Entry: PS00452

General information about the entry
Entry name GUANYLATE_CYCLASE_1
Accession number PS00452
Entry type PATTERN
Date MAY-1991 (CREATED); DEC-2004 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation PDOC00425
Name and characterization of the entry
DescriptionGuanylate cyclase signature.
Pattern [GD]-[VI]-[LIVM]-x(0,1)-[GS]-x(5)-[FY]-x-[LIVM]-[FYWL]-[GS]-[DNTHKWE]- [DNTAS]-[IV]-[DNTAY]-x(5)-[DEC].
Numerical results
  • UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052.
  • Total number of hits in UniProtKB/Swiss-Prot: 120 hits in 90 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 120 hits in 90 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 0 hits in 0 different sequences
  • Number of known missed hits: 20
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0
  • Precision (true hits / (true hits + false positives)): 100.00 %
  • Recall (true hits / (true hits + false negatives)): 85.71 %
Comments
  • Taxonomic range: Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
  • Maximum known number of repetitions of the pattern in a single protein: 2
  • VERSION: 1
Cross-references
UniProtKB/Swiss-Prot True positive hits:
ADCY1_BOVIN (P19754), ADCY1_HUMAN (Q08828), ADCY1_MOUSE (O88444), 
ADCY2_DROME (Q9VW60), ADCY2_HUMAN (Q08462), ADCY2_MOUSE (Q80TL1), 
ADCY2_RAT   (P26769), ADCY3_HUMAN (O60266), ADCY3_MOUSE (Q8VHH7), 
ADCY3_RAT   (P21932), ADCY4_HUMAN (Q8NFM4), ADCY4_MOUSE (Q91WF3), 
ADCY4_RAT   (P26770), ADCY5_CANFA (P30803), ADCY5_HUMAN (O95622), 
ADCY5_MOUSE (P84309), ADCY5_RABIT (P40144), ADCY5_RAT   (Q04400), 
ADCY6_CANFA (P30804), ADCY6_HUMAN (O43306), ADCY6_MOUSE (Q01341), 
ADCY6_RAT   (Q03343), ADCY7_BOVIN (Q29450), ADCY7_HUMAN (P51828), 
ADCY7_MOUSE (P51829), ADCY8_HUMAN (P40145), ADCY8_MOUSE (P97490), 
ADCY8_RAT   (P40146), ADCY9_CHICK (Q9DGG6), ADCY9_HUMAN (O60503), 
ADCY9_MOUSE (P51830), ADCY9_XENLA (P98999), ANPRA_HUMAN (P16066), 
ANPRA_MOUSE (P18293), ANPRA_RAT   (P18910), ANPRB_ANGJA (P55202), 
ANPRB_BOVIN (P46197), ANPRB_HUMAN (P20594), ANPRB_MOUSE (Q6VVW5), 
ANPRB_RAT   (P16067), CYA1_DROME  (P32870), CYA1_MYCBO  (P0A4Y1), 
CYA1_MYCTU  (P0A4Y0), CYAA_DICDI  (Q03100), CYAG_DICDI  (Q03101), 
GCY1_CAEEL  (Q09435), GCY31_CAEEL (Q86C56), GCY32_CAEEL (Q6DNF7), 
GCY33_CAEEL (P90895), GCY34_CAEEL (P92006), GCY35_CAEEL (O02298), 
GCY36_CAEEL (Q6DNF4), GCY37_CAEEL (Q6DNF3), GCY3E_DROME (Q07553), 
GCY8E_DROME (Q8INF0), GCYA1_BOVIN (P19687), GCYA2_HUMAN (P33402), 
GCYA2_RAT   (Q9WVI4), GCYA3_CANFA (Q4ZHS0), GCYA3_HUMAN (Q02108), 
GCYA3_MOUSE (Q9ERL9), GCYA3_RAT   (P19686), GCYB1_BOVIN (P16068), 
GCYB1_CANFA (Q4ZHR9), GCYB1_HUMAN (Q02153), GCYB1_MOUSE (O54865), 
GCYB1_RAT   (P20595), GCYB2_HUMAN (O75343), GCYB2_RAT   (P22717), 
GCYDA_DROME (Q9VEU6), GCYDB_DROME (Q9VEU5), GCYH_DROME  (Q07093), 
GCY_STRPU   (P16065), GUC2C_CAVPO (P70106), GUC2C_HUMAN (P25092), 
GUC2C_MOUSE (Q3UWA6), GUC2C_PIG   (P55204), GUC2C_RAT   (P23897), 
GUC2D_BOVIN (P55203), GUC2D_CANFA (O19179), GUC2D_HUMAN (Q02846), 
GUC2D_RAT   (P51839), GUC2E_MOUSE (P52785), GUC2E_RAT   (P51840), 
GUC2F_BOVIN (O02740), GUC2F_HUMAN (P51841), GUC2F_MOUSE (Q5SDA5), 
GUC2F_RAT   (P51842), GUC2G_MOUSE (Q6TL19), GUC2G_RAT   (P55205)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
ADCYA_HUMAN (Q96PN6), ADCYA_MOUSE (Q8C0T9), ADCYA_RABIT (Q866F4), 
ADCYA_RAT   (Q9Z286), CYAA_NEUCR  (Q01631), CYAD_DICDI  (Q55F68), 
GCA_DICDI   (Q553Y7), PAL1F_EUGGR (P84738), PALFB_EUGGR (P84737), 
PALST_EUGGR (P84739), PBL1F_EUGGR (P84742), PBLFB_EUGGR (P84741), 
PBLST_EUGGR (P84743), PCYAA_ASTLO (Q76L34), PCYAA_EUGGR (Q8S9F2), 
PCYAB_ASTLO (Q76L33), PCYAB_EUGGR (Q8S9F1), YR818_MIMIV (Q5UQG7), 
YR826_MIMIV (Q7T6X2), YR831_MIMIV (Q7T6Y2)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]
1AB8; 1AWK; 1AWL; 1AWM; 1AWN; 1AZS; 1CJK; 1CJT; 1CJU; 1CJV; 1CS4; 1CUL; 1TL7; 1U0H; 1YK9; 2GVD; 2GVZ; 2WZ1; 3C14; 3C15; 3C16; 3G82; 3MAA; 3UVJ;

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