Entry: PS00471

General information about the entry
Entry name SMALL_CYTOKINES_CXC
Accession number PS00471
Entry type PATTERN
Date MAY-1991 (CREATED); APR-2006 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation PDOC00434
Name and characterization of the entry
DescriptionSmall cytokines (intercrine/chemokine) C-x-C subfamily signature.
Pattern C-x-C-[LIVMS]-x(4,6)-[LIVMFY]-x(2)-[RKSEQNA]-x-[LIVM]-x(2)-[LIVMA]-x(5)- [STAG]-x(2)-C-x(3)-[EQ]-[LIVM](2)-x(9,10)-C-[LV]-[DN].
Numerical results
  • UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052.
  • Total number of hits in UniProtKB/Swiss-Prot: 64 hits in 64 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 64 hits in 64 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 0 hits in 0 different sequences
  • Number of known missed hits: 15
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 2
  • Precision (true hits / (true hits + false positives)): 100.00 %
  • Recall (true hits / (true hits + false negatives)): 81.01 %
Comments
  • Taxonomic range: Eukaryotes
  • Maximum known number of repetitions of the pattern in a single protein: 1
  • `Interesting' site in the pattern: 1,disulfide
  • `Interesting' site in the pattern: 3,disulfide
  • `Interesting' site in the pattern: 16,disulfide
  • `Interesting' site in the pattern: 21,disulfide
  • VERSION: 2
Cross-references
UniProtKB/Swiss-Prot True positive hits:
AMC2_PIG    (P22952), AMC_RABIT   (P82535), CXCL2_HUMAN (P19875), 
CXCL2_MOUSE (P10889), CXCL2_RAT   (P30348), CXCL3_HUMAN (P19876), 
CXCL3_MOUSE (Q6W5C0), CXCL3_RAT   (Q10746), CXCL5_HUMAN (P42830), 
CXCL5_MOUSE (P50228), CXCL5_RAT   (P97885), CXCL6_BOVIN (P80221), 
CXCL6_HORSE (Q8MIN2), CXCL6_HUMAN (P80162), CXCL7_HUMAN (P02775), 
CXCL7_PIG   (P43030), CXCL9_BOVIN (A9QWP9), CXCL9_HUMAN (Q07325), 
CXCL9_MOUSE (P18340), CXL10_BOVIN (Q2KIQ8), CXL10_CANFA (Q5KSV9), 
CXL10_HUMAN (P02778), CXL10_MACMU (Q8MIZ1), CXL10_MACNE (Q865F5), 
CXL10_MOUSE (P17515), CXL10_RAT   (P48973), CXL11_BOVIN (A9QWQ1), 
CXL11_HUMAN (O14625), CXL11_MOUSE (Q9JHH5), CXL13_HUMAN (O43927), 
CXL13_MOUSE (O55038), CXL15_MOUSE (Q9WVL7), GRO2_RABIT  (P47854), 
GROA_BOVIN  (O46676), GROA_CAVPO  (O55235), GROA_CRIGR  (P09340), 
GROA_HUMAN  (P09341), GROA_MOUSE  (P12850), GROA_RAT    (P14095), 
GROA_SHEEP  (O46678), GROB_BOVIN  (O46677), GROG_BOVIN  (O46675), 
IL8_BOVIN   (P79255), IL8_CANFA   (P41324), IL8_CAVPO   (P49113), 
IL8_CERAT   (P46653), IL8_CHICK   (P08317), IL8_DASNO   (Q102R3), 
IL8_FELCA   (Q9XSX5), IL8_HORSE   (O62812), IL8_HUMAN   (P10145), 
IL8_MACMU   (P67813), IL8_MACNE   (P67814), IL8_PIG     (P26894), 
IL8_RABIT   (P19874), IL8_SHEEP   (P36925), IL8_TURTR   (Q7YRB5), 
PF4V_HUMAN  (P10720), PLF4_BOVIN  (P02777), PLF4_HUMAN  (P02776), 
PLF4_MOUSE  (Q9Z126), PLF4_PIG    (P30034), PLF4_RAT    (P06765), 
PLF4_SHEEP  (P30035)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
CXL14_HUMAN (O95715), CXL14_MOUSE (Q9WUQ5), CXL16_BOVIN (Q29RT9), 
CXL16_HUMAN (Q9H2A7), CXL16_MOUSE (Q8BSU2), CXL16_PIG   (Q9GKE2), 
CXL16_RAT   (Q6AXU5), SDF1_FELCA  (O62657), SDF1_HUMAN  (P48061), 
SDF1_MOUSE  (P40224), SDF1_XENLA  (Q8UUJ9), SDF1_XENTR  (Q5EBF6), 
VCC1_BOVIN  (A4IFR0), VCC1_HUMAN  (Q6UXB2), VCC1_MOUSE  (Q5UW37)
`Potential' hits (partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences):
GRO1_RABIT  (P30782), PLF4_RABIT  (P83470)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

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Retrieve the sequence logo from the alignment

PDB
[Detailed view]		 1F9P; 1F9Q; 1F9R; 1F9S; 1IL8; 1ILP; 1ILQ; 1MGS; 1MI2; 1MSG; 1MSH; 1NAP; 1O7Y; 1O7Z; 1O80; 1PFM; 1PFN; 1PLF; 1QE6; 1QNK; 1RHP; 1RJT; 1ROD; 1TVX; 2IL8; 2R3Z; 3IL8; 3N52;

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