Entry: PS00652

Forthcoming changes to the profile format
General information about the entry

Entry name [info] TNFR_NGFR_1
Accession [info] PS00652
Entry type [info] PATTERN
Date [info] JUN-1992 (CREATED); DEC-2004 (DATA UPDATE); SEP-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00561

Name and characterization of the entry

Description [info] TNFR/NGFR family cysteine-rich region signature.
Pattern [info]
C-x(4,6)-[FYH]-x(5,10)-C-x(0,2)-C-x(2,3)-C-x(7,11)-C-x(4,6)-[DNEQSKP]-
{PD}-{CP}-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_10 which contains 546'790 sequence entries.


Total number of hits 160 in 102 different sequences
Number of true positive hits 132 in 74 different sequences
Number of 'unknown' hits
Number of false positive hits 28 in 28 different sequences
Number of false negative sequences 19
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 82.50 %
Recall (true positives / (true positives + false negatives)) 87.42 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 3
Site [info] disulfide at position 1
Site [info] disulfide at position 5
Site [info] disulfide at position 7
Site [info] disulfide at position 9
Site [info] disulfide at position 11
Site [info] disulfide at position 16
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
74 sequences

A53R_VACCW  (P24756), A53_VACCC   (P21071), CD27_HUMAN  (P26842), 
CD27_MOUSE  (P41272), CRMB_CAMPM  (P68636), CRMB_CAMPS  (P68637), 
CRMB_CWPXG  (O73559), CRMB_VAR67  (P34015), TNF6B_HUMAN (O95407), 
TNR11_HUMAN (Q9Y6Q6), TNR11_MOUSE (O35305), TNR14_HUMAN (Q92956), 
TNR16_CHICK (P18519), TNR16_HUMAN (P08138), TNR16_MOUSE (Q9Z0W1), 
TNR16_RAT   (P07174), TNR19_HUMAN (Q9NS68), TNR19_MOUSE (Q9JLL3), 
TNR1A_BOVIN (O19131), TNR1A_HUMAN (P19438), TNR1A_MOUSE (P25118), 
TNR1A_PIG   (P50555), TNR1A_RAT   (P22934), TNR1B_HUMAN (P20333), 
TNR1B_MOUSE (P25119), TNR1B_RAT   (Q80WY6), TNR21_HUMAN (O75509), 
TNR21_MOUSE (Q9EPU5), TNR22_MOUSE (Q9ER62), TNR23_MOUSE (Q9ER63), 
TNR25_HUMAN (Q93038), TNR26_MOUSE (P83626), TNR27_HUMAN (Q9HAV5), 
TNR27_MOUSE (Q8BX35), TNR3_HUMAN  (P36941), TNR3_MOUSE  (P50284), 
TNR4_HUMAN  (P43489), TNR4_MOUSE  (P47741), TNR4_RAT    (P15725), 
TNR5_BOVIN  (Q28203), TNR5_CALJA  (Q3LRP1), TNR5_CANFA  (Q7YRL5), 
TNR5_HORSE  (Q3ZTK5), TNR5_HUMAN  (P25942), TNR5_MOUSE  (P27512), 
TNR5_PIG    (Q8SQ34), TNR6_BOVIN  (P51867), TNR6_CERAT  (Q9BDN4), 
TNR6_HUMAN  (P25445), TNR6_MACFA  (Q9TSN4), TNR6_MACMU  (Q9BDP2), 
TNR6_MACNE  (Q9BDN0), TNR6_MOUSE  (P25446), TNR6_PIG    (O77736), 
TNR6_RAT    (Q63199), TNR8_HUMAN  (P28908), TNR8_MOUSE  (Q60846), 
TNR9_HUMAN  (Q07011), TNR9_MOUSE  (P20334), TR10A_HUMAN (O00220), 
TR10B_HUMAN (O14763), TR10B_MOUSE (Q9QZM4), TR10C_HUMAN (O14798), 
TR10D_HUMAN (Q9UBN6), TR11B_BOVIN (A5D7R1), TR11B_HUMAN (O00300), 
TR11B_MOUSE (O08712), TR11B_RAT   (O08727), TR13B_HUMAN (O14836), 
UL144_HCMVM (F5HAM0), UL144_HCMVO (Q68396), USP3_PINMG  (H2A0M8), 
VT2_MYXVL   (P29825), VT2_RFVKA   (P25943)
» More

UniProtKB/Swiss-Prot
False negative sequences
19 sequences

ACCR2_ARATH (O80963), C22L_VACCC  (P21106), CRI4_MAIZE  (O24585), 
EDAR_HUMAN  (Q9UNE0), EDAR_MOUSE  (Q9R187), EDAR_ORYLA  (Q90VY2), 
TNR12_HUMAN (Q9NP84), TNR12_MOUSE (Q9CR75), TNR17_HUMAN (Q02223), 
TNR17_MOUSE (O88472), TNR18_HUMAN (Q9Y5U5), TNR18_MOUSE (O35714), 
TNR8_RAT    (P97525), TR13B_MOUSE (Q9ET35), TR13C_HUMAN (Q96RJ3), 
TR13C_MOUSE (Q9D8D0), TR19L_HUMAN (Q969Z4), TR19L_MACFA (Q9N092), 
TR19L_MOUSE (Q8BX43)
» More

UniProtKB/Swiss-Prot
False positive sequences
28 sequences

DEFI8_DROME (Q9VTT9), EPI1_CAEEL  (Q21313), GG3_ARATH   (Q6AWT8), 
IGFR1_BOVIN (A5PJC7), KR134_HYLAG (Q4W7H1), KR134_HYLLA (Q4W7H0), 
KR134_MACFA (Q4W7G9), KR134_MACFU (Q4W7G8), KR134_SAPAP (Q4W7G7), 
KRA21_HUMAN (Q9BYU5), KRA22_HUMAN (Q9BYT5), KRA43_HUMAN (Q9BYR4), 
KRA44_HUMAN (Q9BYR3), KRA45_HUMAN (Q9BYR2), KRA47_HUMAN (Q9BYR0), 
KRA49_HUMAN (Q9BYQ8), KRA59_HUMAN (P26371), LAMA5_HUMAN (O15230), 
LAMA5_MOUSE (Q61001), M1BL1_HUMAN (P0DM35), MDFI_HUMAN  (Q99750), 
MEDEA_ARATH (O65312), MT4_HUMAN   (P47944), TRI42_HUMAN (Q8IWZ5), 
TRI42_MOUSE (Q9D2H5), UL32_EHV2   (Q66671), YL264_MIMIV (Q5UPU7), 
YL724_MIMIV (Q5UNX6)
» More

PDB
[Detailed view]
42 PDB

1D0G; 1D4V; 1DU3; 1EXT; 1FT4; 1JMA; 1NCF; 1SG1; 1TNR; 1ZA3; 2AW2; 2H9G; 2HEV; 2HEY; 3ALQ; 3BUK; 3IJ2; 3K51; 3ME2; 3ME4; 3MHD; 3MI8; 3QBQ; 3QD6; 3QO4; 3TJE; 3U3P; 3U3Q; 3U3S; 3U3T; 3U3V; 3URF; 4E4D; 4FHQ; 4GIQ; 4I9X; 4J6G; 4KGG; 4KGQ; 4MSV; 4MXW; 4OD2
» More

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission