Entry: PS00477

General information about the entry
Entry name ALPHA_2_MACROGLOBULIN
Accession number PS00477
Entry type PATTERN
Date MAY-1991 (CREATED); MAY-1991 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation PDOC00440
Name and characterization of the entry
DescriptionAlpha-2-macroglobulin family thiolester region signature.
Pattern [PG]-x-[GS]-C-[GA]-E-[EQ]-x-[LIVM].
Numerical results
  • UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052.
  • Total number of hits in UniProtKB/Swiss-Prot: 44 hits in 44 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 39 hits in 39 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 5 hits in 5 different sequences
  • Number of known missed hits: 6
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 6
  • Precision (true hits / (true hits + false positives)): 88.64 %
  • Recall (true hits / (true hits + false negatives)): 86.67 %
Comments
  • Taxonomic range: Eukaryotes
  • Maximum known number of repetitions of the pattern in a single protein: 1
  • `Interesting' site in the pattern: 4,thiolester
  • `Interesting' site in the pattern: 7,thiolester
  • VERSION: 1
Cross-references
UniProtKB/Swiss-Prot True positive hits:
A1I3_RAT    (P14046), A1M_RAT     (Q63041), A2MG_BOVIN  (Q7SIH1), 
A2MG_HUMAN  (P01023), A2MG_PONAB  (Q5R4N8), A2MG_RAT    (P06238), 
A2ML1_HUMAN (A8K2U0), A2MP_MOUSE  (Q6GQT1), A2M_HOMAM   (P20737), 
A2M_MOUSE   (Q61838), A2M_OCTVU   (P30800), A2M_PACLE   (P20738), 
CD109_HUMAN (Q6YHK3), CD109_MOUSE (Q8R422), CO31_AUSSU  (Q0ZZJ6), 
CO3_BOVIN   (Q2UVX4), CO3_CAVPO   (P12387), CO3_EPTBU   (P98094), 
CO3_HUMAN   (P01024), CO3_LAMJA   (Q00685), CO3_MOUSE   (P01027), 
CO3_NAJKA   (Q91132), CO3_NAJNA   (Q01833), CO3_ONCMY   (P98093), 
CO3_RABIT   (P12247), CO3_RAT     (P01026), CO4A_HUMAN  (P0C0L4), 
CO4B_HUMAN  (P0C0L5), CO4B_MOUSE  (P01029), CO4_BOVIN   (P01030), 
CO4_RAT     (P08649), CPMD8_HUMAN (Q8IZJ3), MUG1_MOUSE  (P28665), 
MUG1_RAT    (Q03626), MUG2_MOUSE  (P28666), MUG2_RAT    (Q6IE52), 
OVOS_ANAPL  (P20739), OVOS_MOUSE  (Q3UU35), PZP_HUMAN   (P20742)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
CO32_AUSSU  (A0RZC6), CO5_HUMAN   (P01031), CO5_MOUSE   (P06684), 
OVOS1_HUMAN (Q6IE37), OVOS2_HUMAN (Q6IE36), OVOS_CHICK  (P20740)
`Potential' hits (partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences):
CO3_PIG     (P01025), CO3_XENLA   (P23667), CO4_CAVPO   (P19069), 
CO5_BOVIN   (P12082), CO5_PIG     (P01032), CO5_RAT     (P08650)
False positive hits (sequences which do not belong to the set under consideration):
GALT5_HUMAN (Q7Z7M9), GALT5_MOUSE (Q8C102), GALT5_RAT   (O88422), 
ISPE_CHLAB  (Q5L568), ISPE_CHLCV  (Q821X0)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]		 2A73; 2B39; 2HR0; 2I07; 2ICF; 2WII; 2WIN; 2XWB; 2XWJ; 3G6J; 3L5N; 4FXG; 4FXK;

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