Entry: PS00501

General information about the entry

Entry name [info] SPASE_I_1
Accession [info] PS00501
Entry type [info] PATTERN
Date [info] MAY-1991 (CREATED); DEC-2004 (DATA UPDATE); JUN-2015 (INFO UPDATE).
PROSITE Doc. [info] PDOC00418
Associated ProRule [info] PRU10097

Name and characterization of the entry

Description [info] Signal peptidases I serine active site.
Pattern [info]
[GS]-{PR}-S-M-{RS}-[PS]-[AT]-[LF].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2015_08 which contains 320'201 sequence entries.


Total number of hits 183 in 183 different sequences
Number of true positive hits 121 in 121 different sequences
Number of 'unknown' hits 0
Number of false positive hits 62 in 62 different sequences
Number of false negative sequences 21
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 66.12 %
Recall (true positives / (true positives + false negatives)) 85.21 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 3
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
121 sequences

IMP1_YEAST  (P28627), IMP2_YEAST  (P46972), LEP1_BACAM  (P41026), 
LEP1_SYNY3  (P72660), LEP2_BACAM  (P41025), LEP2_SYNY3  (P73157), 
LEPP_BACNA  (P37943), LEPQ_BACNA  (Q57350), LEPS_BACSU  (P28628), 
LEPT_BACSU  (P71013), LEPU_BACSU  (P42959), LEPV_BACSU  (O07560), 
LEP_AQUAE   (O67088), LEP_BACCL   (P41027), LEP_BACLI   (P42668), 
LEP_BUCAI   (P57347), LEP_BUCAP   (Q8K9R0), LEP_BUCBP   (Q89AM6), 
LEP_ECOLI   (P00803), LEP_HAEIN   (P44454), LEP_MYCLE   (O33021), 
LEP_MYCTO   (P9WKA0), LEP_MYCTU   (P9WKA1), LEP_PHOLA   (Q51876), 
LEP_PSEAE   (Q9I5G7), LEP_PSEFL   (P26844), LEP_SALTI   (P0A1W3), 
LEP_SALTY   (P0A1W2), LEP_STAAC   (Q5HHB9), LEP_STAAM   (P0A067), 
LEP_STAAN   (P0A068), LEP_STAAR   (Q6GIC3), LEP_STAAS   (Q6GAW1), 
LEP_STAAU   (P0A070), LEP_STAAW   (P0A069), LEP_STRPN   (O07344), 
LEP_STRR6   (P59662), PLSP1_ARATH (Q8H0W1), SC11A_BOVIN (P67810), 
SC11A_CANFA (P67811), SC11A_HUMAN (P67812), SC11A_MOUSE (Q9R0P6), 
SC11A_PONAB (Q5R9C7), SC11A_RAT   (P42667), SC11B_HUMAN (P0C7V7), 
SC11C_CANFA (P13679), SC11C_HUMAN (Q9BY50), SC11C_MOUSE (Q9D8V7), 
SC11C_PONAB (Q5RC30), SC11C_RAT   (Q9WTR7), SEC11_AJEC8 (F0UDD2), 
SEC11_AJECG (C0NKT8), SEC11_AJECH (C6HB29), SEC11_AJECN (A6QX24), 
SEC11_AJEDR (C5G8L5), SEC11_AJEDS (C5JJG5), SEC11_ARTBC (D4ALL0), 
SEC11_ARTGP (E4V4X0), SEC11_ARTOC (C5FQ45), SEC11_ASHGO (Q759W4), 
SEC11_ASPCL (A1CL29), SEC11_ASPFC (B0XWT3), SEC11_ASPFU (Q4WYF4), 
SEC11_ASPOR (Q2UBW3), SEC11_ASPTN (Q0CQC5), SEC11_CANAL (Q5A869), 
SEC11_CANAW (C4YNJ0), SEC11_CANDC (B9WKT4), SEC11_CANTT (C5M4J6), 
SEC11_CHAGB (Q2H1P3), SEC11_CLAL4 (C4Y3D4), SEC11_COCP7 (C5PA33), 
SEC11_COCPS (E9CXH2), SEC11_COLGM (E3QXY4), SEC11_DEBHA (Q6BP15), 
SEC11_DICDI (Q86JD4), SEC11_EMENI (Q5B8K4), SEC11_GROCL (F0XJH4), 
SEC11_KLULA (Q6CMR5), SEC11_LACBS (B0D4L0), SEC11_LACTC (C5DDH1), 
SEC11_LEPMJ (E5A8D2), SEC11_LODEL (A5DS09), SEC11_MAGO7 (A4RGA1), 
SEC11_METAQ (E9E796), SEC11_METRA (E9F8V9), SEC11_NECH7 (C7ZHK5), 
SEC11_NEOFI (A1D6D8), SEC11_NEUCR (Q7RY44), SEC11_OGAPD (E7R7C4), 
SEC11_PARBA (C1GU90), SEC11_PARBD (C1FYD2), SEC11_PARBP (C0S3S0), 
SEC11_PENCW (B6HC89), SEC11_PENMQ (B6Q5G0), SEC11_PICGU (A5DIZ8), 
SEC11_PICPG (C4QXP7), SEC11_PICST (A3LXS1), SEC11_PODAN (B2B3T2), 
SEC11_PYRTR (B2WEL2), SEC11_PYRTT (E3RR70), SEC11_SCHCM (D8Q7Q5), 
SEC11_SCLS1 (A7E716), SEC11_TALSN (B8M5K5), SEC11_TRIVH (D4D5I1), 
SEC11_TUBMM (D5GNC3), SEC11_UNCRE (C4JYM4), SEC11_VERA1 (C9S8G0), 
SEC11_YEAS1 (B3LTI7), SEC11_YEAS2 (C7GLT4), SEC11_YEAS7 (A6ZVU2), 
SEC11_YEAS8 (C8ZAS4), SEC11_YEASA (E7KDY6), SEC11_YEASB (E7Q587), 
SEC11_YEASL (E7KQ01), SEC11_YEAST (P15367), SEC11_YEASV (E7LVX4), 
SEC11_YEASZ (E7QG89), SEC11_ZYGRC (C5E3W1), TPP1_ARATH  (O04348), 
TPP2_ARATH  (Q9M9Z2)
» More

UniProtKB/Swiss-Prot
False negative sequences
21 sequences

IMP1L_HUMAN (Q96LU5), IMP1L_MOUSE (Q9CQU8), IMP1L_XENTR (Q28I39), 
IMP2L_BOVIN (Q2KI92), IMP2L_DANRE (Q6AZD4), IMP2L_HUMAN (Q96T52), 
IMP2L_MOUSE (Q8BPT6), IMP2L_SCHPO (Q9UST2), IMP2L_XENLA (Q5PQ63), 
LEPH_STAAC  (Q5HHC0), LEPH_STAAM  (P0A063), LEPH_STAAN  (P0A064), 
LEPH_STAAR  (Q6GIC4), LEPH_STAAS  (Q6GAW2), LEPH_STAAU  (P0A066), 
LEPH_STAAW  (P0A065), LEP_HELPJ   (Q9ZLQ5), LEP_HELPY   (O25300), 
LEP_RICCN   (Q92JB1), LEP_RICPR   (Q9ZE32), SEC11_YARLI (Q6CAG9)
» More

UniProtKB/Swiss-Prot
False positive sequences
62 sequences

ALDO1_ARATH (Q7G193), AQPZ_ECO57  (Q8X6K6), AQPZ_ECOL6  (P60845), 
AQPZ_ECOLI  (P60844), AQPZ_SHIFL  (O68874), ATG12_ASPCL (A1CTJ1), 
ATG12_ASPFU (A4D9P4), ATG12_ASPOR (Q2UMW6), ATG12_COCIM (Q1E8C2), 
ATG12_MAGO7 (Q51P78), ATG12_NEOFI (A1DMW6), CDKL5_HUMAN (O76039), 
DDL_SYNPW   (A5GML7), ERF1_CAEEL  (O16520), FREM1_HUMAN (Q5H8C1), 
GNL3L_BOVIN (Q3T0J9), GNL3L_HUMAN (Q9NVN8), LVSD_DICDI  (Q55AV3), 
L_CHAVB     (B2C4J3), NAGA_HUMAN  (Q9Y303), NFAA_DICDI  (Q55AR6), 
O51S1_HUMAN (Q8NGJ8), PEPF1_LACLC (P54124), PEPF_LACLA  (Q9CEV7), 
PLSX_PARDP  (A1B363), PLSX_RUEST  (Q1GI68), POC1A_MOUSE (Q8JZX3), 
PPE19_MYCTO (P9WI24), PPE19_MYCTU (P9WI25), PR2_DROME   (Q9I7F7), 
RIMB2_MOUSE (Q80U40), RIMB2_RAT   (Q9JIR1), RS9_STRCO   (Q53875), 
SNL4_ARATH  (O04539), SNT2_YEAST  (P53127), STU1_SCHPO  (O42874), 
TBB1_AVESA  (P25862), TBB1_ORYSJ  (Q43594), TBB1_WHEAT  (Q9ZRB2), 
TBB2_ELEIN  (Q9ZPN9), TBB2_WHEAT  (Q9ZRB1), TBB3_GOSHI  (Q6VAF8), 
TBB3_PEA    (P29502), TBB4_ELEIN  (Q9ZPN7), TBB4_ORYSJ  (P45960), 
TBB5_MAIZE  (Q43697), TBB5_WHEAT  (Q9ZRA8), TBB6_ARATH  (P29514), 
TBB6_MAIZE  (Q41783), TBB6_ORYSJ  (Q76FS3), TBB8_MAIZE  (Q41785), 
TBB8_ORYSJ  (Q76FS2), TBB_HORVU   (P93176), TDA7_CANGA  (Q6FNJ6), 
TPIS_GRAGA  (P48492), TPO5_YEAST  (P36029), TRM51_VITVI (F6H2F8), 
UPP3_SCHPO  (Q9US43), VPS10_NECH7 (C7YGZ0), Y017_OSHVF  (Q6R7K6), 
ZF69B_HUMAN (Q9UJL9), ZN598_DANRE (Q6PFK1)
» More

PDB
[Detailed view]
5 PDB

1B12; 1KN9; 1T7D; 3IIQ; 3S04

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission