Entry: PS00652

General information about the entry

Entry name [info] TNFR_NGFR_1
Accession [info] PS00652
Entry type [info] PATTERN
Date [info] JUN-1992 (CREATED); DEC-2004 (DATA UPDATE); MAY-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC00561

Name and characterization of the entry

Description [info] TNFR/NGFR family cysteine-rich region signature.
Pattern [info]
C-x(4,6)-[FYH]-x(5,10)-C-x(0,2)-C-x(2,3)-C-x(7,11)-C-x(4,6)-[DNEQSKP]-
{PD}-{CP}-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_06 which contains 551'385 sequence entries.


Total number of hits 160 in 102 different sequences
Number of true positive hits 132 in 74 different sequences
Number of 'unknown' hits 0
Number of false positive hits 28 in 28 different sequences
Number of false negative sequences 20
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 82.50 %
Recall (true positives / (true positives + false negatives)) 86.84 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 3
Site [info] disulfide at position 1
Site [info] disulfide at position 5
Site [info] disulfide at position 7
Site [info] disulfide at position 9
Site [info] disulfide at position 11
Site [info] disulfide at position 16
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
74 sequences

A53R_VACCW  (P24756    ), A53_VACCC   (P21071    ), CD27_HUMAN  (P26842    ), 
CD27_MOUSE  (P41272    ), CRMB_CAMPM  (P68636    ), CRMB_CAMPS  (P68637    ), 
CRMB_CWPXG  (O73559    ), CRMB_VAR67  (P34015    ), TNF6B_HUMAN (O95407    ), 
TNR11_HUMAN (Q9Y6Q6    ), TNR11_MOUSE (O35305    ), TNR14_HUMAN (Q92956    ), 
TNR16_CHICK (P18519    ), TNR16_HUMAN (P08138    ), TNR16_MOUSE (Q9Z0W1    ), 
TNR16_RAT   (P07174    ), TNR19_HUMAN (Q9NS68    ), TNR19_MOUSE (Q9JLL3    ), 
TNR1A_BOVIN (O19131    ), TNR1A_HUMAN (P19438    ), TNR1A_MOUSE (P25118    ), 
TNR1A_PIG   (P50555    ), TNR1A_RAT   (P22934    ), TNR1B_HUMAN (P20333    ), 
TNR1B_MOUSE (P25119    ), TNR1B_RAT   (Q80WY6    ), TNR21_HUMAN (O75509    ), 
TNR21_MOUSE (Q9EPU5    ), TNR22_MOUSE (Q9ER62    ), TNR23_MOUSE (Q9ER63    ), 
TNR25_HUMAN (Q93038    ), TNR26_MOUSE (P83626    ), TNR27_HUMAN (Q9HAV5    ), 
TNR27_MOUSE (Q8BX35    ), TNR3_HUMAN  (P36941    ), TNR3_MOUSE  (P50284    ), 
TNR4_HUMAN  (P43489    ), TNR4_MOUSE  (P47741    ), TNR4_RAT    (P15725    ), 
TNR5_BOVIN  (Q28203    ), TNR5_CALJA  (Q3LRP1    ), TNR5_CANLF  (Q7YRL5    ), 
TNR5_HORSE  (Q3ZTK5    ), TNR5_HUMAN  (P25942    ), TNR5_MOUSE  (P27512    ), 
TNR5_PIG    (Q8SQ34    ), TNR6_BOVIN  (P51867    ), TNR6_CERAT  (Q9BDN4    ), 
TNR6_HUMAN  (P25445    ), TNR6_MACFA  (Q9TSN4    ), TNR6_MACMU  (Q9BDP2    ), 
TNR6_MACNE  (Q9BDN0    ), TNR6_MOUSE  (P25446    ), TNR6_PIG    (O77736    ), 
TNR6_RAT    (Q63199    ), TNR8_HUMAN  (P28908    ), TNR8_MOUSE  (Q60846    ), 
TNR9_HUMAN  (Q07011    ), TNR9_MOUSE  (P20334    ), TR10A_HUMAN (O00220    ), 
TR10B_HUMAN (O14763    ), TR10B_MOUSE (Q9QZM4    ), TR10C_HUMAN (O14798    ), 
TR10D_HUMAN (Q9UBN6    ), TR11B_BOVIN (A5D7R1    ), TR11B_HUMAN (O00300    ), 
TR11B_MOUSE (O08712    ), TR11B_RAT   (O08727    ), TR13B_HUMAN (O14836    ), 
UL144_HCMVM (F5HAM0    ), UL144_HCMVO (Q68396    ), USP3_PINMG  (H2A0M8    ), 
VT2_MYXVL   (P29825    ), VT2_RFVKA   (P25943    )
» more

UniProtKB/Swiss-Prot
False negative sequences
20 sequences

ACCR2_ARATH (O80963    ), C22L_VACCC  (P21106    ), CRI4_MAIZE  (O24585    ), 
EDAR_HUMAN  (Q9UNE0    ), EDAR_MOUSE  (Q9R187    ), EDAR_ORYLA  (Q90VY2    ), 
TNR12_HUMAN (Q9NP84    ), TNR12_MOUSE (Q9CR75    ), TNR17_HUMAN (Q02223    ), 
TNR17_MOUSE (O88472    ), TNR18_HUMAN (Q9Y5U5    ), TNR18_MOUSE (O35714    ), 
TNR8_RAT    (P97525    ), TR13B_MOUSE (Q9ET35    ), TR13C_HUMAN (Q96RJ3    ), 
TR13C_MOUSE (Q9D8D0    ), TR19L_HUMAN (Q969Z4    ), TR19L_MACFA (Q9N092    ), 
TR19L_MOUSE (Q8BX43    ), WGN_DROME   (Q9VWS4    )
» more

UniProtKB/Swiss-Prot
False positive sequences
28 sequences

DEFI8_DROME (Q9VTT9    ), EPI1_CAEEL  (Q21313    ), GG3_ARATH   (Q6AWT8    ), 
IGFR1_BOVIN (A5PJC7    ), KR134_HYLAG (Q4W7H1    ), KR134_HYLLA (Q4W7H0    ), 
KR134_MACFA (Q4W7G9    ), KR134_MACFU (Q4W7G8    ), KR134_SAPAP (Q4W7G7    ), 
KRA21_HUMAN (Q9BYU5    ), KRA22_HUMAN (Q9BYT5    ), KRA43_HUMAN (Q9BYR4    ), 
KRA44_HUMAN (Q9BYR3    ), KRA45_HUMAN (Q9BYR2    ), KRA47_HUMAN (Q9BYR0    ), 
KRA49_HUMAN (Q9BYQ8    ), KRA59_HUMAN (P26371    ), LAMA5_HUMAN (O15230    ), 
LAMA5_MOUSE (Q61001    ), M1BL1_HUMAN (P0DM35    ), MDFI_HUMAN  (Q99750    ), 
MEDEA_ARATH (O65312    ), MT4_HUMAN   (P47944    ), TRI42_HUMAN (Q8IWZ5    ), 
TRI42_MOUSE (Q9D2H5    ), UL32_EHV2   (Q66671    ), YL264_MIMIV (Q5UPU7    ), 
YL724_MIMIV (Q5UNX6    )
» more

PDB
[Detailed view]
47 PDB

1D0G; 1D4V; 1DU3; 1EXT; 1FT4; 1JMA; 1NCF; 1SG1; 1TNR; 1ZA3; 2AW2; 2H9G; 2HEV; 2HEY; 3ALQ; 3BUK; 3IJ2; 3K51; 3ME2; 3ME4; 3MHD; 3MI8; 3QBQ; 3QD6; 3QO4; 3TJE; 3U3P; 3U3Q; 3U3S; 3U3T; 3U3V; 3URF; 3X3F; 4E4D; 4FHQ; 4GIQ; 4I9X; 4J6G; 4KGG; 4KGQ; 4MSV; 4MXW; 4N90; 4OD2; 4RSU; 4YN0; 5BNQ
» more

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