PROSITE logo

PROSITE entry PS00652


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] TNFR_NGFR_1
Accession [info] PS00652
Entry type [info] PATTERN
Date [info] 01-JUN-1992 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00561

Name and characterization of the entry

Description [info] TNFR/NGFR family cysteine-rich region signature.
Pattern [info] 
C-x(4,6)-[FYH]-x(5,10)-C-x(0,2)-C-x(2,3)-C-x(7,11)-C-x(4,6)-[DNEQSKP]-
{PD}-{CP}-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.


Total number of hits 178 in 117 different sequences
Number of true positive hits 138 in 78 different sequences
Number of 'unknown' hits 1
Number of false positive hits 39 in 38 different sequences
Number of false negative sequences 20
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 77.97 %
Recall (true positives / (true positives + false negatives)) 87.34 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 3
Site [info] disulfide at position 1
Site [info] disulfide at position 5
Site [info] disulfide at position 7
Site [info] disulfide at position 9
Site [info] disulfide at position 11
Site [info] disulfide at position 16
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 78 sequences 

A53R_VACCW  (P24756), A53_VACCC   (P21071), CD27_HUMAN  (P26842), 

CD27_MOUSE  (P41272), CRMB_CAMPM  (P68636), CRMB_CAMPS  (P68637), 
CRMB_CWPXG  (O73559), CRMB_MONPV  (P0DTN0), CRMB_VAR67  (P0DSV7), 
CRMB_VARV   (P0DSV8), TNF6B_HUMAN (O95407), TNR11_HUMAN (Q9Y6Q6), 
TNR11_MOUSE (O35305), TNR14_HUMAN (Q92956), TNR14_MOUSE (Q80WM9), 
TNR16_CHICK (P18519), TNR16_HUMAN (P08138), TNR16_MOUSE (Q9Z0W1), 
TNR16_RAT   (P07174), TNR19_HUMAN (Q9NS68), TNR19_MOUSE (Q9JLL3), 
TNR1A_BOVIN (O19131), TNR1A_HUMAN (P19438), TNR1A_MOUSE (P25118), 
TNR1A_PIG   (P50555), TNR1A_RAT   (P22934), TNR1B_HUMAN (P20333), 
TNR1B_MOUSE (P25119), TNR1B_RAT   (Q80WY6), TNR21_HUMAN (O75509), 
TNR21_MOUSE (Q9EPU5), TNR21_RAT   (D3ZF92), TNR22_MOUSE (Q9ER62), 
TNR23_MOUSE (Q9ER63), TNR25_HUMAN (Q93038), TNR26_MOUSE (P83626), 
TNR27_HUMAN (Q9HAV5), TNR27_MOUSE (Q8BX35), TNR3_HUMAN  (P36941), 
TNR3_MOUSE  (P50284), TNR4_HUMAN  (P43489), TNR4_MOUSE  (P47741), 
TNR4_RAT(P15725), TNR5_BOVIN  (Q28203), TNR5_CALJA  (Q3LRP1), 
TNR5_CANLF  (Q7YRL5), TNR5_HORSE  (Q3ZTK5), TNR5_HUMAN  (P25942), 
TNR5_MOUSE  (P27512), TNR5_PIG(Q8SQ34), TNR6_BOVIN  (P51867), 
TNR6_CERAT  (Q9BDN4), TNR6_HUMAN  (P25445), TNR6_MACFA  (Q9TSN4), 
TNR6_MACMU  (Q9BDP2), TNR6_MACNE  (Q9BDN0), TNR6_MOUSE  (P25446), 
TNR6_PIG(O77736), TNR6_RAT(Q63199), TNR8_HUMAN  (P28908), 
TNR8_MOUSE  (Q60846), TNR9_HUMAN  (Q07011), TNR9_MOUSE  (P20334), 
TR10A_HUMAN (O00220), TR10B_HUMAN (O14763), TR10B_MOUSE (Q9QZM4), 
TR10C_HUMAN (O14798), TR10D_HUMAN (Q9UBN6), TR11B_BOVIN (A5D7R1), 
TR11B_HUMAN (O00300), TR11B_MOUSE (O08712), TR11B_RAT   (O08727), 
TR13B_HUMAN (O14836), UL144_HCMVM (F5HAM0), UL144_HCMVO (Q68396), 
USP3_PINMG  (H2A0M8), VT2_MYXVL   (P29825), VT2_RFVKA   (P25943)
» more

UniProtKB/Swiss-Prot
False negative sequences		 20 sequences 

ACCR2_ARATH (O80963), C22L_VACCC  (P21106), CRI4_MAIZE  (O24585), 

EDAR_HUMAN  (Q9UNE0), EDAR_MOUSE  (Q9R187), EDAR_ORYLA  (Q90VY2), 
TNR12_HUMAN (Q9NP84), TNR12_MOUSE (Q9CR75), TNR17_HUMAN (Q02223), 
TNR17_MOUSE (O88472), TNR18_HUMAN (Q9Y5U5), TNR18_MOUSE (O35714), 
TNR8_RAT(P97525), TR13B_MOUSE (Q9ET35), TR13C_HUMAN (Q96RJ3), 
TR13C_MOUSE (Q9D8D0), TR19L_HUMAN (Q969Z4), TR19L_MACFA (Q9N092), 
TR19L_MOUSE (Q8BX43), WGN_DROME   (Q9VWS4)
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

SCGR7_HUMAN (A0A286YF01)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			38 sequences
			


			
DEFI8_DROME (Q9VTT9), EPI1_CAEEL  (Q21313), GG3_ARATH   (Q6AWT8), 

			
IGFR1_BOVIN (A5PJC7), KR134_HYLAG (Q4W7H1), KR134_HYLLA (Q4W7H0), 
KR134_MACFA (Q4W7G9), KR134_MACFU (Q4W7G8), KR134_SAPAP (Q4W7G7), 
KR416_HUMAN (G5E9R7), KRA21_HUMAN (Q9BYU5), KRA22_HUMAN (Q9BYT5), 
KRA43_HUMAN (Q9BYR4), KRA44_HUMAN (Q9BYR3), KRA45_HUMAN (Q9BYR2), 
KRA47_HUMAN (Q9BYR0), KRA49_HUMAN (Q9BYQ8), KRA59_HUMAN (P26371), 
LAMA5_HUMAN (O15230), LAMA5_MOUSE (Q61001), M1BL1_HUMAN (P0DM35), 
MDFI_HUMAN  (Q99750), MEDEA_ARATH (O65312), MT4_HUMAN   (P47944), 
PTPR_CAEEL  (H2KZM6), SCGR2_HUMAN (A0A286YFB4), SCGR3_HUMAN (A0A286YF60), 
SCGR4_HUMAN (A0A286YEV6), SCGR5_HUMAN (A0A286YF46), SCGR6_HUMAN (A0A286YF77), 
SCGR8_HUMAN (A0A286YFG1), SCGR9_HUMAN (P0DSO2), STIG1_SOLLC (Q6EEH1), 
TRI42_HUMAN (Q8IWZ5), TRI42_MOUSE (Q9D2H5), UL32_EHV2   (Q66671), 
YL264_MIMIV (Q5UPU7), YL724_MIMIV (Q5UNX6)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			97 PDB
			


			1D0G; 1D4V; 1DU3; 1EXT; 1FT4; 1JMA; 1NCF; 1SG1; 1TNR; 1ZA3; 2AW2; 2H9G; 
			
				2HEV; 2HEY; 3ALQ; 3BUK; 3IJ2; 3K51; 3ME2; 3ME4; 3MHD; 3MI8; 3QBQ; 3QD6; 
				3QO4; 3THM; 3TJE; 3U3P; 3U3Q; 3U3S; 3U3T; 3U3V; 3URF; 3X3F; 4E4D; 4FHQ; 
				4GIQ; 4I9X; 4J6G; 4KGG; 4KGQ; 4MSV; 4MXW; 4N90; 4OD2; 4RSU; 4YN0; 5BNQ; 
				5CIR; 5DMI; 5DMJ; 5IHL; 5L36; 5T2Q; 5T2R; 5TL5; 5TLJ; 5TLK; 5WI8; 5WIW; 
				5WJF; 6A3V; 6A3W; 6BWV; 6CPR; 6CU0; 6FAX; 6MGP; 6MHR; 6MI2; 6MKZ; 6NG3; 
				6OGX; 6OKM; 6OKN; 6PE8; 6PE9; 6T3J; 6Y8K; 7D4B; 7KP7; 7KP8; 7KPB; 7KX0; 
				7MSG; 7MSJ; 7P3I; 7YK4; 7YXU; 8AG1; 8DPX; 8DS5; 8GYE; 8HLB; 8OZ3; 8YX1; 
				8YX9
			
			

			» more