q9WU22), PTN5_HUMAN  (P54829), PTN5_MOUSE  (P54830), 
PTN5_RAT    (P35234), PTN6_HUMAN  (P29350), PTN6_MOUSE  (P29351), 
PTN6_RAT    (P81718), PTN7_HUMAN  (P35236), PTN7_MOUSE  (Q8BUM3), 
PTN7_RAT    (P49445), PTN9_HUMAN  (P43378), PTN9_MOUSE  (O35239), 
PTN9_RAT    (Q641Z2), PTP10_DROME (P35992), PTP1_ARATH  (O82656), 
PTP1_CAEEL  (P28191), PTP1_DICDI  (P34137), PTP1_YEAST  (P25044), 
PTP2_DICDI  (P34138), PTP2_NPVOP  (O10273), PTP2_YEAST  (P29461), 
PTP3_CHLMO  (Q39491), PTP3_DICDI  (P54637), PTP3_YEAST  (P40048), 
PTP4_CAEEL  (P28192), PTP5_CAEEL  (P34442), PTP61_DROME (Q9W0G1), 
PTP69_DROME (P16620), PTP99_DROME (P35832), PTPC1_BOVIN (A7E379), 
PTPC1_DANRE (A1L1R5), PTPC1_HUMAN (A2A3K4), PTPC1_MOUSE (Q6NZK8), 
PTPH2_MDBVW (Q5I146), PTPH3_MDBVW (Q5I145), PTPH4_MDBVW (Q5I143), 
PTPH_AMEPV  (Q9EMX1), PTPM1_DROME (Q86BN8), PTPM1_HUMAN (Q8WUK0), 
PTPM1_MOUSE (Q66GT5), PTPM1_RAT   (P0C089), PTPR2_HUMAN (Q92932), 
PTPR2_MACNE (O02695), PTPR2_MOUSE (P80560), PTPR2_RAT   (Q63475), 
PTPRA_HUMAN (P18433), PTPRA_MOUSE (P18052), PTPRA_RAT   (Q03348), 
PTPRB_HUMAN (P23467), PTPRB_MOUSE (B2RU80), PTPRC_CYPCA (Q9IBD8), 
PTPRC_HUMAN (P08575), PTPRC_MOUSE (P06800), PTPRC_RAT   (P04157), 
PTPRD_HUMAN (P23468), PTPRD_MOUSE (Q64487), PTPRE_HUMAN (P23469), 
PTPRE_MOUSE (P49446), PTPRE_RAT   (B2GV87), PTPRF_BOVIN (A7MBJ4), 
PTPRF_DANRE (A4IFW2), PTPRF_HUMAN (P10586), PTPRF_MOUSE (A2A8L5), 
PTPRF_RAT   (Q64604), PTPRG_CHICK (Q98936), PTPRG_HUMAN (P23470), 
PTPRG_MOUSE (Q05909), PTPRH_HUMAN (Q9HD43), PTPRJ_CHICK (Q9W6V5), 
PTPRJ_HUMAN (Q12913), PTPRJ_MOUSE (Q64455), PTPRK_HUMAN (Q15262), 
PTPRK_MOUSE (P35822), PTPRM_HUMAN (P28827), PTPRM_MOUSE (P28828), 
PTPRN_BOVIN (P56722), PTPRN_HUMAN (Q16849), PTPRN_MOUSE (Q60673), 
PTPRN_RAT   (Q63259), PTPRO_HUMAN (Q16827), PTPRO_MOUSE (E9Q612), 
PTPRQ_HUMAN (Q9UMZ3), PTPRQ_MOUSE (P0C5E4), PTPRQ_RAT   (O88488), 
PTPRR_HUMAN (Q15256), PTPRR_MOUSE (Q62132), PTPRR_RAT   (O08617), 
PTPRS_HUMAN (Q13332), PTPRS_MOUSE (B0V2N1), PTPRS_RAT   (Q64605), 
PTPRT_HUMAN (O14522), PTPRT_MOUSE (Q99M80), PTPRU_CHICK (Q6YI48), 
PTPRU_DANRE (B3DK56), PTPRU_HUMAN (Q92729), PTPRU_MOUSE (B1AUH1), 
PTPRV_MOUSE (P70289), PTPRV_RAT   (Q64612), PTPRZ_HUMAN (P23471), 
PTPRZ_RAT   (Q62656), PTPR_CAEEL  (H2KZM6), PTPX_CANAW  (P43078), 
PTP_NPVAC   (P24656), PYP1_SCHPO  (P27574), PYP2_SCHPO  (P32586), 
PYP3_SCHPO  (P32587), SDP1_YEAST  (P40479), SIW14_YEAST (P53965), 
SPTP_SALPA  (Q5PEA9), SPTP_SALTI  (P74851), SPTP_SALTY  (P74873), 
SSH1_HUMAN  (Q8WYL5), SSH1_MOUSE  (Q76I79), SSH2_HUMAN  (Q76I76), 
SSH2_MOUSE  (Q5SW75), SSH3_HUMAN  (Q8TE77), SSH3_MOUSE  (Q8K330), 
SSH3_RAT    (Q5XIS1), SSH_DROME   (Q6NN85), SSH_XENLA   (Q6IVY4), 
TP4AB_DICDI (Q86IL4), VF197_IIV3  (Q196Z3), VF197_IIV6  (Q91FX3), 
VHP1_CAEEL  (Q10038), Y1500_ARATH (Q9ZVN4), Y669_CUPNH  (P40289), 
YAV4_XANCP  (P0A0W0), YAV4_XANEU  (P0A0W1), YMR1_SCHPO  (O13819), 
YMR1_YEAST  (P47147), YNBD_ECOLI  (P76093), YNF3_SCHPO  (Q9UUF3), 
YOPH_YEREN  (P15273), YOPH_YERPS  (P08538)
» More

UniProtKB/Swiss-Prot
False negative sequences
81 sequences

CDKN3_HUMAN (Q16667), D1060_DICDI (Q1ZXG8), DS22B_DANRE (Q566R7), 
DSP4_ARATH  (Q9FEB5), DSP4_CASSA  (G4LTX4), DUPD1_XENLA (Q4KL92), 
DUPD1_XENTR (A4IHU7), DUS12_HUMAN (Q9UNI6), DUS12_MOUSE (Q9D0T2), 
DUS12_RAT   (Q9JIM4), DUS19_HUMAN (Q8WTR2), DUS19_MOUSE (Q8K4T5), 
DUS22_HUMAN (Q9NRW4), DUS22_MOUSE (Q99N11), DUS22_XENLA (Q6GQJ8), 
DUS22_XENTR (Q5XHB2), DUS27_HUMAN (Q5VZP5), DUS27_MOUSE (Q148W8), 
DUS28_HUMAN (Q4G0W2), DUS28_MOUSE (Q8BTR5), DUS6_BOVIN  (Q2KJ36), 
DUS6_HUMAN  (Q16828), DUS6_MOUSE  (Q9DBB1), DUS6_RAT    (Q64346), 
DUS7_HUMAN  (Q16829), DUS7_MOUSE  (Q91Z46), DUS7_RAT    (Q63340), 
DUS9_HUMAN  (Q99956), LSF1_ARATH  (F4J117), LSF2_ARATH  (Q9SRK5), 
MTMRC_DANRE (A2BGG1), MTMRC_HUMAN (Q9C0I1), MTMRC_MOUSE (Q80TA6), 
MTMRC_PONAB (Q5R989), MTMRC_RAT   (Q5FVM6), MTMR_DICDI  (Q54GQ1), 
OCA1_ASHGO  (Q75B37), OCA1_CANAL  (Q59XY9), OCA1_CANGA  (Q6FSZ8), 
OCA1_DEBHA  (Q6BLZ8), OCA1_KLULA  (Q6CTE4), OCA1_PICGU  (A5DE24), 
OCA1_PICST  (A3LW52), OCA1_USTMA  (Q4P7L6), OCA1_YARLI  (Q6C4X9), 
OCA1_YEAS7  (A6ZRY1), OCA1_YEAST  (P50946), OCA6_YEAST  (Q12454), 
PMP1_SCHPO  (O13453), PTN13_HUMAN (Q12923), PTN13_MOUSE (Q64512), 
PTP1_NPVOP  (O10274), PTPD1_MDBVW (Q5I154), PTPH1_MDBVW (Q5I147), 
PTPH5_MDBVW (Q5I142), PTPH_MIMIV  (Q5UR74), PTPJ1_MDBVW (Q5I141), 
PTPJ2_MDBVW (Q5I139), PTPJ3_MDBVW (Q5I138), PTPJ4_MDBVW (Q5I137), 
PTPN1_MDBVW (Q5I128), PTPN2_MDBVW (Q5I127), PTPN3_MDBVW (Q5I124), 
PVH1_SCHPO  (O13632), PVH1_YEAST  (Q02256), TP4A1_HUMAN (Q93096), 
TP4A1_MACFA (Q9TSM6), TP4A1_MOUSE (Q63739), TP4A1_PONAB (Q5R7J8), 
TP4A1_RAT   (Q78EG7), TP4A2_HUMAN (Q12974), TP4A2_MOUSE (O70274), 
TP4A2_RAT   (Q6P9X4), TP4A3_BOVIN (A2VDT1), TP4A3_HUMAN (O75365), 
TP4A3_MOUSE (Q9D658), TP4AA_DICDI (Q54DU9), Y7071_DICDI (Q550K8), 
YK13_CAEEL  (P34337), YKCA_CAEEL  (P42083), YO42_CAEEL  (P34680)
» More

UniProtKB/Swiss-Prot
'Partial' sequences
27 sequences

PTP10_STYPL (P28202), PTP11_STYPL (P28203), PTP12_STYPL (P28204), 
PTP13_STYPL (P28205), PTP14_STYPL (P28206), PTP15_STYPL (P28207), 
PTP16_STYPL (P28208), PTP17_STYPL (P28209), PTP18_STYPL (P28210), 
PTP19_STYPL (P28211), PTP1_STYPL  (P28193), PTP20_STYPL (P28212), 
PTP21_STYPL (P28213), PTP22_STYPL (P28214), PTP23_STYPL (P28215), 
PTP24_STYPL (P28216), PTP25_STYPL (P28217), PTP26_STYPL (P28218), 
PTP27_STYPL (P28219), PTP2_STYPL  (P28194), PTP3_STYPL  (P28195), 
PTP4_STYPL  (P28196), PTP5_STYPL  (P28197), PTP6_STYPL  (P28198), 
PTP7_STYPL  (P28199), PTP8_STYPL  (P28200), PTP9_STYPL  (P28201)
» More

UniProtKB/Swiss-Prot
False positive sequences
12 sequences

MTMRE_HUMAN (Q8NCE2), MTMRE_MOUSE (Q8VEL2), P64_BYVU    (Q08541), 
PTEN_CANFA  (P60483), PTEN_HUMAN  (P60484), PTEN_MOUSE  (O08586), 
PTEN_SCHPO  (O94526), PTEN_XENLA  (Q9PUT6), TEP1_YEAST  (P53916), 
TPTE2_HUMAN (Q6XPS3), TPTE2_MACFA (Q4R6N0), TPTE_HUMAN  (P56180)
» More

PDB
[Detailed view]
241 PDB

1BZC; 1BZH; 1BZJ; 1C83; 1C84; 1C85; 1C86; 1C87; 1C88; 1ECV; 1G4U; 1G4W; 1G7F; 1G7G; 1GFY; 1GWZ; 1I9S; 1JF7; 1JLN; 1KAK; 1KAV; 1L8G; 1L8K; 1LAR; 1LQF; 1NL9; 1NNY; 1NO6; 1NWE; 1NWL; 1NZ7; 1OEM; 1OES; 1OHC; 1OHD; 1ONY; 1ONZ; 1P15; 1PA9; 1PH0; 1PXH; 1PYN; 1Q1M; 1Q6J; 1Q6M; 1Q6N; 1Q6P; 1Q6S; 1Q6T; 1QXK; 1RPM; 1SUG; 1T48; 1T49; 1T4J; 1VHR; 1WAX; 1XBO; 1XRI; 1XXV; 1YFO; 1YN9; 1YPT; 1YTN; 1YTW; 1ZC0; 1ZZW; 2A3K; 2A8B; 2AHS; 2AZR; 2B07; 2B3O; 2B49; 2BGD; 2BGE; 2BIJ; 2BZL; 2C46; 2C7S; 2CFV; 2CM2; 2CM3; 2CM7; 2CM8; 2CMA; 2CMB; 2CMC; 2CNE; 2CNF; 2CNG; 2CNH; 2CNI; 2E0T; 2ESB; 2F6F; 2F6T; 2F6V; 2F6W; 2F6Y; 2F6Z; 2F70; 2F71; 2FH7; 2FJM; 2FJN; 2G59; 2GJT; 2GP0; 2GWO; 2H02; 2H03; 2H04; 2H4G; 2H4K; 2H4V; 2HB1; 2HC1; 2HC2; 2HNP; 2HNQ; 2HY3; 2I1Y; 2I3R; 2I3U; 2I42; 2I4E; 2I4G; 2I4H; 2I5X; 2I75; 2IMG; 2J16; 2JJD; 2NLK; 2NT7; 2NTA; 2NV5; 2OC3; 2OOQ; 2OUD; 2P4D; 2P6X; 2PA5; 2PBN; 2PQ5; 2Q05; 2Q47; 2QBP; 2QBQ; 2QBR; 2QBS; 2QCJ; 2QCT; 2QDC; 2QEP; 2SHP; 2VEU; 2VEV; 2VEW; 2VEX; 2VEY; 2WGP; 2Y96; 2YF0; 2ZMM; 2ZN7; 3A5J; 3A5K; 3B7O; 3BLT; 3BLU; 3BM8; 3CWE; 3D9C; 3EAX; 3EB1; 3F81; 3F99; 3F9A; 3F9B; 3H2X; 3I7Z; 3I80; 3MOW; 3O4S; 3O4T; 3O4U; 3O5X; 3QCB; 3QCC; 3QCD; 3QCE; 3QCF; 3QCG; 3QCH; 3QCI; 3QCJ; 3QCK; 3QCL; 3QCM; 3QCN; 3QKP; 3QKQ; 3RGO; 3S3E; 3S3F; 3S3H; 3S3K; 3SME; 3SR9; 3U96; 3ZM0; 3ZM1; 3ZM2; 3ZM3; 4BJO; 4BPC; 4DGP; 4DGX; 4ERC; 4GE2; 4GE5; 4GE6; 4GS0; 4GWF; 4H1O; 4H34; 4HJP; 4I8N; 4ICZ; 4J51; 4NWF; 4NWG; 4OHD; 4OHE; 4OHH; 4OHI; 4OHL; 4QAH; 4QBE
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