Entry: PS00501

General information about the entry

Entry name [info] SPASE_I_1
Accession [info] PS00501
Entry type [info] PATTERN
Date [info] MAY-1991 (CREATED); DEC-2004 (DATA UPDATE); JUN-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC00418
Associated ProRule [info] PRU10097

Name and characterization of the entry

Description [info] Signal peptidases I serine active site.
Pattern [info]
[GS]-{PR}-S-M-{RS}-[PS]-[AT]-[LF].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_08 which contains 551'987 sequence entries.


Total number of hits 183 in 183 different sequences
Number of true positive hits 121 in 121 different sequences
Number of 'unknown' hits 0
Number of false positive hits 62 in 62 different sequences
Number of false negative sequences 21
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 66.12 %
Recall (true positives / (true positives + false negatives)) 85.21 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 3
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
121 sequences

IMP1_YEAST  (P28627    ), IMP2_YEAST  (P46972    ), LEP1_BACAM  (P41026    ), 
LEP1_SYNY3  (P72660    ), LEP2_BACAM  (P41025    ), LEP2_SYNY3  (P73157    ), 
LEPP_BACNA  (P37943    ), LEPQ_BACNA  (Q57350    ), LEPS_BACSU  (P28628    ), 
LEPT_BACSU  (P71013    ), LEPU_BACSU  (P42959    ), LEPV_BACSU  (O07560    ), 
LEP_AQUAE   (O67088    ), LEP_BACCL   (P41027    ), LEP_BACLI   (P42668    ), 
LEP_BUCAI   (P57347    ), LEP_BUCAP   (Q8K9R0    ), LEP_BUCBP   (Q89AM6    ), 
LEP_ECOLI   (P00803    ), LEP_HAEIN   (P44454    ), LEP_MYCLE   (O33021    ), 
LEP_MYCTO   (P9WKA0    ), LEP_MYCTU   (P9WKA1    ), LEP_PHOLA   (Q51876    ), 
LEP_PSEAE   (Q9I5G7    ), LEP_PSEFL   (P26844    ), LEP_SALTI   (P0A1W3    ), 
LEP_SALTY   (P0A1W2    ), LEP_STAAC   (Q5HHB9    ), LEP_STAAM   (P0A067    ), 
LEP_STAAN   (P0A068    ), LEP_STAAR   (Q6GIC3    ), LEP_STAAS   (Q6GAW1    ), 
LEP_STAAU   (P0A070    ), LEP_STAAW   (P0A069    ), LEP_STRPN   (O07344    ), 
LEP_STRR6   (P59662    ), PLSP1_ARATH (Q8H0W1    ), SC11A_BOVIN (P67810    ), 
SC11A_CANLF (P67811    ), SC11A_HUMAN (P67812    ), SC11A_MOUSE (Q9R0P6    ), 
SC11A_PONAB (Q5R9C7    ), SC11A_RAT   (P42667    ), SC11B_HUMAN (P0C7V7    ), 
SC11C_CANLF (P13679    ), SC11C_HUMAN (Q9BY50    ), SC11C_MOUSE (Q9D8V7    ), 
SC11C_PONAB (Q5RC30    ), SC11C_RAT   (Q9WTR7    ), SEC11_AJEC8 (F0UDD2    ), 
SEC11_AJECG (C0NKT8    ), SEC11_AJECH (C6HB29    ), SEC11_AJECN (A6QX24    ), 
SEC11_AJEDR (C5G8L5    ), SEC11_AJEDS (C5JJG5    ), SEC11_ARTBC (D4ALL0    ), 
SEC11_ARTGP (E4V4X0    ), SEC11_ARTOC (C5FQ45    ), SEC11_ASHGO (Q759W4    ), 
SEC11_ASPCL (A1CL29    ), SEC11_ASPFC (B0XWT3    ), SEC11_ASPFU (Q4WYF4    ), 
SEC11_ASPOR (Q2UBW3    ), SEC11_ASPTN (Q0CQC5    ), SEC11_CANAL (Q5A869    ), 
SEC11_CANAW (C4YNJ0    ), SEC11_CANDC (B9WKT4    ), SEC11_CANTT (C5M4J6    ), 
SEC11_CHAGB (Q2H1P3    ), SEC11_CLAL4 (C4Y3D4    ), SEC11_COCP7 (C5PA33    ), 
SEC11_COCPS (E9CXH2    ), SEC11_COLGM (E3QXY4    ), SEC11_DEBHA (Q6BP15    ), 
SEC11_DICDI (Q86JD4    ), SEC11_EMENI (Q5B8K4    ), SEC11_GROCL (F0XJH4    ), 
SEC11_KLULA (Q6CMR5    ), SEC11_LACBS (B0D4L0    ), SEC11_LACTC (C5DDH1    ), 
SEC11_LEPMJ (E5A8D2    ), SEC11_LODEL (A5DS09    ), SEC11_MAGO7 (A4RGA1    ), 
SEC11_METAQ (E9E796    ), SEC11_METRA (E9F8V9    ), SEC11_NECH7 (C7ZHK5    ), 
SEC11_NEOFI (A1D6D8    ), SEC11_NEUCR (Q7RY44    ), SEC11_OGAPD (E7R7C4    ), 
SEC11_PARBA (C1GU90    ), SEC11_PARBD (C1FYD2    ), SEC11_PARBP (C0S3S0    ), 
SEC11_PENRW (B6HC89    ), SEC11_PICGU (A5DIZ8    ), SEC11_PICPG (C4QXP7    ), 
SEC11_PICST (A3LXS1    ), SEC11_PODAN (B2B3T2    ), SEC11_PYRTR (B2WEL2    ), 
SEC11_PYRTT (E3RR70    ), SEC11_SCHCM (D8Q7Q5    ), SEC11_SCLS1 (A7E716    ), 
SEC11_TALMQ (B6Q5G0    ), SEC11_TALSN (B8M5K5    ), SEC11_TRIVH (D4D5I1    ), 
SEC11_TUBMM (D5GNC3    ), SEC11_UNCRE (C4JYM4    ), SEC11_VERA1 (C9S8G0    ), 
SEC11_YEAS1 (B3LTI7    ), SEC11_YEAS2 (C7GLT4    ), SEC11_YEAS7 (A6ZVU2    ), 
SEC11_YEAS8 (C8ZAS4    ), SEC11_YEASA (E7KDY6    ), SEC11_YEASB (E7Q587    ), 
SEC11_YEASL (E7KQ01    ), SEC11_YEAST (P15367    ), SEC11_YEASV (E7LVX4    ), 
SEC11_YEASZ (E7QG89    ), SEC11_ZYGRC (C5E3W1    ), TPP1_ARATH  (O04348    ), 
TPP2_ARATH  (Q9M9Z2    )
» more

UniProtKB/Swiss-Prot
False negative sequences
21 sequences

IMP1L_HUMAN (Q96LU5    ), IMP1L_MOUSE (Q9CQU8    ), IMP1L_XENTR (Q28I39    ), 
IMP2L_BOVIN (Q2KI92    ), IMP2L_DANRE (Q6AZD4    ), IMP2L_HUMAN (Q96T52    ), 
IMP2L_MOUSE (Q8BPT6    ), IMP2L_SCHPO (Q9UST2    ), IMP2L_XENLA (Q5PQ63    ), 
LEPH_STAAC  (Q5HHC0    ), LEPH_STAAM  (P0A063    ), LEPH_STAAN  (P0A064    ), 
LEPH_STAAR  (Q6GIC4    ), LEPH_STAAS  (Q6GAW2    ), LEPH_STAAU  (P0A066    ), 
LEPH_STAAW  (P0A065    ), LEP_HELPJ   (Q9ZLQ5    ), LEP_HELPY   (O25300    ), 
LEP_RICCN   (Q92JB1    ), LEP_RICPR   (Q9ZE32    ), SEC11_YARLI (Q6CAG9    )
» more

UniProtKB/Swiss-Prot
False positive sequences
62 sequences

ALDO1_ARATH (Q7G193    ), AQPZ_ECO57  (Q8X6K6    ), AQPZ_ECOL6  (P60845    ), 
AQPZ_ECOLI  (P60844    ), AQPZ_SHIFL  (O68874    ), ATG12_ASPCL (A1CTJ1    ), 
ATG12_ASPFU (A4D9P4    ), ATG12_ASPOR (Q2UMW6    ), ATG12_COCIM (Q1E8C2    ), 
ATG12_MAGO7 (Q51P78    ), ATG12_NEOFI (A1DMW6    ), CDKL5_HUMAN (O76039    ), 
DDL_SYNPW   (A5GML7    ), ERF1_CAEEL  (O16520    ), FREM1_HUMAN (Q5H8C1    ), 
GNL3L_BOVIN (Q3T0J9    ), GNL3L_HUMAN (Q9NVN8    ), LVSD_DICDI  (Q55AV3    ), 
L_CHAVB     (B2C4J3    ), NAGA_HUMAN  (Q9Y303    ), NFAA_DICDI  (Q55AR6    ), 
O51S1_HUMAN (Q8NGJ8    ), PEPF1_LACLC (P54124    ), PEPF_LACLA  (Q9CEV7    ), 
PLSX_PARDP  (A1B363    ), PLSX_RUEST  (Q1GI68    ), POC1A_MOUSE (Q8JZX3    ), 
PPE19_MYCTO (P9WI24    ), PPE19_MYCTU (P9WI25    ), PR2_DROME   (Q9I7F7    ), 
RIMB2_MOUSE (Q80U40    ), RIMB2_RAT   (Q9JIR1    ), RS9_STRCO   (Q53875    ), 
SNL4_ARATH  (O04539    ), SNT2_YEAST  (P53127    ), STU1_SCHPO  (O42874    ), 
TBB1_AVESA  (P25862    ), TBB1_ORYSJ  (Q43594    ), TBB1_WHEAT  (Q9ZRB2    ), 
TBB2_ELEIN  (Q9ZPN9    ), TBB2_WHEAT  (Q9ZRB1    ), TBB3_GOSHI  (Q6VAF8    ), 
TBB3_PEA    (P29502    ), TBB4_ELEIN  (Q9ZPN7    ), TBB4_ORYSJ  (P45960    ), 
TBB5_MAIZE  (Q43697    ), TBB5_WHEAT  (Q9ZRA8    ), TBB6_ARATH  (P29514    ), 
TBB6_MAIZE  (Q41783    ), TBB6_ORYSJ  (Q76FS3    ), TBB8_MAIZE  (Q41785    ), 
TBB8_ORYSJ  (Q76FS2    ), TBB_HORVU   (P93176    ), TDA7_CANGA  (Q6FNJ6    ), 
TPIS_GRAGA  (P48492    ), TPO5_YEAST  (P36029    ), TRM51_VITVI (F6H2F8    ), 
UPP3_SCHPO  (Q9US43    ), VPS10_NECH7 (C7YGZ0    ), Y017_OSHVF  (Q6R7K6    ), 
ZF69B_HUMAN (Q9UJL9    ), ZN598_DANRE (Q6PFK1    )
» more

PDB
[Detailed view]
8 PDB

1B12; 1KN9; 1T7D; 3IIQ; 3S04; 4WVH; 4WVI; 4WVJ

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