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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00647


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PURL: https://purl.expasy.org/prosite/signature/PS00647

Direct ScanProsite submission
General information about the entry

Entry name [info] THYMID_PHOSPHORYLASE
Accession [info] PS00647
Entry type [info] PATTERN
Date [info] 01-JUN-1992 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00557

Name and characterization of the entry

Description [info] Thymidine and pyrimidine-nucleoside phosphorylases signature.
Pattern [info] 
[SA]-[GS]-R-[GA]-[LIV]-x(2)-[TAP]-[GAS]-G-T-x-D-x-[LIVMF]-[EDS].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 181 in 181 different sequences
Number of true positive hits 181 in 181 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 1
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 99.45 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 181 sequences 

AMPP1_ARCFU (O28928), AMPP2_ARCFU (O28927), AMPPA_HYPBU (A2BJU0), 

AMPPA_META3 (A6UUN0), AMPPA_METAC (Q8TL01), AMPPA_METB6 (A7I5N0), 
AMPPA_METBF (Q466X0), AMPPA_METBU (Q12Z64), AMPPA_METHJ (Q2FTS5), 
AMPPA_METJA (Q58081), AMPPA_METLZ (A2SPI9), AMPPA_METM5 (A4FZL0), 
AMPPA_METM6 (A9A6M7), AMPPA_METM7 (A6VIW6), AMPPA_METMA (Q8Q0P9), 
AMPPA_METMJ (A3CSY4), AMPPA_METMP (Q6M0E4), AMPPA_METTP (A0B6C9), 
AMPPA_METVS (A6URW3), AMPPA_NATPD (Q3IP82), AMPPA_PYRAB (Q9V163), 
AMPPA_PYRFU (Q8U0I2), AMPPA_PYRHO (O59251), AMPPA_THEGJ (C5A1L9), 
AMPPA_THEKO (Q5JCX3), AMPPA_THEON (B6YWT7), AMPPA_THEPD (A1RWC3), 
AMPPA_THESM (C6A2A0), PDP_BACSU   (P39142), PDP_GEOSE   (P77836), 
PDP_STAA3   (Q2FEZ3), PDP_STAA8   (Q2FWC1), PDP_STAAB   (Q2YUL7), 
PDP_STAAC   (Q5HE64), PDP_STAAM   (Q99SC3), PDP_STAAN   (Q7A4D0), 
PDP_STAAR   (Q6GET9), PDP_STAAS   (Q6G7H4), PDP_STAAW   (Q8NVF6), 
PDP_STAEQ   (Q5HM85), PDP_STAES   (Q8CNH8), PDP_STAHJ   (Q4L818), 
RBKTP_AZOC5 (A8IA58), RBKTP_CUPNH (Q0K3R9), RBKTP_CUPPJ (Q46UT0), 
RBKTP_CUPTR (B2AIF3), RBKTP_ROSDO (Q16A32), TYPH1_ACISJ (A1W631), 
TYPH1_CUPNH (Q0KA59), TYPH2_ACISJ (A1W9B0), TYPH2_CUPPJ (Q46S32), 
TYPH_AERHH  (A0KPE3), TYPH_AERS4  (A4SRU3), TYPH_AGRFC  (Q8UJ08), 
TYPH_ALBFT  (Q21W90), TYPH_ALIF1  (Q5E7J6), TYPH_ALIFM  (B5FA99), 
TYPH_ALISL  (B6ENG4), TYPH_BRADU  (Q89QK7), TYPH_BRASB  (A5EG87), 
TYPH_BRASO  (A4YRL1), TYPH_BURCH  (A0KCQ9), TYPH_BURCJ  (B4EPB7), 
TYPH_BURL3  (Q39PA6), TYPH_BURM7  (A3MAQ6), TYPH_BURMA  (Q62EC5), 
TYPH_BURMS  (A1UY21), TYPH_BURO0  (B1KC83), TYPH_BURO1  (Q1BV59), 
TYPH_BURP0  (A3P8N2), TYPH_BURP6  (A3NN77), TYPH_BURPS  (Q63IV6), 
TYPH_CHESB  (Q11BH8), TYPH_CHRVO  (Q7NRT0), TYPH_COLP3  (Q483R6), 
TYPH_CROS8  (A7MGA9), TYPH_ECO24  (A7ZVS5), TYPH_ECO27  (B7UR10), 
TYPH_ECO45  (B7MNI9), TYPH_ECO55  (B7LEM8), TYPH_ECO57  (Q8XB35), 
TYPH_ECO5E  (B5Z4R4), TYPH_ECO7I  (B7NW62), TYPH_ECO81  (B7MTC8), 
TYPH_ECO8A  (B7LXU4), TYPH_ECODH  (B1XFJ2), TYPH_ECOHS  (A8A8B1), 
TYPH_ECOL6  (Q8FA52), TYPH_ECOLC  (B1IS37), TYPH_ECOLI  (P07650), 
TYPH_ECOLU  (B7NH50), TYPH_ECOSE  (B6I6M9), TYPH_ECOSM  (B1LEI7), 
TYPH_ENT38  (A4W699), TYPH_ERWT9  (B2VH51), TYPH_ESCF3  (B7LNS2), 
TYPH_HAHCH  (Q2SLV0), TYPH_HUMAN  (P19971), TYPH_IDILO  (Q5QXT8), 
TYPH_KLEP3  (B5Y276), TYPH_KLEP7  (A6THZ7), TYPH_LEGPA  (Q5X2M8), 
TYPH_LEGPC  (A5IFN1), TYPH_LEGPH  (Q5ZWR3), TYPH_LEGPN  (Q8RNP4), 
TYPH_MARMM  (Q0ATA0), TYPH_METCA  (Q607P2), TYPH_MYCGE  (P47297), 
TYPH_MYCPI  (P47717), TYPH_MYCPN  (P75052), TYPH_MYCTO  (P9WFS0), 
TYPH_MYCTU  (P9WFS1), TYPH_NITHX  (Q1QM39), TYPH_PARL1  (A7HYS8), 
TYPH_PECAS  (Q6D991), TYPH_PHOPR  (Q6LUH3), TYPH_POLSJ  (Q12E97), 
TYPH_PROMH  (B4EWA3), TYPH_PSYIN  (A1SYK5), TYPH_RALN1  (Q8Y2X7), 
TYPH_RHILO  (Q98GV5), TYPH_RHIME  (Q92T50), TYPH_RHOP5  (Q07J10), 
TYPH_RHOPA  (Q6N2A3), TYPH_RHOPB  (Q20Z21), TYPH_RHOPS  (Q13B59), 
TYPH_RHOPT  (B3QKL9), TYPH_SALA4  (B5F525), TYPH_SALAR  (A9MRA6), 
TYPH_SALCH  (Q57G40), TYPH_SALDC  (B5FTC6), TYPH_SALEP  (B5R2J7), 
TYPH_SALG2  (B5R9V0), TYPH_SALHS  (B4TH00), TYPH_SALNS  (B4T4H1), 
TYPH_SALPA  (Q5PK22), TYPH_SALPK  (B5BAJ8), TYPH_SALSV  (B4TU42), 
TYPH_SALTI  (Q8XF46), TYPH_SALTY  (Q7CP66), TYPH_SERP5  (A8G9H7), 
TYPH_SHEAM  (A1S475), TYPH_SHEB2  (B8E6P5), TYPH_SHEB5  (A3D7J3), 
TYPH_SHEB8  (A6WRB7), TYPH_SHEB9  (A9KZ79), TYPH_SHEDO  (Q12QG2), 
TYPH_SHEFN  (Q086F9), TYPH_SHEHH  (B0TQ90), TYPH_SHELP  (A3QGT2), 
TYPH_SHEON  (Q8EHK3), TYPH_SHEPA  (A8H727), TYPH_SHEPC  (A4Y9A7), 
TYPH_SHEPW  (B8CKI5), TYPH_SHESA  (A0KU08), TYPH_SHESH  (A8FYQ8), 
TYPH_SHESM  (Q0HLE9), TYPH_SHESR  (Q0HXQ3), TYPH_SHESW  (A1RH88), 
TYPH_SHEWM  (B1KRP7), TYPH_SHIB3  (B2TZR5), TYPH_SHIBS  (Q31SV7), 
TYPH_SHIDS  (Q327L4), TYPH_SHIF8  (Q0SX29), TYPH_SHIFL  (Q83P01), 
TYPH_SHISS  (Q3YU11), TYPH_SINFN  (C3MBH0), TYPH_SINMW  (A6UET3), 
TYPH_SODGM  (Q2NW05), TYPH_SPHAL  (Q1GQ92), TYPH_STUS1  (A4VHV6), 
TYPH_TOLAT  (C4LAA1), TYPH_VIBCH  (Q9KPL8), TYPH_VIBPA  (Q87M23), 
TYPH_VIBVU  (Q8DBT1), TYPH_VIBVY  (Q7MI39), TYPH_YERE8  (A1JJ98), 
TYPH_YERP3  (A7FMH4), TYPH_YERPE  (Q74PY8), TYPH_YERPS  (Q66EV9), 
TYPH_YERPY  (B1JL36)
» more

UniProtKB/Swiss-Prot
False negative sequences		 1 sequence 

AMPPA_METAR (Q0W5A8)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			2 sequences
			


			
TYPH_LACRH  (P19663), TYPH_METHO  (P43050)


				
	

	

		PDB
[Detailed view]		
		
			23 PDB
			


			pdb_00001azy; pdb_00001brw; pdb_00001otp; pdb_00001tpt; pdb_00001uou; pdb_00002j0f; pdb_00002tpt; pdb_00002wk5; pdb_00002wk6; pdb_00003h5q; pdb_00004ead; pdb_00004eaf; 
			
				pdb_00004ga4; pdb_00004ga5; pdb_00004ga6; pdb_00004lhm; pdb_00004x46; pdb_00004xr5; pdb_00004yek; pdb_00004yyy; pdb_00005ep8; pdb_00005ey3; pdb_00005oln
			
			

			» more