Entry: PS00640

General information about the entry

Entry name [info] THIOL_PROTEASE_ASN
Accession [info] PS00640
Entry type [info] PATTERN
Date [info] JUN-1992 (CREATED); NOV-1995 (DATA UPDATE); JUN-2015 (INFO UPDATE).
PROSITE Doc. [info] PDOC00126
Associated ProRule [info] PRU10090

Name and characterization of the entry

Description [info] Eukaryotic thiol (cysteine) proteases asparagine active site.
Pattern [info]
[FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-x(2)-G-[LFYW]-
[LIVMFYG]-x-[LIVMF].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2015_08 which contains 320'201 sequence entries.


Total number of hits 181 in 181 different sequences
Number of true positive hits 181 in 181 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 123
Number of 'partial' sequences 25
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 59.54 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 6
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
181 sequences

A494_ARATH  (P43295), ACP1_ENTHI  (P36184), ACP2_ENTHI  (P36185), 
ACTN_ACTCH  (P00785), ACTN_ACTDE  (A5HII1), ALEUL_ARATH (Q8RWQ9), 
ALEU_ARATH  (Q8H166), ALEU_HORVU  (P05167), ANAN_ANACO  (P80884), 
BROM1_ANACO (O23791), CATB1_GIAIN (P92131), CATB2_GIAIN (P92132), 
CATB3_GIAIN (P92133), CATB_BOVIN  (P07688), CATB_CHICK  (P43233), 
CATB_HUMAN  (P07858), CATB_MACFA  (Q4R5M2), CATB_MOUSE  (P10605), 
CATB_PIG    (A1E295), CATB_PONAB  (Q5R6D1), CATB_RAT    (P00787), 
CATC_BOVIN  (Q3ZCJ8), CATC_CANFA  (O97578), CATC_HUMAN  (P53634), 
CATC_MACFA  (Q60HG6), CATC_MOUSE  (P97821), CATC_PLAF7  (Q8IIJ9), 
CATC_PONAB  (Q5RB02), CATC_RAT    (P80067), CATH_BOVIN  (Q3T0I2), 
CATH_HUMAN  (P09668), CATH_MOUSE  (P49935), CATH_PIG    (O46427), 
CATH_RAT    (P00786), CATJ_MOUSE  (Q9R014), CATJ_RAT    (Q63088), 
CATK_BOVIN  (Q5E968), CATK_CANFA  (Q3ZKN1), CATK_CHICK  (Q90686), 
CATK_HUMAN  (P43235), CATK_MACFA  (P61276), CATK_MACMU  (P61277), 
CATK_PIG    (Q9GLE3), CATK_RABIT  (P43236), CATK_RAT    (O35186), 
CATL1_BOVIN (P25975), CATL1_CANFA (Q9GL24), CATL1_CHICK (P09648), 
CATL1_CHLAE (Q9GKL8), CATL1_FELCA (P25773), CATL1_HUMAN (P07711), 
CATL1_MOUSE (P06797), CATL1_PIG   (Q28944), CATL1_RAT   (P07154), 
CATL1_SHEEP (Q10991), CATL2_BOVIN (Q5E998), CATL2_HUMAN (O60911), 
CATLL_FASHE (Q24940), CATLL_PHACE (O97397), CATL_BRUPA  (O17473), 
CATL_DROME  (Q95029), CATL_SARPE  (Q26636), CATL_SCHMA  (Q26534), 
CATQ_RAT    (Q9QZE3), CATR_MOUSE  (Q9JIA9), CATS_BOVIN  (P25326), 
CATS_CANFA  (Q8HY81), CATS_HUMAN  (P25774), CATS_MOUSE  (O70370), 
CATS_RAT    (Q02765), CATS_SAIBB  (Q8HY82), CATV_GVCPM  (O91466), 
CATV_GVXN   (Q9PYY5), CATV_NPVAC  (P25783), CATV_NPVAH  (Q80LP4), 
CATV_NPVAP  (Q91CL9), CATV_NPVBM  (P41721), CATV_NPVBS  (Q9YWK4), 
CATV_NPVCD  (Q6VTL7), CATV_NPVCF  (P41715), CATV_NPVEP  (Q91GE3), 
CATV_NPVHC  (Q9WGE0), CATV_NPVHZ  (Q8V5U0), CATV_NPVLD  (Q9YMP9), 
CATV_NPVMC  (Q8QLK1), CATV_NPVOP  (O10364), CATV_NPVR1  (Q8B9D5), 
CATV_NPVSE  (Q9J8B9), CATW_FELCA  (Q9TST1), CATW_HUMAN  (P56202), 
CATW_MOUSE  (P56203), CATZ_BOVIN  (P05689), CATZ_HUMAN  (Q9UBR2), 
CATZ_MOUSE  (Q9WUU7), CATZ_RAT    (Q9R1T3), CEP1_ARATH  (Q9FGR9), 
CEP2_ARATH  (Q9STL4), CEP3_ARATH  (Q9STL5), CPGP1_ZINOF (P82473), 
CPP1_ENTHI  (Q01957), CPP2_ENTHI  (Q01958), CPP3_ENTHI  (Q06964), 
CPR1_ARATH  (Q9LT77), CPR1_CAEEL  (P25807), CPR1_DROME  (Q9VN93), 
CPR2_ARATH  (Q9LXW3), CPR3_CAEEL  (P43507), CPR4_CAEEL  (P43508), 
CPR5_CAEEL  (P43509), CPR6_CAEEL  (P43510), CRUST_PANBO (Q86GF7), 
CYSEP_PHAVU (P25803), CYSEP_RICCO (O65039), CYSEP_VIGMU (P12412), 
CYSP1_DICDI (P04988), CYSP1_HAECO (P19092), CYSP1_HOMAM (P13277), 
CYSP1_HORVU (P25249), CYSP1_LEIPI (P35591), CYSP1_MAIZE (Q10716), 
CYSP1_ORYSJ (Q7XR52), CYSP1_OSTOS (P25802), CYSP2_DICDI (P04989), 
CYSP2_HAECO (P25793), CYSP2_HOMAM (P25782), CYSP2_HORVU (P25250), 
CYSP2_LEIPI (Q05094), CYSP2_MAIZE (Q10717), CYSP3_HOMAM (P25784), 
CYSP3_OSTOS (Q06544), CYSP3_SOLLC (Q40143), CYSP4_BRANA (P25251), 
CYSP4_DICDI (P54639), CYSP5_DICDI (P54640), CYSP6_DICDI (Q94503), 
CYSP7_DICDI (Q94504), CYSP_HEMSP  (P43156), CYSP_PEA    (P25804), 
CYSP_PLAFA  (P25805), CYSP_PLAVN  (P46102), CYSP_PLAVS  (P42666), 
CYSP_SCHJA  (P43157), CYSP_SCHMA  (P25792), CYSP_THEAN  (P25781), 
CYSP_THEPA  (P22497), CYSP_TRYBB  (P14658), CYSP_TRYCR  (P25779), 
ERVB_TABDI  (P60994), ERVC_TABDI  (P83654), GCP1_ARATH  (Q94B08), 
LMCPA_LEIME (P25775), LMCPB_LEIME (P36400), MDO1_PSEMR  (P83443), 
ORYA_ORYSJ  (P25776), ORYB_ORYSJ  (P25777), ORYC_ORYSJ  (P25778), 
P34_SOYBN   (P22895), PAPA1_CARPA (P00784), PAPA2_CARPA (P14080), 
PAPA3_CARPA (P10056), PAPA4_CARPA (P05994), PAPA5_CARPA (P05993), 
PEPT1_DERFA (P16311), PEPT1_DERPT (P08176), PEPT1_EURMA (P25780), 
PEPT1_PSOOV (Q1EIQ3), RD19A_ARATH (P43296), RD21A_ARATH (P43297), 
SAG12_ARATH (Q9FJ47), SAG39_ORYSI (A2XQE8), SAG39_ORYSJ (Q7XWK5), 
SERA_PLAF7  (Q9TY95), SERA_PLAFD  (P69193), SERA_PLAFG  (P69192), 
SILIC_PETFI (Q6YD92), TEST2_MOUSE (Q80UB0), TEST2_RAT   (P15242), 
TINAG_BOVIN (Q3SZI1), TINAG_HUMAN (Q9UJW2), XCP2_ARATH  (Q9LM66), 
YCF2E_CAEEL (P90850)
» More

UniProtKB/Swiss-Prot
False negative sequences
123 sequences

361L_IIV6   (Q91FG3), BLH1_YEAST  (Q01532), BLMH_CHICK  (P87362), 
BLMH_HUMAN  (Q13867), BLMH_RAT    (P70645), BROM2_ANACO (P14518), 
CAN10_HUMAN (Q9HC96), CAN10_MACFA (Q95LP4), CAN10_MOUSE (Q9ESK3), 
CAN10_RAT   (Q9ES66), CAN11_HUMAN (Q9UMQ6), CAN12_HUMAN (Q6ZSI9), 
CAN12_MOUSE (Q9ER56), CAN13_HUMAN (Q6MZZ7), CAN13_MOUSE (Q3UW68), 
CAN13_RAT   (Q5BK10), CAN14_HUMAN (A8MX76), CAN15_HUMAN (O75808), 
CAN15_MOUSE (Q9JLG8), CAN1_BOVIN  (Q27970), CAN1_HUMAN  (P07384), 
CAN1_MACFA  (Q9GLG2), CAN1_MOUSE  (O35350), CAN1_PIG    (P35750), 
CAN1_PONAB  (Q5NVS7), CAN1_RAT    (P97571), CAN2_BOVIN  (Q27971), 
CAN2_CHICK  (Q92178), CAN2_HUMAN  (P17655), CAN2_MACFA  (Q9GLG1), 
CAN2_MOUSE  (O08529), CAN2_RAT    (Q07009), CAN3_BOVIN  (P51186), 
CAN3_CHICK  (Q92177), CAN3_HUMAN  (P20807), CAN3_MACFA  (Q9GLG7), 
CAN3_MOUSE  (Q64691), CAN3_PIG    (P43368), CAN3_RAT    (P16259), 
CAN3_SHEEP  (Q9TTH8), CAN5_CAEEL  (Q22036), CAN5_HUMAN  (O15484), 
CAN5_MOUSE  (O08688), CAN5_RAT    (Q8R4C0), CAN6_HUMAN  (Q9Y6Q1), 
CAN6_MOUSE  (O35646), CAN6_RAT    (O88501), CAN7_HUMAN  (Q9Y6W3), 
CAN7_MOUSE  (Q9R1S8), CAN7_PIG    (A0FKG7), CAN8_HUMAN  (A6NHC0), 
CAN8_MOUSE  (Q91VA3), CAN8_RAT    (Q78EJ9), CAN9_HUMAN  (O14815), 
CAN9_MOUSE  (Q9D805), CAN9_RAT    (O35920), CANA_DROME  (Q11002), 
CANB_DROME  (Q9VT65), CANC_DROME  (Q9VXH6), CAND_DROME  (P27398), 
CANX_CHICK  (P00789), CAN_CAEEL   (P34308), CAN_SCHMA   (P27730), 
CAT7_MOUSE  (Q91ZF2), CAT7_RAT    (D3ZZ07), CATC_SCHMA  (Q26563), 
CATF_HUMAN  (Q9UBX1), CATF_MOUSE  (Q9R013), CATK_MOUSE  (P55097), 
CATL1_PARTE (Q94714), CATL2_PARTE (A0E358), CATL3_PARTE (Q94715), 
CATM_MOUSE  (Q9JL96), CATO_HUMAN  (P43234), CATO_MOUSE  (Q8BM88), 
CATV_NPVST  (Q91BH1), CFAD_DICDI  (Q54TR1), CPGP2_ZINOF (P82474), 
CPLA_DICDI  (Q8MUF9), CPR3_ARATH  (Q9SUT0), CPR4_ARATH  (Q9SUS9), 
CTSB_DICDI  (Q54QD9), CYSP3_DICDI (Q23894), CYSPL_SOLLC (P20721), 
DEK1_ARATH  (Q8RVL2), DEK1_MAIZE  (Q8RVL1), DEK1_ORYSJ  (Q6ZFZ4), 
ECPA_STAEP  (P0C0P9), ECPA_STAEQ  (Q5HKF6), ECPA_STAES  (P0C0Q0), 
GMSA_DICDI  (Q54ME1), MEX1_JACME  (P84346), MEX2_JACME  (P84347), 
PEPC_LACDL  (Q48543), PEPC_LACHE  (Q10744), PEPC_LACLA  (Q9CEG3), 
PEPC_LACLC  (Q04723), PEPC_LISIN  (Q928V0), PEPC_LISMO  (O69192), 
PEPC_STRTR  (Q56115), PEPE_LACHE  (P94870), PEPG_LACDL  (P94869), 
PEPW_LACDL  (P94868), SSPB_STAA8  (Q2FZL3), SSPB_STAAC  (Q5HH36), 
SSPB_STAAM  (Q99V46), SSPB_STAAN  (Q7A6A7), SSPB_STAAR  (Q6GI35), 
SSPB_STAAS  (Q6GAG5), SSPB_STAAU  (P0C1S6), SSPB_STAAW  (Q8NX99), 
SSPP_STAA8  (Q2G2R8), SSPP_STAAC  (Q5HEL3), SSPP_STAAM  (P65825), 
SSPP_STAAN  (P65826), SSPP_STAAR  (Q6GFE8), SSPP_STAAS  (Q6G824), 
SSPP_STAAU  (P81297), SSPP_STAAW  (Q8NVS9), TPR_PORGI   (P25806), 
VF224_IIV3  (Q197D6), VF224_IIV6  (Q91FU7), XCP1_ARATH  (O65493)
» More

UniProtKB/Swiss-Prot
'Partial' sequences
25 sequences

BLMH_RABIT  (P13019), CAL1_CALGI  (P20728), CAN1_RABIT  (P06815), 
CAN2_PIG    (P43367), CAN2_RABIT  (P06814), CATB_COTJA  (P81494), 
CATB_SHEEP  (P83205), CATL1_FASHE (Q09093), CATL2_FASHE (P80342), 
CATL3_FASHE (P80532), CATL4_FASHE (P80528), CATL9_FASHE (P80533), 
CYSB_FASHE  (P80529), CYSP1_CARCN (P32954), CYSP2_CARCN (P32955), 
CYSP3_CARCN (P32956), CYSP4_CARCN (P32957), CYSP_TRIFO  (P33403), 
CYSP_TRIVA  (P33404), HP29_SARPE  (P29184), KARA_BROPL  (P22442), 
MDO2_PSEMR  (P83447), PEPT1_DERMI (P16312), PHIG1_PHIGI (P84789), 
THPA_THADA  (P21381)
» More

PDB
[Detailed view]
223 PDB

1AEC; 1AIM; 1ATK; 1AU0; 1AU2; 1AU3; 1AU4; 1AYU; 1AYV; 1AYW; 1BGO; 1BP4; 1BQI; 1BY8; 1CJL; 1CPJ; 1CS8; 1CSB; 1CTE; 1CVZ; 1DEU; 1EF7; 1EWL; 1EWM; 1EWO; 1EWP; 1F29; 1F2A; 1F2B; 1F2C; 1FH0; 1GEC; 1GLO; 1GMY; 1HUC; 1ICF; 1ITO; 1IWD; 1JQP; 1K3B; 1KHP; 1KHQ; 1ME3; 1ME4; 1MEG; 1MEM; 1MHW; 1MIR; 1MS6; 1NB3; 1NB5; 1NL6; 1NLJ; 1NPZ; 1NQC; 1O0E; 1PAD; 1PBH; 1PCI; 1PE6; 1PIP; 1POP; 1PPD; 1PPN; 1PPO; 1PPP; 1Q6K; 1QDQ; 1S4V; 1SNK; 1SP4; 1STF; 1THE; 1TU6; 1U9Q; 1U9V; 1U9W; 1U9X; 1VSN; 1XKG; 1YAL; 1YK7; 1YK8; 1YT7; 2ACT; 2AIM; 2AS8; 2ATO; 2AUX; 2AUZ; 2BDL; 2C0Y; 2CIO; 2DC6; 2DC7; 2DC8; 2DC9; 2DCA; 2DCB; 2DCC; 2DCD; 2DJF; 2DJG; 2F1G; 2F7D; 2FO5; 2FTD; 2FYE; 2G6D; 2H7J; 2HH5; 2HHN; 2HXZ; 2IPP; 2NQD; 2O6X; 2OP3; 2OZ2; 2PAD; 2PBH; 2PNS; 2R6N; 2R9M; 2R9N; 2R9O; 2VHS; 2WBF; 2XU1; 2XU3; 2XU4; 2XU5; 2YJ2; 2YJ8; 2YJ9; 2YJB; 2YJC; 3AI8; 3BC3; 3C9E; 3CBJ; 3CBK; 3CH2; 3CH3; 3D6S; 3E1Z; 3H6S; 3H7D; 3H89; 3H8B; 3H8C; 3HD3; 3HHA; 3HWN; 3I06; 3IEJ; 3IMA; 3IUT; 3IV2; 3K24; 3K9M; 3KFQ; 3KKU; 3KSE; 3KW9; 3KWB; 3KWN; 3KWZ; 3KX1; 3LFY; 3LXS; 3MPE; 3MPF; 3N3G; 3N4C; 3O0U; 3O1G; 3OF8; 3OF9; 3OVX; 3OVZ; 3PBH; 3PDF; 3RVV; 3RVW; 3RVX; 3TNX; 3USV; 4AXL; 4AXM; 4BPV; 4BQV; 4BS5; 4BS6; 4BSQ; 4CDC; 4CDD; 4CDE; 4CDF; 4DMX; 4DMY; 4KLB; 4KP9; 4LEG; 4MZO; 4MZS; 4N79; 4N8W; 4OEL; 4OEM; 4P6E; 4P6G; 4PAD; 4PI3; 4PP1; 4PP2; 4W5B; 4W5C; 4XUI; 5PAD; 6PAD; 7PCK; 8PCH; 9PAP
» More

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission