Entry: PS00652

General information about the entry
Entry name TNFR_NGFR_1
Accession number PS00652
Entry type PATTERN
Date JUN-1992 (CREATED); DEC-2004 (DATA UPDATE); APR-2013 (INFO UPDATE).
PROSITE Documentation PDOC00561
Name and characterization of the entry
DescriptionTNFR/NGFR family cysteine-rich region signature.
Pattern C-x(4,6)-[FYH]-x(5,10)-C-x(0,2)-C-x(2,3)-C-x(7,11)-C-x(4,6)-[DNEQSKP]- {PD}-{CP}-C.
Numerical results
  • UniProtKB/Swiss-Prot release number: 2013_06, total number of sequence entries in that release: 540261.
  • Total number of hits in UniProtKB/Swiss-Prot: 159 hits in 101 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 132 hits in 74 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 27 hits in 27 different sequences
  • Number of known missed hits: 19
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0
  • Precision (true hits / (true hits + false positives)): 83.02 %
  • Recall (true hits / (true hits + false negatives)): 87.42 %
Comments
  • Taxonomic range: Eukaryotes, Eukaryotic viruses
  • Maximum known number of repetitions of the pattern in a single protein: 3
  • `Interesting' site in the pattern: 1,disulfide
  • `Interesting' site in the pattern: 5,disulfide
  • `Interesting' site in the pattern: 7,disulfide
  • `Interesting' site in the pattern: 9,disulfide
  • `Interesting' site in the pattern: 11,disulfide
  • `Interesting' site in the pattern: 16,disulfide
  • VERSION: 1
Cross-references
UniProtKB/Swiss-Prot True positive hits:
A53R_VACCW  (P24756), A53_VACCC   (P21071), CD27_HUMAN  (P26842), 
CD27_MOUSE  (P41272), CRMB_CAMPM  (P68636), CRMB_CAMPS  (P68637), 
CRMB_CWPXG  (O73559), CRMB_VAR67  (P34015), TNF6B_HUMAN (O95407), 
TNR11_HUMAN (Q9Y6Q6), TNR11_MOUSE (O35305), TNR14_HUMAN (Q92956), 
TNR16_CHICK (P18519), TNR16_HUMAN (P08138), TNR16_MOUSE (Q9Z0W1), 
TNR16_RAT   (P07174), TNR19_HUMAN (Q9NS68), TNR19_MOUSE (Q9JLL3), 
TNR1A_BOVIN (O19131), TNR1A_HUMAN (P19438), TNR1A_MOUSE (P25118), 
TNR1A_PIG   (P50555), TNR1A_RAT   (P22934), TNR1B_HUMAN (P20333), 
TNR1B_MOUSE (P25119), TNR1B_RAT   (Q80WY6), TNR21_HUMAN (O75509), 
TNR21_MOUSE (Q9EPU5), TNR22_MOUSE (Q9ER62), TNR23_MOUSE (Q9ER63), 
TNR25_HUMAN (Q93038), TNR26_MOUSE (P83626), TNR27_HUMAN (Q9HAV5), 
TNR27_MOUSE (Q8BX35), TNR3_HUMAN  (P36941), TNR3_MOUSE  (P50284), 
TNR4_HUMAN  (P43489), TNR4_MOUSE  (P47741), TNR4_RAT    (P15725), 
TNR5_BOVIN  (Q28203), TNR5_CALJA  (Q3LRP1), TNR5_CANFA  (Q7YRL5), 
TNR5_HORSE  (Q3ZTK5), TNR5_HUMAN  (P25942), TNR5_MOUSE  (P27512), 
TNR5_PIG    (Q8SQ34), TNR6_BOVIN  (P51867), TNR6_CERAT  (Q9BDN4), 
TNR6_HUMAN  (P25445), TNR6_MACFA  (Q9TSN4), TNR6_MACMU  (Q9BDP2), 
TNR6_MACNE  (Q9BDN0), TNR6_MOUSE  (P25446), TNR6_PIG    (O77736), 
TNR6_RAT    (Q63199), TNR8_HUMAN  (P28908), TNR8_MOUSE  (Q60846), 
TNR9_HUMAN  (Q07011), TNR9_MOUSE  (P20334), TR10A_HUMAN (O00220), 
TR10B_HUMAN (O14763), TR10B_MOUSE (Q9QZM4), TR10C_HUMAN (O14798), 
TR10D_HUMAN (Q9UBN6), TR11B_BOVIN (A5D7R1), TR11B_HUMAN (O00300), 
TR11B_MOUSE (O08712), TR11B_RAT   (O08727), TR13B_HUMAN (O14836), 
UL144_HCMVM (F5HAM0), UL144_HCMVO (Q68396), USP3_PINMG  (H2A0M8), 
VT2_MYXVL   (P29825), VT2_RFVKA   (P25943)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
ACCR2_ARATH (O80963), C22L_VACCC  (P21106), CRI4_MAIZE  (O24585), 
EDAR_HUMAN  (Q9UNE0), EDAR_MOUSE  (Q9R187), EDAR_ORYLA  (Q90VY2), 
TNR12_HUMAN (Q9NP84), TNR12_MOUSE (Q9CR75), TNR17_HUMAN (Q02223), 
TNR17_MOUSE (O88472), TNR18_HUMAN (Q9Y5U5), TNR18_MOUSE (O35714), 
TNR8_RAT    (P97525), TR13B_MOUSE (Q9ET35), TR13C_HUMAN (Q96RJ3), 
TR13C_MOUSE (Q9D8D0), TR19L_HUMAN (Q969Z4), TR19L_MACFA (Q9N092), 
TR19L_MOUSE (Q8BX43)
False positive hits (sequences which do not belong to the set under consideration):
DEFI8_DROME (Q9VTT9), EPI1_CAEEL  (Q21313), IGFR1_BOVIN (A5PJC7), 
KR134_CEBAP (Q4W7G7), KR134_HYLAG (Q4W7H1), KR134_HYLLA (Q4W7H0), 
KR134_MACFA (Q4W7G9), KR134_MACFU (Q4W7G8), KRA21_HUMAN (Q9BYU5), 
KRA22_HUMAN (Q9BYT5), KRA43_HUMAN (Q9BYR4), KRA44_HUMAN (Q9BYR3), 
KRA45_HUMAN (Q9BYR2), KRA47_HUMAN (Q9BYR0), KRA49_HUMAN (Q9BYQ8), 
KRA59_HUMAN (P26371), LAMA5_HUMAN (O15230), LAMA5_MOUSE (Q61001), 
M1BL1_HUMAN (P0DM35), MDFI_HUMAN  (Q99750), MEDEA_ARATH (O65312), 
MT4_HUMAN   (P47944), TRI42_HUMAN (Q8IWZ5), TRI42_MOUSE (Q9D2H5), 
UL32_EHV2   (Q66671), YL264_MIMIV (Q5UPU7), YL724_MIMIV (Q5UNX6)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]		 1BZI; 1CDF; 1D0G; 1D4V; 1DU3; 1EXT; 1FT4; 1JMA; 1NCF; 1SG1; 1TNR; 1ZA3; 2AW2; 2H9G; 2HEV; 2HEY; 3ALQ; 3BUK; 3IJ2; 3K51; 3ME2; 3ME4; 3MHD; 3MI8; 3QBQ; 3QD6; 3QO4; 3TJE; 3U3P; 3U3Q; 3U3S; 3U3T; 3U3V; 3URF; 4E4D; 4FHQ; 4GIQ; 4I9X; 4J6G;

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